Acute, short-term hypercapnia improves microvascular oxygenation of the colon in an animal model of sepsis

Microvascular Research

Volumn 90, Issue , 2013, Pages 180-186

  Stübs, Charlotte C M ^a   Picker, Olaf ^a   Schulz, Jan ^a   Obermiller, Katja ^a   Barthel, Franziska ^a   Hahn, Anna Maria ^a   Bauer, Inge ^a   Beck, Christopher ^a  

^a UNIVERSITY HOSPITAL DÜSSELDORF   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON DIOXIDE; CYTOKINE; INTERLEUKIN 10; INTERLEUKIN 6; TROMETAMOL; TUMOR NECROSIS FACTOR ALPHA;

ACIDOSIS; ANALYTIC METHOD; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL CARBON DIOXIDE TENSION; ARTERIAL GAS; ARTICLE; ARTIFICIAL VENTILATION; ASCENDING COLON; CLINICAL EFFECTIVENESS; COLON BLOOD FLOW; CYTOKINE RESPONSE; HYPERCAPNIA; MALE; MICROCIRCULATION; NONHUMAN; OXYGENATION; PRIORITY JOURNAL; RAT; SEPSIS; SHAM PROCEDURE; SPLANCHNIC BLOOD FLOW; TISSUE REFLECTANCE SPECTROPHOTOMETRY;

ANIMALIA; RATTUS NORVEGICUS;

ACIDOSIS; ACUTE DISEASE; ANIMALS; CARBON DIOXIDE; COLON; DISEASE MODELS, ANIMAL; HYPERCAPNIA; INFLAMMATION MEDIATORS; INTERLEUKIN-10; INTERLEUKIN-6; MALE; MICROCIRCULATION; OXYGEN; PARTIAL PRESSURE; RATS; RATS, WISTAR; SEPSIS; SPLANCHNIC CIRCULATION; TIME FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84888427683     PISSN: 00262862     EISSN: 10959319     Source Type: Journal    
DOI: 10.1016/j.mvr.2013.07.008     Document Type: Article

References (41)

1. Akca O., et al. Hypercapnia improves tissue oxygenation. Anesthesiology 2002, 97:801-806.
2. Andersson A., et al. Gut microcirculatory and mitochondrial effects of hyperdynamic endotoxaemic shock and norepinephrine treatment. British 2012, 108:254-261.
3. Balestra G.M., et al. Microcirculation and mitochondria in sepsis: getting out of breath. Curr. Opin. Anaesthesiol. 2009, 22:184-190.
4. Beaudin A.E., et al. Cerebral and myocardial blood flow responses to hypercapnia and hypoxia in humans. Am. J. Physiol. Heart Circ. Physiol. 2011, 301:H1678-H1686.
5. Boerma E.C., et al. Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis. Crit. Care Med. 2007, 19:19.
6. Clark J.A., Coopersmith C.M. Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness. Shock 2007, 28:384-393.
7. Contreras M., et al. Hypercapnic acidosis attenuates ventilation-induced lung injury by a nuclear factor-kappaB-dependent mechanism. Crit. Care Med. 2012, 40:2622-2630.
8. De Backer D., et al. Microvascular blood flow is altered in patients with sepsis. Am. J. Respir. Crit. Care Med. 2002, 166:98-104.
9. De Backer D., et al. Microcirculatory alterations in patients with severe sepsis: impact of time of assessment and relationship with outcome. Crit. Care Med. 2013, 41:791-799.
10. Farquhar I., et al. Decreased capillary density in vivo in bowel mucosa of rats with normotensive sepsis. J. Surg. Res. 1996, 61:190-196.
11. Fechner G., et al. Modified spectrometry (O2C device) of intraoperative microperfusion predicts organ function after kidney transplantation: a pilot study. Transplant. Proc. 2009, 41:3575-3579.
12. Gandjbakhche A.H., et al. Visible-light photon migration through myocardium in vivo. Am. J. Physiol. 1999, 277:H698-H704.
13. Giunti C., et al. Effect of tris-hydroxymethyl aminomethane on intracellular pH õdepends on the extracellular non-bicarbonate buffering capacity. Transl. Res. 2007, 150:350-356.
14. Gnaegi A., et al. Moderate hypercapnia exerts beneficial effects on splanchnic energy metabolism during endotoxemia. Intensive Care Med. 2009, 35:1297-1304.
15. Higgins B.D., et al. Differential effects of buffered hypercapnia versus hypercapnic acidosis on shock and lung injury induced by systemic sepsis. Anesthesiology 2009, 111:1317-1326.
16. Ince C. The microcirculation is the motor of sepsis. Crit. Care 2005, 9:S13-S19.
17. 2 on cytokine concentrations in endotoxin-stimulated human whole blood. Crit. Care Med. 2008, 36:2823-2827.
18. Komori M., et al. Permissive range of hypercapnia for improved peripheral microcirculation and cardiac output in rabbits. Crit. Care Med. 2007, 35:2171-2175.
19. Krug A. Mikrozirkulation und Sauerstoffversorgung des Gewebes, Methode des so genannten O2C (oxygen to see). Phlebologie 2007, 36:300-312.
20. Laffey J.G., et al. Buffering hypercapnic acidosis worsens acute lung injury. Am. J. Respir. Crit. Care Med. 2000, 161:141-146.
21. Laffey J.G., et al. Hypercapnic acidosis attenuates endotoxin-induced acute lung injury. Am. J. Respir. Crit. Care Med. 2004, 169:46-56.
22. Lustig M.K., et al. Colon ascendens stent peritonitis-a model of sepsis adopted to the rat: physiological, microcirculatory and laboratory changes. Shock 2007, 28:59-64.
23. Maier S., et al. Cecal ligation and puncture versus colon ascendens stent peritonitis: two distinct animal models for polymicrobial sepsis. Shock 2004, 21:505-511.
24. Morisaki H., et al. Hypercapnic acidosis minimizes endotoxin-induced gut mucosal injury in rabbits. Intensive Care Med. 2009, 35:129-135.
25. Morris G.P., et al. Hapten-induced model of chronic inflammation and ulceration in the rat colon. Gastroenterology 1989, 96:795-803.
26. + channels in parenchymal microvessels of the rat cerebral cortex. Anesthesiology 2003, 99:1333-1339.
27. Nichol A.D., et al. Infection-induced lung injury is worsened after renal buffering of hypercapnic acidosis. Crit. Care Med. 2009, 37:2953-2961.
28. Nomura F., et al. Effects of hypercarbic acidotic reperfusion on recovery of myocardial function after cardioplegic ischemia in neonatal lambs. Circulation 1994, 90:II321-II327.
29. Norozian F.M., et al. Therapeutic hypercapnia enhances the inflammatory response to endotoxin in the lung of spontaneously breathing rats. Crit. Care Med. 2011, 39:1400-1406.
30. O'Croinin D.F., et al. Sustained hypercapnic acidosis during pulmonary infection increases bacterial load and worsens lung injury. Crit. Care Med. 2008, 36:2128-2135.
31. O'Toole D., et al. Hypercapnic acidosis attenuates pulmonary epithelial wound repair by an NF-kappaB dependent mechanism. Thorax 2009, 64:976-982.
32. Sakr Y. Techniques to assess tissue oxygenation in the clinical setting. Transfus. Apher. Sci. 2010, 43:79-94.
33. Sakr Y., et al. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit. Care Med. 2004, 32:1825-1831.
34. Sakr Y., et al. Characterization of buccal microvascular response in patients with septic shock. Eur. J. Anaesthesiol. 2010, 27:388-394.
35. Scheeren T.W. Monitoring the microcirculation in the critically ill patient: reflectance spectroscopy. Intensive Care Med. 2011, 37:1045-1046.
36. Schwartges I., et al. Hypercapnia induces a concentration-dependent increase in gastric mucosal oxygenation in dogs. Intensive Care Med. 2008, 34(10):1898-1906. (Oct).
37. Vannucci R.C., et al. Carbon dioxide protects the perinatal brain from hypoxic-ischemic damage: an experimental study in the immature rat. Pediatrics 1995, 95:868-874.
38. Verdant C.L., et al. Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit. Care Med. 2009, 37:2875-2881.
39. Wang X., et al. Hypercapnic acidosis activates KATP channels in vascular smooth muscles. Circ. Res. 2003, 92:1225-1232.
40. 2 selectively inhibits interleukin-6 and tumor necrosis factor expression and decreases phagocytosis in the macrophage. FASEB 2010, 24:2178-2190.
41. Wu S.Y., et al. Hypercapnic acidosis attenuates reperfusion injury in isolated and perfused rat lungs. Crit. Care Med. 2012, 40:553-559.