Linaclotide, through activation of guanylate cyclase C, acts locally in the gastrointestinal tract to elicit enhanced intestinal secretion and transit

European Journal of Pharmacology

Volumn 649, Issue 1-3, 2010, Pages 328-335

  Busby, Robert W ^a   Bryant, Alexander P ^a   Bartolini, Wilmin P ^a   Cordero, Etchell A ^a   Hannig, Gerhard ^a   Kessler, Marco M ^a   Mahajan Miklos, Shalina ^a   Pierce, Christine M ^a   Solinga, Robert M ^a   Sun, Li Jing ^a   Tobin, Jenny V ^a   Kurtz, Caroline B ^a   Currie, Mark G ^a  

^a IRONWOOD PHARMACEUTICALS INC   (United States)

Author keywords

Chronic constipation; Cyclic guanosine monophosphate; Guanylate cyclase C; Irritable bowel syndrome with constipation; Linaclotide

Indexed keywords

ATRIAL NATRIURETIC FACTOR RECEPTOR; CELL ENZYME; CYCLIC GMP; GASTROINTESTINAL AGENT; GUANYLIN; LINACLOTIDE; NATRIURETIC PEPTIDE RECEPTOR C; PEPSIN A; UNCLASSIFIED DRUG; UROGUANYLIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CARCINOMA CELL; COLON CARCINOMA; CONTROLLED STUDY; DIGESTION; DISULFIDE BOND; DOSE RESPONSE; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; ENZYME ACTIVATION; EXPERIMENTAL LIGATION; EXPERIMENTAL MODEL; FEMALE; HUMAN; HUMAN CELL; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; INCUBATION TIME; INTESTINE LOOP; INTESTINE SECRETION; INTESTINE TRANSIT TIME; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PH MEASUREMENT; PRIORITY JOURNAL; RAT; STOMACH ACID SECRETION; STOMACH JUICE;

ANIMALS; BINDING, COMPETITIVE; BIOLOGICAL AVAILABILITY; CELL LINE; CELLS, CULTURED; CONSTIPATION; CYCLIC GMP; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; FEMALE; GASTROINTESTINAL TRANSIT; HUMANS; INTESTINAL MUCOSA; INTESTINAL SECRETIONS; IRRITABLE BOWEL SYNDROME; LAXATIVES; MALE; PEPTIDES; PROTEIN CONFORMATION; PROTEIN STABILITY; RATS; RECEPTORS, GUANYLATE CYCLASE-COUPLED; RECEPTORS, PEPTIDE;

EID: 78049283798     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.09.019     Document Type: Article

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