Two randomized trials of linaclotide for chronic constipation

New England Journal of Medicine

Volumn 365, Issue 6, 2011, Pages 527-536

  Lembo, Anthony J ^a,b   Schneier, Harvey A ^c   Shiff, Steven J ^c   Kurtz, Caroline B ^d   MacDougall, James E ^d   Jia, Xinwei D ^c   Shao, James Z ^d   Lavins, Bernard J ^d   Currie, Mark G ^d   Fitch, Donald A ^d   Jeglinski, Brenda I ^d   Eng, Paul ^c   Fox, Susan M ^c   Johnston, Jeffrey M ^d  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c FOREST RESEARCH INSTITUTE   (United States)

^d IRONWOOD PHARMACEUTICALS INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LINACLOTIDE; PLACEBO;

ABDOMINAL PAIN; ADULT; AGED; ARTICLE; BLOOD CHEMISTRY; BLOOD EXAMINATION; CONSTIPATION; CONTROLLED STUDY; DEFECATION; DIARRHEA; DOUBLE BLIND PROCEDURE; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG RESPONSE; DRUG SAFETY; DRUG WITHDRAWAL; ELECTROCARDIOGRAM; FEMALE; FLATULENCE; HUMAN; INTESTINE DISTENSION; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PATIENT MONITORING; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RHINOPHARYNGITIS; SIDE EFFECT; SINUSITIS; UPPER ABDOMINAL PAIN; UPPER RESPIRATORY TRACT INFECTION; URINALYSIS; VITAL SIGN;

EID: 80051640525     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1010863     Document Type: Article

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