A new automated NaCl based robust method for routine production of gallium-68 labeled peptides

Applied Radiation and Isotopes

Volumn 76, Issue , 2013, Pages 46-54

  Schultz, Michael K ^a   Mueller, Dirk ^b   Baum, Richard P ^b   Leonard Watkins, G ^a   Breeman, Wouter A P ^c  

^a UNIVERSITY OF IOWA   (United States)

^b ZENTRALKLINIK BAD BERKA   (Germany)

^c ERASMUS MEDICAL CENTER   (Netherlands)

Author keywords

DOTA peptides; Gallium 68; Ion Exchange; NaCl; Positron emission tomography; Radiopharmaceuticals

Indexed keywords

GALLIUM-68; GENERATOR SYSTEMS; NACL; PRODUCTION OF; RADIOPHARMACEUTICALS; ROBUST METHODS; SPECIFIC ACTIVITY;

ACETONE; ION EXCHANGE; ORGANIC SOLVENTS; PEPTIDES; POSITRON EMISSION TOMOGRAPHY;

GALLIUM;

ACETONE; GALLIUM EDOTREOTIDE GA 68; GALLIUM TETRAXETAN OCTREOTATE GA 68; ORGANIC SOLVENT; RADIOPHARMACEUTICAL AGENT; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEVICES; EQUIPMENT DESIGN; FLUID HANDLING SYSTEM; GENERAL DEVICE; INTERMETHOD COMPARISON; ISOTOPE LABELING; PRIORITY JOURNAL; PROTEIN BINDING; RADIOPHARMACEUTICAL AUTOMATED GENERATOR;

AUTOMATION; GALLIUM RADIOISOTOPES; ISOTOPE LABELING; OCTREOTIDE; RADIONUCLIDE GENERATORS; RADIOPHARMACEUTICALS; SODIUM CHLORIDE; SOFTWARE;

EID: 84878162429     PISSN: 09698043     EISSN: 18729800     Source Type: Journal    
DOI: 10.1016/j.apradiso.2012.08.011     Document Type: Article

References (16)

1. Baum R.P., Prasad V., Hommann M., Hörsch D. Receptor PET/CT imaging of neuroendocrine tumors. Recent Results Cancer Res 2008, 170:225-242.
2. Baum R.P., Prasad V.P.E.T. and PET/CT Imaging of Neuroendocrine Tumors. Principles and Practice of PET and PET/CT 2008, 411-437. Wolters Kluwer/Lippincott Williams and Wilkins, Philadelphia. 2nd Ed. R.L. Wahl (Ed.).
3. Breeman W.A., de Jong M., de Blois E., Bernard B.F., Konijnenberg M., Krenning E.P. Radiolabelling DOTA-peptides with 68Ga. Eur. J. Nucl. Med. Mol. Imaging 2005, 32:478-485.
4. De Decker M., Turner J.H. Automated module radiolabeling of peptides and antibodies with gallium-68, lutetium-177 and iodine-131. Cancer Biother. Radiopharm 2012, 27:72-76.
5. Dwivedi D.K., Snehlata, Dwivedi A.K., Lochab S.P., Kumar R., Naswa N., Sharma P., Malhotra A., Bandopadhayaya G.P., Bal C., Pant G.S. Radiation exposure to nuclear medicine personnel handling positron emitters from Ge-68/Ga-68 generator. Indian J. Nucl. Med. 2011, 26:86-90.
6. Fani M., Maecke H.R. Radiopharmaceutical development of radiolabelled peptides. Eur. J. Nucl. Med Mol. Imaging 2012, 39(Suppl 1):11-30.
7. Ginj M., Maecke H.R. Radiometallo-labeled peptides in tumor diagnosis and therapy. Met. Ions Biol. Syst. 2004, 42:109-142.
8. Maecke H.R., Hofmann M., Haberkorn U. (68)Ga-labeled peptides in tumor imaging. J. Nuc. Med.: Off. Publ., Soc. Nucl. Med. 2005, 46(Suppl 1):172S-178S.
9. Mueller D., Klette I., Gottschaldt M., Baum R.P. Radiolabeling of fragile macroligands with Ga-68. J. Labelled Compd. Radiopharm 2009, 52:477.
10. 68Ga generator eluate for the labelling of fragile peptides. Abstracts of Poster Presentations (Chemistry). World J. Nucl. Med. 2011, 10(P-008):73-89.
11. Mueller D., Klette I., Baum R.P., Gottschaldt M., Schultz M.K., Breeman W.A.P. Simplified NaCl based (68)Ga concentration and labeling procedure for rapid synthesis of (68)Ga radiopharmaceuticals in high radiochemical purity. Bioconjug. Chem. 2012, 23(8):1712-1717.
12. Prata M.I. Gallium-68: A New Trend in PET Radiopharmacy. Curr Radiopharm. 2012, 5:142-149.
13. Roesch F., Baum R.P. Generator-based PET radiopharmaceuticals for molecular imaging of tumours: On the way to THERANOSTICS. Dalton Trans. 2011, 40:6104-6111.
14. 68Ga radionuclide generator initiates new developments in 68 Ga radiopharmaceutical chemistry. Curr. Top Med. Chem. 2010, 10:1633-1668.
15. Schreiter N.F., Brenner W., Nogami M., Buchert R., Huppertz A., Pape U.F., Prasad V., Hamm B., Maurer M.H. Cost comparison of 111In-DTPA-octreotide scintigraphy and 68Ga-DOTATOC PET/CT for staging enteropancreatic neuroendocrine tumours. Eur. J. Nucl. Med. Mol. Imaging 2012, 39:72-82.
16. Zhernosekov K.P., Filosofov D.V., Baum R.P., Aschoff P., Bihl H., Razbash A.A., Jahn M., Jennewein M., Rosch F. Processing of generator-produced 68Ga for medical application. J. Nucl. Med. 2007, 48:1741-1748.