Gut microcirculatory and mitochondrial effects of hyperdynamic endotoxaemic shock and norepinephrine treatment

British Journal of Anaesthesia

Volumn 108, Issue 2, 2012, Pages 254-261

  Andersson, A ^a,b   Rundgren, M ^d   Kalman, S ^a,b   Rooyackers, O ^a,b   Brattstrom, O ^c   Oldner, A ^c   Eriksson, S ^d   Frithiof, R ^d  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Department for Clinical Science Intervention and Technology ^*  (Sweden)

^c Department of Physiology and Pharmacology   (Sweden)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

laser Doppler; perfusion pressure; sepsis; sheep; sidestream dark field imaging

Indexed keywords

ENDOTOXIN; NORADRENALIN;

ACIDOSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENDOTOXEMIA; INTESTINE BIOPSY; MICROCIRCULATION; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK; SHEEP; TONOMETRY; VIDEO MICROSCOPY;

EID: 84856279677     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aer379     Document Type: Article

References (38)

1. De Backer D, Creteur J, Preiser JC, Dubois MJ, Vincent JL. Micro-vascular blood flow is altered in patients with sepsis. Am J Respir Crit Care Med 2002; 166: 98-104 (Pubitemid 34693970)
2. Carré JE, Singer M. Cellular energetic metabolism in sepsis: the need for a systems approach. Biochim Biophys Acta 2008; 1777: 763-71
3. Sakr Y, Dubois MJ, De Backer D, Creteur J, Vincent JL. Persistent microcirculatory alterations are associated with organ failure and death in patients with septic shock. Crit Care Med 2004; 32: 1825-31 (Pubitemid 39202356)
4. Brealey D, Brand M, Hargreaves I, et al. Association between mito-chondrial dysfunction and severity and outcome of septic shock. Lancet 2002; 360: 219-23 (Pubitemid 34804650)
5. De Backer D, Creteur J, Dubois MJ, et al. The effects of dobuta-mine on microcirculatory alterations in patients with septic shock are independent of its systemic effects. Crit Care Med 2006; 34: 403-8 (Pubitemid 43145619)
6. Andersson A, Fenhammar J, Weitzberg E, Sollevi A, Hjelmqvist H, Frithiof R. Endothelin-mediated gut microcirculatory dysfunction during porcine endotoxaemia. Br J Anaesth 2010; 105: 640-7
7. Dellinger RP, Levy MM, Carlet JM, et al. Surviving sepsis campaign: international guidelines for management of severe sepsis and septic shock: 2008. Intensive Care Med 2008; 34: 17-60
8. Krejci V, Hiltebrand LB, Sigurdsson GH. Effects of epinephrine, nor-epinephrine, and phenylephrine on microcirculatory blood flow in the gastrointestinal tract in sepsis. Crit Care Med 2006; 34: 1456-63
9. Jhanji S, Stirling S, Patel N, Hinds CJ, Pearse RM. The effect of increasing doses of norepinephrine on tissue oxygenation and microvascular flow in patients with septic shock. Crit Care Med 2009; 37: 1961-6
10. Dubin A, Pozo MO, Casabella CA, et al. Increasing arterial blood pressure with norepinephrine does not improve microcirculatory blood flow: a prospective study. Crit Care 2009; 13: R92
11. Boerma EC, van der Voort PH, Spronk PE, Ince C. Relationship between sublingual and intestinal microcirculatory perfusion in patients with abdominal sepsis. Crit Care Med 2007; 35: 1055-6
12. Dubin A, Edul VS, Pozo MO, et al. Persistent villi hypoperfusion explains intramucosal acidosis in sheep endotoxaemia. Crit Care Med 2008; 36: 535-42 (Pubitemid 351158630)
13. Verdant CL, De Backer D, Bruhn A, et al. Evaluation of sublingual and gut mucosal microcirculation in sepsis: a quantitative analysis. Crit Care Med 2009; 37: 2875-81
14. Nakajima Y, Baudry N, Duranteau J, Vicaut E. Microcirculation in intestinal villi: a comparison between hemorrhagic and endo-toxin shock. Am J Respir Crit Care Med 2001; 164: 1526-30 (Pubitemid 33124038)
15. Clark JA, Coopersmith CM. Intestinal crosstalk: a new paradigm for understanding the gut as the "motor" of critical illness. Shock 2007; 28: 384-93 (Pubitemid 47421846)
16. Treggiari MM, Romand JA, Burgener D, Suter PM, Aneman A. Effect of increasing norepinephrine dosage on regional blood flow in a porcinemodelofendotoxinshock.CritCareMed2002;30:1334-39 (Pubitemid 34620981)
17. Revelly JP, Liaudet L, Frascarolo P, Joseph JM, Martinet O, Markert M. Effects of norepinephrine on the distribution of intestinal blood flow and tissue adenosine triphosphate content in endotoxic shock. Crit Care Med 2000; 28: 2500-6 (Pubitemid 30604460)
18. Nakajima Y, Baudry N, Duranteau J, Vicaut E. Effects of vasopres-sin, norepinephrine, and L-arginine on intestinal microcirculation in endotoxaemia. Crit Care Med 2006; 34: 1752-7 (Pubitemid 43810059)
19. Schmidt W, Schweppenhäuser W, Secchi A, Gebhard MM, Martin E, Schmidt H. Influence of epinephrine and norepinephrine on intestinal villous blood flow during endotoxaemia. J Crit Care 1999; 14: 99-105 (Pubitemid 29278268)
20. Krouzecky A, Matejovic M, Radej J, Rokyta R Jr, Novak I. Perfusion pressure manipulation in porcine sepsis: effects on intestinal haemodynamics. Physiol Res 2006; 55: 527-33 (Pubitemid 44611197)
21. NaculFE, Guia IL, Lessa MA, Tibiriçá E.The effectsofvasoactive drugs on intestinal functional capillary density in endotoxemic rats: intra-vital video-microscopy analysis. Anesth Analg 2010; 110: 547-54
22. De Backer D, Hollenberg S, Boerma C, et al. How to evaluate the microcirculation: report of a round table conference. Crit Care 2007; 11: R101
23. Trzeciak S, Dellinger RP, Parrillo JE, et al. Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to haemodynamics, oxygen transport, and survival. Ann Emerg Med 2007; 49: 88-98.
24. Fredriksson K, Hammarqvist F, Strigard K, et al. Derangements in mitochondrial metabolism in intercostal and leg muscle of critically ill patients with sepsis induced multiple organ failure. Am J Physiol Endocrinol Metab 2006; 291: E1044-50
25. Fredriksson K, Tjader I, Keller P, et al. Dysregulation of mitochon-drial dynamics and the muscle transcriptome in ICU patients suffering from sepsis induced multiple organ failure. PLoS ONE 2008; 3: e3686
26. Ince C. The microcirculation is the motor of sepsis. Crit Care 2005; 9: S13-9 (Pubitemid 41498527)
27. Fredriksson K, Rooyackers O. Mitochondrial function in sepsis: respiratory versus leg muscle. Crit Care Med 2007; 35: S449-53 (Pubitemid 47312178)
28. Ahlbeck K, Fredriksson K, Rooyackers O, et al. Signs of critical illness polyneuropathy and myopathy can be seen early in the ICU course. Acta Anaesthesiol Scand 2009; 53: 717-23
29. Crouser ED, Julian MW, Blaho DV, Pfeiffer DR. Endotoxin-induced mitochondrial damage correlates with impaired respiratory activity. Crit Care Med 2002; 30: 276-84 (Pubitemid 34158107)
30. Protti A, Carré J, Frost MT, et al. Succinate recovers mitochondrial oxygen consumption in septic rat skeletal muscle. Crit Care Med 2007; 35: 2150-5 (Pubitemid 47326453)
31. Piel DA, Gruber PJ, Weinheimer CJ, et al. Mitochondrial resuscitation with exogenous cytochrome c in the septic heart. Crit Care Med 2007; 35: 2120-7 (Pubitemid 47326449)
32. Porta F, Takala J, Weikert C, et al. Effects of prolonged endotoxae-mia on liver, skeletal muscle and kidney mitochondrial function. Crit Care 2006; 10: R118
33. Wu LL, Tang C, Liu MS. Hyper-and hypocardiodynamic states are associated with externalization and internalization, respectively, of alpha-adrenergic receptors in rat heart during sepsis. Shock 1997; 7: 318-23 (Pubitemid 127654287)
34. Tang C, Liu MS. Initial externalization followed by internalization of beta-adrenergic receptors in rat heart during sepsis. Am J Physiol 1996; 270: R254-63
35. Creteur J, De Backer D, Sakr Y, Koch M, Vincent JL. Sublingual capnometry tracks microcirculatory changes in septic patients. Intensive Care Med 2006; 32: 516-23
36. Crissinger KD, Kvietys PR, Granger DN. Autoregulatory escape from norepinephrine infusion: roles of adenosine and histamine. Am J Physiol 1988; 254: G560-5
37. Regueira T, Bänziger B, Djafarzadeh S, et al. Norepinephrine to increase blood pressure in endotoxaemic pigs is associated with improved hepatic mitochondrial respiration. Crit Care 2008; 12: R88
38. Hiltebrand LB, Krejci V, Banic A, Erni D, Wheatley AM, Sigurdsson GH. Dynamic study of the distribution of microcircula-tory blood flow in multiple splanchnic organs in septic shock. Crit Care Med 2000; 28: 3233-41