메뉴 건너뛰기




Volumn 110, Issue 48, 2013, Pages 19537-19542

Keratin 16 regulates innate immunity in response to epidermal barrier breach

Author keywords

Epidermis; Intermediate filament

Indexed keywords

CYTOKERATIN 16; CYTOKERATIN 17; FILAGGRIN;

EID: 84888354152     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1309576110     Document Type: Article
Times cited : (150)

References (66)
  • 2
    • 33845951211 scopus 로고    scopus 로고
    • DAMPs, PAMPs and alarmins: All we need to know about danger
    • Bianchi ME (2007) DAMPs, PAMPs and alarmins: All we need to know about danger. J Leukoc Biol 81(1): 1-5.
    • (2007) J Leukoc Biol , vol.81 , Issue.1 , pp. 1-5
    • Bianchi, M.E.1
  • 3
    • 3042688916 scopus 로고    scopus 로고
    • S100 proteins in the epidermis
    • Eckert RL, et al. (2004) S100 proteins in the epidermis. J Invest Dermatol 123(1): 23-33.
    • (2004) J Invest Dermatol , vol.123 , Issue.1 , pp. 23-33
    • Eckert, R.L.1
  • 4
    • 20544442905 scopus 로고    scopus 로고
    • Alarmins: Chemotactic activators of immune responses
    • Oppenheim JJ, Yang D (2005) Alarmins: Chemotactic activators of immune responses. Curr Opin Immunol 17(4): 359-365.
    • (2005) Curr Opin Immunol , vol.17 , Issue.4 , pp. 359-365
    • Oppenheim, J.J.1    Yang, D.2
  • 5
    • 61349169039 scopus 로고    scopus 로고
    • AMPed up immunity: How antimicrobial peptides have multiple roles in immune defense
    • Lai Y, Gallo RL (2009) AMPed up immunity: How antimicrobial peptides have multiple roles in immune defense. Trends Immunol 30(3): 131-141.
    • (2009) Trends Immunol , vol.30 , Issue.3 , pp. 131-141
    • Lai, Y.1    Gallo, R.L.2
  • 6
    • 67649208478 scopus 로고    scopus 로고
    • The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer
    • Ehrchen JM, Sunderkötter C, Foell D, Vogl T, Roth J (2009) The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer. J Leukoc Biol 86(3): 557-566.
    • (2009) J Leukoc Biol , vol.86 , Issue.3 , pp. 557-566
    • Ehrchen, J.M.1    Sunderkötter, C.2    Foell, D.3    Vogl, T.4    Roth, J.5
  • 7
    • 6344278488 scopus 로고    scopus 로고
    • Intermediate filaments and tissue repair
    • DePianto D, Coulombe PA (2004) Intermediate filaments and tissue repair. Exp Cell Res 301(1): 68-76.
    • (2004) Exp Cell Res , vol.301 , Issue.1 , pp. 68-76
    • Depianto, D.1    Coulombe, P.A.2
  • 8
    • 84862627407 scopus 로고    scopus 로고
    • A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair
    • Rotty JD, Coulombe PA (2012) A wound-induced keratin inhibits Src activity during keratinocyte migration and tissue repair. J Cell Biol 197(3): 381-389.
    • (2012) J Cell Biol , vol.197 , Issue.3 , pp. 381-389
    • Rotty, J.D.1    Coulombe, P.A.2
  • 9
    • 33646552082 scopus 로고    scopus 로고
    • Keratin 17 modulates hair follicle cycling in a TNFalphadependent fashion
    • Tong X, Coulombe PA (2006) Keratin 17 modulates hair follicle cycling in a TNFalphadependent fashion. Genes Dev 20(10): 1353-1364.
    • (2006) Genes Dev , vol.20 , Issue.10 , pp. 1353-1364
    • Tong, X.1    Coulombe, P.A.2
  • 10
    • 33745003902 scopus 로고    scopus 로고
    • A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth
    • Kim S, Wong P, Coulombe PA (2006) A keratin cytoskeletal protein regulates protein synthesis and epithelial cell growth. Nature 441(7091): 362-365.
    • (2006) Nature , vol.441 , Issue.7091 , pp. 362-365
    • Kim, S.1    Wong, P.2    Coulombe, P.A.3
  • 11
    • 77957584091 scopus 로고    scopus 로고
    • Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin
    • Depianto D, Kerns ML, Dlugosz AA, Coulombe PA (2010) Keratin 17 promotes epithelial proliferation and tumor growth by polarizing the immune response in skin. Nat Genet 42(10): 910-914.
    • (2010) Nat Genet , vol.42 , Issue.10 , pp. 910-914
    • Depianto, D.1    Kerns, M.L.2    Dlugosz, A.A.3    Coulombe, P.A.4
  • 12
    • 33645026707 scopus 로고    scopus 로고
    • Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia
    • Haider AS, et al. (2006) Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia. J Invest Dermatol 126(4): 869-881.
    • (2006) J Invest Dermatol , vol.126 , Issue.4 , pp. 869-881
    • Haider, A.S.1
  • 13
    • 32944475361 scopus 로고    scopus 로고
    • Clinical and pathological features of pachyonychia congenita
    • Leachman SA, et al. (2005) Clinical and pathological features of pachyonychia congenita. J Investig Dermatol Symp Proc 10(1): 3-17.
    • (2005) J Investig Dermatol Symp Proc , vol.10 , Issue.1 , pp. 3-17
    • Leachman, S.A.1
  • 14
    • 84859785430 scopus 로고    scopus 로고
    • Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders
    • Lessard JC, Coulombe PA (2012) Keratin 16-null mice develop palmoplantar keratoderma, a hallmark feature of pachyonychia congenita and related disorders. J Invest Dermatol 132(5): 1384-1391.
    • (2012) J Invest Dermatol , vol.132 , Issue.5 , pp. 1384-1391
    • Lessard, J.C.1    Coulombe, P.A.2
  • 15
    • 26944457753 scopus 로고    scopus 로고
    • Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice
    • Cooper L, Johnson C, Burslem F, Martin P (2005) Wound healing and inflammation genes revealed by array analysis of 'macrophageless' PU.1 null mice. Genome Biol 6(1):R5.
    • (2005) Genome Biol , vol.6 , Issue.1
    • Cooper, L.1    Johnson, C.2    Burslem, F.3    Martin, P.4
  • 16
    • 33847663702 scopus 로고    scopus 로고
    • Gene expression profiling of cutaneous wound healing
    • Deonarine K, et al. (2007) Gene expression profiling of cutaneous wound healing. J Transl Med 5:11.
    • (2007) J Transl Med , vol.5 , pp. 11
    • Deonarine, K.1
  • 17
    • 49049104637 scopus 로고    scopus 로고
    • Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome
    • Roy S, Khanna S, Rink C, Biswas S, Sen CK (2008) Characterization of the acute temporal changes in excisional murine cutaneous wound inflammation by screening of the wound-edge transcriptome. Physiol Genomics 34(2): 162-184.
    • (2008) Physiol Genomics , vol.34 , Issue.2 , pp. 162-184
    • Roy, S.1    Khanna, S.2    Rink, C.3    Biswas, S.4    Sen, C.K.5
  • 18
    • 63649143438 scopus 로고    scopus 로고
    • Dynamic expression of epidermal caspase 8 simulates a wound healing response
    • Lee P, et al. (2009) Dynamic expression of epidermal caspase 8 simulates a wound healing response. Nature 458(7237): 519-523.
    • (2009) Nature , vol.458 , Issue.7237 , pp. 519-523
    • Lee, P.1
  • 19
    • 0030035021 scopus 로고    scopus 로고
    • Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: Defining a potential role for keratin 16
    • Paladini RD, Takahashi K, Bravo NS, Coulombe PA (1996) Onset of re-epithelialization after skin injury correlates with a reorganization of keratin filaments in wound edge keratinocytes: Defining a potential role for keratin 16. J Cell Biol 132(3): 381-397.
    • (1996) J Cell Biol , vol.132 , Issue.3 , pp. 381-397
    • Paladini, R.D.1    Takahashi, K.2    Bravo, N.S.3    Coulombe, P.A.4
  • 20
    • 63649143888 scopus 로고    scopus 로고
    • Genetic architecture of mouse skin inflammation and tumour susceptibility
    • Quigley DA, et al. (2009) Genetic architecture of mouse skin inflammation and tumour susceptibility. Nature 458(7237): 505-508.
    • (2009) Nature , vol.458 , Issue.7237 , pp. 505-508
    • Quigley, D.A.1
  • 21
    • 77957773112 scopus 로고    scopus 로고
    • Skin cornification proteins provide global link between ROS detoxification and cell migration during wound healing
    • Vermeij WP, Backendorf C (2010) Skin cornification proteins provide global link between ROS detoxification and cell migration during wound healing. PLoS ONE 5(8):e11957.
    • (2010) PLoS ONE , vol.5 , Issue.8
    • Vermeij, W.P.1    Backendorf, C.2
  • 22
    • 84860530952 scopus 로고    scopus 로고
    • Nrf2 links epidermal barrier function with antioxidant defense
    • Schäfer M, et al. (2012) Nrf2 links epidermal barrier function with antioxidant defense. EMBO Mol Med 4(5): 364-379.
    • (2012) EMBO Mol Med , vol.4 , Issue.5 , pp. 364-379
    • Schäfer, M.1
  • 23
    • 0024256223 scopus 로고
    • Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis
    • Hawley-Nelson P, Roop DR, Cheng CK, Krieg TM, Yuspa SH (1988) Molecular cloning of mouse epidermal cystatin A and detection of regulated expression in differentiation and tumorigenesis. Mol Carcinog 1(3): 202-211.
    • (1988) Mol Carcinog , vol.1 , Issue.3 , pp. 202-211
    • Hawley-Nelson, P.1    Roop, D.R.2    Cheng, C.K.3    Krieg, T.M.4    Yuspa, S.H.5
  • 24
    • 0037447315 scopus 로고    scopus 로고
    • SCCA2-like serpins mediate genetic predisposition to skin tumors
    • Gariboldi M, et al. (2003) SCCA2-like serpins mediate genetic predisposition to skin tumors. Cancer Res 63(8): 1871-1875.
    • (2003) Cancer Res , vol.63 , Issue.8 , pp. 1871-1875
    • Gariboldi, M.1
  • 25
    • 0032532129 scopus 로고    scopus 로고
    • The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs
    • Takahashi K, Yan B, Yamanishi K, Imamura S, Coulombe PA (1998) The two functional keratin 6 genes of mouse are differentially regulated and evolved independently from their human orthologs. Genomics 53(2): 170-183.
    • (1998) Genomics , vol.53 , Issue.2 , pp. 170-183
    • Takahashi, K.1    Yan, B.2    Yamanishi, K.3    Imamura, S.4    Coulombe, P.A.5
  • 26
    • 84867186262 scopus 로고    scopus 로고
    • Cytokeratins mediate epithelial innate defense through their antimicrobial properties
    • Tam C, Mun JJ, Evans DJ, Fleiszig SM (2012) Cytokeratins mediate epithelial innate defense through their antimicrobial properties. J Clin Invest 122(10): 3665-3677.
    • (2012) J Clin Invest , vol.122 , Issue.10 , pp. 3665-3677
    • Tam, C.1    Mun, J.J.2    Evans, D.J.3    Fleiszig, S.M.4
  • 27
    • 33645988531 scopus 로고    scopus 로고
    • Inflammation in epithelial skin tumours: Old stories and new ideas
    • Mueller MM (2006) Inflammation in epithelial skin tumours: Old stories and new ideas. Eur J Cancer 42(6): 735-744.
    • (2006) Eur J Cancer , vol.42 , Issue.6 , pp. 735-744
    • Mueller, M.M.1
  • 28
    • 0024328320 scopus 로고
    • The use of retinoic acid to probe the relation between hyperproliferation- associated keratins and cell proliferation in normal and malignant epidermal cells
    • Kopan R, Fuchs E (1989) The use of retinoic acid to probe the relation between hyperproliferation- associated keratins and cell proliferation in normal and malignant epidermal cells. J Cell Biol 109(1): 295-307.
    • (1989) J Cell Biol , vol.109 , Issue.1 , pp. 295-307
    • Kopan, R.1    Fuchs, E.2
  • 29
    • 34250835251 scopus 로고    scopus 로고
    • The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes
    • Feldmeyer L, et al. (2007) The inflammasome mediates UVB-induced activation and secretion of interleukin-1beta by keratinocytes. Curr Biol 17(13): 1140-1145.
    • (2007) Curr Biol , vol.17 , Issue.13 , pp. 1140-1145
    • Feldmeyer, L.1
  • 30
    • 84873562874 scopus 로고    scopus 로고
    • Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18
    • Roth W, et al. (2012) Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18. J Cell Sci 125(Pt 22): 5269-5279.
    • (2012) J Cell Sci , vol.125 , Issue.PART 22 , pp. 5269-5279
    • Roth, W.1
  • 31
    • 36248998854 scopus 로고    scopus 로고
    • Induction of inflammatory cytokines by a keratin mutation and their repression by a small molecule in a mouse model for EBS
    • Lu H, et al. (2007) Induction of inflammatory cytokines by a keratin mutation and their repression by a small molecule in a mouse model for EBS. J Invest Dermatol 127(12): 2781-2789.
    • (2007) J Invest Dermatol , vol.127 , Issue.12 , pp. 2781-2789
    • Lu, H.1
  • 32
    • 0026706275 scopus 로고
    • Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice
    • Wood LC, Jackson SM, Elias PM, Grunfeld C, Feingold KR (1992) Cutaneous barrier perturbation stimulates cytokine production in the epidermis of mice. J Clin Invest 90(2): 482-487.
    • (1992) J Clin Invest , vol.90 , Issue.2 , pp. 482-487
    • Wood, L.C.1    Jackson, S.M.2    Elias, P.M.3    Grunfeld, C.4    Feingold, K.R.5
  • 33
    • 0028295190 scopus 로고
    • Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin
    • Nickoloff BJ, Naidu Y (1994) Perturbation of epidermal barrier function correlates with initiation of cytokine cascade in human skin. J Am Acad Dermatol 30(4): 535-546.
    • (1994) J Am Acad Dermatol , vol.30 , Issue.4 , pp. 535-546
    • Nickoloff, B.J.1    Naidu, Y.2
  • 34
    • 77951090253 scopus 로고    scopus 로고
    • Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury
    • Harder J, et al. (2010) Enhanced expression and secretion of antimicrobial peptides in atopic dermatitis and after superficial skin injury. J Invest Dermatol 130(5): 1355-1364.
    • (2010) J Invest Dermatol , vol.130 , Issue.5 , pp. 1355-1364
    • Harder, J.1
  • 35
    • 23944459169 scopus 로고    scopus 로고
    • Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin
    • Yoo J, et al. (2005) Spontaneous atopic dermatitis in mice expressing an inducible thymic stromal lymphopoietin transgene specifically in the skin. J Exp Med 202(4): 541-549.
    • (2005) J Exp Med , vol.202 , Issue.4 , pp. 541-549
    • Yoo, J.1
  • 36
    • 78650183999 scopus 로고    scopus 로고
    • Gene from a psoriasis susceptibility locus primes the skin for inflammation
    • Wolf R, et al. (2010) Gene from a psoriasis susceptibility locus primes the skin for inflammation. Sci Transl Med 2(61):61ra90.
    • (2010) Sci Transl Med , vol.2 , Issue.61
    • Wolf, R.1
  • 38
    • 84872174180 scopus 로고    scopus 로고
    • Keratins mediate localization of hemidesmosomes and repress cell motility
    • Seltmann K, et al. (2013) Keratins mediate localization of hemidesmosomes and repress cell motility. J Invest Dermatol 133(1): 181-190.
    • (2013) J Invest Dermatol , vol.133 , Issue.1 , pp. 181-190
    • Seltmann, K.1
  • 39
    • 36148957902 scopus 로고    scopus 로고
    • Mechanotransduction of keratinocytes in culture and in the epidermis
    • Reichelt J (2007) Mechanotransduction of keratinocytes in culture and in the epidermis. Eur J Cell Biol 86(11-12): 807-816.
    • (2007) Eur J Cell Biol , vol.86 , Issue.11-12 , pp. 807-816
    • Reichelt, J.1
  • 40
    • 0036683057 scopus 로고    scopus 로고
    • Role of integrins in regulating epidermal adhesion, growth and differentiation
    • Watt FM (2002) Role of integrins in regulating epidermal adhesion, growth and differentiation. EMBO J 21(15): 3919-3926.
    • (2002) EMBO J , vol.21 , Issue.15 , pp. 3919-3926
    • Watt, F.M.1
  • 41
    • 84873553796 scopus 로고    scopus 로고
    • RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1
    • Pedersen E, et al. (2012) RAC1 in keratinocytes regulates crosstalk to immune cells by Arp2/3-dependent control of STAT1. J Cell Sci 125(Pt 22): 5379-5390.
    • (2012) J Cell Sci , vol.125 , Issue.PART 22 , pp. 5379-5390
    • Pedersen, E.1
  • 42
    • 0037827698 scopus 로고    scopus 로고
    • Regulation of interleukin-1alpha expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease
    • Hobbs RM, Watt FM (2003) Regulation of interleukin-1alpha expression by integrins and epidermal growth factor receptor in keratinocytes from a mouse model of inflammatory skin disease. J Biol Chem 278(22): 19798-19807.
    • (2003) J Biol Chem , vol.278 , Issue.22 , pp. 19798-19807
    • Hobbs, R.M.1    Watt, F.M.2
  • 43
    • 4143073758 scopus 로고    scopus 로고
    • Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions
    • Hobbs RM, Silva-Vargas V, Groves R, Watt FM (2004) Expression of activated MEK1 in differentiating epidermal cells is sufficient to generate hyperproliferative and inflammatory skin lesions. J Invest Dermatol 123(3): 503-515.
    • (2004) J Invest Dermatol , vol.123 , Issue.3 , pp. 503-515
    • Hobbs, R.M.1    Silva-Vargas, V.2    Groves, R.3    Watt, F.M.4
  • 44
    • 80054753943 scopus 로고    scopus 로고
    • Pushing back: Wound mechanotransduction in repair and regeneration
    • Wong VW, Akaishi S, Longaker MT, Gurtner GC (2011) Pushing back: Wound mechanotransduction in repair and regeneration. J Invest Dermatol 131(11): 2186-2196.
    • (2011) J Invest Dermatol , vol.131 , Issue.11 , pp. 2186-2196
    • Wong, V.W.1    Akaishi, S.2    Longaker, M.T.3    Gurtner, G.C.4
  • 45
    • 84855555498 scopus 로고    scopus 로고
    • Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling
    • Wong VW, et al. (2012) Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling. Nat Med 18(1): 148-152.
    • (2012) Nat Med , vol.18 , Issue.1 , pp. 148-152
    • Wong, V.W.1
  • 46
    • 84860165740 scopus 로고    scopus 로고
    • Mammalian MAPK signal transduction pathways activated by stress and inflammation: A 10-year update
    • Kyriakis JM, Avruch J (2012) Mammalian MAPK signal transduction pathways activated by stress and inflammation: A 10-year update. Physiol Rev 92(2): 689-737.
    • (2012) Physiol Rev , vol.92 , Issue.2 , pp. 689-737
    • Kyriakis, J.M.1    Avruch, J.2
  • 47
    • 0242664638 scopus 로고    scopus 로고
    • Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun
    • Wang YN, Chang WC (2003) Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun. J Biol Chem 278(46): 45848-45857.
    • (2003) J Biol Chem , vol.278 , Issue.46 , pp. 45848-45857
    • Wang, Y.N.1    Chang, W.C.2
  • 48
    • 30044444532 scopus 로고    scopus 로고
    • Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression
    • Wang YN, Chen YJ, Chang WC (2006) Activation of extracellular signal-regulated kinase signaling by epidermal growth factor mediates c-Jun activation and p300 recruitment in keratin 16 gene expression. Mol Pharmacol 69(1): 85-98.
    • (2006) Mol Pharmacol , vol.69 , Issue.1 , pp. 85-98
    • Wang, Y.N.1    Chen, Y.J.2    Chang, W.C.3
  • 49
    • 34848899559 scopus 로고    scopus 로고
    • ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression
    • Chen YJ, Wang YN, Chang WC (2007) ERK2-mediated C-terminal serine phosphorylation of p300 is vital to the regulation of epidermal growth factor-induced keratin 16 gene expression. J Biol Chem 282(37): 27215-27228.
    • (2007) J Biol Chem , vol.282 , Issue.37 , pp. 27215-27228
    • Chen, Y.J.1    Wang, Y.N.2    Chang, W.C.3
  • 50
    • 78650116927 scopus 로고    scopus 로고
    • Differential modulation of keratin expression by sulforaphane occurs via Nrf2-dependent and -independent pathways in skin epithelia
    • Kerns M, DePianto D, Yamamoto M, Coulombe PA (2010) Differential modulation of keratin expression by sulforaphane occurs via Nrf2-dependent and -independent pathways in skin epithelia. Mol Biol Cell 21(23): 4068-4075.
    • (2010) Mol Biol Cell , vol.21 , Issue.23 , pp. 4068-4075
    • Kerns, M.1    Depianto, D.2    Yamamoto, M.3    Coulombe, P.A.4
  • 51
    • 0032563572 scopus 로고    scopus 로고
    • Directed expression of keratin 16 to the progenitor basal cells of transgenic mouse skin delays skin maturation
    • Paladini RD, Coulombe PA (1998) Directed expression of keratin 16 to the progenitor basal cells of transgenic mouse skin delays skin maturation. J Cell Biol 142(4): 1035-1051.
    • (1998) J Cell Biol , vol.142 , Issue.4 , pp. 1035-1051
    • Paladini, R.D.1    Coulombe, P.A.2
  • 52
    • 77953012548 scopus 로고    scopus 로고
    • Stress-activated cap'n'collar transcription factors in aging and human disease
    • Sykiotis GP, Bohmann D (2010) Stress-activated cap'n'collar transcription factors in aging and human disease. Sci Signal 3(112):re3.
    • (2010) Sci Signal , vol.3 , Issue.112
    • Sykiotis, G.P.1    Bohmann, D.2
  • 53
    • 46749098378 scopus 로고    scopus 로고
    • A novel role of the NRF2 transcription factor in the regulation of arsenite-mediated keratin 16 gene expression in human keratinocytes
    • Endo H, Sugioka Y, Nakagi Y, Saijo Y, Yoshida T (2008) A novel role of the NRF2 transcription factor in the regulation of arsenite-mediated keratin 16 gene expression in human keratinocytes. Environ Health Perspect 116(7): 873-879.
    • (2008) Environ Health Perspect , vol.116 , Issue.7 , pp. 873-879
    • Endo, H.1    Sugioka, Y.2    Nakagi, Y.3    Saijo, Y.4    Yoshida, T.5
  • 54
    • 33646561819 scopus 로고    scopus 로고
    • Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing
    • auf dem Keller U, et al. (2006) Nrf transcription factors in keratinocytes are essential for skin tumor prevention but not for wound healing. Mol Cell Biol 26(10): 3773-3784.
    • (2006) Mol Cell Biol , vol.26 , Issue.10 , pp. 3773-3784
    • Auf Dem Keller, U.1
  • 55
    • 79960060305 scopus 로고    scopus 로고
    • Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
    • DeNicola GM, et al. (2011) Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature 475(7354): 106-109.
    • (2011) Nature , vol.475 , Issue.7354 , pp. 106-109
    • Denicola, G.M.1
  • 56
    • 84870848726 scopus 로고    scopus 로고
    • Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero
    • Huebner AJ, et al. (2012) Amniotic fluid activates the nrf2/keap1 pathway to repair an epidermal barrier defect in utero. Dev Cell 23(6): 1238-1246.
    • (2012) Dev Cell , vol.23 , Issue.6 , pp. 1238-1246
    • Huebner, A.J.1
  • 57
    • 47949120781 scopus 로고    scopus 로고
    • Innate immune modulation of keratinocytes by antikeratin 16 antibodies
    • Wu C, Li C, Wei L, Zheng Z (2008) Innate immune modulation of keratinocytes by antikeratin 16 antibodies. Exp Dermatol 17(8): 645-652.
    • (2008) Exp Dermatol , vol.17 , Issue.8 , pp. 645-652
    • Wu, C.1    Li, C.2    Wei, L.3    Zheng, Z.4
  • 58
    • 58549121134 scopus 로고    scopus 로고
    • Effects of antikeratin 16 antibodies on the expression of Toll-like receptors 2 and 4 in keratinocytes
    • Wu C, Luan Q, Li C, Zheng Z (2009) Effects of antikeratin 16 antibodies on the expression of Toll-like receptors 2 and 4 in keratinocytes. Clin Exp Dermatol 34(2): 236-239.
    • (2009) Clin Exp Dermatol , vol.34 , Issue.2 , pp. 236-239
    • Wu, C.1    Luan, Q.2    Li, C.3    Zheng, Z.4
  • 59
    • 34547671041 scopus 로고    scopus 로고
    • The psoriatic transcriptome closely resembles that induced by interleukin-1 in cultured keratinocytes: Dominance of innate immune responses in psoriasis
    • Mee JB, Johnson CM, Morar N, Burslem F, Groves RW (2007) The psoriatic transcriptome closely resembles that induced by interleukin-1 in cultured keratinocytes: Dominance of innate immune responses in psoriasis. Am J Pathol 171(1): 32-42.
    • (2007) Am J Pathol , vol.171 , Issue.1 , pp. 32-42
    • Mee, J.B.1    Johnson, C.M.2    Morar, N.3    Burslem, F.4    Groves, R.W.5
  • 61
    • 76349084709 scopus 로고    scopus 로고
    • First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder
    • Leachman SA, et al. (2010) First-in-human mutation-targeted siRNA phase Ib trial of an inherited skin disorder. Mol Ther 18(2): 442-446.
    • (2010) Mol Ther , vol.18 , Issue.2 , pp. 442-446
    • Leachman, S.A.1
  • 62
    • 32944469964 scopus 로고    scopus 로고
    • Treatment of pachyonychia congenita
    • Milstone LM, et al. (2005) Treatment of pachyonychia congenita. J Investig Dermatol Symp Proc 10(1): 18-20.
    • (2005) J Investig Dermatol Symp Proc , vol.10 , Issue.1 , pp. 18-20
    • Milstone, L.M.1
  • 63
    • 84861184577 scopus 로고    scopus 로고
    • Generic and personalized RNAi-based therapeutics for a dominant-negative epidermal fragility disorder
    • Leslie Pedrioli DM, et al. (2012) Generic and personalized RNAi-based therapeutics for a dominant-negative epidermal fragility disorder. J Invest Dermatol 132(6): 1627-1635.
    • (2012) J Invest Dermatol , vol.132 , Issue.6 , pp. 1627-1635
    • Leslie Pedrioli, D.M.1
  • 65
    • 84861232240 scopus 로고    scopus 로고
    • An appraisal of oral retinoids in the treatment of pachyonychia congenita
    • Gruber R, et al. (2012) An appraisal of oral retinoids in the treatment of pachyonychia congenita. J Am Acad Dermatol 66(6):e193-e199.
    • (2012) J Am Acad Dermatol , vol.66 , Issue.6
    • Gruber, R.1
  • 66
    • 79954882368 scopus 로고    scopus 로고
    • Statins downregulate K6a promoter activity: A possible therapeutic avenue for pachyonychia congenita
    • Zhao Y, Gartner U, Smith FJ, McLean WH (2011) Statins downregulate K6a promoter activity: A possible therapeutic avenue for pachyonychia congenita. J Invest Dermatol 131(5): 1045-1052.
    • (2011) J Invest Dermatol , vol.131 , Issue.5 , pp. 1045-1052
    • Zhao, Y.1    Gartner, U.2    Smith, F.J.3    McLean, W.H.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.