A novel role of the NRF2 transcription factor in the regulation of arsenite-mediated keratin 16 gene expression in human keratinocytes

Environmental Health Perspectives

Volumn 116, Issue 7, 2008, Pages 873-879

  Endo, Hitoshi ^a   Sugioka, Yoshihiko ^a   Nakagi, Yoshihiko ^a   Saijo, Yasuaki ^a   Yoshida, Takahiko ^a  

^a ASAHIKAWA MEDICAL COLLEGE   (Japan)

Author keywords

Antioxidant response element; Arsenic; Hyperkeratosis; Keratin 16 (K16); Keratinocytes; Nuclear factor erythroid derived 2 related factor 2 (NRF2); Transcription

Indexed keywords

ANTIOXIDANT; ARSENITE SODIUM; BINDING PROTEIN; CYTOKERATIN 16; LUCIFERASE; MESSENGER RNA; THIOREDOXIN; TRANSCRIPTION FACTOR AP 1; TRANSCRIPTION FACTOR NRF2;

ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; DETOXIFICATION; DISEASE ASSOCIATION; ENZYME ASSAY; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HYPERKERATOSIS; KERATINOCYTE; MOLECULAR MECHANICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN FUNCTION; PROTEIN INDUCTION; PROTEIN SYNTHESIS; PROTEIN TARGETING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKIN CANCER; TRANSCRIPTION REGULATION; UPREGULATION; WESTERN BLOTTING;

ARSENITES; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION; HUMANS; KERATIN-16; KERATINOCYTES; NF-E2-RELATED FACTOR 2; RNA, MESSENGER; SODIUM COMPOUNDS; TRANS-ACTIVATION (GENETICS);

EID: 46749098378     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.10696     Document Type: Article

References (38)

1. Bagla P, Kaiser J. 1996. India's spreading health crisis draws global arsenic experts. Science 274:174-175.
2. Bloom DA, Jaiswal AK. 2003. Phosphorylation of Nrt2 at Ser40 by protein kinase C in response to antioxidants leads to the release of Nrf2 from INrf2, but is not required for Nrt2 stabilization/accumulation in the nucleus and transcriptional activation of antioxidant response element-mediated NAD(P)H:quinone oxidoreductase-1 gene expression. J Biol Chem 278:44675-4682.
3. Chan XL, Varner SE, Rao AS, Grey JY, Thomas S, Cook CK, et al. 2003. Laminar flow induction of antioxidant response element-mediated genes in endothelial cells. A novel anti-inflammatory mechanism. J Biol Chem 278:703-711.
4. Cöl M, Cöl C, Soran A, Sayli BS, Oztürk S. 1999. Arsenic-related Bowen's disease, palmar keratosis, and skin cancer. Environ Health Perspect 107:687-689.
5. Dinkova-Kostova AT, Holtzclaw WD, Cole RN, Itoh K, Wakabayashi N, Katoh Y, et al. 2002. Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants. Proc Natl Acad Sci USA 99:11908-11913.
6. Eferl R, Wagner EF. 2003. AP-1: a double-edged sword in tumorigenesis. Nat Rev Cancer 3:859-868.
7. Haider AS, Peters SB, Kaporis H, Cardinale I, Fei J, Ott J, et al. 2006. Genomic analysis defines a cancer-specific gene expression signature for human squamous cell carcinoma and distinguishes malignant hyperproliferation from benign hyperplasia. J Invest Dermatol 126:869-881.
8. Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, et al. 2000. Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem 275:16023-16029.
9. Jiang CK, Magnaldo T, Ohtsuki M, Freedberg IM, Bernard F, Blumenberg M. 1993. Epidermal growth factor and transforming growth factor alpha specifically induce the activation- and hyperproliferation-associated keratins 6 and 16 Proc Natl Acad Sci USA 90:6786-6790.
10. Kim YC, Masutani H, Yamaguchi Y, Itoh K, Yamamoto M, Yodoi J. 2001. Hemin-induced activation of the thioredoxin gene by Nrf2. A differential regulation of the antioxidant responsive element by a switch of its binding factors. J Biol Chem 276:18390-18406.
11. Lee CH, Chen JS, Sun YL, Liao WT, Zheng YW, Chai CZ, et al. 2006. Defective beta1-integrins expression in arsenical keratosis and arsenic-treated cultured human karatinocytes. J Cutan Pathol 33:129-138.
12. McLellan F. 2002. Arsenic contamination affects millions in Bangladesh. Lancet 359:1127.
13. McMahon M, Itoh K, Yamamoto M, Chanas SA, Henderson CJ, McLellan LI, et al. 2001. The Cap'n'Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification and glutathione biosynthetic enzymes. Cancer Res 61:3299-3307.
14. McMahon M, Itoh K, Yamamoto M, Hayes JD. 2003. Keap1 - dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression. J Biol Chem 278:21592-21600.
15. Moi P, Chan K, Asunis I, Cao A, Kan YW. 1994. Isolation of NF-E2-related factor 2 (Nrf2), a NF-E2-like basic leucine zipper transcriptional activator that binds to the tandem NF-E2/AP1 repeat of the beta-globin locus control region. Proc Natl Acad Sci USA 91:9926-9930.
16. Moll R, Franke WW, Schiller DL, Geiger B, Krepler R, 1982. The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors and cultured cells. Cell 31:11-24.
17. Moll R, Franke WW, Volc-Platzer B, Krepler R. 1982. Different keratin polypeptides in epidermis and other epithelia of human skin: a specific cytokeratin of molecular weight 46,000 in epithelia of the pilosebaceous tract and basal cell epitheliomas. J Cell Biol (35:285-295.
18. Motohashi H, O'Connor T, Katsuoka F, Engel JO, Yamamoto M 2002. Integration and diversity of the regulatory network composed of Maf and CNC families of transcription factors. Gene 294:1-12.
19. National Center for Biotechnology Information. 2007. GenBank overview. Available: http://www.ncbi.nlm.nih.gov/Genbank/index.html [accessed 10 December 2007].
20. Nguyen T, Sherratt PJ, Huang HC, Yang CS, Pickett CB. 2003. Increased protein stability as a mechanism that enhances Nrf2-mediated transcriptional activation of the antioxidant response element. Degradation of Nrf2 by the 26 S proteasome. J Biol Chem 278:4536-4541.
21. Pi J, Qu W, Reece JM, Kumagai Y, Waalkes MP. 2003. Transcription factor Nrf2 activation by inorganic arsenic in cultured keratinocytes: involvement of hydrogen peroxide. Exp Cell Res 290:234-245.
22. Rossman TG, Uddin AN, Burns FJ. 2004. Evidence that arsenite acts as a cocarcinogen in skin cancer. Toxicol Appl Pharmacol 198:394-404.
23. Rushmore TH, Morton MR, Pickett CB. 1991. The antioxidant responsive element. Activation by oxidative stress and identification of the DNA consensus sequence required for functional activity. J Biol Chem 266:11632-11639.
24. Sakurai A, Nishimoto M, Himeno S, Imura N, Tsujimoto M, Kunimoto M, et al. 2005. Transcriptional regulation of thioredoxin reductase 1 expression by cadmium in vascular endothelial cells: role of NF-E2-related factor-2. J Cell Physiol 203:529-537.
25. So HS, Kim HJ, Lee JH, Park SY, Park C, Kim YH, et al. 2006. Flunarizine induces Nrf2-mediated transcriptional activation of heme oxygenase-1 in protection of auditory cells from cisplatin. Cell Death Differ 13:1763-1715.
26. Stewart D, Killeen E, Naquin R, Alam S, Alam J. 2003. Degradation of transcription factor Nrf2 via the ubiquitin-proteasome pathway and stabilization by cadmium. J Biol Chem 278:2396-2402.
27. Sugioka Y, Watanabe T, Inagaki Y, Kushida M, Niioka M, Endo H, et al. 2004. c-Jun NH2-terminal kinase pathway is involved in constitutive matrix metalloproteinase-1 expression in a hepatocellular carcinoma-derived cell line. Int J Cancer 109:867-874.
28. Takahashi K, Folmer J, Coulombe PA. 1994. Increased expression of keratin 16 causes anomalies in cytoarchitecture and keratinization in transgenic mouse skin. J Cell Biol 127:505-520.
29. Tchounwou PB, Centeno JA, Patlolla AK. 2004. Arsenic toxicity, mutagenesis, and carcinogenesis - a health risk assessment and management approach. Mol Cell Biochem 255:47-55.
30. Wakabayashi N, Dinkova-Kostova AT, Holtzclaw WD, Kang MI, Kobayashi A, Yamamoto M, et al. 2004. Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers. Proc Natl Acad Sci USA 101:2040-2045.
31. Wakabayashi N, Itoh K, Wakabayashi J, Motohashi H, Noda S, Takahashi S, et al. 2003. Keap1-null mutation leads to post-natal lethality due to constitutive Nrf2 activation. Nat Genet 35:238-245.
32. Wang YN, Chang WC. 2003. Induction of disease-associated keratin 16 gene expression by epidermal growth factor is regulated through cooperation of transcription factors Sp1 and c-Jun. J Biol Chem 278:45848-45857.
33. Wasserman WW, Fahl WE. 1997. Functional antioxidant responsive elements. Proc Natl Acad Sci USA 94:5361-5366.
34. Wild AC, Gipp JJ, Mulcahy T. 1998. Overlapping antioxidant response element and PMA response element sequences mediate basal and beta-naphthoflavone-induced expression of the human gamma-glutamylcysteine synthetase catalytic subunit gene. Biochem J 332(Pt 2):373-381.
35. Wu MM, Kuo TL, Hwang YH, Chen CJ. 1989. Dose-response relation between arsenic concentration in well water and mortality from cancers and vascular diseases. Am J Epidemiol 130:1123-1132.
36. Xie T, Belinsky M, Xu Y, Jaiswal AK. 1995. ARE- and TRE-mediated regulation of gene expression. Response to xanobiotics and antioxidants. J Biol Chem 270:6894-6900.
37. Yoshida T, Yamauchi H, Fan Sun G. 2004. Chronic health effects in people exposed to arsenic via the drinking water: dose-response relationships in review. Toxicol Appl Pharmacol 198:243-252.
38. Yu HS, Chiou KS, Chen GS, Yang RC, Chang SF. 1993. Progressive alterations of cytokeratin expressions in the process of chronic arsenism. J Dermatol 20:741-745.