Synthesis and in-vitro biological activity of macrocyclic urea Chk1 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 17, Issue 23, 2007, Pages 6499-6504

  Li, Gaoquan ^a   Tao, Zhi Fu ^a   Tong, Yunsong ^a   Przytulinska, Magdalena K ^a   Kovar, Peter ^a   Merta, Philip ^a   Chen, Zehan ^a   Zhang, Haiying ^a   Sowin, Thomas ^a   Rosenberg, Saul H ^a   Lin, Nan Horng ^a  

^a ABBOTT LABORATORIES   (United States)

Author keywords

Chk1 inhibitor; Macrocyclic urea

Indexed keywords

AMIDE; CHECKPOINT KINASE 1 INHIBITOR; DOXORUBICIN; ENZYME INHIBITOR; HALIDE; UNCLASSIFIED DRUG; UREA;

ARTICLE; BIOLOGICAL ACTIVITY; CELL ASSAY; CELL CYCLE ARREST; CYTOTOXICITY; DRUG MECHANISM; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; HYDROGENATION; IN VITRO STUDY; NUCLEAR MAGNETIC RESONANCE; SUBSTITUTION REACTION;

CELL LINE, TUMOR; HELA CELLS; HUMANS; MACROCYCLIC COMPOUNDS; PROTEIN KINASE INHIBITORS; PROTEIN KINASES; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 35648980993     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2007.09.088     Document Type: Article

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