Intestinal GUCY2C prevents TGF-β secretion coordinating desmoplasia and hyperproliferation in colorectal cancer

Cancer Research

Volumn 73, Issue 22, 2013, Pages 6654-6666

  Gibbons, Ahmara V ^a,c   Lin, Jieru E ^a   Kim, Gilbert W ^a   Marszalowicz, Glen P ^b   Li, Peng ^a,d   Stoecker, Brian A ^a   Blomain, Erik S ^a   Rattan, Satish ^a   Snook, Adam E ^a   Schulz, Stephanie ^a   Waldman, Scott A ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b DREXEL UNIVERSITY   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

NATRIURETIC PEPTIDE RECEPTOR C; PROTEIN KINASE B; SCATTER FACTOR; SCATTER FACTOR RECEPTOR; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA ANTIBODY; TRANSFORMING GROWTH FACTOR BETA RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL; CELL ACTIVATION; CELL PROLIFERATION; COLON CARCINOGENESIS; COLORECTAL CANCER; CONTROLLED STUDY; CYTOKINE RELEASE; ENTEROPATHY; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; GENE SILENCING; HOMEOSTASIS; HUMAN; HUMAN CELL; INTESTINE DESMOPLASIA; MOUSE; MYOFIBROBLAST; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; SIGNAL TRANSDUCTION;

ANIMALS; CACO-2 CELLS; CELL PROLIFERATION; CELL TRANSFORMATION, NEOPLASTIC; COLORECTAL NEOPLASMS; DOWN-REGULATION; EPITHELIAL-MESENCHYMAL TRANSITION; FIBROSIS; HCT116 CELLS; HUMANS; INTESTINES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RECEPTORS, GUANYLATE CYCLASE-COUPLED; RECEPTORS, PEPTIDE; STEM CELL NICHE; TRANSFORMING GROWTH FACTOR BETA;

EID: 84888371164     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-13-0887     Document Type: Article

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