Cytokeratins mediate epithelial innate defense through their antimicrobial properties

Journal of Clinical Investigation

Volumn 122, Issue 10, 2012, Pages 3665-3677

  Tam, Connie ^a   Mun, James J ^a   Evans, David J ^a,b   Fleiszig, Suzanne M J ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b TOURO UNIVERSITY CALIFORNIA   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE; CARBOXY TERMINAL TELOPEPTIDE; CYTOKERATIN; CYTOKERATIN 6; CYTOKERATIN 6A; GLYCINE; GLYCINE RICH C TERMINAL FRAGMENT; KERATIN DERIVED ANTIMICROBIAL PEPTIDE; POLYPEPTIDE ANTIBIOTIC AGENT; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ALPHA HELIX; AMINO ACID SUBSTITUTION; ANIMAL EXPERIMENT; ANTIBACTERIAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BACTERICIDAL ACTIVITY; BACTERIUM ADHERENCE; CELL FRACTIONATION; CELL LYSATE; CELL PERMEABILIZATION; CELL PROTECTION; CONTROLLED STUDY; CORNEA; CORNEA EPITHELIUM; CORNEAL EPITHELIAL CELL; CYTOTOXICITY; DRUG BINDING; DRUG STRUCTURE; DRUG SYNTHESIS; EPITHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; INNATE IMMUNITY; MEDIATOR; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PSEUDOMONAS AERUGINOSA;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; BACTERIA; BACTERIAL ADHESION; CELL FRACTIONATION; CELL LINE; CELL MEMBRANE; CELL WALL; CONJUNCTIVITIS, BACTERIAL; EPITHELIAL CELLS; EPITHELIUM, CORNEAL; HUMANS; IMMUNITY, INNATE; KERATIN-6; MASS SPECTROMETRY; MICE; MICE, INBRED C57BL; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; RNA INTERFERENCE; RNA, SMALL INTERFERING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84867186262     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI64416     Document Type: Article

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