Cationic eluate pretreatment for automated synthesis of [68Ga]CPCR4.2

Nuclear Medicine and Biology

Volumn 41, Issue 1, 2014, Pages 84-89

  Martin, René ^a   Jüttler, Steffen ^a   Müller, Marco ^a   Wester, Hans Jürgen ^b  

^a ABX Advanced Biochemical Compounds GmbH   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Automated production; Cationic purification; Gallium; Generator; Peptides

Indexed keywords

GALLIUM CPCR4.2 GA 68; GALLIUM DOTANOC GA 68; GALLIUM DOTATATE GA 68; GALLIUM TRAP(RGD)3 GA 68; RADIOISOTOPE; TRACER; UNCLASSIFIED DRUG;

ARTICLE; CATION EXCHANGE; CONCENTRATION RESPONSE; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ELUTION; EXTRACTION; ISOTOPE LABELING; PROCESS DEVELOPMENT; PROCESS OPTIMIZATION; RADIOISOTOPE DECAY;

AUTOMATED PRODUCTION; CATIONIC PURIFICATION; GALLIUM; GENERATOR; PEPTIDES;

AUTOMATION; CHEMISTRY TECHNIQUES, SYNTHETIC; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; GALLIUM RADIOISOTOPES; PEPTIDES;

EID: 84888384433     PISSN: 09698051     EISSN: 18729614     Source Type: Journal    
DOI: 10.1016/j.nucmedbio.2013.09.002     Document Type: Article

References (29)

1. Prata I.M. Gallium-68: a new trend in PET radiopharmacy. Curr Radiopharm 2012, 108:142-149.
2. 68Ga radiopharmaceutical chemistry. Curr Top Med Chem 2010, 10:1633-1668.
3. Schottelius M., Wester H.J. Molecular imaging targeting peptide receptors. Methods 2009, 48:161-177.
4. 4 solutions. J Chromatogr A 1964, 13:503-535.
5. Saito N. Selected data on ion exchange separations in radioanalytical chemistry. Pure Appl Chem 1984, 56:523-539.
6. 68Ga for medical application. J Nucl Med 2007, 48:1741-1748.
7. 68Ga-labelled DOTA-derivatised peptide ligands. Eur J Nucl Med Mol Imaging 2004, 31:1097-1104.
8. 68Ga. Eur J Nucl Med Mol Imaging 2005, 32:478-485.
9. 68Ga radiopharmaceuticals in high radiochemical purity. Bioconjugate Chem 2012, 23:1712-1717.
10. Wang Y., Luther K. Genetically manipulated progenitor/stem cells restore function to the infarcted heart via the SDF-1α/CXCR4 signaling pathway. Prog Mol Biol Transl Sci 2012, 111:265-284.
11. Feng Y., Broder C.C., Kennedy P.E., Berger E.A. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane. G Protein-Coupled Receptor. Science 1996, 272:872-877.
12. Schultz M.K., Mueller D., Baum R.P., Watkins G.L., Breeman W.A. A new automated NaCl based robust method for routine production of gallium-68 labeled peptides. Appl Radiat Isot 2013, 76:46-54.
13. 68Ga-labeled highly specific targeted contrast agent. J Nucl Med 2011, 52:1803-1810.
14. Demmer O., Frank A.O., Hagn F., Schottelius M., Marinelli L., Cosconati S., et al. A conformationally frozen peptoid boosts CXCR4 affinity and anti-HIV activity. Angew Chem Int Ed Engl 2012, 51:8110-8113.
15. Demmer O., Dijkgraaf I., Schumacher U., Marinelli L., Cosconati S., Gourni E., et al. Design, synthesis, and functionalization of dimeric peptides targeting chemokine receptor CXCR4. J Med Chem 2011, 54:7648-7662.
16. Demmer O., Gourni E., Schumacher U., Kessler H., Wester H.J. PET imaging of CXCR4 receptors in cancer by a new optimized ligand. ChemMedChem 2011, 6:1789-1791.
17. 68Ga generator and aspects of radiolabelling DOTA-peptides. Appl Radiat Isot 2011, 69:308-315.
18. Anderegg G., Arnaud-Neu F., Delgado R., Felcman J., Popov K. Critical evaluation of stability constants of metal complexes of complexones for biomedical and environmental applications. Pure Appl Chem 2005, 77:1445-1495.
19. Notni J., Šiměcek J., Hermann P., Wester H.J. TRAP, a powerful and versatile framework for gallium-68 radiopharmaceuticals. Chem Eur J 2011, 17:14718-14722.
20. Šimeček J., Zemek O., Hermann P., Wester H.J., Notni J. A monoreactive bifunctional triazacyclononane phosphinate chelator with high selectivity for gallium-68. ChemMedChem 2012, 7:1375-1378.
21. 68Ga generator eluates?. ChemMedChem 2013, 8:95-103.
22. Notni J., Pohle K., Wester H.J. Comparative gallium-68 labeling of TRAP-, NOTA-, and DOTA-peptides: practical consequences for the future of gallium-68-PET. EJNMMI Res 2012, 2:28-32.
23. 3. Nucl Med Biol 2013, 40:33-41.
24. Šiměcek J., Schulz M., Notni J., Plutnar J., Kubíček V., Havlíčková J., et al. Complexation of metal ions with TRAP (1,4,7-triazacyclononane-phosphinic acid) ligands and 1,4,7-triazacyclononane-1,4,7-triacetic acid: phosphinate-containing ligands as unique chelators for trivalent gallium. Inorg Chem 2011, 51:577-590.
25. Eder M., Schäfer M., Bauder-Wüst U., Hull W.E., Wängler C., Mier W., et al. 68Ga-complex lipophilicity and the targeting property of a urea-based PSMA inhibitor for PET imaging. Bioconjug Chem 2012, 23:688-697.
26. Afshar-Oromieh A., Malcher A., Eder M., Eisenhut M., Linhart H.G., Hadaschik B.A., et al. PET imaging with a [68Ga]gallium-labelled PSMA ligand for the diagnosis of prostate cancer: biodistribution in humans and first evaluation of tumour lesions. Eur J Nucl Med Mol Imaging 2013, 40:486-495.
27. Brogsitter C, Schottelius M, Zöphel K, Kotzerke J, Wester HJ. Twins in spirit: DOTATATE and high-affinity-DOTATATE. Eur J Nucl Med Mol Imaging. 2013 [Epub ahead of print] PubMed PMID: 23963295.
28. Brogsitter C, Schottelius M, Zöphel K, Kotzerke J, Wester HJ. Erratum to: Twins in spirit: DOTATATE and high-affinity DOTATATE. Eur J Nucl Med Mol Imaging. 2013. [Epub ahead of print] PubMed PMID: 24057458.
29. Brogsitter C, Zöphel K, Hartmann H, Schottelius M, Wester HJ, Kotzerke J. Twins in Spirit Part II: DOTATATE and High Affinity DOTATATE - the Clinical Experience (submitted).