Synthetic remodeling of the chartreusin pathway to tune antiproliferative and antibacterial activities

Journal of the American Chemical Society

Volumn 135, Issue 46, 2013, Pages 17408-17416

  Ueberschaar, Nico ^a   Xu, Zhongli ^a   Scherlach, Kirstin ^a   Metsä Ketelä, Mikko ^b   Bretschneider, Tom ^a   Dahse, Hans Martin ^a   Görls, Helmar ^c   Hertweck, Christian ^a,c  

^a HANS KNÖLL INSTITUTE   (Germany)

^b UNIVERSITY OF TURKU   (Finland)

^c FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI-BACTERIAL ACTIVITY; ANTI-CANCER THERAPEUTICS; ANTIMYCOBACTERIAL ACTIVITY; BIOLOGICAL EVALUATION; COLORECTAL CANCER CELL; PATHWAY ENGINEERINGS; POLYKETIDE SYNTHASES; SYNTHETIC PROTOCOLS;

CELL CULTURE; FUNCTIONAL GROUPS; NETWORK ARCHITECTURE;

SUGARS;

(1-2) ABEO CHARTREUSIN; AGLYCONE; BROMOCHARTREUSIN; CHARTREUSIN; CISPLATIN; COUMARIN; DESMETHYLCHARTREUSIN; DOXORUBICIN; EPIRUBICIN; ETHYLCHARTREUSIN; ETHYNYLCHARTREUSIN; HYDROXYCHARTREUSIN; IMATINIB; METHOXYCHARTREUSIN; METHYLCHARTREUSIN; POLYKETIDE SYNTHASE; POLYPHENOL DERIVATIVE; TETRACYCLINE; UNCLASSIFIED DRUG; VANCOMYCIN; VINYLCHARTREUSIN;

ANTIBACTERIAL ACTIVITY; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER CELL CULTURE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG CYTOTOXICITY; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ENZYME ENGINEERING; HUMAN; HUMAN CELL; MOLECULAR MODEL; MUTANT; MUTATION; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANTI-BACTERIAL AGENTS; ANTINEOPLASTIC AGENTS; BENZOPYRANS; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; ENTEROCOCCUS; GLYCOSIDES; HELA CELLS; HT29 CELLS; HUMANS; K562 CELLS; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MYCOBACTERIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84888362597     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja4080024     Document Type: Article

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