Influence of feeding and intracoronary dose on insulin-mediated relative akt phosphorylation in the porcine myocardium

Cardiovascular Therapeutics

Volumn 31, Issue 6, 2013, Pages e125-e132

  Slettom, Grete ^a   Jonassen, Anne Kristine ^b   Breivik, Lars ^b   Seifert, Reinhard ^a   Nordrehaug, Jan Erik ^a,b  

^a HAUKELAND UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF BERGEN   (Norway)

Author keywords

Akt; Cardioprotection; Insulin; Myocardial infarction; Pig

Indexed keywords

ACETYLSALICYLIC ACID; CLOPIDOGREL; GLUCOSE; INSULIN; PROTEIN KINASE B;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIET RESTRICTION; DOSE RESPONSE; ENZYME PHOSPHORYLATION; EXPERIMENTAL PIG; FEEDING; FEMALE; GLUCOSE BLOOD LEVEL; HEART; HEART MUSCLE; HEART MUSCLE BIOPSY; IMMUNOBLOTTING; IN VIVO STUDY; INSULIN INFUSION; LEFT CORONARY ARTERY; NONHUMAN; PRIORITY JOURNAL;

AKT; CARDIOPROTECTION; INSULIN; MYOCARDIAL INFARCTION; PIG;

ANIMALS; BLOOD GLUCOSE; EATING; FEMALE; HEMODYNAMICS; INSULIN; MYOCARDIUM; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; SWINE;

EID: 84888318233     PISSN: 17555914     EISSN: 17555922     Source Type: Journal    
DOI: 10.1111/1755-5922.12046     Document Type: Article

References (45)

1. Hausenloy DJ, Yellon DM. New directions for protecting the heart against ischaemia-reperfusion injury: Targeting the reperfusion injury salvage kinase (RISK)-pathway. Cardiovasc Res 2004;61:448-460.
2. Muniyappa R, Montagnani M, Koh KK, Quon MJ. Cardiovascular actions of insulin. Endocr Rev 2007;28:463-491.
3. Parcellier A, Tintignac LA, Zhuravleva E, Hemmings BA. PKB and the mitochondria: AKTing on apoptosis. Cell Signal 2008;20:21-30.
4. Ovize M, Baxter GF, Di Lisa F, et al. Postconditioning and protection from reperfusion injury: Where do we stand? Position paper from the Working Group of Cellular Biology of the Heart of the European Society of Cardiology. Cardiovasc Res 2010;87:406-423.
5. Jonassen AK, Sack MN, Mjøs OD, Yellon DM. Myocardial protection by insulin at reperfusion requires early administration and is mediated via Akt and p70s6 kinase cell-survival signaling. Circ Res 2001;89:1191-1198.
6. Gao F, Gao E, Yue T-L, et al. Nitric oxide mediates the antiapoptotic effect of insulin in myocardial ischemia-reperfusion: The roles of PI3-kinase, Akt, and endothelial nitric oxide synthase phosphorylation. Circulation 2002;105:1497-1502.
7. Zhang H-X, Zang Y-M, Huo J-H, et al. Physiologically tolerable insulin reduces myocardial injury and improves cardiac functional recovery in myocardial ischemic/reperfused dogs. J Cardiovasc Pharmacol 2006;48:306-313.
8. Zhang HF, Fan Q, Qian XX, et al. Role of insulin in the anti-apoptotic effect of glucose-insulin-potassium in rabbits with acute myocardial ischemia and reperfusion. Apoptosis 2004;9:777-783.
9. Díaz R, Goyal A, Mehta SR, et al. Glucose-insulin-potassium therapy in patients with ST-segment elevation myocardial infarction. JAMA 2007;298:2399-2405.
10. Díaz RR, Paolasso EAE, Piegas LSL, et al. Metabolic modulation of acute myocardial infarction. The ECLA (Estudios Cardiológicos Latinoamérica) Collaborative Group. Circulation 1998;98:2227-2234.
11. Mehta SR, Yusuf S, Díaz R, et al. Effect of glucose-insulin-potassium infusion on mortality in patients with acute ST-segment elevation myocardial infarction: The CREATE-ECLA randomized controlled trial. JAMA 2005;293:437-446.
12. Ceremuzyński L, Budaj A, Czepiel A, et al. Low-dose glucose-insulin-potassium is ineffective in acute myocardial infarction: Results of a randomized multicenter Pol-GIK trial. Cardiovasc Drugs Ther 1999;13:191-200.
13. van der Horst ICC, Zijlstra F, van t Hof AWJ, et al. Glucose-insulin-potassium infusion inpatients treated with primary angioplasty for acute myocardial infarction: The glucose-insulin-potassium study: A randomized trial. J Am Coll Cardiol 2003;42:784-791.
14. Selker HP, Beshansky JR, Sheehan PR, et al. Out-of-hospital administration of intravenous glucose-insulin-potassium in patients with suspected acute coronary syndromes: The IMMEDIATE randomized controlled trial. JAMA 2012;307:1925-1933.
15. Howell NJ, Ashrafian H, Drury NE, et al. Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: Results from the Hypertrophy, Insulin, Glucose, and Electrolytes (HINGE) trial. Circulation 2011;123:170-177.
16. Heusch G, Skyschally A, Schulz R. The in-situ pig heart with regional ischemia/reperfusion - Ready for translation. J Mol Cell Cardiol 2011;50:951-963.
17. Timmers L, Henriques JPS, de Kleijn DPV, et al. Exenatide reduces infarct size and improves cardiac function in a porcine model of ischemia and reperfusion injury. J Am Coll Cardiol 2009;53:501-510.
18. Skyschally A, van Caster P, Boengler K, et al. Ischemic postconditioning in pigs no causal role for RISK activation. Circ Res 2009;104:15-18.
19. Chaudhuri A, Dandona P, Fonseca V. Cardiovascular benefits of exogenous insulin. J Clin Endocrinol Metab 2012;97:3079-3091.
20. Helgeland E, Guvag S, Jonassen AK. Insulin induced cytoprotection by mimicking postconditioning at myocardial reperfusion. J Mol Cell Cardiol 2007;42:S185-S186.
21. Slettom G, Jonassen AK, Tuseth V, et al. Percutaneous catheter-based intracoronary infusion of insulin - A dose finding study in the porcine model. Basic Clin Pharmacol Toxicol 2011;108:414-420.
22. Semenas E, Nozari A, Wiklund L. Sex differences in cardiac injury after severe haemorrhage and ventricular fibrillation in pigs. Resuscitation 2010;81:1718-1722.
23. Fanneløp T, Dahle GO, Matre K, Segadal L, Grong K. An anaesthetic protocol in the young domestic pig allowing neuromuscular blockade for studies of cardiac function following cardioplegic arrest and cardiopulmonary bypass. Acta Anaesthesiol Scand 2004;48:1144-1154.
24. Breivik L, Helgeland E, Aarnes EK, Mrdalj J, Jonassen AK. Remote postconditioning by humoral factors in effluent from ischemic preconditioned rat hearts is mediated via PI3K/Akt-dependent cell-survival signaling at reperfusion. Basic Res Cardiol 2011;106:135-145.
25. Geraci M. lqmm: Linear Quantile Mixed Models. R package version 1.02. The R Foundation for Statistical Computing, Vienna, Austria, 2013.
26. Pinheiro J, Bates D, DebRoy S, Sarkar D and the R Development Core Team. nlme: Linear and Nonlinear Mixed Effects Models. R package version 3.1-105. The R Foundation for Statistical Computing, Vienna, Austria, 2013.
27. Malhotra A, Vashistha H, Yadav VS, et al. Inhibition of p66ShcA redox activity in cardiac muscle cells attenuates hyperglycemia-induced oxidative stress and apoptosis. Am J Physiol Heart Circ Physiol 2009;296:H380-H388.
28. Raphael J, Gozal Y, Navot N, Zuo Z. Hyperglycemia inhibits anesthetic-induced postconditioning in the rabbit heart via modulation of phosphatidylinositol-3-kinase/Akt and endothelial nitric oxide synthase signaling. J Cardiovasc Pharmacol 2010;55:348-357.
29. Timmer JR, van der Horst ICC, Ottervanger JP, et al. Prognostic value of admission glucose in non-diabetic patients with myocardial infarction. Am Heart J 2004;148:399-404.
30. Su H, Sun X, Ma H, et al. Acute hyperglycemia exacerbates myocardial ischemia/reperfusion injury and blunts cardioprotective effect of GIK. Am J Physiol Endocrinol Metab 2007;293:629-635.
31. Ronnett GV, Knutson VP, Lane MD. Insulin-induced down-regulation of insulin receptors in 3T3-L1 adipocytes. Altered rate of receptor inactivation. J Biol Chem 1982;257:4285-4291.
32. Krupp M, Lane MD. On the mechanism of ligand-induced down-regulation of insulin receptor level in the liver cell. J Biol Chem 1981;256:1689-1694.
33. Ruddock MW, Stein A, Landaker E, et al. Saturated fatty acids inhibit hepatic insulin action by modulating insulin receptor expression and post-receptor signalling. J Biochem 2008;144:599-607.
34. Kokubun E, Hirabara SM, Fiamoncini J, Curi R, Haebisch H. Changes of glycogen content in liver, skeletal muscle, and heart from fasted rats. Cell Biochem Funct 2009;27:488-495.
35. Halbirk M, Nørrelund H, Møller N, Schmitz O, Bøtker HE, Wiggers H. Short-term changes in circulating insulin and free fatty acids affect Nt-pro-BNP levels in heart failure patients. Int J Cardiol 2010;144:140-142.
36. Tanabe A, Naruse M, Wasada T, et al. Effects of acute hyperinsulinemia on plasma atrial and brain natriuretic peptide concentrations. Eur J Endocrinol 1995;132:693-698.
37. Yu QQ, Gao FF, Ma XLX. Insulin says NO to cardiovascular disease. Cardiovasc Res 2011;89:516-524.
38. Landsberg L. Insulin-mediated sympathetic stimulation: Role in the pathogenesis of obesity-related hypertension (or, how insulin affects blood pressure, and why). J Hypertens 2001;19(3 Pt 2):523-528.
39. Wu YY, Barrett EJE, Long WW, Liu ZZ. Glucocorticoids differentially modulate insulin-mediated protein and glycogen synthetic signaling downstream of protein kinase B in rat myocardium. Endocrinology 2004;145:1161-1166.
40. Musiolik J, van Caster P, Skyschally A, et al. Reduction of infarct size by gentle reperfusion without activation of reperfusion injury salvage kinases in pigs. Cardiovasc Res 2010;85:110-117.
41. Apstein CS, Opie LH. A challenge to the metabolic approach to myocardial ischaemia. Eur Heart J 2005;26:956-959.
42. Taegtmeyer H, Khalaf KI. Letter by Taegtmeyer and Khalaf regarding article, "Glucose-insulin-potassium reduces the incidence of low cardiac output episodes after aortic valve replacement for aortic stenosis in patients with left ventricular hypertrophy: Results from the hypertrophy, insulin, glucose, and electrolytes (HINGE) trial". Circulation 2011;124:e385; author reply e386.
43. Bronisz A, Kozinski M, Magielski P, et al. Stress hyperglycaemia in patients with first myocardial infarction. Int J Clin Pract 2012;66:592-601.
44. Lazzeri C, Valente S, Chiostri M, Picariello C, Gensini GF. Correlates of acute insulin resistance in the early phase of non-diabetic ST-elevation myocardial infarction. Diab Vasc Dis Res 2011;8:35-42.
45. Task Force on the management of ST-segment elevation acute myocardial infarction of the European Society of Cardiology (ESC), Steg PG, James SK, et al. ESC guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2012;33:2569-2619.