메뉴 건너뛰기




Volumn 34, Issue 6, 2013, Pages 810-821

Immunotherapy in lung cancer: B7-bombers and other new developments

Author keywords

cytotoxic T lymphocyte antigen 4 (CTLA 4); driver immunosuppressors; immunoediting; membrane associated glycoprotein (MUC 1); programmed cell death 1 (PD 1)

Indexed keywords

ADENOVIRUS VECTOR; AMP 224; ANTINEOPLASTIC AGENT; BELAGENPUMATUCEL L; BIOLOGICAL MARKER; BMS 936559; CXCL9 CHEMOKINE; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4; DENDRITIC CELL VACCINE; DSB MPDL 3280A; EMEPEPIMUT S; GM CD40L BYTANDER VACCINE; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IPILIMUMAB; KILLER CELL IMMUNOGLOBULIN LIKE RECEPTOR; LAMBROLIZUMAB; LIRILUMAB; MELANOMA ANTIGEN 3; MK 3475; MPDL3280A; MUCIN 1; NIVOLUMAB; PEMETREXED; PEPTIDE VACCINE; PLASMID VECTOR; PROGRAMMED DEATH 1 LIGAND 1; RACOTUMOMAB; TECEMOTIDE; TG 4010; TG4010; TICILIMUMAB; TUMOR ANTIGEN; TUMOR VACCINE; UNCLASSIFIED DRUG; URELIMAB;

EID: 84888347627     PISSN: 10693424     EISSN: 10989048     Source Type: Journal    
DOI: 10.1055/s-0033-1358551     Document Type: Article
Times cited : (5)

References (137)
  • 1
    • 84862776855 scopus 로고    scopus 로고
    • Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting
    • Matsushita H., Vesely M. D., Koboldt D. C., et al. Cancer exome analysis reveals a T-cell-dependent mechanism of cancer immunoediting. Nature: 2012; 482 7385 400 404
    • (2012) Nature , vol.482 , Issue.7385 , pp. 400-404
    • Matsushita, H.1    Vesely, M.D.2    Koboldt, D.C.3
  • 2
    • 51349090152 scopus 로고    scopus 로고
    • Alteration of the immunological synapse in lung cancer: A microenvironmental approach
    • Derniame S., Vignaud J. M., Faure G. C., Béné M. C. Alteration of the immunological synapse in lung cancer: a microenvironmental approach. Clin Exp Immunol: 2008; 154 1 48 55
    • (2008) Clin Exp Immunol , vol.154 , Issue.1 , pp. 48-55
    • Derniame, S.1    Vignaud, J.M.2    Faure, G.C.3    Béné, M.C.4
  • 3
    • 84886945726 scopus 로고    scopus 로고
    • Involvement of STAT3 in immune evasion during lung tumorigenesis
    • Kida H., Ihara S., Kumanogoh A. Involvement of STAT3 in immune evasion during lung tumorigenesis. OncoImmunology: 2013; 2 1 e22653
    • (2013) OncoImmunology , vol.2 , Issue.1
    • Kida, H.1    Ihara, S.2    Kumanogoh, A.3
  • 4
    • 79959864289 scopus 로고    scopus 로고
    • Non-small cell lung cancer induces an immunosuppressive phenotype of dendritic cells in tumor microenvironment by upregulating B7-H3
    • Schneider T., Hoffmann H., Dienemann H., et al. Non-small cell lung cancer induces an immunosuppressive phenotype of dendritic cells in tumor microenvironment by upregulating B7-H3. J Thorac Oncol: 2011; 6 7 1162 1168
    • (2011) J Thorac Oncol , vol.6 , Issue.7 , pp. 1162-1168
    • Schneider, T.1    Hoffmann, H.2    Dienemann, H.3
  • 5
    • 84857037901 scopus 로고    scopus 로고
    • High transforming growth factor
    • β expression represents an important prognostic parameter for surgically resected non-small cell lung cancer
    • Sterlacci W., Wolf D., Savic S., et al. High transforming growth factor. β expression represents an important prognostic parameter for surgically resected non-small cell lung cancer. Hum Pathol: 2012; 43 3 339 349
    • (2012) Hum Pathol , vol.43 , Issue.3 , pp. 339-349
    • Sterlacci, W.1    Wolf, D.2    Savic, S.3
  • 6
    • 84886944141 scopus 로고    scopus 로고
    • Within tumors, interactions between T cells and tumor cells are impeded by the extracellular matrix
    • Salmon H., Donnadieu E. Within tumors, interactions between T cells and tumor cells are impeded by the extracellular matrix. OncoImmunology: 2012; 1 6 992 994
    • (2012) OncoImmunology , vol.1 , Issue.6 , pp. 992-994
    • Salmon, H.1    Donnadieu, E.2
  • 7
    • 84857826513 scopus 로고    scopus 로고
    • Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors
    • Salmon H., Franciszkiewicz K., Damotte D., et al. Matrix architecture defines the preferential localization and migration of T cells into the stroma of human lung tumors. J Clin Invest: 2012; 122 3 899 910
    • (2012) J Clin Invest , vol.122 , Issue.3 , pp. 899-910
    • Salmon, H.1    Franciszkiewicz, K.2    Damotte, D.3
  • 8
    • 33646368439 scopus 로고    scopus 로고
    • Is downregulation of MHC class I antigen expression in human non-small cell lung cancer associated with prolonged survival?
    • DOI 10.1007/s00262-005-0085-7
    • Ramnath N., Tan D., Li Q., et al. Is downregulation of MHC class I antigen expression in human non-small cell lung cancer associated with prolonged survival? Cancer Immunol Immunother: 2006; 55 8 891 899 (Pubitemid 43673578)
    • (2006) Cancer Immunology, Immunotherapy , vol.55 , Issue.8 , pp. 891-899
    • Ramnath, N.1    Tan, D.2    Li, Q.3    Hylander, B.L.4    Bogner, P.5    Ryes, L.6    Ferrone, S.7
  • 9
    • 78649416004 scopus 로고    scopus 로고
    • Clinical relevance and functional implications for human leucocyte antigen-g expression in non-small-cell lung cancer
    • Lin A., Zhu C. C., Chen H. X., et al. Clinical relevance and functional implications for human leucocyte antigen-g expression in non-small-cell lung cancer. J Cell Mol Med: 2010; 14 9 2318 2329
    • (2010) J Cell Mol Med , vol.14 , Issue.9 , pp. 2318-2329
    • Lin, A.1    Zhu, C.C.2    Chen, H.X.3
  • 10
    • 84876414840 scopus 로고    scopus 로고
    • Prognostic implications of human leukocyte antigen class i expression in patients who underwent surgical resection for non-small-cell lung cancer
    • Hanagiri T., Shigematsu Y., Kuroda K., et al. Prognostic implications of human leukocyte antigen class I expression in patients who underwent surgical resection for non-small-cell lung cancer. J Surg Res: 2013; 181 2 e57 e63
    • (2013) J Surg Res , vol.181 , Issue.2
    • Hanagiri, T.1    Shigematsu, Y.2    Kuroda, K.3
  • 12
    • 84857219446 scopus 로고    scopus 로고
    • Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment
    • Lesokhin A. M., Hohl T. M., Kitano S., et al. Monocytic CCR2(+) myeloid-derived suppressor cells promote immune escape by limiting activated CD8 T-cell infiltration into the tumor microenvironment. Cancer Res: 2012; 72 4 876 886
    • (2012) Cancer Res , vol.72 , Issue.4 , pp. 876-886
    • Lesokhin, A.M.1    Hohl, T.M.2    Kitano, S.3
  • 13
    • 84879637291 scopus 로고    scopus 로고
    • Reciprocal relationship between myeloid-derived suppressor cells and T cells
    • Nagaraj S., Youn J-I, Gabrilovich D. I. Reciprocal relationship between myeloid-derived suppressor cells and T cells. J Immunol: 2013; 191 1 17 23
    • (2013) J Immunol , vol.191 , Issue.1 , pp. 17-23
    • Nagaraj, S.1    Youn, J.-I.2    Gabrilovich, D.I.3
  • 14
    • 80053369273 scopus 로고    scopus 로고
    • Lung cancer vaccines
    • Kelly R. J., Giaccone G. Lung cancer vaccines. Cancer J: 2011; 17 5 302 308
    • (2011) Cancer J , vol.17 , Issue.5 , pp. 302-308
    • Kelly, R.J.1    Giaccone, G.2
  • 15
    • 84863783251 scopus 로고    scopus 로고
    • Increase of regulatory T cells in metastatic stage and CTLA-4 over expression in lymphocytes of patients with non-small cell lung cancer (NSCLC)
    • Erfani N., Mehrabadi S. M., Ghayumi M. A., et al. Increase of regulatory T cells in metastatic stage and CTLA-4 over expression in lymphocytes of patients with non-small cell lung cancer (NSCLC). Lung Cancer: 2012; 77 2 306 311
    • (2012) Lung Cancer , vol.77 , Issue.2 , pp. 306-311
    • Erfani, N.1    Mehrabadi, S.M.2    Ghayumi, M.A.3
  • 16
    • 67650823037 scopus 로고    scopus 로고
    • The prevalence of FOXP3+ regulatory T-cells in peripheral blood of patients with NSCLC
    • Li L., Chao Q. G., Ping L. Z., et al. The prevalence of FOXP3+ regulatory T-cells in peripheral blood of patients with NSCLC. Cancer Biother Radiopharm: 2009; 24 3 357 367
    • (2009) Cancer Biother Radiopharm , vol.24 , Issue.3 , pp. 357-367
    • Li, L.1    Chao, Q.G.2    Ping, L.Z.3
  • 17
    • 76749084659 scopus 로고    scopus 로고
    • Randomized phase II clinical trial comparing tremelimumab (CP-675,206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC)
    • abstract 8071
    • Zatloukal P., Heo D., Park K., et al. Randomized phase II clinical trial comparing tremelimumab (CP-675,206) with best supportive care (BSC) following first-line platinum-based therapy in patients (pts) with advanced non-small cell lung cancer (NSCLC). J Clin Oncol: 2009; 27 (15S):abstract 8071
    • (2009) J Clin Oncol , vol.27 , Issue.15 S
    • Zatloukal, P.1    Heo, D.2    Park, K.3
  • 18
    • 84863911486 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase II study
    • Lynch T. J., Bondarenko I., Luft A., et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line treatment in stage IIIB/IV non-small-cell lung cancer: results from a randomized, double-blind, multicenter phase II study. J Clin Oncol: 2012; 30 17 2046 2054
    • (2012) J Clin Oncol , vol.30 , Issue.17 , pp. 2046-2054
    • Lynch, T.J.1    Bondarenko, I.2    Luft, A.3
  • 19
    • 73149092567 scopus 로고    scopus 로고
    • Guidelines for the evaluation of immune therapy activity in solid tumors: Immune-related response criteria
    • Wolchok J. D., Hoos A., O'Day S., et al. Guidelines for the evaluation of immune therapy activity in solid tumors: immune-related response criteria. Clin Cancer Res: 2009; 15 23 7412 7420
    • (2009) Clin Cancer Res , vol.15 , Issue.23 , pp. 7412-7420
    • Wolchok, J.D.1    Hoos, A.2    O'Day, S.3
  • 20
    • 84862161854 scopus 로고    scopus 로고
    • Ipilimumab (MDX-010) in the treatment of non-small cell lung cancer
    • Genova C., Rijavec E., Barletta G., et al. Ipilimumab (MDX-010) in the treatment of non-small cell lung cancer. Expert Opin Biol Ther: 2012; 12 7 939 948
    • (2012) Expert Opin Biol Ther , vol.12 , Issue.7 , pp. 939-948
    • Genova, C.1    Rijavec, E.2    Barletta, G.3
  • 21
    • 84871532643 scopus 로고    scopus 로고
    • Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: Results from a randomized, double-blind, multicenter phase 2 trial
    • Reck M., Bondarenko I., Luft A., et al. Ipilimumab in combination with paclitaxel and carboplatin as first-line therapy in extensive-disease-small-cell lung cancer: results from a randomized, double-blind, multicenter phase 2 trial. Ann Oncol: 2013; 24 1 75 83
    • (2013) Ann Oncol , vol.24 , Issue.1 , pp. 75-83
    • Reck, M.1    Bondarenko, I.2    Luft, A.3
  • 22
    • 84867583274 scopus 로고    scopus 로고
    • Tumor-infiltrating lymphocytes predict response to chemotherapy in patients with advance non-small cell lung cancer
    • Liu H., Zhang T., Ye J., et al. Tumor-infiltrating lymphocytes predict response to chemotherapy in patients with advance non-small cell lung cancer. Cancer Immunol Immunother: 2012; 61 10 1849 1856
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.10 , pp. 1849-1856
    • Liu, H.1    Zhang, T.2    Ye, J.3
  • 23
    • 84865567620 scopus 로고    scopus 로고
    • What future opportunities may immuno-oncology provide for improving the treatment of patients with lung cancer
    • Reck M. What future opportunities may immuno-oncology provide for improving the treatment of patients with lung cancer? Ann Oncol: 2012; 23 08 viii28 34
    • (2012) Ann Oncol , vol.23 , Issue.8
    • Reck, M.1
  • 25
    • 34648828497 scopus 로고    scopus 로고
    • PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status
    • DOI 10.1097/QAD.0b013e3282eee548, PII 0000203020071001000002
    • Sauce D., Almeida J. R., Larsen M., et al. PD-1 expression on human CD8 T cells depends on both state of differentiation and activation status. AIDS: 2007; 21 15 2005 2013 (Pubitemid 47462149)
    • (2007) AIDS , vol.21 , Issue.15 , pp. 2005-2013
    • Sauce, D.1    Almeida, J.R.2    Larsen, M.3    Haro, L.4    Autran, B.5    Freeman, G.J.6    Appay, V.7
  • 27
    • 4243096258 scopus 로고    scopus 로고
    • B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression
    • DOI 10.1158/1078-0432.CCR-04-0428
    • Konishi J., Yamazaki K., Azuma M., Kinoshita I., Dosaka-Akita H., Nishimura M. B7-H1 expression on non-small cell lung cancer cells and its relationship with tumor-infiltrating lymphocytes and their PD-1 expression. Clin Cancer Res: 2004; 10 15 5094 5100 (Pubitemid 39106851)
    • (2004) Clinical Cancer Research , vol.10 , Issue.15 , pp. 5094-5100
    • Konishi, J.1    Yamazaki, K.2    Azuma, M.3    Kinoshita, I.4    Dosaka-Akita, H.5    Nishimura, M.6
  • 28
    • 84888318610 scopus 로고    scopus 로고
    • PD-L1 gene expression in Japanese lung cancer patients
    • Sasaki H., Suzuki A., Shitara M., et al. PD-L1 gene expression in Japanese lung cancer patients. Biomedical Reports: 2013; 1 1 93 96
    • (2013) Biomedical Reports , vol.1 , Issue.1 , pp. 93-96
    • Sasaki, H.1    Suzuki, A.2    Shitara, M.3
  • 29
    • 84879465848 scopus 로고    scopus 로고
    • Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1)
    • Velcheti V., Rimm D. L., Schalper K. A. Sarcomatoid lung carcinomas show high levels of programmed death ligand-1 (PD-L1). J Thorac Oncol: 2013; 8 6 803 805
    • (2013) J Thorac Oncol , vol.8 , Issue.6 , pp. 803-805
    • Velcheti, V.1    Rimm, D.L.2    Schalper, K.A.3
  • 30
    • 84875238628 scopus 로고    scopus 로고
    • Tumor B7-H1 and B7-H3 expression in squamous cell carcinoma of the lung
    • Boland J. M., Kwon E. D., Harrington S. M., et al. Tumor B7-H1 and B7-H3 Expression in Squamous Cell Carcinoma of the Lung. Clin Lung Cancer: 2013; 14 2 157 163
    • (2013) Clin Lung Cancer , vol.14 , Issue.2 , pp. 157-163
    • Boland, J.M.1    Kwon, E.D.2    Harrington, S.M.3
  • 31
    • 80052476869 scopus 로고    scopus 로고
    • High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation
    • Mu C-Y, Huang J-A, Chen Y., Chen C., Zhang X-G. High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation. Med Oncol: 2011; 28 3 682 688
    • (2011) Med Oncol , vol.28 , Issue.3 , pp. 682-688
    • Mu, C.-Y.1    Huang, J.-A.2    Chen, Y.3    Chen, C.4    Zhang, X.-G.5
  • 32
    • 84901639205 scopus 로고    scopus 로고
    • Association between single nucleotide polymorphism of PD-L1 gene and non-small cell lung cancer susceptibility in a Chinese population
    • Nov 21. doi:10.1111/ajco.12037. [Epub ahead of print]
    • Chen Y. B., Mu C. Y., Chen C., Huang J. A. Association between single nucleotide polymorphism of PD-L1 gene and non-small cell lung cancer susceptibility in a Chinese population. Asia Pac J Clin Oncol: 2012; Nov 21. doi:10.1111/ajco.12037. [Epub ahead of print]
    • (2012) Asia Pac J Clin Oncol
    • Chen, Y.B.1    Mu, C.Y.2    Chen, C.3    Huang, J.A.4
  • 33
    • 84869080530 scopus 로고    scopus 로고
    • Induced expression of B7-H3 on the lung cancer cells and macrophages suppresses T-cell mediating anti-tumor immune response
    • Chen C., Shen Y., Qu Q. X., Chen X. Q., Zhang X. G., Huang J. A. Induced expression of B7-H3 on the lung cancer cells and macrophages suppresses T-cell mediating anti-tumor immune response. Exp Cell Res: 2013; 319 1 96 102
    • (2013) Exp Cell Res , vol.319 , Issue.1 , pp. 96-102
    • Chen, C.1    Shen, Y.2    Qu, Q.X.3    Chen, X.Q.4    Zhang, X.G.5    Huang, J.A.6
  • 34
    • 70350323631 scopus 로고    scopus 로고
    • Diagnosis value of serum B7-H3 expression in non-small cell lung cancer
    • Zhang G., Xu Y., Lu X., et al. Diagnosis value of serum B7-H3 expression in non-small cell lung cancer. Lung Cancer: 2009; 66 2 245 249
    • (2009) Lung Cancer , vol.66 , Issue.2 , pp. 245-249
    • Zhang, G.1    Xu, Y.2    Lu, X.3
  • 35
    • 33745605153 scopus 로고    scopus 로고
    • B7-H3 and B7-H4 expression in non-small-cell lung cancer
    • DOI 10.1016/j.lungcan.2006.05.012, PII S0169500206002315
    • Sun Y., Wang Y., Zhao J., et al. B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer: 2006; 53 2 143 151 (Pubitemid 43994236)
    • (2006) Lung Cancer , vol.53 , Issue.2 , pp. 143-151
    • Sun, Y.1    Wang, Y.2    Zhao, J.3    Gu, M.4    Giscombe, R.5    Lefvert, A.K.6    Wang, X.7
  • 36
    • 34347390225 scopus 로고    scopus 로고
    • 4IgB7-H3 is the major isoform expressed on immunocytes as well as malignant cells
    • Zhou Y. H., Chen Y. J., Ma Z. Y., et al. 4IgB7-H3 is the major isoform expressed on immunocytes as well as malignant cells. Tissue Antigens: 2007; 70 2 96 104
    • (2007) Tissue Antigens , vol.70 , Issue.2 , pp. 96-104
    • Zhou, Y.H.1    Chen, Y.J.2    Ma, Z.Y.3
  • 37
    • 77957664158 scopus 로고    scopus 로고
    • Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer
    • Zhang Y., Huang S., Gong D., Qin Y., Shen Q. Programmed death-1 upregulation is correlated with dysfunction of tumor-infiltrating CD8+ T lymphocytes in human non-small cell lung cancer. Cell Mol Immunol: 2010; 7 5 389 395
    • (2010) Cell Mol Immunol , vol.7 , Issue.5 , pp. 389-395
    • Zhang, Y.1    Huang, S.2    Gong, D.3    Qin, Y.4    Shen, Q.5
  • 38
    • 84888379047 scopus 로고    scopus 로고
    • Survival and long-term safety in cancer patients receiving the PD-1 antibody nivolumab
    • In press
    • Topalian S. L., Brahmer J. R., McDermott D. F., et al. Survival and Long-Term Safety in Cancer Patients Receiving the PD-1 Antibody Nivolumab. N Engl J Med: 2013;; In press
    • (2013) N Engl J Med
    • Topalian, S.L.1    Brahmer, J.R.2    McDermott, D.F.3
  • 39
    • 84888383165 scopus 로고    scopus 로고
    • A phase i study of nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus platinum-based doublet chemotherapy (PT-doublet) in chemotherapy-naive non-small cell lung cancer (NSCLC) patients (pts)
    • abstract 8072
    • Rizvi N. A phase I study of nivolumab (anti-PD-1; BMS-936558, ONO-4538) plus platinum-based doublet chemotherapy (PT-doublet) in chemotherapy-naive non-small cell lung cancer (NSCLC) patients (pts). J Clin Oncol: 2013; 31 (Suppl;):abstract 8072
    • (2013) J Clin Oncol , vol.31 , Issue.SUPPL.
    • Rizvi, N.1
  • 40
    • 84879777241 scopus 로고    scopus 로고
    • Nivolumab plus ipilimumab in advanced melanoma
    • Wolchok J. D., Kluger H., Callahan M. K., et al. Nivolumab plus ipilimumab in advanced melanoma. N Engl J Med: 2013; 369 2 122 133
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 122-133
    • Wolchok, J.D.1    Kluger, H.2    Callahan, M.K.3
  • 41
    • 84872514622 scopus 로고    scopus 로고
    • Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
    • Lipson E. J., Sharfman W. H., Drake C. G., et al. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin Cancer Res: 2013; 19 2 462 468
    • (2013) Clin Cancer Res , vol.19 , Issue.2 , pp. 462-468
    • Lipson, E.J.1    Sharfman, W.H.2    Drake, C.G.3
  • 42
    • 84871196652 scopus 로고    scopus 로고
    • Phase i study of MK-3475 (anti-PD-1 monoclonal antibody) in patients with advanced solid tumors
    • abstract 2512
    • Patnaik A., Kang S. P., Tolcher A. W., et al. Phase I study of MK-3475 (anti-PD-1 monoclonal antibody) in patients with advanced solid tumors. J Clin Oncol: 2012; 30 (15S):abstract 2512
    • (2012) J Clin Oncol , vol.30 , Issue.15 S
    • Patnaik, A.1    Kang, S.P.2    Tolcher, A.W.3
  • 43
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • Hamid O., Robert C., Daud A., et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med: 2013; 369 2 134 144
    • (2013) N Engl J Med , vol.369 , Issue.2 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3
  • 45
    • 80053161751 scopus 로고    scopus 로고
    • Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms
    • Mkrtichyan M., Najjar Y. G., Raulfs E. C., et al. Anti-PD-1 synergizes with cyclophosphamide to induce potent anti-tumor vaccine effects through novel mechanisms. Eur J Immunol: 2011; 41 10 2977 2986
    • (2011) Eur J Immunol , vol.41 , Issue.10 , pp. 2977-2986
    • Mkrtichyan, M.1    Najjar, Y.G.2    Raulfs, E.C.3
  • 46
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • Brahmer J. R., Tykodi S. S., Chow L. Q., et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med: 2012; 366 26 2455 2465
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3
  • 47
    • 84887262315 scopus 로고    scopus 로고
    • A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors
    • abstract 3000
    • Herbst R. A study of MPDL3280A, an engineered PD-L1 antibody in patients with locally advanced or metastatic tumors. J Clin Oncol: 2013; 31 (15S):abstract 3000
    • (2013) J Clin Oncol , vol.31 , Issue.15 S
    • Herbst, R.1
  • 48
    • 84880746773 scopus 로고    scopus 로고
    • Biomarkers and associations with the clinical activity of PD-L1 blockade in a MPDL3280A study
    • abstract 3001
    • Powderly J. D. Biomarkers and associations with the clinical activity of PD-L1 blockade in a MPDL3280A study. J Clin Oncol: 2013; 31 (15S):abstract 3001
    • (2013) J Clin Oncol , vol.31 , Issue.15 S
    • Powderly, J.D.1
  • 49
    • 33748098860 scopus 로고    scopus 로고
    • PD-L1 is induced in hepatocytes by viral infection and by interferon-α and -γ and mediates T cell apoptosis
    • Mühlbauer M., Fleck M., Schütz C., et al. PD-L1 is induced in hepatocytes by viral infection and by interferon-. α and -γ and mediates T cell apoptosis. J Hepatol: 2006; 45 4 520 528
    • (2006) J Hepatol , vol.45 , Issue.4 , pp. 520-528
    • Mühlbauer, M.1    Fleck, M.2    Schütz, C.3
  • 50
    • 84857316912 scopus 로고    scopus 로고
    • Impact of collection and storage of lung tumor tissue on whole genome expression profiling
    • Freidin M. B., Bhudia N., Lim E., Nicholson A. G., Cookson W. O., Moffatt M. F. Impact of collection and storage of lung tumor tissue on whole genome expression profiling. J Mol Diagn: 2012; 14 2 140 148
    • (2012) J Mol Diagn , vol.14 , Issue.2 , pp. 140-148
    • Freidin, M.B.1    Bhudia, N.2    Lim, E.3    Nicholson, A.G.4    Cookson, W.O.5    Moffatt, M.F.6
  • 51
    • 84865416551 scopus 로고    scopus 로고
    • B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets
    • Mkrtichyan M. NY, Najjar Y. G., Raulfs E. C., et al. B7-DC-Ig enhances vaccine effect by a novel mechanism dependent on PD-1 expression level on T cell subsets. J Immunol: 2012; 189 5 2338 2347
    • (2012) J Immunol , vol.189 , Issue.5 , pp. 2338-2347
    • Mkrtichyan, M.N.1    Najjar, Y.G.2    Raulfs, E.C.3
  • 52
    • 84887262780 scopus 로고    scopus 로고
    • AMP-224, a fusion protein that targets PD-1
    • Smothers F., Hoos A., Langermann S., et al. AMP-224, a fusion protein that targets PD-1. Ann Oncol: 2013; 24 01 i7 i17
    • (2013) Ann Oncol , vol.24 , Issue.1
    • Smothers, F.1    Hoos, A.2    Langermann, S.3
  • 53
    • 84888352977 scopus 로고    scopus 로고
    • Clinical and pharmacodynamic (PD) results of a phase i trial with AMP-224 (B7-DC Fc) that binds to the PD-1 receptor
    • abstract 3044
    • Infante J. Clinical and pharmacodynamic (PD) results of a phase I trial with AMP-224 (B7-DC Fc) that binds to the PD-1 receptor. J Clin Oncol: 2013; 31 (15S):abstract 3044
    • (2013) J Clin Oncol , vol.31 , Issue.15 S
    • Infante, J.1
  • 54
    • 0034740653 scopus 로고    scopus 로고
    • CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells
    • Jacobs R., Hintzen G., Kemper A., et al. CD56bright cells differ in their KIR repertoire and cytotoxic features from CD56dim NK cells. Eur J Immunol: 2001; 31 10 3121 3127
    • (2001) Eur J Immunol , vol.31 , Issue.10 , pp. 3121-3127
    • Jacobs, R.1    Hintzen, G.2    Kemper, A.3
  • 56
    • 77956617099 scopus 로고    scopus 로고
    • Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors
    • Al Omar S., Middleton D., Marshall E., et al. Associations between genes for killer immunoglobulin-like receptors and their ligands in patients with solid tumors. Hum Immunol: 2010; 71 10 976 981
    • (2010) Hum Immunol , vol.71 , Issue.10 , pp. 976-981
    • Al Omar, S.1    Middleton, D.2    Marshall, E.3
  • 57
    • 84864022729 scopus 로고    scopus 로고
    • Increased numbers but functional defects of CD56+CD3+ cells in lung cancer
    • Al Omar S. Y., Marshall E., Middleton D., Christmas S. E. Increased numbers but functional defects of CD56+CD3+ cells in lung cancer. Int Immunol: 2012; 24 7 409 415
    • (2012) Int Immunol , vol.24 , Issue.7 , pp. 409-415
    • Al Omar, S.Y.1    Marshall, E.2    Middleton, D.3    Christmas, S.E.4
  • 58
    • 79953300281 scopus 로고    scopus 로고
    • Increased killer immunoglobulin-like receptor expression and functional defects in natural killer cells in lung cancer
    • Al Omar S. Y., Marshall E., Middleton D., Christmas S. E. Increased killer immunoglobulin-like receptor expression and functional defects in natural killer cells in lung cancer. Immunology: 2011; 133 1 94 104
    • (2011) Immunology , vol.133 , Issue.1 , pp. 94-104
    • Al Omar, S.Y.1    Marshall, E.2    Middleton, D.3    Christmas, S.E.4
  • 59
    • 0242468143 scopus 로고    scopus 로고
    • Functional and molecular characterization of a KIR3DL2/p140 expressing tumor-specific cytotoxic T lymphocyte clone infiltrating a human lung carcinoma
    • DOI 10.1038/sj.onc.1206627
    • Dorothée G., Echchakir H., Le Maux Chansac B., et al. Functional and molecular characterization of a KIR3DL2/p140 expressing tumor-specific cytotoxic T lymphocyte clone infiltrating a human lung carcinoma. Oncogene: 2003; 22 46 7192 7198 (Pubitemid 37378551)
    • (2003) Oncogene , vol.22 , Issue.46 , pp. 7192-7198
    • Dorothee, G.1    Echchakir, H.2    Chansac, B.L.M.3    Vergnon, I.4    Hage, F.E.5    Moretta, A.6    Bensussan, A.7    Chouaib, S.8    Mami-Chouaib, F.9
  • 60
    • 84865395817 scopus 로고    scopus 로고
    • KIR2DL2/S2 and HLA-C C1C1 genotype is associated with better response to treatment and prolonged survival of patients with non-small cell lung cancer in a Polish Caucasian population
    • Wiśniewski A., Jankowska R., Passowicz-Muszyńska E., et al. KIR2DL2/S2 and HLA-C C1C1 genotype is associated with better response to treatment and prolonged survival of patients with non-small cell lung cancer in a Polish Caucasian population. Hum Immunol: 2012; 73 9 927 931
    • (2012) Hum Immunol , vol.73 , Issue.9 , pp. 927-931
    • Wiśniewski, A.1    Jankowska, R.2    Passowicz-Muszyńska, E.3
  • 61
    • 84888340426 scopus 로고    scopus 로고
    • A phase i dose-escalation and cohort expansion study of lirilumab (anti-KIR; BMS-986015) administered in combination with nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients (Pts) with advanced refractory solid tumors
    • abstract TPS3110
    • Sanborn R. A phase I dose-escalation and cohort expansion study of lirilumab (anti-KIR; BMS-986015) administered in combination with nivolumab (anti-PD-1; BMS-936558; ONO-4538) in patients (Pts) with advanced refractory solid tumors. J Clin Oncol: 2013; 31 (15S):abstract TPS3110
    • (2013) J Clin Oncol , vol.31 , Issue.15 S
    • Sanborn, R.1
  • 62
    • 84919615477 scopus 로고    scopus 로고
    • A Phase i Study of Lirilumab (BMS-986015), an Anti-KIR Monoclonal Antibody, Administered with Ipilimumab, an Anti-CTLA-4 Monoclonal Antibody, in Patients with Select Advanced Solid Tumors
    • abstract TPS3106
    • Rizvi N. A., Infante J. R., Gibney G. T., et al. A Phase I Study of Lirilumab (BMS-986015), an Anti-KIR Monoclonal Antibody, Administered with Ipilimumab, an Anti-CTLA-4 Monoclonal Antibody, in Patients with Select Advanced Solid Tumors. J Clin Oncol: 2013; 31 (15S):abstract TPS3106
    • (2013) J Clin Oncol , vol.31 , Issue.15 S
    • Rizvi, N.A.1    Infante, J.R.2    Gibney, G.T.3
  • 63
    • 55949113750 scopus 로고    scopus 로고
    • Phase i study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA)
    • abstract 3007
    • Sznol M., Hodi F., Margolin K., et al. Phase I study of BMS-663513, a fully human anti-CD137 agonist monoclonal antibody, in patients (pts) with advanced cancer (CA). J Clin Oncol: 2008; 26 (15S):abstract 3007
    • (2008) J Clin Oncol , vol.26 , Issue.15 S
    • Sznol, M.1    Hodi, F.2    Margolin, K.3
  • 64
    • 77952343328 scopus 로고    scopus 로고
    • Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
    • Matsuzaki J., Gnjatic S., Mhawech-Fauceglia P., et al. Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. Proc Natl Acad Sci U S A: 2010; 107 17 7875 7880
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.17 , pp. 7875-7880
    • Matsuzaki, J.1    Gnjatic, S.2    Mhawech-Fauceglia, P.3
  • 65
    • 79951684125 scopus 로고    scopus 로고
    • PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice
    • Okazaki T., Okazaki I. M., Wang J., et al. PD-1 and LAG-3 inhibitory co-receptors act synergistically to prevent autoimmunity in mice. J Exp Med: 2011; 208 2 395 407
    • (2011) J Exp Med , vol.208 , Issue.2 , pp. 395-407
    • Okazaki, T.1    Okazaki, I.M.2    Wang, J.3
  • 66
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • Woo S-R, Turnis M. E., Goldberg M. V., et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res: 2012; 72 4 917 927
    • (2012) Cancer Res , vol.72 , Issue.4 , pp. 917-927
    • Woo, S.-R.1    Turnis, M.E.2    Goldberg, M.V.3
  • 67
    • 80455140226 scopus 로고    scopus 로고
    • Telomerase peptide vaccination in NSCLC: A phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial
    • Brunsvig P. F., Kyte J. A., Kersten C., et al. Telomerase peptide vaccination in NSCLC: a phase II trial in stage III patients vaccinated after chemoradiotherapy and an 8-year update on a phase I/II trial. Clin Cancer Res: 2011; 17 21 6847 6857
    • (2011) Clin Cancer Res , vol.17 , Issue.21 , pp. 6847-6857
    • Brunsvig, P.F.1    Kyte, J.A.2    Kersten, C.3
  • 68
    • 0034671810 scopus 로고    scopus 로고
    • + T cell ignorance and induction of anti-tumor immunity by peptide-pulsed APC
    • Dalyot-Herman N., Bathe O. F., Malek T. R. Reversal of CD8+ T cell ignorance and induction of anti-tumor immunity by peptide-pulsed APC. J Immunol: 2000; 165 12 6731 6737 (Pubitemid 32001136)
    • (2000) Journal of Immunology , vol.165 , Issue.12 , pp. 6731-6737
    • Dalyot-Herman, N.1    Bathe, O.F.2    Malek, T.R.3
  • 69
    • 0029839058 scopus 로고    scopus 로고
    • Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo
    • Boczkowski D., Nair S. K., Snyder D., Gilboa E. Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. J Exp Med: 1996; 184 2 465 472 (Pubitemid 26324100)
    • (1996) Journal of Experimental Medicine , vol.184 , Issue.2 , pp. 465-472
    • Boczkowski, D.1    Nair, S.K.2    Snyder, D.3    Gilboa, E.4
  • 70
    • 0033526861 scopus 로고    scopus 로고
    • Dendritic cells infiltrating tumors cotransduced with granulocyte/macrophage colony-stimulating factor (GM-CSF) and CD40 ligand genes take up and present endogenous tumor-associated antigens, and prime naive mice for a cytotoxic T lymphocyte response
    • DOI 10.1084/jem.190.1.125
    • Chiodoni C., Paglia P., Stoppacciaro A., Rodolfo M., Parenza M., Colombo M. P. Dendritic cells infiltrating tumors cotransduced with granulocyte/ macrophage colony-stimulating factor (GM-CSF) and CD40 ligand genes take up and present endogenous tumor-associated antigens, and prime naive mice for a cytotoxic T lymphocyte response. J Exp Med: 1999; 190 1 125 133 (Pubitemid 29330129)
    • (1999) Journal of Experimental Medicine , vol.190 , Issue.1 , pp. 125-133
    • Chiodoni, C.1    Paglia, P.2    Stoppacciaro, A.3    Rodolfo, M.4    Parenza, M.5    Colombo, M.P.6
  • 71
    • 0028289244 scopus 로고
    • Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha
    • Sallusto F., Lanzavecchia A. Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha. J Exp Med: 1994; 179 4 1109 1118
    • (1994) J Exp Med , vol.179 , Issue.4 , pp. 1109-1118
    • Sallusto, F.1    Lanzavecchia, A.2
  • 73
    • 34447504841 scopus 로고    scopus 로고
    • 10-Year follow-up of gene-modified adenoviral-based therapy in 146 non-small-cell lung cancer patients
    • DOI 10.1038/sj.cgt.7701048, PII 7701048
    • Nemunaitis J., Vorhies J. S., Pappen B., Senzer N. 10-year follow-up of gene-modified adenoviral-based therapy in 146 non-small-cell lung cancer patients. Cancer Gene Ther: 2007; 14 8 762 763 (Pubitemid 47080358)
    • (2007) Cancer Gene Therapy , vol.14 , Issue.8 , pp. 762-763
    • Nemunaitis, J.1    Vorhies, J.S.2    Pappen, B.3    Senzer, N.4
  • 75
    • 0033543076 scopus 로고    scopus 로고
    • A universal granulocyte-macrophage colony-stimulating factor-producing bystander cell line for use in the formulation of autologous tumor cell- based vaccines
    • DOI 10.1089/10430349950017347
    • Borrello I., Sotomayor E. M., Cooke S., Levitsky H. I. A universal granulocyte-macrophage colony-stimulating factor-producing bystander cell line for use in the formulation of autologous tumor cell-based vaccines. Hum Gene Ther: 1999; 10 12 1983 1991 (Pubitemid 29387912)
    • (1999) Human Gene Therapy , vol.10 , Issue.12 , pp. 1983-1991
    • Borrello, I.1    Sotomayor, E.M.2    Cooke, S.3    Levitsky, H.I.4
  • 76
    • 33646776056 scopus 로고    scopus 로고
    • Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX vaccine in advanced-stage non-small-cell lung cancer
    • Nemunaitis J., Jahan T., Ross H., et al. Phase 1/2 trial of autologous tumor mixed with an allogeneic GVAX vaccine in advanced-stage non-small-cell lung cancer. Cancer Gene Ther: 2006; 13 6 555 562
    • (2006) Cancer Gene Ther , vol.13 , Issue.6 , pp. 555-562
    • Nemunaitis, J.1    Jahan, T.2    Ross, H.3
  • 77
    • 77955771348 scopus 로고    scopus 로고
    • GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells
    • Morales J. K., Kmieciak M., Knutson K. L., Bear H. D., Manjili M. H. GM-CSF is one of the main breast tumor-derived soluble factors involved in the differentiation of CD11b-Gr1- bone marrow progenitor cells into myeloid-derived suppressor cells. Breast Cancer Res Treat: 2010; 123 1 39 49
    • (2010) Breast Cancer Res Treat , vol.123 , Issue.1 , pp. 39-49
    • Morales, J.K.1    Kmieciak, M.2    Knutson, K.L.3    Bear, H.D.4    Manjili, M.H.5
  • 78
    • 4344590947 scopus 로고    scopus 로고
    • High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells
    • DOI 10.1158/0008-5472.CAN-04-0757
    • Serafini P., Carbley R., Noonan K. A., Tan G., Bronte V., Borrello I. High-dose granulocyte-macrophage colony-stimulating factor-producing vaccines impair the immune response through the recruitment of myeloid suppressor cells. Cancer Res: 2004; 64 17 6337 6343 (Pubitemid 39129439)
    • (2004) Cancer Research , vol.64 , Issue.17 , pp. 6337-6343
    • Serafini, P.1    Carbley, R.2    Noonan, K.A.3    Tan, G.4    Bronte, V.5    Borrello, I.6
  • 79
    • 50949115267 scopus 로고    scopus 로고
    • Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines
    • Morse M. A., Hobeika A. C., Osada T., et al. Depletion of human regulatory T cells specifically enhances antigen-specific immune responses to cancer vaccines. Blood: 2008; 112 3 610 618
    • (2008) Blood , vol.112 , Issue.3 , pp. 610-618
    • Morse, M.A.1    Hobeika, A.C.2    Osada, T.3
  • 80
    • 63549100184 scopus 로고    scopus 로고
    • Regulatory T-cell-mediated attenuation of T-cell responses to the NY-ESO-1 ISCOMATRIX vaccine in patients with advanced malignant melanoma
    • Nicholaou T., Ebert L. M., Davis I. D., et al. Regulatory T-cell-mediated attenuation of T-cell responses to the NY-ESO-1 ISCOMATRIX vaccine in patients with advanced malignant melanoma. Clin Cancer Res: 2009; 15 6 2166 2173
    • (2009) Clin Cancer Res , vol.15 , Issue.6 , pp. 2166-2173
    • Nicholaou, T.1    Ebert, L.M.2    Davis, I.D.3
  • 81
  • 82
    • 0034894711 scopus 로고    scopus 로고
    • Characterization of human non-small cell lung cancer (NSCLC) cell lines for expression of MHC, co-stimulatory molecules and tumor-associated antigens
    • DOI 10.1016/S0169-5002(01)00210-0, PII S0169500201002100
    • Wroblewski J. M., Bixby D. L., Borowski C., Yannelli J. R. Characterization of human non-small cell lung cancer (NSCLC) cell lines for expression of MHC, co-stimulatory molecules and tumor-associated antigens. Lung Cancer: 2001; 33 2-3 181 194 (Pubitemid 32707899)
    • (2001) Lung Cancer , vol.33 , Issue.2-3 , pp. 181-194
    • Wroblewski, J.M.1    Bixby, D.L.2    Borowski, C.3    Yannelli, J.R.4
  • 85
    • 0029812593 scopus 로고    scopus 로고
    • Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation
    • Cella M., Scheidegger D., Palmer-Lehmann K., Lane P., Lanzavecchia A., Alber G. Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation. J Exp Med: 1996; 184 2 747 752 (Pubitemid 26324129)
    • (1996) Journal of Experimental Medicine , vol.184 , Issue.2 , pp. 747-752
    • Cella, M.1    Scheidegger, D.2    Palmer-Lehmann, K.3    Lane, P.4    Lanzavecchia, A.5    Alber, G.6
  • 87
    • 33846602242 scopus 로고    scopus 로고
    • A phase-I trial using a universal GM-CSF-producing and CD40L-expressing bystander cell line (GM.CD40L) in the formulation of autologous tumor cell-based vaccines for cancer patients with stage IV disease
    • DOI 10.1245/s10434-006-9196-4
    • Dessureault S., Noyes D., Lee D., et al. A phase-I trial using a universal GM-CSF-producing and CD40L-expressing bystander cell line (GM.CD40L) in the formulation of autologous tumor cell-based vaccines for cancer patients with stage IV disease. Ann Surg Oncol: 2007; 14 2 869 884 (Pubitemid 46175338)
    • (2007) Annals of Surgical Oncology , vol.14 , Issue.2 , pp. 869-884
    • Dessureault, S.1    Noyes, D.2    Lee, D.3    Dunn, M.4    Janssen, W.5    Cantor, A.6    Sotomayor, E.7    Messina, J.8    Antonia, S.J.9
  • 88
    • 73449090459 scopus 로고    scopus 로고
    • Regulated expression of CCL21 in the prostate tumor microenvironment inhibits tumor growth and metastasis in an orthotopic model of prostate cancer
    • Yousefieh N., Hahto S. M., Stephens A. L., Ciavarra R. P. Regulated expression of CCL21 in the prostate tumor microenvironment inhibits tumor growth and metastasis in an orthotopic model of prostate cancer. Cancer Microenviron: 2009; 2 1 59 67
    • (2009) Cancer Microenviron , vol.2 , Issue.1 , pp. 59-67
    • Yousefieh, N.1    Hahto, S.M.2    Stephens, A.L.3    Ciavarra, R.P.4
  • 89
    • 84871574719 scopus 로고    scopus 로고
    • Beyond the standard of care: A review of novel immunotherapy trials for the treatment of lung cancer
    • Hall R. D., Gray J. E., Chiappori A. A. Beyond the standard of care: a review of novel immunotherapy trials for the treatment of lung cancer. Cancer Control: 2013; 20 1 22 31
    • (2013) Cancer Control , vol.20 , Issue.1 , pp. 22-31
    • Hall, R.D.1    Gray, J.E.2    Chiappori, A.A.3
  • 91
    • 0034785348 scopus 로고    scopus 로고
    • TGF-β signaling in tumor suppression and cancer progression
    • Derynck R., Akhurst R. J., Balmain A. TGF-. β signaling in tumor suppression and cancer progression. Nat Genet: 2001; 29 2 117 129
    • (2001) Nat Genet , vol.29 , Issue.2 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 92
  • 93
    • 1542388144 scopus 로고    scopus 로고
    • Significance of expression of TGF-beta in pulmonary metastasis in non-small cell lung cancer tissues
    • Saji H., Nakamura H., Awut I., et al. Significance of expression of TGF-beta in pulmonary metastasis in non-small cell lung cancer tissues. Ann Thorac Cardiovasc Surg: 2003; 9 5 295 300
    • (2003) Ann Thorac Cardiovasc Surg , vol.9 , Issue.5 , pp. 295-300
    • Saji, H.1    Nakamura, H.2    Awut, I.3
  • 95
    • 67651091694 scopus 로고    scopus 로고
    • Phase II trial of Belagenpumatucel-L, a TGF-β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients
    • Nemunaitis J., Nemunaitis M., Senzer N., et al. Phase II trial of Belagenpumatucel-L, a TGF-. β2 antisense gene modified allogeneic tumor vaccine in advanced non small cell lung cancer (NSCLC) patients. Cancer Gene Ther: 2009; 16 8 620 624
    • (2009) Cancer Gene Ther , vol.16 , Issue.8 , pp. 620-624
    • Nemunaitis, J.1    Nemunaitis, M.2    Senzer, N.3
  • 96
    • 84888375762 scopus 로고    scopus 로고
    • INSPIRE Accessed June 2013
    • INSPIRE. Is the Lucanix Phase 3 Trial Over? 2012. http://www.inspire.com/ groups/lung-cancer-survivors/discussion/is-lucanix-phase-3-trial-over/. Accessed June 2013
    • (2012) Is the Lucanix Phase 3 Trial Over?
  • 98
    • 0028989973 scopus 로고
    • MUC-1 epithelial tumor mucin-based immunity and cancer vaccines
    • Finn O. J., Jerome K. R., Henderson R. A., et al. MUC-1 epithelial tumor mucin-based immunity and cancer vaccines. Immunol Rev: 1995; 145 1 61 89
    • (1995) Immunol Rev , vol.145 , Issue.1 , pp. 61-89
    • Finn, O.J.1    Jerome, K.R.2    Henderson, R.A.3
  • 99
    • 0030784601 scopus 로고    scopus 로고
    • Serum cytokines and tumour markers in patients with non-small cell carcinoma of the lung
    • Bansal A. S., Bruce J., Devine P. L., Scells B., Zimmermann P. V. Serum cytokines and tumour markers in patients with non-small cell carcinoma of the lung. Dis Markers: 1997; 13 3 195 199 (Pubitemid 27494089)
    • (1997) Disease Markers , vol.13 , Issue.3 , pp. 195-199
    • Bansal, A.S.1    Bruce, J.2    Devine, P.L.3    Scells, B.4    Zimmermann, P.V.5
  • 100
    • 0030466993 scopus 로고    scopus 로고
    • Comparison of O-linked carbohydrate chains in MUC-1 mucin from normal breast epithelial cell lines and breast carcinoma cell lines: Demonstration of simpler and fewer glycan chains in tumor cells
    • DOI 10.1074/jbc.271.52.33325
    • Lloyd K. O., Burchell J., Kudryashov V., Yin B. W., Taylor-Papadimitriou J. Comparison of O-linked carbohydrate chains in MUC-1 mucin from normal breast epithelial cell lines and breast carcinoma cell lines: demonstration of simpler and fewer glycan chains in tumor cells. J Biol Chem: 1996; 271 52 33325 33334 (Pubitemid 27010142)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.52 , pp. 33325-33334
    • Lloyd, K.O.1    Burchell, J.2    Kudryashov, V.3    Yin, B.W.T.4    Taylor-Papadimitriou, J.5
  • 101
    • 0027499492 scopus 로고
    • Mucin synthesis and secretion in various human epithelial cancer cell lines that express the MUC-1 mucin gene
    • Dahiya R., Kwak K-S, Byrd J. C., Ho S., Yoon W. H., Kim Y. S. Mucin synthesis and secretion in various human epithelial cancer cell lines that express the MUC-1 mucin gene. Cancer Res: 1993; 53 6 1437 1443 (Pubitemid 23097129)
    • (1993) Cancer Research , vol.53 , Issue.6 , pp. 1437-1443
    • Dahiya, R.1    Kwak, K.-S.2    Byrd, J.C.3    Ho, S.4    Yoon, W.-H.5    Kim, Y.S.6
  • 104
    • 78649235731 scopus 로고    scopus 로고
    • A multicenter open-label study to assess the safety of a new formulation of BLP25 liposome vaccine in patients with unresectable stage III non-small-cell lung cancer
    • Butts C., Murray R. N., Smith C. J., et al. A multicenter open-label study to assess the safety of a new formulation of BLP25 liposome vaccine in patients with unresectable stage III non-small-cell lung cancer. Clin Lung Cancer: 2010; 11 6 391 395
    • (2010) Clin Lung Cancer , vol.11 , Issue.6 , pp. 391-395
    • Butts, C.1    Murray, R.N.2    Smith, C.J.3
  • 105
    • 80054742888 scopus 로고    scopus 로고
    • Updated survival analysis in patients with stage IIIB or IV non-small-cell lung cancer receiving BLP25 liposome vaccine (L-BLP25): Phase IIB randomized, multicenter, open-label trial
    • Butts C., Maksymiuk A., Goss G., et al. Updated survival analysis in patients with stage IIIB or IV non-small-cell lung cancer receiving BLP25 liposome vaccine (L-BLP25): phase IIB randomized, multicenter, open-label trial. J Cancer Res Clin Oncol: 2011; 137 9 1337 1342
    • (2011) J Cancer Res Clin Oncol , vol.137 , Issue.9 , pp. 1337-1342
    • Butts, C.1    Maksymiuk, A.2    Goss, G.3
  • 106
    • 84885810417 scopus 로고    scopus 로고
    • START: A phase III study of L-BLP25 cancer immunotherapy for unresectable stage III non-small cell lung cancer
    • abstract 7500
    • Butts C. START: A phase III study of L-BLP25 cancer immunotherapy for unresectable stage III non-small cell lung cancer. J Clin Oncol: 2013; 31 (15S):abstract 7500
    • (2013) J Clin Oncol , vol.31 , Issue.15 S
    • Butts, C.1
  • 108
    • 81255127285 scopus 로고    scopus 로고
    • Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small-cell lung cancer: A controlled phase 2B trial
    • Quoix E., Ramlau R., Westeel V., et al. Therapeutic vaccination with TG4010 and first-line chemotherapy in advanced non-small-cell lung cancer: a controlled phase 2B trial. Lancet Oncol: 2011; 12 12 1125 1133
    • (2011) Lancet Oncol , vol.12 , Issue.12 , pp. 1125-1133
    • Quoix, E.1    Ramlau, R.2    Westeel, V.3
  • 109
    • 50349090322 scopus 로고    scopus 로고
    • A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV Non-small cell lung cancer
    • Ramlau R., Quoix E., Rolski J., et al. A phase II study of Tg4010 (Mva-Muc1-Il2) in association with chemotherapy in patients with stage III/IV Non-small cell lung cancer. J Thorac Oncol: 2008; 3 7 735 744
    • (2008) J Thorac Oncol , vol.3 , Issue.7 , pp. 735-744
    • Ramlau, R.1    Quoix, E.2    Rolski, J.3
  • 110
    • 84874746116 scopus 로고    scopus 로고
    • Cancer targeting vaccines: Surrogate measures of activity
    • Nemunaitis J. Cancer targeting vaccines: surrogate measures of activity. Hum Vaccin Immunother: 2013; 9 1 213 218
    • (2013) Hum Vaccin Immunother , vol.9 , Issue.1 , pp. 213-218
    • Nemunaitis, J.1
  • 111
    • 84892808887 scopus 로고    scopus 로고
    • TIME: A phase IIb/III randomized, double-blind, placebo-controlled study comparing first-line therapy with or without TG4010 immunotherapy product in patients with stage IV non-small cell lung cancer (NSCLC)
    • abstract TPS7610
    • Quoix E. A., Nemunaitis J. J., Burzykowski T., Bastien B., Lacoste G. TIME: A phase IIb/III randomized, double-blind, placebo-controlled study comparing first-line therapy with or without TG4010 immunotherapy product in patients with stage IV non-small cell lung cancer (NSCLC). J Clin Oncol: 2012; 30 (15S):abstract TPS7610
    • (2012) J Clin Oncol , vol.30 , Issue.15 S
    • Quoix, E.A.1    Nemunaitis, J.J.2    Burzykowski, T.3    Bastien, B.4    Lacoste, G.5
  • 115
    • 0033693387 scopus 로고    scopus 로고
    • A MAGE-A3 peptide presented by HLA-DP4 is recognized on tumor cells by CD4+ cytolytic T lymphocytes
    • Schultz E. S., Lethé B., Cambiaso C. L., et al. A MAGE-A3 peptide presented by HLA-DP4 is recognized on tumor cells by CD4+ cytolytic T lymphocytes. Cancer Res: 2000; 60 22 6272 6275
    • (2000) Cancer Res , vol.60 , Issue.22 , pp. 6272-6275
    • Schultz, E.S.1    Lethé, B.2    Cambiaso, C.L.3
  • 117
    • 42549106307 scopus 로고    scopus 로고
    • Final results of a multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of MAGE-A3 immunotherapeutic as adjuvant therapy in stage IB/II non-small cell lung cancer (NSCLC)
    • abstract 7554
    • Vansteenkiste J., Zielinski M., Linder A., et al. Final results of a multi-center, double-blind, randomized, placebo-controlled phase II study to assess the efficacy of MAGE-A3 immunotherapeutic as adjuvant therapy in stage IB/II non-small cell lung cancer (NSCLC). J Clin Oncol: 2007; 25 (18S):abstract 7554
    • (2007) J Clin Oncol , vol.25 , Issue.18 S
    • Vansteenkiste, J.1    Zielinski, M.2    Linder, A.3
  • 118
    • 70349417094 scopus 로고    scopus 로고
    • Association of gene expression signature and clinical efficacy of MAGE-A3 antigenspecific cancer immunotherapeutic (ASCI) as adjuvant therapy in resected stage IB/II non-small cell lung cancer (NSCLC)
    • abstract 7501
    • Vansteenkiste J., Zielinski M., Dahabreh I., et al. Association of gene expression signature and clinical efficacy of MAGE-A3 antigenspecific cancer immunotherapeutic (ASCI) as adjuvant therapy in resected stage IB/II non-small cell lung cancer (NSCLC). J Clin Oncol: 2008; 26 (15S):abstract 7501
    • (2008) J Clin Oncol , vol.26 , Issue.15 S
    • Vansteenkiste, J.1    Zielinski, M.2    Dahabreh, I.3
  • 120
    • 84888366975 scopus 로고    scopus 로고
    • Booster vaccination of non-small cell lung cancer (NSCLC) patients with MAGEA3 protein and AS02B adjuvant. in ASCO Annual Meeting Proceedings Part i
    • abstract 3015
    • Atanackovic D., Altorki N., Cao Y., et al. Booster vaccination of non-small cell lung cancer (NSCLC) patients with MAGEA3 protein and AS02B adjuvant. In ASCO Annual Meeting Proceedings Part I. J Clin Oncol: 2007; 25 (18S):abstract 3015
    • (2007) J Clin Oncol , vol.25 , Issue.18 S
    • Atanackovic, D.1    Altorki, N.2    Cao, Y.3
  • 121
    • 84888324750 scopus 로고    scopus 로고
    • MAGRIT phase III trial in adjuvant NSCLC: MAGE-A3 gene expression frequency on the first 2150 patients screened and demographics of first patients randomized
    • De Pas T., Kim J-H, Zarogoulidis K., et al. MAGRIT phase III trial in adjuvant NSCLC: MAGE-A3 gene expression frequency on the first 2150 patients screened and demographics of first patients randomized. J Thorac Oncol: 2009; 4 9 S331 S332
    • (2009) J Thorac Oncol , vol.4 , Issue.9
    • De Pas, T.1    Kim, J.-H.2    Zarogoulidis, K.3
  • 122
    • 77249089345 scopus 로고    scopus 로고
    • MAGRIT: The largest-ever phase III lung cancer trial aims to establish a novel tumor-specific approach to therapy
    • Tyagi P., Mirakhur B. MAGRIT: the largest-ever phase III lung cancer trial aims to establish a novel tumor-specific approach to therapy. Clin Lung Cancer: 2009; 10 5 371 374
    • (2009) Clin Lung Cancer , vol.10 , Issue.5 , pp. 371-374
    • Tyagi, P.1    Mirakhur, B.2
  • 123
    • 84856732045 scopus 로고    scopus 로고
    • Ninth annual meeting of the Association for Cancer Immunotherapy (CIMT 2011), May 25-27, 2011, Mainz, Germany
    • Hobohm K., Seppmann T., Britten C. M., Hoff H. Ninth annual meeting of the Association for Cancer Immunotherapy (CIMT 2011), May 25-27, 2011, Mainz, Germany. Cancer Immunol Immunother: 2012; 61 1 137 143
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.1 , pp. 137-143
    • Hobohm, K.1    Seppmann, T.2    Britten, C.M.3    Hoff, H.4
  • 124
    • 67650394884 scopus 로고    scopus 로고
    • Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer
    • van Cruijsen H., Ruiz M. G., van der Valk P., de Gruijl T. D., Giaccone G. Tissue micro array analysis of ganglioside N-glycolyl GM3 expression and signal transducer and activator of transcription (STAT)-3 activation in relation to dendritic cell infiltration and microvessel density in non-small cell lung cancer. BMC Cancer: 2009; 9 1 180
    • (2009) BMC Cancer , vol.9 , Issue.1 , pp. 180
    • Van Cruijsen, H.1    Ruiz, M.G.2    Van Der Valk, P.3    De Gruijl, T.D.4    Giaccone, G.5
  • 125
    • 84866058213 scopus 로고    scopus 로고
    • Immunoreactivity of the 14F7 Mab (Raised against N-Glycolyl GM3 Ganglioside) as a positive prognostic factor in non-small-cell lung cancer
    • 2012:235418. doi:10.1155/2012/235418. Epub 2012 Feb 26
    • Blanco R., Rengifo C. E., Cedeño M., Frómeta M., Rengifo E., Carr A. Immunoreactivity of the 14F7 Mab (Raised against N-Glycolyl GM3 Ganglioside) as a positive prognostic factor in non-small-cell lung cancer. Patholog Res Int: 2012;;2012:235418. doi:10.1155/2012/235418. Epub 2012 Feb 26
    • (2012) Patholog Res Int
    • Blanco, R.1    Rengifo, C.E.2    Cedeño, M.3    Frómeta, M.4    Rengifo, E.5    Carr, A.6
  • 126
    • 30444446808 scopus 로고    scopus 로고
    • Role of tumour-associated N-glycolylated variant of GM3 ganglioside in cancer progression: Effect over CD4 expression on T cells
    • DOI 10.1007/s00262-005-0041-6
    • de Leòn J., Fernández A., Mesa C., Clavel M., Fernández L. E. Role of tumour-associated N-glycolylated variant of GM3 ganglioside in cancer progression: effect over CD4 expression on T cells. Cancer Immunol Immunother: 2006; 55 4 443 450 (Pubitemid 43076896)
    • (2006) Cancer Immunology, Immunotherapy , vol.55 , Issue.4 , pp. 443-450
    • De Leon, J.1    Fernandez, A.2    Mesa, C.3    Clavel, M.4    Fernandez, L.E.5
  • 127
    • 84888322429 scopus 로고    scopus 로고
    • Anti-idiotype antibodies in cancer treatment
    • doi:10.3389/fonc.2013.00037
    • Gomez D. E., Vázquez A. M., Alonso D. F., Macías A. Anti-idiotype antibodies in cancer treatment. Front Oncol: 2013; 3 37. doi:10.3389/fonc.2013.00037
    • (2013) Front Oncol , vol.3 , pp. 37
    • Gomez, D.E.1    Vázquez, A.M.2    Alonso, D.F.3    Macías, A.4
  • 128
    • 80053386829 scopus 로고    scopus 로고
    • Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: A retrospective analysis
    • Shaw A. T., Yeap B. Y., Solomon B. J., et al. Effect of crizotinib on overall survival in patients with advanced non-small-cell lung cancer harbouring ALK gene rearrangement: a retrospective analysis. Lancet Oncol: 2011; 12 11 1004 1012
    • (2011) Lancet Oncol , vol.12 , Issue.11 , pp. 1004-1012
    • Shaw, A.T.1    Yeap, B.Y.2    Solomon, B.J.3
  • 130
    • 0036195744 scopus 로고    scopus 로고
    • Assessing clinical significance in measuring oncology patient quality of life: Introduction to the symposium, content overview, and definition of terms
    • Sloan J. A., Cella D., Frost M., Guyatt G. H., Sprangers M., Symonds T.; Clinical Significance Consensus Meeting Group. Assessing clinical significance in measuring oncology patient quality of life: introduction to the symposium, content overview, and definition of terms. Mayo Clin Proc: 2002; 77 4 367 370 (Pubitemid 34260745)
    • (2002) Mayo Clinic Proceedings , vol.77 , Issue.4 , pp. 367-370
    • Sloan, J.A.1    Cella, D.2    Frost, M.3    Guyatt, G.H.4    Sprangers, M.5    Symonds, T.6
  • 131
    • 85027930332 scopus 로고    scopus 로고
    • Rethinking the metastatic cascade as a therapeutic target
    • Mina L. A., Sledge G. W. Jr. Rethinking the metastatic cascade as a therapeutic target. Nat Rev Clin Oncol: 2011; 8 6 325 332
    • (2011) Nat Rev Clin Oncol , vol.8 , Issue.6 , pp. 325-332
    • Mina, L.A.1    Sledge Jr., G.W.2
  • 132
    • 84855612343 scopus 로고    scopus 로고
    • The challenge and promise of the genomic era
    • Sledge G. W. Jr. The challenge and promise of the genomic era. J Clin Oncol: 2012; 30 2 203 209
    • (2012) J Clin Oncol , vol.30 , Issue.2 , pp. 203-209
    • Sledge Jr., G.W.1
  • 133
    • 79951966897 scopus 로고    scopus 로고
    • Addition of bevacizumab to chemotherapy for treatment of solid tumors: Similar results but different conclusions
    • Ocaña A., Amir E., Vera F., Eisenhauer E. A., Tannock I. F. Addition of bevacizumab to chemotherapy for treatment of solid tumors: similar results but different conclusions. J Clin Oncol: 2011; 29 3 254 256
    • (2011) J Clin Oncol , vol.29 , Issue.3 , pp. 254-256
    • Ocaña, A.1    Amir, E.2    Vera, F.3    Eisenhauer, E.A.4    Tannock, I.F.5
  • 134
    • 84865165918 scopus 로고    scopus 로고
    • The price we pay for progress: A meta-analysis of harms of newly approved anticancer drugs
    • Niraula S., Seruga B., Ocana A., et al. The price we pay for progress: a meta-analysis of harms of newly approved anticancer drugs. J Clin Oncol: 2012; 30 24 3012 3019
    • (2012) J Clin Oncol , vol.30 , Issue.24 , pp. 3012-3019
    • Niraula, S.1    Seruga, B.2    Ocana, A.3
  • 135
    • 80053238941 scopus 로고    scopus 로고
    • Delivering affordable cancer care in high-income countries
    • Sullivan R., Peppercorn J., Sikora K., et al. Delivering affordable cancer care in high-income countries. Lancet Oncol: 2011; 12 10 933 980
    • (2011) Lancet Oncol , vol.12 , Issue.10 , pp. 933-980
    • Sullivan, R.1    Peppercorn, J.2    Sikora, K.3
  • 136
    • 84856021675 scopus 로고    scopus 로고
    • New challenges in endpoints for drug development in advanced melanoma
    • Ribas A., Hersey P., Middleton M. R., et al. New challenges in endpoints for drug development in advanced melanoma. Clin Cancer Res: 2012; 18 2 336 341
    • (2012) Clin Cancer Res , vol.18 , Issue.2 , pp. 336-341
    • Ribas, A.1    Hersey, P.2    Middleton, M.R.3
  • 137
    • 84888374982 scopus 로고    scopus 로고
    • Blockade of PD-L1 Mediated Immunosupression for Cancer Therapy-MEDI4736, Monoclonal Antibody Discovery and Preclinical Development [abstract from 27th Annual Scientific Meeting of the Society for Immunotherapy of Cancer]
    • Stewart R., Mulgrew K., Wang S., et al. Blockade of PD-L1 Mediated Immunosupression for Cancer Therapy-MEDI4736, Monoclonal Antibody Discovery and Preclinical Development [abstract from 27th Annual Scientific Meeting of the Society for Immunotherapy of Cancer]. J Immunother: 2012; 35 9S 765 766
    • (2012) J Immunother , vol.35 , Issue.9 S , pp. 765-766
    • Stewart, R.1    Mulgrew, K.2    Wang, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.