Genetically manipulated progenitor/stem cells restore function to the infarcted heart via the SDF-1α/CXCR4 signaling pathway

Progress in Molecular Biology and Translational Science

Volumn 111, Issue , 2012, Pages 265-284

  Wang, Yigang ^a   Luther, Kristin ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Cell mobilization; Myocardial infarction; Progenitor stem cells; SDF 1 CXCR4

Indexed keywords

EID: 84865324291     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-398459-3.00012-5     Document Type: Chapter

References (72)

1. T. Nagasawa, H. Kikutani, and T. Kishimoto Molecular cloning and structure of a pre-B-cell growth-stimulating factor Proc Natl Acad Sci USA 91 1994 2305 2309 (Pubitemid 24092092)
2. K. Tashiro, H. Tada, R. Heilker, M. Shirozu, T. Nakano, and T. Honjo Signal sequence trap: a cloning strategy for secreted proteins and type I membrane proteins Science 261 1993 600 603 (Pubitemid 23278369)
3. K.C. Koch, W.M. Schaefer, E.A. Liehn, C. Rammos, D. Mueller, and J. Schroeder Effect of catheter-based transendocardial delivery of stromal cell-derived factor 1alpha on left ventricular function and perfusion in a porcine model of myocardial infarction Basic Res Cardiol 101 2006 69 77 (Pubitemid 43323434)
4. M. Kucia, K. Jankowski, R. Reca, M. Wysoczynski, L. Bandura, and D.J. Allendorf CXCR4-SDF-1 signaling, locomotion, chemotaxis and adhesion J Mol Histol 35 2004 233 245 (Pubitemid 40585309)
5. J.D. Abbott, Y. Huang, D. Liu, R. Hickey, D.S. Krause, and F.J. Giordano Stromal cell-derived factor-1alpha plays a critical role in stem cell recruitment to the heart after myocardial infarction but is not sufficient to induce homing in the absence of injury Circulation 110 2004 3300 3305 (Pubitemid 39557491)
6. Y. Wang, H. Haider, N. Ahmad, D. Zhang, and M. Ashraf Evidence for ischemia induced host-derived bone marrow cell mobilization into cardiac allografts J Mol Cell Cardiol 41 2006 478 487 (Pubitemid 44349132)
7. Y.L. Tang, W. Zhu, M. Cheng, L. Chen, J. Zhang, and T. Sun Hypoxic preconditioning enhances the benefit of cardiac progenitor cell therapy for treatment of myocardial infarction by inducing CXCR4 expression Circ Res 104 2009 1209 1216
8. T. Zhao, D. Zhang, R.W. Millard, M. Ashraf, and Y. Wang Stem cell homing and angiomyogenesis in transplanted hearts are enhanced by combined intramyocardial SDF-1α delivery and endogenous cytokine signaling Am J Physiol Heart Circ Physiol 296 2009 H976 H986
9. A. Saxena, J.E. Fish, M.D. White, S. Yu, J.W. Smyth, and R.M. Shaw Stromal cell-derived factor-1alpha is cardioprotective after myocardial infarction Circulation 117 2008 2224 2231
10. J. Kijowski, M. Baj-Krzyworzeka, M. Majka, R. Reca, L.A. Marquez, and M. Christofidou-Solomidou The SDF-1-CXCR4 axis stimulates VEGF secretion and activates integrins but does not affect proliferation and survival in lymphohematopoietic cells Stem Cells 19 2001 453 466 (Pubitemid 32900088)
11. S. Unzek, M. Zhang, N. Mal, W.R. Mills, K.R. Laurita, and M.S. Penn SDF-1 recruits cardiac stem cell like cells that depolarize in vivo Cell Transplant 16 9 2007 879 886 (Pubitemid 351448605)
12. M. Zhang, N. Mal, M. Kiedrowski, M. Chacko, A.T. Askari, and Z.B. Popovic SDF-1 expression by mesenchymal stem cells results in trophic support of cardiomyocytes after myocardial infarction FASEB J 21 2007 3197 3207 (Pubitemid 47565538)
13. Y.R. Zou, A.H. Kottmann, M. Kuroda, I. Taniuchi, and D.R. Littman Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development Nature 393 1998 595 599 (Pubitemid 28319251)
14. T. Nagasawa, S. Hirota, K. Tachibana, N. Takakura, S. Nishikawa, and Y. Kitamura Defects of B-cell lymphopoiesis and bone-marrow myelopoiesis in mice lacking the CXC chemokine PBSF/SDF-1 Nature 382 1996 635 638 (Pubitemid 26268957)
15. D. Zhang, G.C. Fan, X. Zhou, T. Zhao, Z. Pasha, and M. Xu Over-expression of CXCR4 on mesenchymal stem cells augments myoangiogenesis in the infarcted myocardium J Mol Cell Cardiol 44 2008 281 292
16. M.F. Pittenger, and B.J. Martin Mesenchymal stem cells and their potential as cardiac therapeutics Circ Res 95 2004 9 20 (Pubitemid 38931831)
17. W. Tan, D. Martin, and J.S. Gutkind The Galpha13-Rho signaling axis is required for SDF-1-induced migration through CXCR4 J Biol Chem 281 2006 39542 39549 (Pubitemid 46041914)
18. H. Gerrits, D.S. van Ingen Schenau, N.E. Bakker, A.J. van Disseldorp, A. Strik, and L.S. Hermens Early postnatal lethality and cardiovascular defects in CXCR7-deficient mice Genesis 46 2008 235 245 (Pubitemid 351961759)
19. S.F. Gilbert Developmental biology 8th ed 2006 Sinauer Associates Inc Sunderland, MA pp. 483-488
20. J.C. Kovacic, J. Moore, A. Herbert, D. Ma, M. Boehm, and R.M. Graham Endothelial progenitor cells, angioblasts, and angiogenesis - old terms reconsidered from a current perspective Trends Cardiovasc Med 18 2 2008 45 51 (Pubitemid 351282492)
21. T. Asahara, T. Murohara, and A. Sullivan Isolation of putative progenitor endothelial cells for angiogenesis Science 275 1997 964 967 (Pubitemid 27087709)
22. P.M. Vanhoutte, H. Shimokawa, E.H. Tang, and M. Feletou Endothelial dysfunction and vascular disease Acta Physiol (Oxf) 196 2 2009 193 222
23. F. Herodin, P. Bourin, J.F. Mayol, J.J. Lataillade, and M. Drouet Short-term injection of antiapoptotic cytokine combinations soon after lethal gamma-irradiation promotes survival Blood 101 2003 2609 2616 (Pubitemid 36857620)
24. M.M. Zaruba, H.D. Theiss, M. Vallaster, U. Mehl, S. Brunner, and R. David Synergy between CD26/DPP-IV inhibition and G-CSF improves cardiac function after acute myocardial infarction Cell Stem Cell 4 2009 313 323
25. R. Salcedo, K. Wasserman, H.A. Young, M.C. Grimm, O.M. Howard, and M.R. Anver Vascular endothelial growth factor and basic fibroblast growth factor induce expression of CXCR4 on human endothelial cells. In vivo neovascularization induced by stromal-derived factor-1alpha Am J Pathol 154 1999 1125 1135 (Pubitemid 29169747)
26. A.A. Mangi, N. Noiseux, D. Kong, H. He, M. Rezvani, and J.S. Ingwall Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts Nat Med 9 2003 1195 1201 (Pubitemid 37173705)
27. A. Maurel, K. Azarnoush, L. Sabbah, N. Vignier, M. Le Lorc'h, and C. Mandet Can cold or heat shock improve skeletal myoblast engraftment in infarcted myocardium? Transplantation 80 2005 660 665 (Pubitemid 41377755)
28. M. Wysoczynski, R. Reca, J. Ratajczak, M. Kucia, N. Shirvaikar, and M. Honczarenko Incorporation of CXCR4 into membrane lipid rafts primes homing-related responses of hematopoietic progenitor/stem cells to an SDF-1 gradient Blood 105 2005 40 48 (Pubitemid 40053061)
29. J. Kahn, T. Byk, L. Jansson-Sjostrand, I. Petit, S. Shivtiel, and A. Nagler Overexpression of CXCR4 on human CD34 + progenitors increases their proliferation, migration, and NOD/SCID repopulation Blood 103 2004 2942 2949 (Pubitemid 38451665)
30. A. Peled, I. Petit, O. Kollet, M. Magid, T. Ponomaryov, and T. Byk Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4 Science 283 1999 845 848
31. A. Dar, O. Kollet, and T. Lapidot Mutual, reciprocal SDF-1/CXCR4 interactions between hematopoietic and bone marrow stromal cells regulate human stem cell migration and development in NOD/SCID chimeric mice Exp Hematol 34 2006 967 975 (Pubitemid 44080383)
32. H. Sakihama, T. Masunaga, K. Yamashita, T. Hashimoto, M. Inobe, and S. Todo Stromal cell-derived factor-1 and CXCR4 interaction is critical for development of transplant arteriosclerosis Circulation 110 2004 2924 2930 (Pubitemid 39473619)
33. M. Sata, A. Saiura, A. Kunisato, A. Tojo, S. Okada, and T. Tokuhisa Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis Nat Med 8 2002 403 409 (Pubitemid 34407037)
34. A. Zernecke, A. Schober, I. Bot, P. von Hundelshausen, E.A. Liehn, and B. Mopps SDF-1alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells Circ Res 96 2005 784 791 (Pubitemid 40559518)
35. Q. Xiao, S. Ye, F. Oberhollenzer, A. Mayr, M. Jahangiri, and J. Willeit SDF1 gene variation is associated with circulating SDF1alpha level and endothelial progenitor cell number. the Bruneck Study PLoS One 3 2008 e4061
36. D.H. Walter, J. Haendeler, J. Reinhold, U. Rochwalsky, F. Seeger, and J. Honold Impaired CXCR4 signaling contributes to the reduced neovascularization capacity of endothelial progenitor cells from patients with coronary artery disease Circ Res 97 2005 1142 1151
37. A. Kaminski, N. Ma, P. Donndorf, N. Lindenblatt, G. Feldmeier, and L.L. Ong Endothelial NOS is required for SDF-1/CXCR4-mediated peripheral endothelial adhesion of c-kit + bone marrow stem cells Lab Invest 88 2008 58 69
38. P. Menasche, A. Hagege, J.T. Vilquin, M. Desnon, E. Abergel, and B. Pouzet Autologous skeletal myoblast transplantation for severe postinfarction left ventricular dysfunction J Am Coll Cardiol 41 2003 1078 1083 (Pubitemid 36384891)
39. S. Ghadge, S. Muhlstedt, C. Ozcelik, and M. Bader SDF-1α as a therapeutic stem cell homing factor in myocardial infarction Pharmacol Ther 129 2011 97 108
40. V. Shachinger, S. Erbs, A. Elasser, W. Haberbosch, R. Hambrecht, and H. Holschermann Improved clinical outcome after intracoronary administration of bone-marrow-derived progenitor cells in acute myocardial infarction: final 1-year results of the REPAIR-AMI trial Eur Heart J 27 2006 2775 2783 (Pubitemid 44871463)
41. B. Dai, W. Huang, M. Xu, R.W. Millard, M.H. Gao, and K. Hammond Reduced collagen deposition in infarcted myocardium facilitates induced pluripotent stem cell engraftment and angiomyogenesis for improvement of left ventricular function J Am Coll Cardiol 58 20 2011 2118 2127
42. H. Kita-Matsuo, M. Barcova, N. Prigozhina, N. Salomonis, K. Wei, and J.G. Jacot Lentiviral vectors and protocols for creation of stable hESC lines for fluorescent tracking and drug resistance selection of cardiomyocytes PLoS One 4 4 2009 e5046
43. W. Wojakowski, M. Kucia, E. Zuba-Surma, T. Jadczyk, B. Ksiazek, and M.Z. Ratajczak Very small embryonic-like stem cells in cardiovascular repair Pharmacol Ther 129 2011 21 28
44. W. Wojakowski, M. Tendera, M. Kucia, E. Zuba-Surma, K. Milewski, and D. Wallace-Bradley Cardiomyocyte differentiation of bone marrow-derived Oct-4+CXCR4+SSEA-1 + very small embryonic-like stem cells Int J Oncol 37 2 2010 237 247
45. E.K. Zuba-Surma, Y. Guo, H. Taher, S.K. Sanganalmath, G. Hunt, and R.J. Vincent Transplantation of expanded bone marrow-derived very small embryonic-like stem cells (VSEL-SCs) improves left ventricular function and remodelling after myocardial infarction J Cell Mol Med 15 2011 1319 1328
46. L. Benboubker, H. Watier, A. Carion, M.T. Georget, I. Desbois, and P. Colombat Association between the SDF1-3'A allele and high levels of CD34(+) progenitor cells mobilized into peripheral blood in humans Br J Haematol 113 2001 247 250 (Pubitemid 32423330)
47. + cell homing to the infarcted heart Tissue Eng 13 2007 2063 2071 (Pubitemid 47294002)
48. S. Fazel, M. Cimini, L. Liwen Chen, S. Li, D. Angoulvant, and P. Fedak Cardioprotective c-kit + cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines J Clin Invest 116 2006 1865 1877 (Pubitemid 44033311)
49. Z. Cheng, L. Ou, X. Zhou, F. Li, and X. Jia Targeted migration of mesenchymal stem cells modified with CXCR4 gene to infarcted myocardium improves cardiac performance Mol Ther 16 2008 571 579 (Pubitemid 351314998)
50. D. Zhang, W. Huang, B. Dai, T. Zhao, A. Ashraf, and R.W. Millard Genetically manipulated progenitor cell sheet with diprotin A improves myocardial function and repair of infarcted hearts Am J Physiol Heart Circ Physiol 299 2010 H1339 H1347
51. Z.A. Almsherqi, C.S. McLachlan, M.B. Slocinska, F.E. Sluse, R. Navet, and N. Kocherginsky Reduced cardiac output is associated with decreased mitochondrial efficiency in the non-ischemic ventricular wall of the acute myocardial-infarcted dog Cell Res 16 2006 297 305
52. Z. Pasha, Y. Wang, R. Sheikh, D. Zhang, T. Zhao, and M. Ashraf Preconditioning enhances cell survival and differentiation of stem cells during transplantation in infarcted myocardium Cardiovasc Res 77 2008 134 142 (Pubitemid 351195153)
53. P.M. Grossman, Z. Han, M. Palasis, J.J. Barry, and R.J. Lederman Incomplete retention after direct myocardial injection Catheter Cardiovasc Interv 55 2002 392 397 (Pubitemid 34204886)
54. M. Hofmann, K.C. Wollert, G.P. Meyer, A. Menke, L. Arseniev, and B. Hertenstein Monitoring of bone marrow cell homing into the infarcted human myocardium Circulation 111 2005 2198 2202 (Pubitemid 40632435)
55. H. Jawad, N.N. Ali, A.R. Lyon, Q.Z. Chen, S.E. Harding, and A.R. Boccaccini Myocardial tissue engineering. A review J Tissue Eng Regen Med 1 2007 327 342
56. S.A. Taheri, H. Ashraf, M. Merhige, R.S. Miletich, S. Satchidanand, and C. Malik Myoangiogenesis after cell patch cardiomyoplasty and omentopexy in a patient with ischemic cardiomyopathy Tex Heart Inst J 32 4 2005 598 601 (Pubitemid 43275804)
57. D.P. O'Leary Use of the greater omentum in colorectal surgery Dis Colon Rectum 42 1999 533 539 (Pubitemid 29183955)
58. L. O'Shaughnessy Surgical treatment of cardiac ischemia Lancet 232 1937 185 194
59. W. Huang, D. Zhang, R.W. Millard, T. Wang, T. Zhao, and G.C. Fan Gene manipulated peritoneal cell patch repairs infarcted myocardium J Mol Cell Cardiol 48 2010 702 712
60. C.S. Samuel, S. Cendrawan, X.M. Gao, Z. Ming, C. Zhao, and H. Kiriazis Relaxin remodels fibrotic healing following myocardial infarction Lab Invest 91 5 2011 675 690
61. J.R. Venugopal, M.P. Prabhakaran, S. Mukherjee, R. Ravichandran, K. Dan, and S. Ramakrishna Biomaterial strategies for alleviation of myocardial infarction J R Soc Interface 9 66 2012 1 19
62. R. Ravichandran, J.R. Venugopal, S. Sundarrajan, S. Mukherjee, and S. Ramakrishna Poly(Glycerol sebacate)/gelatin core/shell fibrous structure for regeneration of myocardial infarction Tissue Eng Part A 17 9-10 2011 1363 1373
63. A.F. Godier-Furnémont, T.P. Martens, M.S. Koeckert, L. Wan, J. Parks, and K. Arai Composite scaffold provides a cell delivery platform for cardiovascular repair Proc Natl Acad Sci USA 108 19 2011 7974 7979
64. R.T. Pyo, J. Sui, A. Dhume, J. Palomeque, B.C. Blaxall, and G. Diaz CXCR4 modulates contractility in adult cardiac myocytes J Mol Cell Cardiol 41 2006 834 844 (Pubitemid 44635574)
65. J. Chen, E. Chemaly, L. Liang, C. Kho, A. Lee, and J. Park Effects of CXCR4 gene transfer on cardiac function after ischemia-reperfusion injury Am J Pathol 176 2010 1705 1715
66. K.L. Kreutziger, and C.E. Murry Engineered human cardiac tissue Pediatr Cardiol 32 3 2011 334 341
67. S.K. Bhatia Tissue engineering for clinical applications Biotechnol J 5 12 2010 1309 1323
68. J. Cui, J. Li, M. Mathison, F. Tondato, S.P. Mulkey, and C. Micko A clinically relevant large-animal model for evaluation of tissue-engineered cardiac surgical patch materials Cardiovasc Revasc Med 6 2005 113 120 (Pubitemid 41579080)
69. M. Maeda, M. Yamato, M. Kanzaki, H. Iseki, and T. Okano Thoracoscopic cell sheet transplantation with a novel device J Tissue Eng Regen Med 3 2009 255 259
70. H.Kh. Haider, and M. Ashraf Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation J Mol Cell Cardiol 45 2008 554 566
71. V.M. Coffield, Q. Jiang, and L. Su A genetic approach to inactivating chemokine receptors using a modified viral protein Nat Biotechnol 21 2003 1321 1327 (Pubitemid 37356617)
72. J.K. Damas, T. Waehre, A. Yndestad, T. Ueland, F. Muller, and H.G. Eiken Stromal cell-derived factor-1alpha in unstable angina: potential antiinflammatory and matrix-stabilizing effects Circulation 106 2002 36 42 (Pubitemid 34747439)