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Volumn 14, Issue 6, 2013, Pages 492-503

Studies on anticancer activities of lactoferrin and lactoferricin

Author keywords

Application; Cancer; Delta lactoferrin; Drug delivery; Lactoferricin; Lactoferrin; Mechanism; Talactoferrin

Indexed keywords

ANTINEOPLASTIC AGENT; APOLACTOFERRIN B; CASPASE; CYCLIN D1; CYCLIN DEPENDENT KINASE 2; CYCLIN DEPENDENT KINASE INHIBITOR 1; CYCLIN E; DELTA LACTOFERRIN; ENDOTHELIN 1; EPIDERMAL GROWTH FACTOR RECEPTOR 2; FIBROBLAST GROWTH FACTOR 2; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTOFERRICIN; LACTOFERRICIN B; LACTOFERRIN; LTX 302; MITOGEN ACTIVATED PROTEIN KINASE; POLYPHENOL; PROTEIN BCL 2; PROTEIN MDM2; PROTEIN P21; PROTEIN P27; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TALACTOFERRIN; TAMOXIFEN; UNCLASSIFIED DRUG; UNINDEXED DRUG; VASCULOTROPIN; ANGIOGENESIS INHIBITOR;

EID: 84888261969     PISSN: 13892037     EISSN: 18755550     Source Type: Journal    
DOI: 10.2174/13892037113149990066     Document Type: Review
Times cited : (36)

References (119)
  • 1
    • 0036191387 scopus 로고    scopus 로고
    • The physiology of lactoferrin
    • Brock, J. H. The physiology of lactoferrin. Biochem. Cell. Biol., 2002, 80(1), 1-6.
    • (2002) Biochem. Cell. Biol. , vol.80 , Issue.1 , pp. 1-6
    • Brock, J.H.1
  • 2
    • 0037388042 scopus 로고    scopus 로고
    • Dealing with iron: Common structural principles in proteins that transport iron and heme
    • Baker, H. M.; Anderson, B. F.; Baker, E. N. Dealing with iron: common structural principles in proteins that transport iron and heme. Proc. Natl. Acad. Sci. U S A, 2003, 100(7), 3579-3583.
    • (2003) Proc. Natl. Acad. Sci. U S A , vol.100 , Issue.7 , pp. 3579-3583
    • Baker, H.M.1    Anderson, B.F.2    Baker, E.N.3
  • 3
    • 0009665799 scopus 로고
    • An iron-binding protein common to many external secretions
    • Masson, P. L.; Heremans, J. F.; Dive, C. H. An iron-binding protein common to many external secretions. Clinica. Chimica. Acta., 1966, 14(6), 735-739.
    • (1966) Clinica. Chimica. Acta. , vol.14 , Issue.6 , pp. 735-739
    • Masson, P.L.1    Heremans, J.F.2    Dive, C.H.3
  • 4
    • 37249064596 scopus 로고
    • Isolation and characterization of the red siderophilic protein from maternal milk: Lactotransferrin
    • Blanc, B.; Isliker, H.[Isolation and characterization of the red siderophilic protein from maternal milk: lactotransferrin] Bull. Soc. Chim. Biol. (Paris), 1961, 43, 929-943.
    • (1961) Bull. Soc. Chim. Biol. (Paris) , vol.43 , pp. 929-943
    • Blanc, B.1    Isliker, H.2
  • 5
    • 80052412646 scopus 로고    scopus 로고
    • Lactoferrin in human tumours: Immunohistochemical investigations during more than 25 years
    • Tuccari, G.; Barresi, G. Lactoferrin in human tumours: immunohistochemical investigations during more than 25 years. Biometals, 2011, 24(5), 775-784.
    • (2011) Biometals , vol.24 , Issue.5 , pp. 775-784
    • Tuccari, G.1    Barresi, G.2
  • 7
    • 0026475489 scopus 로고
    • Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin
    • Bellamy, W.; Takase, M.; Wakabayashi, H.; Kawase, K.; Tomita, M. Antibacterial spectrum of lactoferricin B, a potent bactericidal peptide derived from the N-terminal region of bovine lactoferrin. J. Appl. Bacteriol., 1992, 73(6), 472-479.
    • (1992) J. Appl. Bacteriol. , vol.73 , Issue.6 , pp. 472-479
    • Bellamy, W.1    Takase, M.2    Wakabayashi, H.3    Kawase, K.4    Tomita, M.5
  • 8
    • 28344438950 scopus 로고    scopus 로고
    • Lactoferricin: A lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties
    • Gifford, J. L.; Hunter, H. N.; Vogel, H. J. Lactoferricin: a lactoferrin-derived peptide with antimicrobial, antiviral, antitumor and immunological properties. Cell. Mol. Life Sci., 2005, 62(22), 2588-2598.
    • (2005) Cell. Mol. Life Sci. , vol.62 , Issue.22 , pp. 2588-2598
    • Gifford, J.L.1    Hunter, H.N.2    Vogel, H.J.3
  • 9
    • 0030940982 scopus 로고    scopus 로고
    • Bovine lactoferrin and lactoferricin, a peptide derived from bovine lactoferrin, inhibit tumor metastasis in mice
    • Yoo, Y. C.; Watanabe, S.; Watanabe, R.; Hata, K.; Shimazaki, K.; Azuma, I. Bovine lactoferrin and lactoferricin, a peptide derived from bovine lactoferrin, inhibit tumor metastasis in mice. Jpn. J. Cancer Res., 1997, 88(2), 184-190.
    • (1997) Jpn. J. Cancer Res. , vol.88 , Issue.2 , pp. 184-190
    • Yoo, Y.C.1    Watanabe, S.2    Watanabe, R.3    Hata, K.4    Shimazaki, K.5    Azuma, I.6
  • 10
    • 0022644310 scopus 로고
    • Isolation and characterization of rhesus monkey milk lactoferrin
    • Davidson, L. A.; Lonnerdal, B. Isolation and characterization of rhesus monkey milk lactoferrin. Pediatr. Res., 1986, 20(2), 197-201.
    • (1986) Pediatr. Res. , vol.20 , Issue.2 , pp. 197-201
    • Davidson, L.A.1    Lonnerdal, B.2
  • 11
    • 0035827177 scopus 로고    scopus 로고
    • Camel lactoferrin, a transferrin-cum-lactoferrin: Crystal structure of camel apolactoferrin at 2.6 A resolution and structural basis of its dual role
    • Khan, J. A.; Kumar, P.; Paramasivam, M.; Yadav, R. S.; Sahani, M. S.; Sharma, S.; Srinivasan, A.; Singh, T. P. Camel lactoferrin, a transferrin-cum-lactoferrin: crystal structure of camel apolactoferrin at 2.6 A resolution and structural basis of its dual role. J. Mol. Biol., 2001, 309(3), 751-761.
    • (2001) J. Mol. Biol. , vol.309 , Issue.3 , pp. 751-761
    • Khan, J.A.1    Kumar, P.2    Paramasivam, M.3    Yadav, R.S.4    Sahani, M.S.5    Sharma, S.6    Srinivasan, A.7    Singh, T.P.8
  • 12
    • 0024232693 scopus 로고
    • Characterization of buffalo lactotransferrin by polyacrylamide gel electrophoresis in 6 M urea
    • Kumar, S.; Bhatia, K. L. Characterization of buffalo lactotransferrin by polyacrylamide gel electrophoresis in 6 M urea. J. Chromatogr., 1988, 434(1), 228-231.
    • (1988) J. Chromatogr. , vol.434 , Issue.1 , pp. 228-231
    • Kumar, S.1    Bhatia, K.L.2
  • 13
    • 0015225776 scopus 로고
    • Lactoferrin in milk from different species
    • Masson, P. L.; Heremans, J. F. Lactoferrin in milk from different species. Comp. Biochem. Physiol. B., 1971, 39(1), 119-129.
    • (1971) Comp. Biochem. Physiol. B. , vol.39 , Issue.1 , pp. 119-129
    • Masson, P.L.1    Heremans, J.F.2
  • 14
    • 0013849080 scopus 로고
    • Immunohistochemical localization of the iron-binding protein lactoferrin in human bronchial glands
    • Masson, P.; Heremans, J. F.; Prignot, J. Immunohistochemical localization of the iron-binding protein lactoferrin in human bronchial glands. Experientia, 1965, 21(10), 604-605.
    • (1965) Experientia , vol.21 , Issue.10 , pp. 604-605
    • Masson, P.1    Heremans, J.F.2    Prignot, J.3
  • 15
    • 0028533570 scopus 로고
    • Comparative study of the iron-binding strengths of equine, bovine and human lactoferrins
    • Shimazaki, K.; Oota, K.; Nitta, K.; Ke, Y. Comparative study of the iron-binding strengths of equine, bovine and human lactoferrins. J. Dairy Res., 1994, 61(4), 563-566.
    • (1994) J. Dairy Res. , vol.61 , Issue.4 , pp. 563-566
    • Shimazaki, K.1    Oota, K.2    Nitta, K.3    Ke, Y.4
  • 17
    • 0029126185 scopus 로고
    • Lactoferrin: A general review
    • Levay, P. F.; Viljoen, M. Lactoferrin: a general review. Haematologica, 1995, 80(3), 252-267.
    • (1995) Haematologica , vol.80 , Issue.3 , pp. 252-267
    • Levay, P.F.1    Viljoen, M.2
  • 18
    • 0018145209 scopus 로고
    • Distribution of transferrin, ferritin, and lactoferrin in human tissues
    • Mason, D. Y.; Taylor, C. R. Distribution of transferrin, ferritin, and lactoferrin in human tissues. J. Clin. Pathol., 1978, 31(4), 316-327.
    • (1978) J. Clin. Pathol. , vol.31 , Issue.4 , pp. 316-327
    • Mason, D.Y.1    Taylor, C.R.2
  • 19
    • 64949166046 scopus 로고    scopus 로고
    • Lactoferrin immuno-expression in human normal and neoplastic bone tissue
    • Ieni, A.; Barresi, V.; Grosso, M.; Rosa, M. A.; Tuccari, G. Lactoferrin immuno-expression in human normal and neoplastic bone tissue. J. Bone Miner. Metab., 2009, 27(3), 364-371.
    • (2009) J. Bone Miner. Metab. , vol.27 , Issue.3 , pp. 364-371
    • Ieni, A.1    Barresi, V.2    Grosso, M.3    Rosa, M.A.4    Tuccari, G.5
  • 20
    • 72949106301 scopus 로고    scopus 로고
    • Immunolocalization of lactoferrin in cartilage-forming neoplasms
    • Ieni, A.; Barresi, V.; Grosso, M.; Rosa, M. A.; Tuccari, G. Immunolocalization of lactoferrin in cartilage-forming neoplasms. J. Orthop. Sci., 2009, 14(6), 732-737.
    • (2009) J. Orthop. Sci. , vol.14 , Issue.6 , pp. 732-737
    • Ieni, A.1    Barresi, V.2    Grosso, M.3    Rosa, M.A.4    Tuccari, G.5
  • 22
    • 0015225776 scopus 로고
    • Lactoferrin in milk from different species
    • Masson, P. L.; Heremans, J. F. Lactoferrin in milk from different species. Comp. Biochem. Physiol. B., 1971, 39(1), 119-129.
    • (1971) Comp. Biochem. Physiol. B. , vol.39 , Issue.1 , pp. 119-129
    • Masson, P.L.1    Heremans, J.F.2
  • 23
    • 0034492988 scopus 로고    scopus 로고
    • Occurrence, structure, biochemical properties and technological characteristics of lactoferrin
    • Steijns, J. M.; van Hooijdonk, A. C. Occurrence, structure, biochemical properties and technological characteristics of lactoferrin. Br. J. Nutr., 2000, 84 Suppl 1, S11-S17.
    • (2000) Br. J. Nutr. , vol.84 , Issue.SUPPL. 1
    • Steijns, J.M.1    van Hooijdonk, A.C.2
  • 24
    • 0024393966 scopus 로고
    • Multiple molecular forms of human lactoferrin. Identification of a class of lactoferrins that possess ribonuclease activity and lack iron-binding capacity
    • Furmanski, P.; Li, Z. P.; Fortuna, M. B.; Swamy, C. V.; Das, M. R. Multiple molecular forms of human lactoferrin. Identification of a class of lactoferrins that possess ribonuclease activity and lack iron-binding capacity. J. Exp. Med., 1989, 170(2), 415-429.
    • (1989) J. Exp. Med. , vol.170 , Issue.2 , pp. 415-429
    • Furmanski, P.1    Li, Z.P.2    Fortuna, M.B.3    Swamy, C.V.4    Das, M.R.5
  • 25
    • 0024389662 scopus 로고
    • Structure of human lactoferrin: Crystallographic structure analysis and refinement at 2.8 A resolution
    • Anderson, B. F.; Baker, H. M.; Norris, G. E.; Rice, D. W.; Baker, E. N. Structure of human lactoferrin: crystallographic structure analysis and refinement at 2.8 A resolution. J. Mol. Biol., 1989, 209(4), 711-734.
    • (1989) J. Mol. Biol. , vol.209 , Issue.4 , pp. 711-734
    • Anderson, B.F.1    Baker, H.M.2    Norris, G.E.3    Rice, D.W.4    Baker, E.N.5
  • 27
    • 0030719461 scopus 로고    scopus 로고
    • Three-dimensional structure of diferric bovine lactoferrin at 2.8 A resolution
    • Moore, S. A.; Anderson, B. F.; Groom, C. R.; Haridas, M.; Baker, E. N. Three-dimensional structure of diferric bovine lactoferrin at 2.8 A resolution. J. Mol. Biol., 1997, 274(2), 222-236.
    • (1997) J. Mol. Biol. , vol.274 , Issue.2 , pp. 222-236
    • Moore, S.A.1    Anderson, B.F.2    Groom, C.R.3    Haridas, M.4    Baker, E.N.5
  • 28
    • 0037388042 scopus 로고    scopus 로고
    • Dealing with iron: Common structural principles in proteins that transport iron and heme
    • Baker, H. M.; Anderson, B. F.; Baker, E. N. Dealing with iron: common structural principles in proteins that transport iron and heme. Proc. Natl. Acad. Sci. U S A, 2003, 100(7), 3579-3583.
    • (2003) Proc. Natl. Acad. Sci. U S A , vol.100 , Issue.7 , pp. 3579-3583
    • Baker, H.M.1    Anderson, B.F.2    Baker, E.N.3
  • 29
    • 34248641665 scopus 로고    scopus 로고
    • A structural comparison of human serum transferrin and human lactoferrin
    • Wally, J.; Buchanan, S. K. A structural comparison of human serum transferrin and human lactoferrin. Biometals, 2007, 20(3-4), 249-262.
    • (2007) Biometals , vol.20 , Issue.3-4 , pp. 249-262
    • Wally, J.1    Buchanan, S.K.2
  • 30
    • 0022416851 scopus 로고
    • Comparison of human lactoferrins from milk and neutrophilic leucocytes. Relative molecular mass, isoelectric point, iron-binding properties and uptake by the liver
    • Moguilevsky, N.; Retegui, L. A.; Masson, P. L. Comparison of human lactoferrins from milk and neutrophilic leucocytes. Relative molecular mass, isoelectric point, iron-binding properties and uptake by the liver. Biochem. J., 1985, 229(2), 353-359.
    • (1985) Biochem. J. , vol.229 , Issue.2 , pp. 353-359
    • Moguilevsky, N.1    Retegui, L.A.2    Masson, P.L.3
  • 31
    • 0032437146 scopus 로고    scopus 로고
    • Direct evidence of the generation in human stomach of an antimicrobial peptide domain (lactoferricin) from ingested lactoferrin
    • Kuwata, H.; Yip, T. T.; Tomita, M.; Hutchens, T. W. Direct evidence of the generation in human stomach of an antimicrobial peptide domain (lactoferricin) from ingested lactoferrin. Biochim. Biophys. Acta, 1998, 1429(1), 129-141.
    • (1998) Biochim. Biophys. Acta , vol.1429 , Issue.1 , pp. 129-141
    • Kuwata, H.1    Yip, T.T.2    Tomita, M.3    Hutchens, T.W.4
  • 34
    • 33744454723 scopus 로고    scopus 로고
    • Synthetic porcine lactoferricin with a 20-residue peptide exhibits antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans
    • Chen, H. L.; Yen, C. C.; Lu, C. Y.; Yu, C. H.; Chen, C. M. Synthetic porcine lactoferricin with a 20-residue peptide exhibits antimicrobial activity against Escherichia coli, Staphylococcus aureus, and Candida albicans. J. Agric. Food Chem., 2006, 54(9), 3277-3282.
    • (2006) J. Agric. Food Chem. , vol.54 , Issue.9 , pp. 3277-3282
    • Chen, H.L.1    Yen, C.C.2    Lu, C.Y.3    Yu, C.H.4    Chen, C.M.5
  • 35
    • 0007654555 scopus 로고    scopus 로고
    • Increased antibacterial activity of 15-residue murine lactoferricin derivatives
    • Strom, M. B.; Rekdal, O.; Stensen, W.; Svendsen, J. S. Increased antibacterial activity of 15-residue murine lactoferricin derivatives. J. Pept. Res., 2001, 57(2), 127-139.
    • (2001) J. Pept. Res. , vol.57 , Issue.2 , pp. 127-139
    • Strom, M.B.1    Rekdal, O.2    Stensen, W.3    Svendsen, J.S.4
  • 37
    • 23044463641 scopus 로고    scopus 로고
    • Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent
    • Hunter, H. N.; Demcoe, A. R.; Jenssen, H.; Gutteberg, T. J.; Vogel, H. J. Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent. Antimicrob. Agents Chemother., 2005, 49(8), 3387-3395.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , Issue.8 , pp. 3387-3395
    • Hunter, H.N.1    Demcoe, A.R.2    Jenssen, H.3    Gutteberg, T.J.4    Vogel, H.J.5
  • 38
    • 0031115106 scopus 로고    scopus 로고
    • Antibacterial peptides of bovine lactoferrin: Purification and characterization
    • Dionysius, D. A.; Milne, J. M. Antibacterial peptides of bovine lactoferrin: purification and characterization. J. Dairy Sci., 1997, 80(4), 667-674.
    • (1997) J. Dairy Sci. , vol.80 , Issue.4 , pp. 667-674
    • Dionysius, D.A.1    Milne, J.M.2
  • 39
    • 0024988330 scopus 로고
    • Complete nucleotide sequence of human mammary gland lactoferrin
    • Rey, M. W.; Woloshuk, S. L.; DeBoer, H. A.; Pieper, F. R. Complete nucleotide sequence of human mammary gland lactoferrin. Nucleic Acids Res., 1990, 18(17), 5288.
    • (1990) Nucleic Acids Res. , vol.18 , Issue.17 , pp. 5288
    • Rey, M.W.1    Woloshuk, S.L.2    DeBoer, H.A.3    Pieper, F.R.4
  • 41
    • 84903421873 scopus 로고    scopus 로고
    • Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin
    • Hwang, P. M.; Zhou, N.; Shan, X.; Arrowsmith, C. H.; Vogel, H. J. Three-dimensional solution structure of lactoferricin B, an antimicrobial peptide derived from bovine lactoferrin. Biochemistry, 1998, 37(12), 4288-4298.
    • (1998) Biochemistry , vol.37 , Issue.12 , pp. 4288-4298
    • Hwang, P.M.1    Zhou, N.2    Shan, X.3    Arrowsmith, C.H.4    Vogel, H.J.5
  • 42
    • 23044463641 scopus 로고    scopus 로고
    • Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent
    • Hunter, H. N.; Demcoe, A. R.; Jenssen, H.; Gutteberg, T. J.; Vogel, H. J. Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent. Antimicrob., Agents Chemother., 2005, 49(8), 3387-3395.
    • (2005) Antimicrob., Agents Chemother. , vol.49 , Issue.8 , pp. 3387-3395
    • Hunter, H.N.1    Demcoe, A.R.2    Jenssen, H.3    Gutteberg, T.J.4    Vogel, H.J.5
  • 44
    • 0344304749 scopus 로고    scopus 로고
    • Anti-HSV activity of lactoferricin analogues is only partly related to their affinity for heparan sulfate
    • Jenssen, H.; Andersen, J. H.; Uhlin-Hansen, L.; Gutteberg, T. J.; Rekdal, O. Anti-HSV activity of lactoferricin analogues is only partly related to their affinity for heparan sulfate. Antiviral Res., 2004, 61(2), 101-109.
    • (2004) Antiviral Res. , vol.61 , Issue.2 , pp. 101-109
    • Jenssen, H.1    Andersen, J.H.2    Uhlin-Hansen, L.3    Gutteberg, T.J.4    Rekdal, O.5
  • 45
    • 23044463641 scopus 로고    scopus 로고
    • Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent
    • Hunter, H. N.; Demcoe, A. R.; Jenssen, H.; Gutteberg, T. J.; Vogel, H. J. Human lactoferricin is partially folded in aqueous solution and is better stabilized in a membrane mimetic solvent. Antimicrob. Agents Chemother., 2005, 49(8), 3387-3395.
    • (2005) Antimicrob. Agents Chemother. , vol.49 , Issue.8 , pp. 3387-3395
    • Hunter, H.N.1    Demcoe, A.R.2    Jenssen, H.3    Gutteberg, T.J.4    Vogel, H.J.5
  • 46
    • 0032929589 scopus 로고    scopus 로고
    • Tumor markers in the diagnosis of pancreatic cancer
    • Cappelli, G.; Paladini, S.; D'Agata, A. Tumor markers in the diagnosis of pancreatic cancer. Tumori, 1999, 85(1 Suppl 1), S19-S21.
    • (1999) Tumori , vol.85 , Issue.1 SUPPL. 1
    • Cappelli, G.1    Paladini, S.2    D'Agata, A.3
  • 47
    • 3543071604 scopus 로고    scopus 로고
    • Sialidase and malignancy: A minireview
    • Miyagi, T.; Wada, T.; Yamaguchi, K.; Hata, K. Sialidase and malignancy: a minireview. Glycoconj. J., 2004, 20(3), 189-198.
    • (2004) Glycoconj. J. , vol.20 , Issue.3 , pp. 189-198
    • Miyagi, T.1    Wada, T.2    Yamaguchi, K.3    Hata, K.4
  • 48
    • 0025743796 scopus 로고
    • Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes
    • Utsugi, T.; Schroit, A. J.; Connor, J.; Bucana, C. D.; Fidler, I. J. Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes. Cancer Res., 1991, 51(11), 3062-3066.
    • (1991) Cancer Res. , vol.51 , Issue.11 , pp. 3062-3066
    • Utsugi, T.1    Schroit, A.J.2    Connor, J.3    Bucana, C.D.4    Fidler, I.J.5
  • 49
    • 0028527479 scopus 로고
    • Back and forth: The regulation and function of transbilayer phospholipid movement in eukaryotic cells
    • Williamson, P.; Schlegel, R. A. Back and forth: the regulation and function of transbilayer phospholipid movement in eukaryotic cells. Mol. Membr. Biol., 1994, 11(4), 199-216.
    • (1994) Mol. Membr. Biol. , vol.11 , Issue.4 , pp. 199-216
    • Williamson, P.1    Schlegel, R.A.2
  • 50
    • 0031043059 scopus 로고    scopus 로고
    • Pathophysiologic implications of membrane phospholipid asymmetry in blood cells
    • Zwaal, R. F.; Schroit, A. J. Pathophysiologic implications of membrane phospholipid asymmetry in blood cells. Blood, 1997, 89(4), 1121-1132.
    • (1997) Blood , vol.89 , Issue.4 , pp. 1121-1132
    • Zwaal, R.F.1    Schroit, A.J.2
  • 51
    • 33746263988 scopus 로고    scopus 로고
    • The cytotoxic effects of human neutrophil peptide-1 (HNP1) and lactoferrin on oral squamous cell carcinoma (OSCC) in vitro
    • McKeown, S. T.; Lundy, F. T.; Nelson, J.; Lockhart, D.; Irwin, C. R.; Cowan, C. G.; Marley, J. J. The cytotoxic effects of human neutrophil peptide-1 (HNP1) and lactoferrin on oral squamous cell carcinoma (OSCC) in vitro. Oral Oncol., 2006, 42(7), 685-690.
    • (2006) Oral Oncol. , vol.42 , Issue.7 , pp. 685-690
    • McKeown, S.T.1    Lundy, F.T.2    Nelson, J.3    Lockhart, D.4    Irwin, C.R.5    Cowan, C.G.6    Marley, J.J.7
  • 52
    • 0034834482 scopus 로고    scopus 로고
    • Biophysical characterization of lipopolysaccharide and lipid A inactivation by lactoferrin
    • Brandenburg, K.; Jurgens, G.; Muller, M.; Fukuoka, S.; Koch, M. H. Biophysical characterization of lipopolysaccharide and lipid A inactivation by lactoferrin. Biol. Chem., 2001, 382(8), 1215-1225.
    • (2001) Biol. Chem. , vol.382 , Issue.8 , pp. 1215-1225
    • Brandenburg, K.1    Jurgens, G.2    Muller, M.3    Fukuoka, S.4    Koch, M.H.5
  • 54
    • 0027978954 scopus 로고
    • Delineation of the glycosaminoglycan-binding site in the human inflammatory response protein lactoferrin
    • Mann, D. M.; Romm, E.; Migliorini, M. Delineation of the glycosaminoglycan-binding site in the human inflammatory response protein lactoferrin. J. Biol. Chem., 1994, 269(38), 23661-23667.
    • (1994) J. Biol. Chem. , vol.269 , Issue.38 , pp. 23661-23667
    • Mann, D.M.1    Romm, E.2    Migliorini, M.3
  • 55
    • 0032445978 scopus 로고    scopus 로고
    • Role of heparan sulphate proteoglycans in the regulation of human lactoferrin binding and activity in the MDA-MB-231 breast cancer cell line
    • Damiens, E.; El, Y. I.; Mazurier, J.; Elass-Rochard, E.; Duthille, I.; Spik, G.; Boilly-Marer, Y. Role of heparan sulphate proteoglycans in the regulation of human lactoferrin binding and activity in the MDA-MB-231 breast cancer cell line. Eur. J. Cell. Biol., 1998, 77(4), 344-351.
    • (1998) Eur. J. Cell. Biol. , vol.77 , Issue.4 , pp. 344-351
    • Damiens, E.1    El, Y.I.2    Mazurier, J.3    Elass-Rochard, E.4    Duthille, I.5    Spik, G.6    Boilly-Marer, Y.7
  • 56
    • 38348999283 scopus 로고    scopus 로고
    • Bovine lactoferricin inhibits basic fibroblast growth factor-and vascular endothelial growth factor165-induced angiogenesis by competing for heparin-like binding sites on endothelial cells
    • Mader, J. S.; Smyth, D.; Marshall, J.; Hoskin, D. W. Bovine lactoferricin inhibits basic fibroblast growth factor-and vascular endothelial growth factor165-induced angiogenesis by competing for heparin-like binding sites on endothelial cells. Am. J. Pathol., 2006, 169(5), 1753-1766.
    • (2006) Am. J. Pathol. , vol.169 , Issue.5 , pp. 1753-1766
    • Mader, J.S.1    Smyth, D.2    Marshall, J.3    Hoskin, D.W.4
  • 57
    • 50849136183 scopus 로고    scopus 로고
    • Protective effects of lactoferrin against intestinal mucosal damage induced by lipopolysaccharide in human intestinal Caco-2 cells
    • Hirotani, Y.; Ikeda, K.; Kato, R.; Myotoku, M.; Umeda, T.; Ijiri, Y.; Tanaka, K. Protective effects of lactoferrin against intestinal mucosal damage induced by lipopolysaccharide in human intestinal Caco-2 cells. Yakugaku Zasshi, 2008, 128(9), 1363-1368.
    • (2008) Yakugaku Zasshi , vol.128 , Issue.9 , pp. 1363-1368
    • Hirotani, Y.1    Ikeda, K.2    Kato, R.3    Myotoku, M.4    Umeda, T.5    Ijiri, Y.6    Tanaka, K.7
  • 58
    • 77953290149 scopus 로고    scopus 로고
    • Immunoregulatory role of lactoferrin-lipopolysaccharide interactions
    • Puddu, P.; Latorre, D.; Valenti, P.; Gessani, S. Immunoregulatory role of lactoferrin-lipopolysaccharide interactions. Biometals, 2010, 23(3), 387-397.
    • (2010) Biometals , vol.23 , Issue.3 , pp. 387-397
    • Puddu, P.1    Latorre, D.2    Valenti, P.3    Gessani, S.4
  • 60
    • 28344453346 scopus 로고    scopus 로고
    • Mammalian lactoferrin receptors: Structure and function
    • Suzuki, Y. A.; Lopez, V.; Lonnerdal, B. Mammalian lactoferrin receptors: structure and function. Cell. Mol. Life Sci., 2005, 62(22), 2560-2575.
    • (2005) Cell. Mol. Life Sci. , vol.62 , Issue.22 , pp. 2560-2575
    • Suzuki, Y.A.1    Lopez, V.2    Lonnerdal, B.3
  • 61
    • 3342947832 scopus 로고    scopus 로고
    • Cellular internalization of lactoferrin in intestinal epithelial cells
    • Ashida, K.; Sasaki, H.; Suzuki, Y. A.; Lonnerdal, B. Cellular internalization of lactoferrin in intestinal epithelial cells. Biometals, 2004, 17(3), 311-315.
    • (2004) Biometals , vol.17 , Issue.3 , pp. 311-315
    • Ashida, K.1    Sasaki, H.2    Suzuki, Y.A.3    Lonnerdal, B.4
  • 62
    • 8844263029 scopus 로고    scopus 로고
    • Neutrophil lactoferrin upregulates the human p53 gene through induction of NF-kappaB activation cascade
    • Oh, S. M.; Pyo, C. W.; Kim, Y.; Choi, S. Y. Neutrophil lactoferrin upregulates the human p53 gene through induction of NF-kappaB activation cascade. Oncogene, 2004, 23(50), 8282-8291.
    • (2004) Oncogene , vol.23 , Issue.50 , pp. 8282-8291
    • Oh, S.M.1    Pyo, C.W.2    Kim, Y.3    Choi, S.Y.4
  • 63
    • 18044397724 scopus 로고    scopus 로고
    • Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines
    • Mader, J. S.; Salsman, J.; Conrad, D. M.; Hoskin, D. W. Bovine lactoferricin selectively induces apoptosis in human leukemia and carcinoma cell lines. Mol. Cancer Ther., 2005, 4(4), 612-624.
    • (2005) Mol. Cancer Ther. , vol.4 , Issue.4 , pp. 612-624
    • Mader, J.S.1    Salsman, J.2    Conrad, D.M.3    Hoskin, D.W.4
  • 64
    • 4344615913 scopus 로고    scopus 로고
    • Anti-HSV activity of lactoferrin and lactoferricin is dependent on the presence of heparan sulphate at the cell surface
    • Andersen, J. H.; Jenssen, H.; Sandvik, K.; Gutteberg, T. J. Anti-HSV activity of lactoferrin and lactoferricin is dependent on the presence of heparan sulphate at the cell surface. J. Med. Virol., 2004, 74(2), 262-271.
    • (2004) J. Med. Virol. , vol.74 , Issue.2 , pp. 262-271
    • Andersen, J.H.1    Jenssen, H.2    Sandvik, K.3    Gutteberg, T.J.4
  • 66
    • 0031589527 scopus 로고    scopus 로고
    • Apoptosis in human leukemic cells induced by lactoferricin, a bovine milk protein-derived peptide: Involvement of reactive oxygen species
    • Yoo, Y. C.; Watanabe, R.; Koike, Y.; Mitobe, M.; Shimazaki, K.; Watanabe, S.; Azuma, I. Apoptosis in human leukemic cells induced by lactoferricin, a bovine milk protein-derived peptide: involvement of reactive oxygen species. Biochem. Biophys. Res. Commun., 1997, 237(3), 624-628.
    • (1997) Biochem. Biophys. Res. Commun. , vol.237 , Issue.3 , pp. 624-628
    • Yoo, Y.C.1    Watanabe, R.2    Koike, Y.3    Mitobe, M.4    Shimazaki, K.5    Watanabe, S.6    Azuma, I.7
  • 67
    • 77957604071 scopus 로고    scopus 로고
    • The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells
    • de Mejia, E. G.; Dia, V. P. The role of nutraceutical proteins and peptides in apoptosis, angiogenesis, and metastasis of cancer cells. Cancer Metastasis Rev., 2010, 29(3), 511-528.
    • (2010) Cancer Metastasis Rev. , vol.29 , Issue.3 , pp. 511-528
    • de Mejia, E.G.1    Dia, V.P.2
  • 68
    • 0033197916 scopus 로고    scopus 로고
    • Lactoferrin inhibits G1 cyclin-dependent kinases during growth arrest of human breast carcinoma cells
    • Damiens, E.; El, Y. I.; Mazurier, J.; Duthille, I.; Spik, G.; Boilly-Marer, Y. Lactoferrin inhibits G1 cyclin-dependent kinases during growth arrest of human breast carcinoma cells. J. Cell Biochem., 1999, 74(3), 486-498.
    • (1999) J. Cell Biochem. , vol.74 , Issue.3 , pp. 486-498
    • Damiens, E.1    El, Y.I.2    Mazurier, J.3    Duthille, I.4    Spik, G.5    Boilly-Marer, Y.6
  • 69
    • 11144226929 scopus 로고    scopus 로고
    • Lactoferrin down-regulates G1 cyclin-dependent kinases during growth arrest of head and neck cancer cells
    • Xiao, Y.; Monitto, C. L.; Minhas, K. M.; Sidransky, D. Lactoferrin down-regulates G1 cyclin-dependent kinases during growth arrest of head and neck cancer cells. Clin. Cancer Res., 2004, 10(24), 8683-8686.
    • (2004) Clin. Cancer Res. , vol.10 , Issue.24 , pp. 8683-8686
    • Xiao, Y.1    Monitto, C.L.2    Minhas, K.M.3    Sidransky, D.4
  • 70
    • 51649120414 scopus 로고    scopus 로고
    • Lactotransferrin: A candidate tumor suppressor-Deficient expression in human nasopharyngeal carcinoma and inhibition of NPC cell proliferation by modulating the mitogen-activated protein kinase pathway
    • Zhou, Y.; Zeng, Z.; Zhang, W.; Xiong, W.; Wu, M.; Tan, Y.; Yi, W.; Xiao, L.; Li, X.; Huang, C.; Cao, L.; Tang, K.; Li, X.; Shen, S.; Li, G. Lactotransferrin: a candidate tumor suppressor-Deficient expression in human nasopharyngeal carcinoma and inhibition of NPC cell proliferation by modulating the mitogen-activated protein kinase pathway. Int. J. Cancer, 2008, 123(9), 2065-2072.
    • (2008) Int. J. Cancer , vol.123 , Issue.9 , pp. 2065-2072
    • Zhou, Y.1    Zeng, Z.2    Zhang, W.3    Xiong, W.4    Wu, M.5    Tan, Y.6    Yi, W.7    Xiao, L.8    Li, X.9    Huang, C.10    Cao, L.11    Tang, K.12    Li, X.13    Shen, S.14    Li, G.15
  • 71
    • 67649236592 scopus 로고    scopus 로고
    • Lactoferricin treatment decreases the rate of cell proliferation of a human colon cancer cell line
    • Freiburghaus, C.; Janicke, B.; Lindmark-Mansson, H.; Oredsson, S. M.; Paulsson, M. A. Lactoferricin treatment decreases the rate of cell proliferation of a human colon cancer cell line. J. Dairy Sci., 2009, 92(6), 2477-2484.
    • (2009) J. Dairy Sci. , vol.92 , Issue.6 , pp. 2477-2484
    • Freiburghaus, C.1    Janicke, B.2    Lindmark-Mansson, H.3    Oredsson, S.M.4    Paulsson, M.A.5
  • 72
    • 67449088334 scopus 로고    scopus 로고
    • Apoptosis in the colonic crypt, colorectal adenomata, and manipulation by chemoprevention
    • West, N. J.; Courtney, E. D.; Poullis, A. P.; Leicester, R. J. Apoptosis in the colonic crypt, colorectal adenomata, and manipulation by chemoprevention. Cancer Epidemiol. Biomarkers Prev., 2009, 18(6), 1680-1687.
    • (2009) Cancer Epidemiol. Biomarkers Prev. , vol.18 , Issue.6 , pp. 1680-1687
    • West, N.J.1    Courtney, E.D.2    Poullis, A.P.3    Leicester, R.J.4
  • 74
    • 84863874277 scopus 로고    scopus 로고
    • BCL-2 family of proteins and mammary cellular fate
    • Colitti, M. BCL-2 family of proteins and mammary cellular fate. Anat. Histol. Embryol., 2012, 41(4), 237-247.
    • (2012) Anat. Histol. Embryol. , vol.41 , Issue.4 , pp. 237-247
    • Colitti, M.1
  • 75
    • 58149134848 scopus 로고    scopus 로고
    • Requirement of the JNK-associated Bcl-2 pathway for human lactoferrin-induced apoptosis in the Jurkat leukemia T cell line
    • Lee, S. H.; Park, S. W.; Pyo, C. W.; Yoo, N. K.; Kim, J.; Choi, S. Y. Requirement of the JNK-associated Bcl-2 pathway for human lactoferrin-induced apoptosis in the Jurkat leukemia T cell line. Biochimie, 2009, 91(1), 102-108.
    • (2009) Biochimie , vol.91 , Issue.1 , pp. 102-108
    • Lee, S.H.1    Park, S.W.2    Pyo, C.W.3    Yoo, N.K.4    Kim, J.5    Choi, S.Y.6
  • 76
    • 77953292382 scopus 로고    scopus 로고
    • E2F1-directed activation of Bcl-2 is correlated with lactoferrininduced apoptosis in Jurkat leukemia T lymphocytes
    • Lee, S. H.; Hwang, H. M.; Pyo, C. W.; Hahm, D. H.; Choi, S. Y. E2F1-directed activation of Bcl-2 is correlated with lactoferrininduced apoptosis in Jurkat leukemia T lymphocytes. Biometals, 2010, 23(3), 507-514.
    • (2010) Biometals , vol.23 , Issue.3 , pp. 507-514
    • Lee, S.H.1    Hwang, H.M.2    Pyo, C.W.3    Hahm, D.H.4    Choi, S.Y.5
  • 77
    • 77952573591 scopus 로고    scopus 로고
    • Bovine lactoferricin induces caspase-independent apoptosis in human B-lymphoma cells and extends the survival of immune-deficient mice bearing Blymphoma xenografts
    • Furlong, S. J.; Mader, J. S.; Hoskin, D. W. Bovine lactoferricin induces caspase-independent apoptosis in human B-lymphoma cells and extends the survival of immune-deficient mice bearing Blymphoma xenografts. Exp. Mol. Pathol., 2010, 88(3), 371-375.
    • (2010) Exp. Mol. Pathol. , vol.88 , Issue.3 , pp. 371-375
    • Furlong, S.J.1    Mader, J.S.2    Hoskin, D.W.3
  • 78
    • 40249087168 scopus 로고    scopus 로고
    • Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin
    • Furlong, S. J.; Ridgway, N. D.; Hoskin, D. W. Modulation of ceramide metabolism in T-leukemia cell lines potentiates apoptosis induced by the cationic antimicrobial peptide bovine lactoferricin. Int. J. Oncol., 2008, 32(3), 537-544.
    • (2008) Int. J. Oncol. , vol.32 , Issue.3 , pp. 537-544
    • Furlong, S.J.1    Ridgway, N.D.2    Hoskin, D.W.3
  • 79
    • 0035863464 scopus 로고    scopus 로고
    • Orally administered bovine lactoferrin systemically inhibits VEGF(165)-mediated angiogenesis in the rat
    • Norrby, K.; Mattsby-Baltzer, I.; Innocenti, M.; Tuneberg, S. Orally administered bovine lactoferrin systemically inhibits VEGF(165)-mediated angiogenesis in the rat. Int. J. Cancer, 2001, 91(2), 236-240.
    • (2001) Int. J. Cancer , vol.91 , Issue.2 , pp. 236-240
    • Norrby, K.1    Mattsby-Baltzer, I.2    Innocenti, M.3    Tuneberg, S.4
  • 81
    • 74049157768 scopus 로고    scopus 로고
    • Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial
    • Kozu, T.; Iinuma, G.; Ohashi, Y.; Saito, Y.; Akasu, T.; Saito, D.; Alexander, D. B.; Iigo, M.; Kakizoe, T.; Tsuda, H. Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial. Cancer Prev. Res. (Phila), 2009, 2(11), 975-983.
    • (2009) Cancer Prev. Res. (Phila) , vol.2 , Issue.11 , pp. 975-983
    • Kozu, T.1    Iinuma, G.2    Ohashi, Y.3    Saito, Y.4    Akasu, T.5    Saito, D.6    Alexander, D.B.7    Iigo, M.8    Kakizoe, T.9    Tsuda, H.10
  • 82
    • 5644252911 scopus 로고    scopus 로고
    • Human apo-lactoferrin enhances angiogenesis mediated by vascular endothelial growth factor A in vivo
    • Norrby, K. Human apo-lactoferrin enhances angiogenesis mediated by vascular endothelial growth factor A in vivo. J. Vasc. Res., 2004, 41(4), 293-304.
    • (2004) J. Vasc. Res. , vol.41 , Issue.4 , pp. 293-304
    • Norrby, K.1
  • 83
    • 33746337305 scopus 로고    scopus 로고
    • Human lactoferrin upregulates expression of KDR/Flk-1 and stimulates VEGF-Amediated endothelial cell proliferation and migration
    • Kim, C. W.; Son, K. N.; Choi, S. Y.; Kim, J. Human lactoferrin upregulates expression of KDR/Flk-1 and stimulates VEGF-Amediated endothelial cell proliferation and migration. FEBS Lett., 2006, 580(18), 4332-4336.
    • (2006) FEBS Lett. , vol.580 , Issue.18 , pp. 4332-4336
    • Kim, C.W.1    Son, K.N.2    Choi, S.Y.3    Kim, J.4
  • 84
    • 0345643514 scopus 로고    scopus 로고
    • Regulation of matrix metalloproteinase expression in tumor invasion
    • Westermarck, J.; Kahari, V. M. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J., 1999, 13(8), 781-792.
    • (1999) FASEB J. , vol.13 , Issue.8 , pp. 781-792
    • Westermarck, J.1    Kahari, V.M.2
  • 85
    • 0034493814 scopus 로고    scopus 로고
    • Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin in animals
    • Tsuda, H.; Sekine, K.; Takasuka, N.; Toriyama-Baba, H.; Iigo, M. Prevention of colon carcinogenesis and carcinoma metastasis by orally administered bovine lactoferrin in animals. Biofactors, 2000, 12(1-4), 83-88.
    • (2000) Biofactors , vol.12 , Issue.1-4 , pp. 83-88
    • Tsuda, H.1    Sekine, K.2    Takasuka, N.3    Toriyama-Baba, H.4    Iigo, M.5
  • 86
    • 0034434232 scopus 로고    scopus 로고
    • Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium
    • Kuhara, T.; Iigo, M.; Itoh, T.; Ushida, Y.; Sekine, K.; Terada, N.; Okamura, H.; Tsuda, H. Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. Nutr. Cancer, 2000, 38(2), 192-199.
    • (2000) Nutr. Cancer , vol.38 , Issue.2 , pp. 192-199
    • Kuhara, T.1    Iigo, M.2    Itoh, T.3    Ushida, Y.4    Sekine, K.5    Terada, N.6    Okamura, H.7    Tsuda, H.8
  • 87
    • 0348109481 scopus 로고    scopus 로고
    • Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: A possible explanation for inhibition of carcinogenesis and metastasis
    • Iigo, M.; Shimamura, M.; Matsuda, E.; Fujita, K.; Nomoto, H.; Satoh, J.; Kojima, S.; Alexander, D. B.; Moore, M. A.; Tsuda, H. Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis. Cytokine, 2004, 25(1), 36-44.
    • (2004) Cytokine , vol.25 , Issue.1 , pp. 36-44
    • Iigo, M.1    Shimamura, M.2    Matsuda, E.3    Fujita, K.4    Nomoto, H.5    Satoh, J.6    Kojima, S.7    Alexander, D.B.8    Moore, M.A.9    Tsuda, H.10
  • 88
    • 0033028757 scopus 로고    scopus 로고
    • Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice
    • Iigo, M.; Kuhara, T.; Ushida, Y.; Sekine, K.; Moore, M. A.; Tsuda, H. Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice. Clin. Exp. Metastasis, 1999, 17(1), 35-40.
    • (1999) Clin. Exp. Metastasis , vol.17 , Issue.1 , pp. 35-40
    • Iigo, M.1    Kuhara, T.2    Ushida, Y.3    Sekine, K.4    Moore, M.A.5    Tsuda, H.6
  • 89
    • 0028231589 scopus 로고
    • Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice
    • Bezault, J.; Bhimani, R.; Wiprovnick, J.; Furmanski, P. Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice. Cancer Res., 1994, 54(9), 2310-2312.
    • (1994) Cancer Res. , vol.54 , Issue.9 , pp. 2310-2312
    • Bezault, J.1    Bhimani, R.2    Wiprovnick, J.3    Furmanski, P.4
  • 90
    • 58149134840 scopus 로고    scopus 로고
    • Anticarcinogenesis pathways activated by bovine lactoferrin in the murine small intestine
    • Iigo, M.; Alexander, D. B.; Long, N.; Xu, J.; Fukamachi, K.; Futakuchi, M.; Takase, M.; Tsuda, H. Anticarcinogenesis pathways activated by bovine lactoferrin in the murine small intestine. Biochimie, 2009, 91(1), 86-101.
    • (2009) Biochimie , vol.91 , Issue.1 , pp. 86-101
    • Iigo, M.1    Alexander, D.B.2    Long, N.3    Xu, J.4    Fukamachi, K.5    Futakuchi, M.6    Takase, M.7    Tsuda, H.8
  • 91
    • 68749110858 scopus 로고    scopus 로고
    • Signaling Transduction Network Mediated by Tumor Suppressor/Susceptibility Genes in NPC
    • Wu, M.; Li, X.; Li, X.; Li, G. Signaling Transduction Network Mediated by Tumor Suppressor/Susceptibility Genes in NPC. Curr. Genomics, 2009, 10(4), 216-222.
    • (2009) Curr. Genomics , vol.10 , Issue.4 , pp. 216-222
    • Wu, M.1    Li, X.2    Li, X.3    Li, G.4
  • 97
    • 77953207726 scopus 로고    scopus 로고
    • Therapeutic vaccination against a murine lymphoma by intratumoral injection of a cationic anticancer peptide
    • Berge, G.; Eliassen, L. T.; Camilio, K. A.; Bartnes, K.; Sveinbjornsson, B.; Rekdal, O. Therapeutic vaccination against a murine lymphoma by intratumoral injection of a cationic anticancer peptide. Cancer Immunol. Immunother., 2010, 59(8), 1285-1294.
    • (2010) Cancer Immunol. Immunother. , vol.59 , Issue.8 , pp. 1285-1294
    • Berge, G.1    Eliassen, L.T.2    Camilio, K.A.3    Bartnes, K.4    Sveinbjornsson, B.5    Rekdal, O.6
  • 100
    • 20444401969 scopus 로고    scopus 로고
    • Pepsin-digested bovine lactoferrin induces apoptotic cell death with JNK/SAPK activation in oral cancer cells
    • Sakai, T.; Banno, Y.; Kato, Y.; Nozawa, Y.; Kawaguchi, M. Pepsin-digested bovine lactoferrin induces apoptotic cell death with JNK/SAPK activation in oral cancer cells. J. Pharmacol. Sci., 2005, 98(1), 41-48.
    • (2005) J. Pharmacol. Sci. , vol.98 , Issue.1 , pp. 41-48
    • Sakai, T.1    Banno, Y.2    Kato, Y.3    Nozawa, Y.4    Kawaguchi, M.5
  • 101
    • 33748912234 scopus 로고    scopus 로고
    • Antiproliferative and apoptosis inducing effect of lactoferrin and black tea polyphenol combination on hamster buccal pouch carcinogenesis
    • Chandra, M. K.; Devaraj, H.; Prathiba, D.; Hara, Y.; Nagini, S. Antiproliferative and apoptosis inducing effect of lactoferrin and black tea polyphenol combination on hamster buccal pouch carcinogenesis. Biochim. Biophys. Acta, 2006, 1760(10), 1536-1544.
    • (2006) Biochim. Biophys. Acta , vol.1760 , Issue.10 , pp. 1536-1544
    • Chandra, M.K.1    Devaraj, H.2    Prathiba, D.3    Hara, Y.4    Nagini, S.5
  • 102
    • 38949127622 scopus 로고    scopus 로고
    • Combination chemoprevention of hamster buccal pouch carcinogenesis by bovine milk lactoferrin and black tea polyphenols
    • Mohan, K. V.; Letchoumy, P. V.; Hara, Y.; Nagini, S. Combination chemoprevention of hamster buccal pouch carcinogenesis by bovine milk lactoferrin and black tea polyphenols. Cancer Invest., 2008, 26(2), 193-201.
    • (2008) Cancer Invest. , vol.26 , Issue.2 , pp. 193-201
    • Mohan, K.V.1    Letchoumy, P.V.2    Hara, Y.3    Nagini, S.4
  • 103
    • 57749186038 scopus 로고    scopus 로고
    • In vitro antioxidative potential of lactoferrin and black tea polyphenols and protective effects in vivo on carcinogen activation, DNA damage, proliferation, invasion, and angiogenesis during experimental oral carcinogenesis
    • Letchoumy, P. V.; Mohan, K. V.; Stegeman, J. J.; Gelboin, H. V.; Hara, Y.; Nagini, S. In vitro antioxidative potential of lactoferrin and black tea polyphenols and protective effects in vivo on carcinogen activation, DNA damage, proliferation, invasion, and angiogenesis during experimental oral carcinogenesis. Oncol. Res., 2008, 17(5), 193-203.
    • (2008) Oncol. Res. , vol.17 , Issue.5 , pp. 193-203
    • Letchoumy, P.V.1    Mohan, K.V.2    Stegeman, J.J.3    Gelboin, H.V.4    Hara, Y.5    Nagini, S.6
  • 104
    • 0034055694 scopus 로고    scopus 로고
    • Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats
    • Tanaka, T.; Kawabata, K.; Kohno, H.; Honjo, S.; Murakami, M.; Ota, T.; Tsuda, H. Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats. Jpn. J. Cancer Res., 2000, 91(1), 25-33.
    • (2000) Jpn. J. Cancer Res. , vol.91 , Issue.1 , pp. 25-33
    • Tanaka, T.1    Kawabata, K.2    Kohno, H.3    Honjo, S.4    Murakami, M.5    Ota, T.6    Tsuda, H.7
  • 105
    • 33744983537 scopus 로고    scopus 로고
    • Lactoferricin-induced apoptosis in estrogen-nonresponsive MDA-MB-435 breast cancer cells is enhanced by C6 ceramide or tamoxifen
    • Furlong, S. J.; Mader, J. S.; Hoskin, D. W. Lactoferricin-induced apoptosis in estrogen-nonresponsive MDA-MB-435 breast cancer cells is enhanced by C6 ceramide or tamoxifen. Oncol. Rep., 2006, 15(5), 1385-1390.
    • (2006) Oncol. Rep. , vol.15 , Issue.5 , pp. 1385-1390
    • Furlong, S.J.1    Mader, J.S.2    Hoskin, D.W.3
  • 106
    • 84055176102 scopus 로고    scopus 로고
    • Effects of adenovirus vectors mediated human lactoferrin cDNA on mice bearing EMT6 breast carcinoma
    • Wang, J.; Li, Q.; Li, K.; Ou, Y.; Han, Z.; Gao, D.; Li, J. Effects of adenovirus vectors mediated human lactoferrin cDNA on mice bearing EMT6 breast carcinoma. Pharmazie, 2011, 66(9), 704-709.
    • (2011) Pharmazie , vol.66 , Issue.9 , pp. 704-709
    • Wang, J.1    Li, Q.2    Li, K.3    Ou, Y.4    Han, Z.5    Gao, D.6    Li, J.7
  • 107
    • 79953251572 scopus 로고    scopus 로고
    • Binding of lactoferrin to IGBP1 triggers apoptosis in a lung adenocarcinoma cell line
    • Li, D.; Sakashita, S.; Morishita, Y.; Kano, J.; Shiba, A.; Sato, T.; Noguchi, M. Binding of lactoferrin to IGBP1 triggers apoptosis in a lung adenocarcinoma cell line. Anticancer Res., 2011, 31(2), 529-534.
    • (2011) Anticancer Res. , vol.31 , Issue.2 , pp. 529-534
    • Li, D.1    Sakashita, S.2    Morishita, Y.3    Kano, J.4    Shiba, A.5    Sato, T.6    Noguchi, M.7
  • 108
    • 77953011030 scopus 로고    scopus 로고
    • Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin
    • Xu, X. X.; Jiang, H. R.; Li, H. B.; Zhang, T. N.; Zhou, Q.; Liu, N. Apoptosis of stomach cancer cell SGC-7901 and regulation of Akt signaling way induced by bovine lactoferrin. J. Dairy Sci., 2010, 93(6), 2344-2350.
    • (2010) J. Dairy Sci. , vol.93 , Issue.6 , pp. 2344-2350
    • Xu, X.X.1    Jiang, H.R.2    Li, H.B.3    Zhang, T.N.4    Zhou, Q.5    Liu, N.6
  • 109
    • 34250883860 scopus 로고    scopus 로고
    • Bovine lactoferricin causes apoptosis in Jurkat T-leukemia cells by sequential permeabilization of the cell membrane and targeting of mitochondria
    • Mader, J. S.; Richardson, A.; Salsman, J.; Top, D.; de Antueno, R.; Duncan, R.; Hoskin, D. W. Bovine lactoferricin causes apoptosis in Jurkat T-leukemia cells by sequential permeabilization of the cell membrane and targeting of mitochondria. Exp. Cell. Res., 2007, 313(12), 2634-2650.
    • (2007) Exp. Cell. Res. , vol.313 , Issue.12 , pp. 2634-2650
    • Mader, J.S.1    Richardson, A.2    Salsman, J.3    Top, D.4    de Antueno, R.5    Duncan, R.6    Hoskin, D.W.7
  • 110
    • 59849112395 scopus 로고    scopus 로고
    • Lack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats
    • Tamano, S.; Sekine, K.; Takase, M.; Yamauchi, K.; Iigo, M.; Tsuda, H. Lack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats. Asian Pac. J. Cancer Prev., 2008, 9(2), 313-316.
    • (2008) Asian Pac. J. Cancer Prev. , vol.9 , Issue.2 , pp. 313-316
    • Tamano, S.1    Sekine, K.2    Takase, M.3    Yamauchi, K.4    Iigo, M.5    Tsuda, H.6
  • 111
    • 0029860472 scopus 로고    scopus 로고
    • Structurebiological activity relationships of 11-residue highly basic peptide segment of bovine lactoferrin
    • Kang, J. H.; Lee, M. K.; Kim, K. L.; Hahm, K. S. Structurebiological activity relationships of 11-residue highly basic peptide segment of bovine lactoferrin. Int. J. Pept. Protein Res., 1996, 48(4), 357-363.
    • (1996) Int. J. Pept. Protein Res. , vol.48 , Issue.4 , pp. 357-363
    • Kang, J.H.1    Lee, M.K.2    Kim, K.L.3    Hahm, K.S.4
  • 113
    • 48749104758 scopus 로고    scopus 로고
    • Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells
    • Spadaro, M.; Caorsi, C.; Ceruti, P.; Varadhachary, A.; Forni, G.; Pericle, F.; Giovarelli, M. Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells. FASEB J., 2008, 22(8), 2747-2757.
    • (2008) FASEB J. , vol.22 , Issue.8 , pp. 2747-2757
    • Spadaro, M.1    Caorsi, C.2    Ceruti, P.3    Varadhachary, A.4    Forni, G.5    Pericle, F.6    Giovarelli, M.7
  • 114
    • 84863113633 scopus 로고    scopus 로고
    • Immunotherapies for non-small-cell lung cancer and mesothelioma
    • Thomas, A.; Hassan, R. Immunotherapies for non-small-cell lung cancer and mesothelioma. Lancet Oncol., 2012, 13(7), e301-e310.
    • (2012) Lancet Oncol. , vol.13 , Issue.7
    • Thomas, A.1    Hassan, R.2
  • 116
    • 0030946524 scopus 로고    scopus 로고
    • Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines
    • Siebert, P. D.; Huang, B. C. Identification of an alternative form of human lactoferrin mRNA that is expressed differentially in normal tissues and tumor-derived cell lines. Proc. Natl. Acad. Sci. U S A, 1997, 94(6), 2198-2203.
    • (1997) Proc. Natl. Acad. Sci. U S A , vol.94 , Issue.6 , pp. 2198-2203
    • Siebert, P.D.1    Huang, B.C.2
  • 117
    • 84861361791 scopus 로고    scopus 로고
    • Lactoferrin, a bird's eye view
    • Vogel, H. J. Lactoferrin, a bird's eye view. Biochem. Cell. Biol., 2012, 90, (3), 233-244.
    • (2012) Biochem. Cell. Biol. , vol.90 , Issue.3 , pp. 233-244
    • Vogel, H.J.1
  • 118
    • 80054819752 scopus 로고    scopus 로고
    • Lactoferrin delivery systems: Approaches for its more effective use
    • Onishi, H. Lactoferrin delivery systems: approaches for its more effective use. Expert Opin. Drug Deliv., 2011, 8(11), 1469-1479.
    • (2011) Expert Opin. Drug Deliv. , vol.8 , Issue.11 , pp. 1469-1479
    • Onishi, H.1
  • 119
    • 84862779216 scopus 로고    scopus 로고
    • Hepatocellular carcinoma targeting effect of PEGylated liposomes modified with lactoferrin
    • Wei, M.; Xu, Y.; Zou, Q.; Tu, L.; Tang, C.; Xu, T.; Deng, L.; Wu, C. Hepatocellular carcinoma targeting effect of PEGylated liposomes modified with lactoferrin. Eur. J. Pharm. Sci., 2012, 46(3), 131-141.
    • (2012) Eur. J. Pharm. Sci. , vol.46 , Issue.3 , pp. 131-141
    • Wei, M.1    Xu, Y.2    Zou, Q.3    Tu, L.4    Tang, C.5    Xu, T.6    Deng, L.7    Wu, C.8


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