Metabolic modulation of acute myocardial infarction: The ECLA glucose- insulin-potassium pilot trial

Circulation

Volumn 98, Issue 21, 1998, Pages 2227-2234

  Díaz, Rafael ^a,g   Paolasso, Ernesto A ^a   Piegas, Leopoldo S ^b   Tajer, Carlos D ^c   Moreno, Manuel Gil ^d   Corvalán, Ramón ^e   Isea, Jesús E ^f   Romero, Graciela ^a  

^a Instituto Cardiovascular de Rosario   (Argentina)

^b INSTITUTO DANTE PAZZANESE DE CARDIOLOGIA   (Brazil)

^c Sanatorio de la Providencia   (Argentina)

^d INSTITUTO NACIONAL DE CARDIOLOGÍA IGNACIO CHÁVEZ   (Mexico)

^e PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

^f Hospital Dr Domingo Luciani   (Venezuela)

^g ECLA   (Argentina)

Author keywords

Coronary disease; Glucose; Insulin; Ischemia; Myocardial infarction; Potassium

Indexed keywords

GLUCOSE; INSULIN; POTASSIUM;

ACUTE HEART INFARCTION; ADULT; AGED; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MORTALITY; PHLEBITIS; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

EID: 0032564373     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.98.21.2227     Document Type: Article

References (28)

1. De Wood MA, Spores J, Notske R, Mouser LT, Burroughs R, Golden MS, Lang HT. Prevalence of total coronary occlusion during the early hours of transmural myocardial infarction. N Engl J Med. 1980;303:897-902.
2. Califf RM. The rationale for thrombolytic therapy. Eur Heart J. 1996;17(suppl E):2-8.
3. Gruppo Italiano per lo Studio della Streptochinasi nell'Infano Miocardico (GISSI). Effectiveness of intravenous thrombolytic treatment in acute myocardial infarction. Lancet. 1986;i:397-402.
4. ISIS-2 Collaborative Group. Randomised trial of intravenous streptokinase, oral aspirin, both, or neither among 17 187 cases of suspected acute myocardial infarction: ISIS-2. Lancet. 1988;ii:349-360.
5. EMERAS (Estudio Multicéntrico Estreptoquinasa Repúblicas de América del Sur) Collaborative Group. Randomised trial of late thrombolysis in patients with suspected acute myocardial infarction. Lancet. 1993;342:767-772.
6. Fibrinolytic Therapy Trialists' Collaborative Group. Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1000 patients. Lancet. 1994;343:311-322.
7. The GUSTO Angiographie Investigators. The effects of tissue plasminogen activator, streptokinase, or both on coronary-artery patency, ventricular function, and survival after acute myocardial infarction. N Engl J Med. 1993;329:1615-1622.
8. Opie LH. Glucose and the metabolism of ischaemic myocardium. Lancet. 1995;345:1520-1521.
9. Sodi-Pallares D, Testelli MR, Fischleder BL. Effects of an intravenous infusion of a potassium-glucose-insulin solution on the electrocardiographic signs of myocardial infarction. Am J Cardiol. 1962;9:166-181.
10. Stanley AW, Moraski RE, Russell RO, Rogers WJ, Mantle JA, Kriesberg RA, McDaniel HG, Rackley CE. Effects of glucose-insulin-potassium on myocardial substrate availability and utilisation in stable coronary artery disease: studies on myocardial carbohydrates, lipid and oxygen arterialcoronary sinus differences in patients with coronary artery disease. Am J Cardiol 1975;36:929-937.
11. Yusuf S, Collins R, Peto R. Why do we need some large, simple, randomized trials? Stat Med. 1984;3:409-422.
12. Yusuf S, Flather M. Magnesium in acute myocardial infarction. BMJ. 1995;310:751-752.
13. Apstein CS, Taegtmeyer H. Glucose-insulin-potassium in acute myocardial infarction: the time has come for a large, prospective trial. Circulation. 1997;96:1074-1077.
14. Zijlstra F, De Boer JM, Hoorntje JC, Reiffers S, Reiber JHC, Suryapranata H. A comparison of immediate coronary angioplasty with intravenous streptokinase in acute myocardial infarction. N Engl J Med. 1993;328:680-684.
15. Grines CL, Browne KF, Marco J, Rothbaum D, Stone GW, O'Keefe J, Overlie P, Donohue B, Chelliah N, Timmis GC, Vlietstra RE, Strzeleck M, Puchrowiczs S, O'Neill WW, for the Primary Angioplasty Myocardial Infarction Study Group. A comparison of immediate angioplasty with thrombolytic therapy for acute myocardial infarction. N Engl J Med. 1993;328:673-679.
16. Gibbons RJ, Holmes DR, Reeder GS, Bailey KR, Hopfenspirger MR, Gersh BJ, for the Mayo Coronary Care Unit, and Catheterization Laboratory Groups. Immediate angioplasty compared with the administration of a thrombolytic agent followed by conservative treatment for myocardial infarction. N Engl J Med. 1993;328:685-691.
17. Ribeiro EE, Silva LA, Cameiro R, D'Oliveira LG, Gasquez A, Amino JG, Tavares JR. Petrizzo A, Torossian S, Duprat Fo R, Buffolo E, Ellis SG. Randomized trial of direct coronary angioplasty vs intravenous streptokinase in acute myocardial infarction. J Am Coll Cardiol. 1993;22:376-380.
18. Elizaga J, Garcia ET, Bueno H. Primary coronary angioplasty vs systemic thrombolysis in acute anterior myocardial infarction: in-hospital results from a prospective randomized trial. Eur Heart J. 1993;14:118. Abstract.
19. Ribichini F, Steffenino G, Dellavalle A, Meinardi F, Vado A, Feola M, Uslengui E. Primary angioplasty vs thrombolysis in inferior acute myocardial infarction with anterior ST-segment depression: a single-center randomized study. J Am Coll Cardiol. 1996;27:221A. Abstract.
20. Opie LH. Metabolism of free fatty acids, glucose and catecholamines in acute myocardial infarction: relation to myocardial ischaemia and infarct size. Am J Cardiol. 1975;36:938-953.
21. Valori C, Thomas M, Shillingford J. Free noradrenaline and adrenaline excretion in relation to clinical syndromes following myocardial infarction. Am J Cardiol. 1967;20:605-617.
22. Oliver MF, Kurien VA, Greenwood TW. Relation between serum free fatty acids and arrhythmias and death after acute myocardial infarction. Lancet. 1968;1:710-714.
23. Sowton E. Cardiac infarction and the glucose-tolerance test. BMJ. 1962;1:84-86.
24. Opie LH. Metabolic response during impending myocardial infarction, I: relevance of studies of glucose and fatty acid metabolism in animals. Circulation. 1972;45:483-490.
25. Oliver MF, Rowe MJ, Vetter N. Metabolic intervention. In: Oliver MF, Julian DG, Donald KW, eds. Effect of Acute Ischaemia on Myocardial Function. Edinburgh, Scotland: Churchill Livingstone; 1972:354.
26. Oliver MF, Opie LH. Effects of glucose and fatty acids on myocardial ischaemia and arrhythmias. Lancet. 1994;343:155-158.
27. Fath-Ordoubadi F, Beatt KJ. Glucose-insulin-potassium therapy for treatment of acute myocardial infarction: an overview of randomized placebo-controlled trials. Circulation. 1997;96:1152-1156.
28. Malmberg K, Ryden L, Efendic S, Herlitz J, Nicol PTS, Waldenstrom A, Wedel H, Welin L, on behalf of the DIGAMI study group Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI): effect on mortality at 1 year. J Am Coll Cardiol. 1995;26:57-65.