Techniques to assess tissue oxygenation in the clinical setting

Transfusion and Apheresis Science

Volumn 43, Issue 1, 2010, Pages 79-94

  Sakr, Yasser ^a  

^a FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; DOBUTAMINE; HEMOGLOBIN; HEMOSIDERIN;

ARTICLE; BLOOD VISCOSITY; BRAIN TUMOR; CAPNOGRAPHY; CRYOGLOBULINEMIA; ERYTHROCYTE TRANSFUSION; HUMAN; LASER DOPPLER FLOWMETRY; MICROCIRCULATION; OXYGEN CONSUMPTION; OXYGEN SATURATION; OXYGEN TRANSPORT; PLETHYSMOGRAPHY; REFLECTOMETRY; TISSUE OXYGENATION;

CELL HYPOXIA; ELECTRODES; HUMANS; LASER-DOPPLER FLOWMETRY; MICROCIRCULATION; OXYGEN; PERFUSION; SPECTROSCOPY, NEAR-INFRARED;

EID: 77955424528     PISSN: 14730502     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transci.2010.05.012     Document Type: Article

References (205)

1. Pries A.R., Neuhaus D., Gaehtgens P. Blood viscosity in tube flow: dependence on diameter and hematocrit. Am J Physiol 1992, 263:H1770-H1778.
2. Johnson P.C. Overview of the microcirculation. Handbook of physiology: microcirculation 2002, xi-xxiv. Elsevier Science, Oxford. R.F. Tuma, V.N. Duran, K. Ley (Eds.).
3. De Backer D., Creteur J., Dubois M.J., Sakr Y., Koch M., Verdant C., et al. The effects of dobutamine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 2006, 34:403-408.
4. De Backer D., Creteur J., Preiser J.C., Dubois M.J., Vincent J.L. Microvascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002, 166:98-104.
5. De Backer D., Dubois M.J. Assessment of the microcirculatory flow in patients in the intensive care unit. Curr Opin Crit Care 2001, 7:200-203.
6. Ince C., Sinaasappel M. Microcirculatory oxygenation and shunting in sepsis and shock. Crit Care Med 1999, 27:1369-1377.
7. Christ F., Bauer A., Brugger D. Different optical methods for clinical monitoring of the microcirculation. Eur Surg Res 2002, 34:145-151.
8. Nilsson G., Lindblom P., Palmer B., Vernersson E., Aberg M. The effect of triglycyl-lysine-vasopressin (terlipressin INN, Glypressin) on skin blood flow, measured with laser Doppler flowmetry, thermography and plethysmography. A dose-response study. Scand J Plast Reconstr Surg Hand Surg 1987, 21:149-157.
9. Knotzer H., Hasibeder W.R. Microcirculatory function monitoring at the bedside - a view from the intensive care. Physiol Meas 2007, 28:R65-R86.
10. Jakobsson A., Nilsson G.E. Prediction of sampling depth and photon pathlength in laser Doppler flowmetry. Med Biol Eng Comput 1993, 31:301-307.
11. 2 clearance, and microsphere estimates of mucosal blood flow. Am J Physiol 1985, 249:G221-G227.
12. Nicholson C.D., Schmitt R.M., Wilke R. The effect of acute and chronic femoral artery ligation on the blood flow through the gastrocnemius muscle of the rat examined using laser Doppler flowmetry and xenon-133 clearance. Int J Microcirc Clin Exp 1985, 4:157-171.
13. Oberg P.A. Laser-Doppler flowmetry. Crit Rev Biomed Eng 1990, 18:125-163.
14. Tyml K., Budreau C.H. Heterogeneity of microvascular response to ischemia in skeletal muscle. Int J Microcirc Clin Exp 1988, 7:205-221.
15. Obeid A.N., Boggett D.M., Barnett N.J., Dougherty G., Rolfe P. Depth discrimination in laser Doppler skin blood flow measurement using different lasers. Med Biol Eng Comput 1988, 26:415-419.
16. Cochrane T., Sheriff S.B., Boulton A.J., Ward J.D., Atkins R.M. Laser Doppler flowmetry: in the assessment of peripheral vascular disorders? A preliminary evaluation. Clin Phys Physiol Meas 1986, 7:31-42.
17. Ubbink D.T., Jacobs M.J., Tangelder G.J., Slaaf D.W., Reneman R.S. The usefulness of capillary microscopy, transcutaneous oximetry and laser Doppler fluxmetry in the assessment of the severity of lower limb ischaemia. Int J Microcirc Clin Exp 1994, 14:34-44.
18. Belboul A., al Khaja N. The effect of protamine on the epicardial microflow and the graft flow in open-heart surgery. Perfusion 1997, 12:99-106.
19. Poschl J.M., Weiss T., Fallahi F., Linderkamp O. Reactive hyperemia of skin microcirculation in septic neonates. Acta Paediatr 1994, 83:808-811.
20. Neviere R., Mathieu D., Chagnon J.L., Lebleu N., Millien J.P., Wattel F. Skeletal muscle microvascular blood flow and oxygen transport in patients with severe sepsis. Am J Respir Crit Care Med 1996, 153:191-195.
21. Young J.D., Cameron E.M. Dynamics of skin blood flow in human sepsis. Intensive Care Med 1995, 21:669-674.
22. Luckner G., Dunser M.W., Stadlbauer K.H., Mayr V.D., Jochberger S., Wenzel V., et al. Cutaneous vascular reactivity and flow motion response to vasopressin in advanced vasodilatory shock and severe postoperative multiple organ dysfunction syndrome. Crit Care 2006, 10:R40.
23. Bocquillon N., Mathieu D., Neviere R., Lefebvre N., Marechal X., Wattel F. Gastric mucosal pH and blood flow during weaning from mechanical ventilation in patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med 1999, 160:1555-1561.
24. Neviere R., Chagnon J.L., Vallet B., Lebleu N., Marechal X., Mathieu D., et al. Dobutamine improves gastrointestinal mucosal blood flow in a porcine model of endotoxic shock. Crit Care Med 1997, 25:1371-1377.
25. Duranteau J., Sitbon P., Teboul J.L., Vicaut E., Anguel N., Richard C., et al. Effects of epinephrine, norepinephrine, or the combination of norepinephrine and dobutamine on gastric mucosa in septic shock. Crit Care Med 1999, 27:893-900.
26. Thoren A., Elam M., Ricksten S.E. Jejunal mucosal perfusion is well maintained during mild hypothermic cardiopulmonary bypass in humans. Anesth Analg 2001, 92:5-11.
27. Thoren A., Elam M., Ricksten S.E. Differential effects of dopamine, dopexamine, and dobutamine on jejunal mucosal perfusion early after cardiac surgery. Crit Care Med 2000, 28:2338-2343.
28. Gardner-Medwin J.M., Taylor J.Y., Macdonald I.A., Powell R.J. An investigation into variability in microvascular skin blood flow and the responses to transdermal delivery of acetylcholine at different sites in the forearm and hand. Br J Clin Pharmacol 1997, 43:391-397.
29. Casadevall M., Panes J., Pique J.M., Bosch J., Teres J., Rodes J. Limitations of laser-Doppler velocimetry and reflectance spectrophotometry in estimating gastric mucosal blood flow. Am J Physiol 1992, 263:G810-G815.
30. Stucker M., Steinberg J., Memmel U., Avermaete A., Hoffmann K., Altmeyer P. Differences in the two-dimensionally measured laser Doppler flow at different skin localisations. Skin Pharmacol Appl Skin Physiol 2001, 14:44-51.
31. Boyle N.H., Roberts P.C., Ng B., Berkenstadt H., McLuckie A., Beale R.J., et al. Scanning laser Doppler is a useful technique to assess foot cutaneous perfusion during femoral artery cannulation. Crit Care 1999, 3:95-100.
32. Boyle N.H., Pearce A., Hunter D., Owen W.J., Mason R.C. Intraoperative scanning laser Doppler flowmetry in the assessment of gastric tube perfusion during esophageal resection. J Am Coll Surg 1999, 188:498-502.
33. Boyle N.H., Pearce A., Hunter D., Owen W.J., Mason R.C. Scanning laser Doppler flowmetry and intraluminal recirculating gas tonometry in the assessment of gastric and jejunal perfusion during oesophageal resection. Br J Surg 1998, 85:1407-1411.
34. Essex T.J., Byrne P.O. A laser Doppler scanner for imaging blood flow in skin. J Biomed Eng 1991, 13:189-194.
35. Wardell K., Jakobsson A., Nilsson G.E. Laser Doppler perfusion imaging by dynamic light scattering. IEEE Trans Biomed Eng 1993, 40:309-316.
36. Nielsen A.N., Fabricius M., Lauritzen M. Scanning laser-Doppler flowmetry of rat cerebral circulation during cortical spreading depression. J Vasc Res 2000, 37:513-522.
37. Briers J.D. Laser Doppler, speckle and related techniques for blood perfusion mapping and imaging. Physiol Meas 2001, 22:R35-R66.
38. Cheng H., Luo Q., Liu Q., Lu Q., Gong H., Zeng S. Laser speckle imaging of blood flow in microcirculation. Phys Med Biol 2004, 49:1347-1357.
39. Dunn A.K., Bolay H., Moskowitz M.A., Boas D.A. Dynamic imaging of cerebral blood flow using laser speckle. J Cereb Blood Flow Metab 2001, 21:195-201.
40. Zaman R.T., Parthasarathy A.B., Vargas G., Chen B., Dunn A.K., Rylander H.G., et al. Perfusion in hamster skin treated with glycerol. Lasers Surg Med 2009, 41:492-503.
41. Liang Y., Fortune B., Cull G., Cioffi G.A., Wang L. Quantification of dynamic blood flow autoregulation in optic nerve head of rhesus monkeys. Exp Eye Res 2010, 90:203-209.
42. Chou N.Y., Winchester L.W. Retinal blood velocity measurements using laser speckle imaging. Conf Proc IEEE Eng Med Biol Soc 2005, 2:1716-1719.
43. Zakharov P., Volker A.C., Wyss M.T., Haiss F., Calcinaghi N., Zunzunegui C., et al. Dynamic laser speckle imaging of cerebral blood flow. Opt Express 2009, 17:13904-13917.
44. Murari K., Li N., Rege A., Jia X., All A., Thakor N. Contrast-enhanced imaging of cerebral vasculature with laser speckle. Appl Opt 2007, 46:5340-5346.
45. Hecht N., Woitzik J., Dreier J.P., Vajkoczy P. Intraoperative monitoring of cerebral blood flow by laser speckle contrast analysis. Neurosurg Focus 2009, 27:E11.
46. Siegemund M., van Bommel J., Ince C. Assessment of regional tissue oxygenation. Intensive Care Med 1999, 25:1044-1060.
47. Harris A.G., Sinitsina I., Messmer .K. The Cytoscan Model E-II, a new reflectance microscope for intravital microscopy: comparison with the standard fluorescence method. J Vasc Res 2000, 37:469-476.
48. Saetzler R.K., Jallo J., Lehr H.A., Philips C.M., Vasthare U., Arfors K.E., et al. Intravital fluorescence microscopy: impact of light-induced phototoxicity on adhesion of fluorescently labeled leukocytes. J Histochem Cytochem 1997, 45:505-513.
49. Friesenecker B., Tsai A.G., Instaglietta M. Capillary perfusion during ischemia-reperfusion in subcutaneous connective tissue and skin muscle. Am J Physiol 1994, 267:H2204-H2212.
50. Steinbauer M., Harris A.G., Abels C., Messmer K. Characterization and prevention of phototoxic effects in intravital fluorescence microscopy in the hamster dorsal skinfold model. Langenbecks Arch Surg 2000, 385:290-298.
51. Rossi D., Mansouri M., Baldovino S., Gennaro M., Naretto C., Alpa M., et al. Nail fold videocapillaroscopy in mixed cryoglobulinaemia. Nephrol Dial Transplant 2004, 19:2245-2249.
52. Morf S., Amann-Vesti B., Forster A., Franzeck U.K., Koppensteiner R., Uebelhart D., et al. Microcirculation abnormalities in patients with fibromyalgia - measured by capillary microscopy and laser fluxmetry. Arthritis Res Ther 2005, 7:R209-R216.
53. Fagrell B., Intaglietta M. Microcirculation: its significance in clinical and molecular medicine. J Intern Med 1997, 241:349-362.
54. Weinberg J.R., Boyle P., Thomas K., Murphy K., Tooke J.E., Guz A. Capillary blood cell velocity is reduced in fever without hypotension. Int J Microcirc Clin Exp 1991, 10:13-19.
55. Groner W., Winkelman J.W., Harris A.G., Ince C., Bouma G.J., Messmer K., et al. Orthogonal polarization spectral imaging: a new method for study of the microcirculation. Nat Med 1999, 5:1209-1212.
56. Sakr Y., Dubois M.J., De Backer D., Creteur J., Vincent J.L. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004, 32:1825-1831.
57. Sakr Y., Chierego M., Piagnerelli M., Verdant C., Dubois M.J., Koch M., et al. Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med 2007, 35:1639-1644.
58. Mathura K.R., Bouma G.J., Ince C. Abnormal microcirculation in brain tumours during surgery. Lancet 2001, 358:1698-1699.
59. Langer S., Hatz R., Harris A.G., Hernandez-Richter T., Maiwald G., Messmer K. Assessing the microcirculation in a burn wound by use of OPS imaging. Eur J Med Res 2001, 6:231-234.
60. Langer S., Harris A.G., Biberthaler P., von Dobschuetz E., Messmer K. Orthogonal polarization spectral imaging as a tool for the assessment of hepatic microcirculation: a validation study. Transplantation 2001, 71:1249-1256.
61. Vollebregt K.C., Boer K., Mathura K.R., de Graaff J.C., Ubbink D.T., Ince C. Impaired vascular function in women with pre-eclampsia observed with orthogonal polarisation spectral imaging. BJOG 2001, 108:1148-1153.
62. Arnold R.C., Parrillo J.E., Phillip D.R., Chansky M.E., Shapiro N.I., Lundy D.J., et al. Point-of-care assessment of microvascular blood flow in critically ill patients. Intensive Care Med 2009, 35:1761-1766.
63. Spronk P.E., Ince C., Gardien M.J., Mathura K.R., Oudemans-van Straaten H.M., Zandstra D.F. Nitroglycerin in septic shock after intravascular volume resuscitation. Lancet 2002, 360:1395-1396.
64. Buchele G.L., Silva E., Ospina-Tascon G.A., Vincent J.L., De Backer D. Effects of hydrocortisone on microcirculatory alterations in patients with septic shock. Crit Care Med 2009, 37:1341-1347.
65. Koch M., De Backer D., Vincent J.L., Barvais L., Hennart D., Schmartz D. Effects of propofol on human microcirculation. Br J Anaesth 2008, 101:473-478.
66. De Backer D., Verdant C., Chierego M., Koch M., Gullo A., Vincent J.L. Effects of drotrecogin alfa activated on microcirculatory alterations in patients with severe sepsis. Crit Care Med 2006, 34:1918-1924.
67. Ince C. The microcirculation is the motor of sepsis. Crit Care 2005, 9(Suppl. 4):S13-S19.
68. Goedhart P.T., Khalilzada M., Bezemer R., Merza J., Ince C. Sidestream Dark Field (SDF) imaging: a novel stroboscopic LED ring-based imaging modality for clinical assessment of the microcirculation. Opt Express 2007, 15:15101-15114.
69. Dubin A., Pozo M.O., Casabella C.A., Palizas F., Murias G., Moseinco M.C., et al. Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care 2009, 13:R92.
70. Boerma E.C., Koopmans M., Konijn A., Kaiferova K., Bakker A.J., van Roon E.N., et al. Effects of nitroglycerin on sublingual microcirculatory blood flow in patients with severe sepsis/septic shock after a strict resuscitation protocol: A double-blind randomized placebo controlled trial. Crit Care Med 2010, 38:93-100.
71. den Uil C.A., Lagrand W.K., Spronk P.E., van Domburg R.T., Hofland J., Luthen C., et al. Impaired sublingual microvascular perfusion during surgery with cardiopulmonary bypass: a pilot study. J Thorac Cardiovasc Surg 2008, 136:129-134.
72. De Backer D., Hollenberg S., Boerma C., Goedhart P., Buchele G., Ospina-Tascon G., et al. How to evaluate the microcirculation: report of a round table conference. Crit Care 2007, 11:R101.
73. Boerma E.C., Mathura K.R., van der Voort P.H., Spronk P.E., Ince C. Quantifying bedside-derived imaging of microcirculatory abnormalities in septic patients: a prospective validation study. Crit Care 2005, 9:R601-R606.
74. Vincent J.L. End-points of resuscitation: arterial blood pressure, oxygen delivery, blood lactate, or...?. Intensive Care Med 1996, 22:3-5.
75. Kreisberg R.A. Lactate homeostasis and lactic acidosis. Ann Intern Med 1980, 92:227-237.
76. Cohen R.D., Simpson R. Lactate metabolism. Anesthesiology 1975, 43:661-673.
77. Weil M.H., Afifi A.A. Experimental and clinical studies on lactate and pyruvate as indicators of the severity of acute circulatory failure (shock). Circulation 1970, 41:989-1001.
78. Levy B., Sadoune L.O., Gelot A.M., Bollaert P.E., Nabet P., Larcan A. Evolution of lactate/pyruvate and arterial ketone body ratios in the early course of catecholamine-treated septic shock. Crit Care Med 2000, 28:114-119.
79. Levy B., Bollaert P.E., Charpentier C., Nace L., Audibert G., Bauer P., et al. Comparison of norepinephrine and dobutamine to epinephrine for hemodynamics, lactate metabolism, and gastric tonometric variables in septic shock: a prospective, randomized study. Intensive Care Med 1997, 23:282-287.
80. Jansen T.C., van Bommel J., Bakker J. Blood lactate monitoring in critically ill patients: a systematic health technology assessment. Crit Care Med 2009, 37:2827-2839.
81. Rivers E., Nguyen B., Havstad S., Ressler J., Muzzin A., Knoblich B., et al. Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 2001, 345:1368-1377.
82. Rady M.Y., Rivers E.P., Nowak R.M. Resuscitation of the critically ill in the ED: responses of blood pressure, heart rate, shock index, central venous oxygen saturation, and lactate. Am J Emerg Med 1996, 14:218-225.
83. Blow O., Magliore L., Claridge J.A., Butler K., Young J.S. The golden hour and the silver day: detection and correction of occult hypoperfusion within 24 hours improves outcome from major trauma. J Trauma 1999, 47:964-969.
84. Rossi A.F., Khan D.M., Hannan R., Bolivar J., Zaidenweber M., Burke R. Goal-directed medical therapy and point-of-care testing improve outcomes after congenital heart surgery. Intensive Care Med 2005, 31:98-104.
85. Claridge J.A., Crabtree T.D., Pelletier S.J., Butler K., Sawyer R.G., Young J.S. Persistent occult hypoperfusion is associated with a significant increase in infection rate and mortality in major trauma patients. J Trauma 2000, 48:8-14.
86. Pearse R., Dawson D., Fawcett J., Rhodes A., Grounds R.M., Bennett E.D. Changes in central venous saturation after major surgery, and association with outcome. Crit Care 2005, 9:R694-R699.
87. Poeze M., Ramsay G., Greve J.W., Singer M. Prediction of postoperative cardiac surgical morbidity and organ failure within 4 hours of intensive care unit admission using esophageal Doppler ultrasonography. Crit Care Med 1999, 27:1288-1294.
88. Polonen P., Hippelainen M., Takala R., Ruokonen E., Takala J. Relationship between intra- and postoperative oxygen transport and prolonged intensive care after cardiac surgery: a prospective study. Acta Anaesthesiol Scand 1997, 41:810-817.
89. Routsi C., Vincent J.L., Bakker J., De Backer D., Lejeune P., d'Hollander A., et al. Relation between oxygen consumption and oxygen delivery in patients after cardiac surgery. Anesth Analg 1993, 77:1104-1110.
90. Shepherd S.J., Pearse R.M. Role of central and mixed venous oxygen saturation measurement in perioperative care. Anesthesiology 2009, 111:649-656.
91. Ander D.S., Jaggi M., Rivers E., Rady M.Y., Levine T.B., Levine A.B., et al. Undetected cardiogenic shock in patients with congestive heart failure presenting to the emergency department. Am J Cardiol 1998, 82:888-891.
92. Krafft P., Steltzer H., Hiesmayr M., Klimscha W., Hammerle A.F. Mixed venous oxygen saturation in critically ill septic shock patients. The role of defined events. Chest 1993, 103:900-906.
93. Moomey C.B., Melton S.M., Croce M.A., Fabian T.C., Proctor K.G. Prognostic value of blood lactate, base deficit, and oxygen-derived variables in an LD50 model of penetrating trauma. Crit Care Med 1999, 27:154-161.
94. Scalea T.M., Hartnett R.W., Duncan A.O., Atweh N.A., Phillips T.F., Sclafani S.J., et al. Central venous oxygen saturation: a useful clinical tool in trauma patients. J Trauma 1990, 30:1539-1543.
95. Bodad D., Muranyi L. Gastrotonometry; an aid to the control of ventilation during artificial respiration. Lancet 1959, 1:181-182.
96. 2 mixtures. J Clin Invest 1964, 43:193-200.
97. Dawson A.M., Trenchard D., Guz A. Small bowel tonometry: assessment of small gut mucosal oxygen tension in dog and man. Nature 1965, 206:943-944.
98. Fiddian-Green R.G., Baker S. Predictive value of the stomach wall pH for complications after cardiac operations: comparison with other monitoring. Crit Care Med 1987, 15:153-156.
99. 2 in intestine during low flow. J Appl Physiol 1994, 76:2443-2451.
100. Pappert D., Rossaint R., Lewandowski K., Kuhlen R., Gerlach H., Falke K.J. Preliminary evaluation of a new continuous intra-arterial blood gas monitoring device. Acta Anaesthesiol Scand Suppl 1995, 107:67-70.
101. 2 in critically ill septic patients. Intensive Care Med 1997, 23:524-529.
102. 2 tonometry: an update on physiology, methodology and clinical applications. Br J Anaesth 2000, 84:74-86.
103. Fink M.P. Gastrointestinal mucosal injury in experimental models of shock, trauma, and sepsis. Crit Care Med 1991, 19:627-641.
104. Fink M.P., Cohn S.M., Lee P.C., Rothschild H.R., Deniz Y.F., Wang H., et al. Effect of lipopolysaccharide on intestinal intramucosal hydrogen ion concentration in pigs: evidence of gut ischemia in a normodynamic model of septic shock. Crit Care Med 1989, 17:641-646.
105. 2 during peritonitis and shock. Chest 1993, 104:1254-1258.
106. Antonsson J.B., Boyle C.C., Kruithoff K.L., Wang H.L., Sacristan E., Rothschild H.R., et al. Validation of tonometric measurement of gut intramural pH during endotoxemia and mesenteric occlusion in pigs. Am J Physiol 1990, 259:G519-G523.
107. Cain S.M., Curtis S.E. Systemic and regional oxygen uptake and lactate flux in endotoxic dogs resuscitated with dextran and dopexamine or dextran alone. Circ Shock 1992, 38:173-181.
108. Kellum J.A., Rico P., Garuba A.K., Pinsky M.R. Accuracy of mucosal pH and mucosal-arterial carbon dioxide tension for detecting mesenteric hypoperfusion in acute canine endotoxemia. Crit Care Med 2000, 28:462-466.
109. Fiddian-Green R.G., Amelin P.M., Herrmann J.B., Arous E., Cutler B.S., Schiedler M., et al. Prediction of the development of sigmoid ischemia on the day of aortic operations. Indirect measurements of intramural pH in the colon. Arch Surg 1986, 121:654-660.
110. Schiedler M.G., Cutler B.S., Fiddian-Green R.G. Sigmoid intramural pH for prediction of ischemic colitis during aortic surgery. A comparison with risk factors and inferior mesenteric artery stump pressures. Arch Surg 1987, 122:881-886.
111. Fiddian-Green R.G., Stanley J.C., Nostrant T., Phillips D. Chronic gastric ischemia. A cause of abdominal pain or bleeding identified from the presence of gastric mucosal acidosis. J Cardiovasc Surg (Torino) 1989, 30:852-859.
112. Boley S.J., Brandt L.J., Veith F.J., Kosches D., Sales C. A new provocative test for chronic mesenteric ischemia. Am J Gastroenterol 1991, 86:888-891.
113. Mythen M.G., Webb A.R. The role of gut mucosal hypoperfusion in the pathogenesis of post-operative organ dysfunction. Intensive Care Med 1994, 20:203-209.
114. Landow L., Andersen L.W. Splanchnic ischaemia and its role in multiple organ failure. Acta Anaesthesiol Scand 1994, 38:626-639.
115. Sautner T., Wessely C., Riegler M., Sedivy R., Gotzinger P., Losert U., et al. Early effects of catecholamine therapy on mucosal integrity, intestinal blood flow, and oxygen metabolism in porcine endotoxin shock. Ann Surg 1998, 228:239-248.
116. Tighe D., Moss R., Bennett D. Porcine hepatic response to sepsis and its amplification by an adrenergic receptor alpha1 agonist and a beta2 antagonist. Clin Sci (Lond) 1998, 95:467-478.
117. Ruokonen E., Uusaro A., Alhava E., Takala J. The effect of dobutamine infusion on splanchnic blood flow and oxygen transport in patients with acute pancreatitis. Intensive Care Med 1997, 23:732-737.
118. Uusaro A., Ruokonen E., Takala J. Gastric mucosal pH does not reflect changes in splanchnic blood flow after cardiac surgery. Br J Anaesth 1995, 74:149-154.
119. Kiefer P., Tugtekin I., Wiedeck H., Bracht H., Geldner G., Georgieff M., et al. Effect of a dopexamine-induced increase in cardiac index on splanchnic hemodynamics in septic shock. Am J Respir Crit Care Med 2000, 161:775-779.
120. Creteur J., De Backer D., Vincent J.L. Does gastric tonometry monitor splanchnic perfusion?. Crit Care Med 1999, 27:2480-2484.
121. Meier-Hellmann A., Bredle D.L., Specht M., Hannemann L., Reinhart K. Dopexamine increases splanchnic blood flow but decreases gastric mucosal pH in severe septic patients treated with dobutamine. Crit Care Med 1999, 27:2166-2171.
122. Roumen R.M., Vreugde J.P., Goris R.J. Gastric tonometry in multiple trauma patients. J Trauma 1994, 36:313-316.
123. Bjorck M., Hedberg B. Early detection of major complications after abdominal aortic surgery: predictive value of sigmoid colon and gastric intramucosal pH monitoring. Br J Surg 1994, 81:25-30.
124. Downing A., Cottam S., Beard C., Potter D. Gastric mucosal pH predicts major morbidity following orthotopic liver transplantation. Transplant Proc 1993, 25:1804.
125. Frenette L., Doblar D.D., Singer D., Cox J., Ronderos J., Poplawski S., et al. Gastric intramural pH as indicator of early allograft viability in orthotopic liver transplantation. Transplantation 1994, 58:292-297.
126. Mythen M.G., Purdy G., Mackie I.J., McNally T., Webb A.R., Machin S.J. Postoperative multiple organ dysfunction syndrome associated with gut mucosal hypoperfusion, increased neutrophil degranulation and C1-esterase inhibitor depletion. Br J Anaesth 1993, 71:858-863.
127. Lebuffe G., Decoene C., Pol A., Prat A., Vallet B. Regional capnometry with air-automated tonometry detects circulatory failure earlier than conventional hemodynamics after cardiac surgery. Anesth Analg 1999, 89:1084-1090.
128. Bouachour G., Guiraud M.P., Gouello J.P., Roy P.M., Alquier P. Gastric intramucosal pH: an indicator of weaning outcome from mechanical ventilation in COPD patients. Eur Respir J 1996, 9:1868-1873.
129. Mohsenifar Z., Hay A., Hay J., Lewis M.I., Koerner S.K. Gastric intramural pH as a predictor of success or failure in weaning patients from mechanical ventilation. Ann Intern Med 1993, 119:794-798.
130. Marik P.E. Gastric intramucosal pH. A better predictor of multiorgan dysfunction syndrome and death than oxygen-derived variables in patients with sepsis. Chest 1993, 104:225-229.
131. Gutierrez G., Bismar H., Dantzker D.R., Silva N. Comparison of gastric intramucosal pH with measures of oxygen transport and consumption in critically ill patients. Crit Care Med 1992, 20:451-457.
132. Doglio G.R., Pusajo J.F., Egurrola M.A., Bonfigli G.C., Parra C., Vetere L., et al. Gastric mucosal pH as a prognostic index of mortality in critically ill patients. Crit Care Med 1991, 19:1037-1040.
133. Gys T., Hubens A., Neels H., Lauwers L.F., Peeters R. Prognostic value of gastric intramural pH in surgical intensive care patients. Crit Care Med 1988, 16:1222-1224.
134. Maynard N., Bihari D., Beale R., Smithies M., Baldock G., Mason R., et al. Assessment of splanchnic oxygenation by gastric tonometry in patients with acute circulatory failure. JAMA 1993, 270:1203-1210.
135. Bennett-Guerrero E., Panah M.H., Bodian C.A., Methikalam B.J., Alfarone J.R., DePerio M., et al. Automated detection of gastric luminal partial pressure of carbon dioxide during cardiovascular surgery using the Tonocap. Anesthesiology 2000, 92:38-45.
136. Pargger H., Hampl K.F., Christen P., Staender S., Scheidegger D. Gastric intramucosal pH-guided therapy in patients after elective repair of infrarenal abdominal aneurysms: is it beneficial?. Intensive Care Med 1998, 24:769-776.
137. Ivatury R.R., Simon R.J., Islam S., Fueg A., Rohman M., Stahl W.M. A prospective randomized study of end points of resuscitation after major trauma: global oxygen transport indices versus organ-specific gastric mucosal pH. J Am Coll Surg 1996, 183:145-154.
138. Barquist E., Kirton O., Windsor J., Hudson-Civetta J., Lynn M., Herman M., et al. The impact of antioxidant and splanchnic-directed therapy on persistent uncorrected gastric mucosal pH in the critically injured trauma patient. J Trauma 1998, 44:355-360.
139. Kirton O.C., Windsor J., Wedderburn R., Hudson-Civetta J., Shatz D.V., Mataragas N.R., et al. Failure of splanchnic resuscitation in the acutely injured trauma patient correlates with multiple organ system failure and length of stay in the ICU. Chest 1998, 113:1064-1069.
140. Hamilton-Davies C., Barclay G.R., Cardigan R.A., McDonald S.J., Purdy G., Machin S.J., et al. Relationship between preoperative endotoxin immune status, gut perfusion, and outcome from cardiac valve replacement surgery. Chest 1997, 112:1189-1196.
141. Duke T.D., Butt W., South M. Predictors of mortality and multiple organ failure in children with sepsis. Intensive Care Med 1997, 23:684-692.
142. Gutierrez G., Palizas F., Doglio G., Wainsztein N., Gallesio A., Pacin J., et al. Gastric intramucosal pH as a therapeutic index of tissue oxygenation in critically ill patients. Lancet 1992, 339:195-199.
143. Gomersall C.D., Joynt G.M., Freebairn R.C., Hung V., Buckley T.A., Oh T.E. Resuscitation of critically ill patients based on the results of gastric tonometry: a prospective, randomized, controlled trial. Crit Care Med 2000, 28:607-614.
144. Nakagawa Y., Weil M.H., Tang W., Sun S., Yamaguchi H., Jin X., et al. Sublingual capnometry for diagnosis and quantitation of circulatory shock. Am J Respir Crit Care Med 1998, 157:1838-1843.
145. Povoas H.P., Weil M.H., Tang W., Moran B., Kamohara T., Bisera J. Comparisons between sublingual and gastric tonometry during hemorrhagic shock. Chest 2000, 118:1127-1132.
146. 2 during hemorrhagic shock. J Appl Physiol 1998, 85:2360-2364.
147. Weil M.H., Nakagawa Y., Tang W., Sato Y., Ercoli F., Finegan R., et al. Sublingual capnometry: a new noninvasive measurement for diagnosis and quantitation of severity of circulatory shock. Crit Care Med 1999, 27:1225-1229.
148. Marik P.E. Sublingual capnography: a clinical validation study. Chest 2001, 120:923-927.
149. Marik P.E., Sibbald W.J. Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA 1993, 269:3024-3029.
150. Maciel A.T., Creteur J., Vincent J.L. Tissue capnometry: does the answer lie under the tongue?. Intensive Care Med 2004, 30:2157-2165.
151. Creteur J., De Backer D., Sakr Y., Koch M., Vincent J.L. Sublingual capnometry tracks microcirculatory changes in septic patients. Intensive Care Med 2006, 32:516-523.
152. Marik P.E., Bankov A. Sublingual capnometry versus traditional markers of tissue oxygenation in critically ill patients. Crit Care Med 2003, 31:818-822.
153. Baron B.J., Dutton R.P., Zehtabchi S., Spanfelner J., Stavile K.L., Khodorkovsky B., et al. Sublingual capnometry for rapid determination of the severity of hemorrhagic shock. J Trauma 2007, 62:120-124.
154. Lubbers D.W. Oxygen electrodes and optodes and their application in vivo. Adv Exp Med Biol 1996, 388:13-34.
155. 2 sensing needle probe. Adv Exp Med Biol 1992, 317:639-644.
156. Sinaasappel M., van Iterson M., Ince C. Microvascular oxygen pressure in the pig intestine during haemorrhagic shock and resuscitation. J Physiol 1999, 514(Pt 1):245-253.
157. 2. A way of selecting patients for hyperoxic treatment. Strahlenther Onkol 1996, 172(Suppl. 2):8-9.
158. 2 monitors. Acta Anaesthesiol Scand Suppl 1995, 104:69-74.
159. Zollinger A., Spahn D.R., Singer T., Zalunardo M.P., Stoehr S., Weder W., et al. Accuracy and clinical performance of a continuous intra-arterial blood-gas monitoring system during thoracoscopic surgery. Br J Anaesth 1997, 79:47-52.
160. Menzel M., Soukup J., Henze D., Engelbrecht K., Senderreck M., Scharf A., et al. Experiences with continuous intra-arterial blood gas monitoring: precision and drift of a pure optode-system. Intensive Care Med 2003, 29:2180-2186.
161. Hopf H.W., Hunt T.K. Comparison of Clark electrode and optode for measurement of tissue oxygen tension. Adv Exp Med Biol 1994, 345:841-847.
162. Rolfe P. In vivo near-infrared spectroscopy. Annu Rev Biomed Eng 2000, 2:715-754.
163. Temmesfeld-Wollbruck B., Szalay A., Mayer K., Olschewski H., Seeger W., Grimminger F. Abnormalities of gastric mucosal oxygenation in septic shock: partial responsiveness to dopexamine. Am J Respir Crit Care Med 1998, 157:1586-1592.
164. Wong N.W., Bondoc E.M., Banez V.P., Hsu R., Leung J.W., Nicholls M.G., et al. Reproducible demonstration of blood flow at duodenal ulcer margins by endoscopic reflectance spectrophotometry. Gastrointest Endosc 1991, 37:455-459.
165. Machens H.G., Pallua N., Mailaender P., Pasel J., Frank K.H., Reimer R., et al. Measurements of tissue blood flow by the hydrogen clearance technique (HCT): a comparative study including laser Doppler flowmetry (LDF) and the Erlangen micro-lightguide spectrophotometer (EMPHO). Microsurgery 1995, 16:808-817.
166. Wolff K.D., Marks C., Uekermann B., Specht M., Frank K.H. Monitoring of flaps by measurement of intracapillary haemoglobin oxygenation with EMPHO II: experimental and clinical study. Br J Oral Maxillofac Surg 1996, 34:524-529.
167. Thum J., Caspary L., Creutzig A., Alexander K. A new method for the assessment of tissue hemoglobin oxygenation in patients with chronic venous insufficiency. Microvasc Res 1996, 51:317-326.
168. Thum J., Caspary L., Creutzig A., Stappler T., Alexander K. Non-invasive determination of dermal hemoglobin oxygenation and concentration in patients with peripheral arterial occlusive disease. Vasa 1997, 26:11-17.
169. Jobsis F.F. Noninvasive, infrared monitoring of cerebral and myocardial oxygen sufficiency and circulatory parameters. Science 1977, 198:1264-1267.
170. Simonson S.G., Piantadosi C.A. Near-infrared spectroscopy. Clinical applications. Crit Care Clin 1996, 12:1019-1029.
171. Colacino J.M., Grubb B., Jobsis F.F. Infra-red technique for cerebral blood flow: comparison with 133Xenon clearance. Neurol Res 1981, 3:17-31.
172. Edwards A.D., Wyatt J.S., Richardson C., Delpy D.T., Cope M., Reynolds E.O. Cotside measurement of cerebral blood flow in ill newborn infants by near infrared spectroscopy. Lancet 1988, 2:770-771.
173. Hongo K., Kobayashi S., Okudera H., Hokama M., Nakagawa F. Noninvasive cerebral optical spectroscopy: depth-resolved measurements of cerebral haemodynamics using indocyanine green. Neurol Res 1995, 17:89-93.
174. Bucher H.U., Edwards A.D., Lipp A.E., Duc G. Comparison between near infrared spectroscopy and 133Xenon clearance for estimation of cerebral blood flow in critically ill preterm infants. Pediatr Res 1993, 33:56-60.
175. Elwell C.E., Cope M., Edwards A.D., Wyatt J.S., Reynolds E.O., Delpy D.T. Measurement of cerebral blood flow in adult humans using near infrared spectroscopy - methodology and possible errors. Adv Exp Med Biol 1992, 317:235-245.
176. De Blasi R.A., Ferrari M., Natali A., Conti G., Mega A., Gasparetto A. Noninvasive measurement of forearm blood flow and oxygen consumption by near-infrared spectroscopy. J Appl Physiol 1994, 76:1388-1393.
177. Tateishi A., Maekawa T., Soejima Y., Sadamitsu D., Yamamoto M., Matsushita M., et al. Qualitative comparison of carbon dioxide-induced change in cerebral near-infrared spectroscopy versus jugular venous oxygen saturation in adults with acute brain disease. Crit Care Med 1995, 23:1734-1738.
178. Sapire K.J., Gopinath S.P., Farhat G., Thakar D.R., Gabrielli A., Jones J.W., et al. Cerebral oxygenation during warming after cardiopulmonary bypass. Crit Care Med 1997, 25:1655-1662.
179. Grubhofer G., Lassnigg A., Manlik F., Marx E., Trubel W., Hiesmayr M. The contribution of extracranial blood oxygenation on near-infrared spectroscopy during carotid thrombendarterectomy. Anaesthesia 1997, 52:116-120.
180. Kirkpatrick P.J., Smielewski P., Whitfield P.C., Czosnyka M., Menon D., Pickard J.D. An observational study of near-infrared spectroscopy during carotid endarterectomy. J Neurosurg 1995, 82:756-763.
181. Cooper P.G., Wilson G.J., Hardman D.T., Kawaguchi O., Huang Y.F., Martinez-Coll A., et al. Blood oxygen desaturation heterogeneity during muscle contraction recorded by near infrared spectroscopy. Adv Exp Med Biol 1997, 428:285-292.
182. Vardi M., Nini A. Near-infrared spectroscopy for evaluation of peripheral vascular disease. A systematic review of literature. Eur J Vasc Endovasc Surg 2008, 35:68-74.
183. Frangioni J.V. New technologies for human cancer imaging. J Clin Oncol 2008, 26:4012-4021.
184. Perrey S. Non-invasive NIR spectroscopy of human brain function during exercise. Methods 2008, 45:289-299.
185. Macnab A.J., Stothers L. Near-infrared spectroscopy: validation of bladder-outlet obstruction assessment using non-invasive parameters. Can J Urol 2008, 15:4241-4248.
186. Macnab A.J., Stothers L. Development of a near-infrared spectroscopy instrument for applications in urology. Can J Urol 2008, 15:4233-4240.
187. Stothers L., Shadgan B., Macnab A. Urological applications of near infrared spectroscopy. Can J Urol 2008, 15:4399-4409.
188. Stothers L., Wilkie D., Lieblich P., Wilson P. Developing a continence care centre using an urban/academic model of continence care. Can J Urol 2008, 15:4084-4090.
189. 2 in critically ill patients. Curr Opin Crit Care 2008, 14:361-366.
190. 2 in septic patients. Intensive Care Med 2007, 33:1549-1556.
191. van Bel F., Lemmers P., Naulaers G. Monitoring neonatal regional cerebral oxygen saturation in clinical practice: value and pitfalls. Neonatology 2008, 94:237-244.
192. Watkin S.L., Spencer S.A., Dimmock P.W., Wickramasinghe Y.A., Rolfe P. A comparison of pulse oximetry and near infrared spectroscopy (NIRS) in the detection of hypoxaemia occurring with pauses in nasal airflow in neonates. J Clin Monit Comput 1999, 15:441-447.
193. Fukui D., Urayama H., Tanaka K., Kawasaki S. Use of near-infrared spectroscopic measurement at the buttocks during abdominal aortic surgery. Circ J 2002, 66:1128-1131.
194. Vallet B. Vascular reactivity and tissue oxygenation. Intensive Care Med 1998, 24:3-11.
195. De Blasi R.A., Palmisani S., Alampi D., Mercieri M., Romano R., Collini S., et al. Microvascular dysfunction and skeletal muscle oxygenation assessed by phase-modulation near-infrared spectroscopy in patients with septic shock. Intensive Care Med 2005, 31:1661-1668.
196. Knotzer H., Pajk W., Dunser M.W., Maier S., Mayr A.J., Ritsch N., et al. Regional microvascular function and vascular reactivity in patients with different degrees of multiple organ dysfunction syndrome. Anesth Analg 2006, 102:1187-1193.
197. Haisjackl M., Hasibeder W., Klaunzer S., Altenberger H., Koller W. Diminished reactive hyperemia in the skin of critically ill patients. Crit Care Med 1990, 18:813-818.
198. Kurth C.D., Steven J.M., Benaron D., Chance B. Near-infrared monitoring of the cerebral circulation. J Clin Monit 1993, 9:163-170.
199. Harris D.N. Near infra-red spectroscopy. Anaesthesia 1995, 50:1015-1016.
200. Harrison D.K. Optical measurement of tissue oxygen saturation. Int J Low Extrem Wounds 2002, 1:191-201.
201. Greenfield A.D., Whitney R.J., Mowbray J.F. Methods for the investigation of peripheral blood flow. Br Med Bull 1963, 19:101-109.
202. Gamble J., Gartside I.B., Christ F. A reassessment of mercury in silastic strain gauge plethysmography for microvascular permeability assessment in man. J Physiol 1993, 464:407-422.
203. Jaap A.J., Shore A.C., Gartside I.B., Gamble J., Tooke J.E. Increased microvascular fluid permeability in young type 1 (insulin-dependent) diabetic patients. Diabetologia 1993, 36:648-652.
204. Christ F., Gamble J., Gartside I.B., Kox W.J. Increased microvascular water permeability in patients with septic shock, assessed with venous congestion plethysmography (VCP). Intensive Care Med 1998, 24:18-27.
205. Ando S., Imaizumi T., Harada S., Hirooka Y., Takeshita A. Atrial natriuretic peptide increases human capillary filtration and venous distensibility. J Hypertens 1992, 10:451-457.