메뉴 건너뛰기




Volumn 23, Issue 3, 2010, Pages 399-409

Cancer prevention by bovine lactoferrin: From animal studies to human trial

Author keywords

Bovine lactoferrin; Chemoprevention; Colorectal cancer

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOKINE; LACTOFERRICIN; LACTOFERRIN; LACTOFERRIN HYDROLYSATE; RECOMBINANT LACTOFERRIN; UNCLASSIFIED DRUG;

EID: 77953270296     PISSN: 09660844     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10534-010-9331-3     Document Type: Conference Paper
Times cited : (93)

References (64)
  • 1
    • 0028231589 scopus 로고
    • Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice
    • 1:CAS:528:DyaK2cXjtFGgtb4%3D 8162571
    • J Bezault R Bhimani J Wiprovnick, et al. 1994 Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice Cancer Res 54 2310 2312 1:CAS:528:DyaK2cXjtFGgtb4%3D 8162571
    • (1994) Cancer Res , vol.54 , pp. 2310-2312
    • Bezault, J.1    Bhimani, R.2    Wiprovnick, J.3
  • 2
    • 0032786495 scopus 로고    scopus 로고
    • Interleukin-18 acts as an angiogenesis and tumor suppressor
    • 1:CAS:528:DyaK1MXotVKitLk%3D 10593867
    • R Cao J Farnebo M Kurimoto, et al. 1999 Interleukin-18 acts as an angiogenesis and tumor suppressor FASEB J 13 2195 2202 1:CAS:528: DyaK1MXotVKitLk%3D 10593867
    • (1999) FASEB J , vol.13 , pp. 2195-2202
    • Cao, R.1    Farnebo, J.2    Kurimoto, M.3
  • 3
    • 0037790592 scopus 로고    scopus 로고
    • Apoptosis and interferons: Role of interferon-stimulated genes as mediators of apoptosis
    • DOI 10.1023/A:1023668705040
    • M Chawla-Sarkar DJ Lindner YF Liu, et al. 2003 Apoptosis and interferons: role of interferon-stimulated genes as mediators of apoptosis Apoptosis 8 237 249 10.1023/A:1023668705040 1:CAS:528:DC%2BD3sXjsF2nt70%3D 12766484 (Pubitemid 36749609)
    • (2003) Apoptosis , vol.8 , Issue.3 , pp. 237-249
    • Chawla-Sarkar, M.1    Lindner, D.J.2    Liu, Y.-F.3    Williams, B.R.4    Sen, G.C.5    Silverman, R.H.6    Borden, E.C.7
  • 4
    • 0037868199 scopus 로고    scopus 로고
    • Interferons and apoptosis
    • DOI 10.1089/107999003766628124
    • MJ Clemens 2003 Interferons and apoptosis J Interferon Cytokine Res 23 277 292 10.1089/107999003766628124 1:CAS:528:DC%2BD3sXltVenu7w%3D 12859854 (Pubitemid 36760748)
    • (2003) Journal of Interferon and Cytokine Research , vol.23 , Issue.6 , pp. 277-292
    • Clemens, M.J.1
  • 5
    • 0021981476 scopus 로고
    • Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold
    • 1:CAS:528:DyaL2MXhs1eisLs%3D 2981589
    • E Cramer KB Pryzwansky JL Villeval, et al. 1985 Ultrastructural localization of lactoferrin and myeloperoxidase in human neutrophils by immunogold Blood 65 423 432 1:CAS:528:DyaL2MXhs1eisLs%3D 2981589
    • (1985) Blood , vol.65 , pp. 423-432
    • Cramer, E.1    Pryzwansky, K.B.2    Villeval, J.L.3
  • 6
    • 45549085804 scopus 로고    scopus 로고
    • Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses
    • G de la Rosa D Yang P Tewary, et al. 2008 Lactoferrin acts as an alarmin to promote the recruitment and activation of APCs and antigen-specific immune responses J Immunol 180 6868 6876
    • (2008) J Immunol , vol.180 , pp. 6868-6876
    • De La Rosa, G.1    Yang, D.2    Tewary, P.3
  • 7
    • 67649236592 scopus 로고    scopus 로고
    • Lactoferricin treatment decreases the rate of cell proliferation of a human colon cancer cell line
    • 10.3168/jds.2008-1851 1:CAS:528:DC%2BD1MXmsFenurw%3D 19447979
    • C Freiburghaus B Janicke H Lindmark-Mansson, et al. 2009 Lactoferricin treatment decreases the rate of cell proliferation of a human colon cancer cell line J Dairy Sci 92 2477 2484 10.3168/jds.2008-1851 1:CAS:528: DC%2BD1MXmsFenurw%3D 19447979
    • (2009) J Dairy Sci , vol.92 , pp. 2477-2484
    • Freiburghaus, C.1    Janicke, B.2    Lindmark-Mansson, H.3
  • 8
    • 6444230922 scopus 로고    scopus 로고
    • Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats
    • DOI 10.1093/carcin/bgh205
    • K Fujita E Matsuda K Sekine, et al. 2004 Lactoferrin enhances Fas expression and apoptosis in the colon mucosa of azoxymethane-treated rats Carcinogenesis 25 1961 1966 10.1093/carcin/bgh205 1:CAS:528:DC%2BD2cXnvVOqt7g%3D 15192017 (Pubitemid 39405916)
    • (2004) Carcinogenesis , vol.25 , Issue.10 , pp. 1961-1966
    • Fujita, K.-I.1    Matsuda, E.2    Sekine, K.3    Iigo, M.4    Tsuda, H.5
  • 9
    • 4344590829 scopus 로고    scopus 로고
    • Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat
    • DOI 10.1016/j.canlet.2004.03.029, PII S0304383504002484
    • K Fujita E Matsuda K Sekine, et al. 2004 Lactoferrin modifies apoptosis-related gene expression in the colon of the azoxymethane-treated rat Cancer Lett 213 21 29 10.1016/j.canlet.2004.03.029 1:CAS:528: DC%2BD2cXmslels78%3D 15312680 (Pubitemid 39118530)
    • (2004) Cancer Letters , vol.213 , Issue.1 , pp. 21-29
    • Fujita, K.-I.1    Matsuda, E.2    Sekine, K.3    Iigo, M.4    Tsuda, H.5
  • 10
    • 0025903508 scopus 로고
    • Influence of lactoferrin on the function of human polymorphonuclear leukocytes and monocytes
    • 1:CAS:528:DyaK3MXktVKrsr0%3D 1849951
    • M Gahr CP Speer B Damerau, et al. 1991 Influence of lactoferrin on the function of human polymorphonuclear leukocytes and monocytes J Leukoc Biol 49 427 433 1:CAS:528:DyaK3MXktVKrsr0%3D 1849951
    • (1991) J Leukoc Biol , vol.49 , pp. 427-433
    • Gahr, M.1    Speer, C.P.2    Damerau, B.3
  • 11
    • 0032895052 scopus 로고    scopus 로고
    • Lactobacilli from human gastrointestinal mucosa are strong stimulators of IL-12 production
    • DOI 10.1046/j.1365-2249.1999.00885.x
    • C Hessle LA Hanson AE Wold 1999 Lactobacilli from human gastrointestinal mucosa are strong stimulators of IL-12 production Clin Exp Immunol 116 276 282 10.1046/j.1365-2249.1999.00885.x 1:STN:280:DyaK1M3ntFSmtA%3D%3D 10337019 (Pubitemid 29219725)
    • (1999) Clinical and Experimental Immunology , vol.116 , Issue.2 , pp. 276-282
    • Hessle, C.1    Hanson, L.A.2    Wold, A.E.3
  • 12
    • 0029845724 scopus 로고    scopus 로고
    • Growth of colorectal polyps: Redetection and evaluation of unresected polyps for a period of three years
    • 10.1136/gut.39.3.449 1:STN:280:DyaK2s7gs12jtw%3D%3D 8949653
    • B Hofstad MH Vatn SN Andersen, et al. 1996 Growth of colorectal polyps: redetection and evaluation of unresected polyps for a period of three years Gut 39 449 456 10.1136/gut.39.3.449 1:STN:280:DyaK2s7gs12jtw%3D%3D 8949653
    • (1996) Gut , vol.39 , pp. 449-456
    • Hofstad, B.1    Vatn, M.H.2    Andersen, S.N.3
  • 13
    • 34548130792 scopus 로고    scopus 로고
    • Lactoferrin modulation of IL-12 and IL-10 response from activated murine leukocytes
    • DOI 10.1007/s00430-007-0041-6
    • SA Hwang KM Wilk YA Bangale, et al. 2007 Lactoferrin modulation of IL-12 and IL-10 response from activated murine leukocytes Med Microbiol Immunol 196 171 180 10.1007/s00430-007-0041-6 1:CAS:528:DC%2BD2sXmsFKiur4%3D 17377816 (Pubitemid 47300255)
    • (2007) Medical Microbiology and Immunology , vol.196 , Issue.3 , pp. 171-180
    • Hwang, S.-A.1    Wilk, K.M.2    Bangale, Y.A.3    Kruzel, M.L.4    Actor, J.K.5
  • 14
    • 0033028757 scopus 로고    scopus 로고
    • Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice
    • 10.1023/A:1026452110786 1:CAS:528:DyaK1MXkslOnurk%3D 10390145
    • M Iigo T Kuhara Y Ushida, et al. 1999 Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice Clin Exp Metastasis 17 35 40 10.1023/A:1026452110786 1:CAS:528:DyaK1MXkslOnurk%3D 10390145
    • (1999) Clin Exp Metastasis , vol.17 , pp. 35-40
    • Iigo, M.1    Kuhara, T.2    Ushida, Y.3
  • 15
    • 0348109481 scopus 로고    scopus 로고
    • Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: A possible explanation for inhibition of carcinogenesis and metastasis
    • DOI 10.1016/j.cyto.2003.09.009
    • M Iigo M Shimamura E Matsuda, et al. 2004 Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: a possible explanation for inhibition of carcinogenesis and metastasis Cytokine 25 36 44 10.1016/j.cyto.2003.09.009 1:CAS:528:DC%2BD3sXpvVWlsrg%3D 14687584 (Pubitemid 37543696)
    • (2004) Cytokine , vol.25 , Issue.1 , pp. 36-44
    • Iigo, M.1    Shimamura, M.2    Matsuda, E.3    Fujita, K.-I.4    Nomoto, H.5    Satoh, J.6    Kojima, S.7    Alexander, D.B.8    Moore, M.A.9    Tsuda, H.10
  • 16
    • 58149136431 scopus 로고    scopus 로고
    • Cancer prevention and anti-metastatic effects by oral administration of bovine lactoferrin
    • T. Takuji T. Hiroyuki (eds). Research Signpost Kerala, India
    • Iigo M, Shimamura M, Hirano S et al (2005) Cancer prevention and anti-metastatic effects by oral administration of bovine lactoferrin. In: Takuji T, Hiroyuki T (eds) Carcinogenesis and modification of carcinogenesis. Research Signpost, Kerala, India, pp 229-242
    • (2005) Carcinogenesis and Modification of Carcinogenesis , pp. 229-242
    • Iigo, M.1    Shimamura, M.2    Hirano, S.3
  • 17
    • 58149134840 scopus 로고    scopus 로고
    • Anticarcinogenesis pathways activated by bovine lactoferrin in the murine small intestine
    • 10.1016/j.biochi.2008.06.012 1:CAS:528:DC%2BD1MXktF2gug%3D%3D 18634843
    • M Iigo DB Alexander N Long, et al. 2009 Anticarcinogenesis pathways activated by bovine lactoferrin in the murine small intestine Biochimie 91 86 101 10.1016/j.biochi.2008.06.012 1:CAS:528:DC%2BD1MXktF2gug%3D%3D 18634843
    • (2009) Biochimie , vol.91 , pp. 86-101
    • Iigo, M.1    Alexander, D.B.2    Long, N.3
  • 18
    • 74049157768 scopus 로고    scopus 로고
    • Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial
    • T Kozu G Iinuma Y Ohashi, et al. 2009 Effect of orally administered bovine lactoferrin on the growth of adenomatous colorectal polyps in a randomized, placebo-controlled clinical trial Cancer Prev Res (Phila Pa) 2 975 983
    • (2009) Cancer Prev Res (Phila Pa) , vol.2 , pp. 975-983
    • Kozu, T.1    Iinuma, G.2    Ohashi, Y.3
  • 19
    • 0029757516 scopus 로고    scopus 로고
    • Diagnosis of colorectal tumorous lesions by magnifying endoscopy
    • 10.1016/S0016-5107(96)70222-5 1:STN:280:DyaK28vjtlOgsg%3D%3D 8836710
    • S Kudo S Tamura T Nakajima, et al. 1996 Diagnosis of colorectal tumorous lesions by magnifying endoscopy Gastrointest Endosc 44 8 14 10.1016/S0016- 5107(96)70222-5 1:STN:280:DyaK28vjtlOgsg%3D%3D 8836710
    • (1996) Gastrointest Endosc , vol.44 , pp. 8-14
    • Kudo, S.1    Tamura, S.2    Nakajima, T.3
  • 20
    • 0034960234 scopus 로고    scopus 로고
    • Pit pattern in colorectal neoplasia: Endoscopic magnifying view
    • 1:STN:280:DC%2BD3Mvotlygug%3D%3D 11315901
    • S Kudo CA Rubio CR Teixeira, et al. 2001 Pit pattern in colorectal neoplasia: endoscopic magnifying view Endoscopy 33 367 373 1:STN:280: DC%2BD3Mvotlygug%3D%3D 11315901
    • (2001) Endoscopy , vol.33 , pp. 367-373
    • Kudo, S.1    Rubio, C.A.2    Teixeira, C.R.3
  • 21
    • 0034434232 scopus 로고    scopus 로고
    • Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium
    • 10.1207/S15327914NC382-8 1:CAS:528:DC%2BD3MXmsF2hs7g%3D 11525597
    • T Kuhara M Iigo T Itoh, et al. 2000 Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium Nutr Cancer 38 192 199 10.1207/S15327914NC382-8 1:CAS:528:DC%2BD3MXmsF2hs7g%3D 11525597
    • (2000) Nutr Cancer , vol.38 , pp. 192-199
    • Kuhara, T.1    Iigo, M.2    Itoh, T.3
  • 22
    • 33745955355 scopus 로고    scopus 로고
    • Oral administration of lactoferrin increases NK cell activity in mice via increased production of IL-18 and type I IFN in the small intestine
    • DOI 10.1089/jir.2006.26.489
    • T Kuhara K Yamauchi Y Tamura, et al. 2006 Oral administration of lactoferrin increases NK cell activity in mice via increased production of IL-18 and type I IFN in the small intestine J Interferon Cytokine Res 26 489 499 10.1089/jir.2006.26.489 1:CAS:528:DC%2BD28XmtFyrs7c%3D 16800788 (Pubitemid 44061089)
    • (2006) Journal of Interferon and Cytokine Research , vol.26 , Issue.7 , pp. 489-499
    • Kuhara, T.1    Yamauchi, K.2    Tamura, Y.3    Okamura, H.4
  • 23
    • 84934441518 scopus 로고    scopus 로고
    • Lactoferrin structure and functions
    • 10.1007/978-0-387-74087-4-6 18183929
    • D Legrand A Pierce E Elass, et al. 2008 Lactoferrin structure and functions Adv Exp Med Biol 606 163 194 10.1007/978-0-387-74087-4-6 18183929
    • (2008) Adv Exp Med Biol , vol.606 , pp. 163-194
    • Legrand, D.1    Pierce, A.2    Elass, E.3
  • 24
    • 0029126185 scopus 로고
    • Lactoferrin: A general review
    • 1:CAS:528:DyaK2MXoslGrsb0%3D 7672721
    • PF Levay M Viljoen 1995 Lactoferrin: a general review Haematologica 80 252 267 1:CAS:528:DyaK2MXoslGrsb0%3D 7672721
    • (1995) Haematologica , vol.80 , pp. 252-267
    • Levay, P.F.1    Viljoen, M.2
  • 26
    • 0029130333 scopus 로고
    • Lactoferrin: Molecular structure and biological function
    • 10.1146/annurev.nu.15.070195.000521 1:CAS:528:DyaK2MXntVCjsrw%3D 8527233
    • B Lonnerdal S Iyer 1995 Lactoferrin: molecular structure and biological function Annu Rev Nutr 15 93 110 10.1146/annurev.nu.15.070195.000521 1:CAS:528:DyaK2MXntVCjsrw%3D 8527233
    • (1995) Annu Rev Nutr , vol.15 , pp. 93-110
    • Lonnerdal, B.1    Iyer, S.2
  • 27
    • 0033946681 scopus 로고    scopus 로고
    • Chemopreventive effects of bovine lactoferrin on N-butyl-N-(4- hydroxybutyl)nitrosamine-induced rat bladder carcinogenesis
    • 1:CAS:528:DC%2BD3cXksVKktLs%3D 10874209
    • C Masuda H Wanibuchi K Sekine, et al. 2000 Chemopreventive effects of bovine lactoferrin on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced rat bladder carcinogenesis Jpn J Cancer Res 91 582 588 1:CAS:528:DC%2BD3cXksVKktLs%3D 10874209
    • (2000) Jpn J Cancer Res , vol.91 , pp. 582-588
    • Masuda, C.1    Wanibuchi, H.2    Sekine, K.3
  • 28
    • 0036457022 scopus 로고    scopus 로고
    • Evidence for the causal role of endogenous interferon-α/β in the regulation of angiogenesis, tumorigenicity, and metastasis of cutaneous neoplasms
    • DOI 10.1023/A:1020923326441
    • MF McCarty D Bielenberg C Donawho, et al. 2002 Evidence for the causal role of endogenous interferon-alpha/beta in the regulation of angiogenesis, tumorigenicity, and metastasis of cutaneous neoplasms Clin Exp Metastasis 19 609 615 10.1023/A:1020923326441 1:CAS:528:DC%2BD38Xotlektrw%3D 12498390 (Pubitemid 35454571)
    • (2002) Clinical and Experimental Metastasis , vol.19 , Issue.7 , pp. 609-615
    • McCarty, M.F.1    Bielenberg, D.2    Donawho, C.3    Bucana, C.D.4    Fidler, I.J.5
  • 29
    • 0025904468 scopus 로고
    • Lactoferrin inducible monocyte cytotoxicity defective in esterase deficient monocytes
    • 10.1111/j.1365-2141.1991.tb08572.x 1:STN:280:DyaK3M7ptVKhsQ%3D%3D 2012751
    • JA McCormick GM Markey TC Morris, et al. 1991 Lactoferrin inducible monocyte cytotoxicity defective in esterase deficient monocytes Br J Haematol 77 287 290 10.1111/j.1365-2141.1991.tb08572.x 1:STN:280:DyaK3M7ptVKhsQ%3D%3D 2012751
    • (1991) Br J Haematol , vol.77 , pp. 287-290
    • McCormick, J.A.1    Markey, G.M.2    Morris, T.C.3
  • 30
    • 0028902218 scopus 로고
    • Dairy proteins protect against dimethylhydrazine-induced intestinal cancers in rats
    • 1:CAS:528:DyaK2MXkvVKrtrc%3D 7722681
    • GH McIntosh GO Regester RK Le Leu, et al. 1995 Dairy proteins protect against dimethylhydrazine-induced intestinal cancers in rats J Nutr 125 809 816 1:CAS:528:DyaK2MXkvVKrtrc%3D 7722681
    • (1995) J Nutr , vol.125 , pp. 809-816
    • McIntosh, G.H.1    Regester, G.O.2    Le Leu, R.K.3
  • 31
    • 0020459189 scopus 로고
    • Contrasting effects of lactoferrin on human lymphocyte and monocyte natural killer activity and antibody-dependent cell-mediated cytotoxicity
    • 1:STN:280:DyaL3s%2FlvVSitg%3D%3D 7142699
    • K Nishiya DA Horwitz 1982 Contrasting effects of lactoferrin on human lymphocyte and monocyte natural killer activity and antibody-dependent cell-mediated cytotoxicity J Immunol 129 2519 2523 1:STN:280: DyaL3s%2FlvVSitg%3D%3D 7142699
    • (1982) J Immunol , vol.129 , pp. 2519-2523
    • Nishiya, K.1    Horwitz, D.A.2
  • 32
    • 0035863464 scopus 로고    scopus 로고
    • Orally administered bovine lactoferrin systemically inhibits VEGF(165)-mediated angiogenesis in the rat
    • 10.1002/1097-0215(200002)9999:9999<::AID-IJC1024>3.3.CO;2-K 1:CAS:528:DC%2BD3MXot1Kisg%3D%3D 11146451
    • K Norrby I Mattsby-Baltzer M Innocenti, et al. 2001 Orally administered bovine lactoferrin systemically inhibits VEGF(165)-mediated angiogenesis in the rat Int J Cancer 91 236 240 10.1002/1097-0215(200002)9999:9999<::AID- IJC1024>3.3.CO;2-K 1:CAS:528:DC%2BD3MXot1Kisg%3D%3D 11146451
    • (2001) Int J Cancer , vol.91 , pp. 236-240
    • Norrby, K.1    Mattsby-Baltzer, I.2    Innocenti, M.3
  • 33
    • 25444497706 scopus 로고    scopus 로고
    • Breast cancer cells stimulate neutrophils to produce oncostatin M: Potential implications for tumor progression
    • DOI 10.1158/0008-5472.CAN-05-1734
    • MM Queen RE Ryan RG Holzer, et al. 2005 Breast cancer cells stimulate neutrophils to produce oncostatin M: potential implications for tumor progression Cancer Res 65 8896 8904 10.1158/0008-5472.CAN-05-1734 1:CAS:528:DC%2BD2MXhtVKiu73P 16204061 (Pubitemid 41377379)
    • (2005) Cancer Research , vol.65 , Issue.19 , pp. 8896-8904
    • Queen, M.M.1    Ryan, R.E.2    Holzer, R.G.3    Keller-Peck, C.R.4    Jorcyk, C.L.5
  • 34
    • 77951139003 scopus 로고    scopus 로고
    • An impending cancer crisis in developing countries: Are we ready for the challenge?
    • 19827904
    • MU Rehman QM Buttar MI Khawaja, et al. 2009 An impending cancer crisis in developing countries: are we ready for the challenge? Asian Pac J Cancer Prev 10 719 720 19827904
    • (2009) Asian Pac J Cancer Prev , vol.10 , pp. 719-720
    • Rehman, M.U.1    Buttar, Q.M.2    Khawaja, M.I.3
  • 35
    • 15644367340 scopus 로고    scopus 로고
    • Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats
    • 1:CAS:528:DyaK2sXksVaht74%3D 9263527
    • K Sekine E Watanabe J Nakamura, et al. 1997 Inhibition of azoxymethane-initiated colon tumor by bovine lactoferrin administration in F344 rats Jpn J Cancer Res 88 523 526 1:CAS:528:DyaK2sXksVaht74%3D 9263527
    • (1997) Jpn J Cancer Res , vol.88 , pp. 523-526
    • Sekine, K.1    Watanabe, E.2    Nakamura, J.3
  • 36
    • 0026691005 scopus 로고
    • Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin
    • 1:CAS:528:DyaK38XksVKmsr8%3D 1564398
    • H Shau A Kim SH Golub 1992 Modulation of natural killer and lymphokine-activated killer cell cytotoxicity by lactoferrin J Leukoc Biol 51 343 349 1:CAS:528:DyaK38XksVKmsr8%3D 1564398
    • (1992) J Leukoc Biol , vol.51 , pp. 343-349
    • Shau, H.1    Kim, A.2    Golub, S.H.3
  • 38
    • 0023160237 scopus 로고
    • Inhibition of angiogenesis by interferons: Effects on tumor- and lymphocyte-induced vascular responses
    • 1:CAS:528:DyaL2sXmtFGqsbk%3D 2441862
    • YA Sidky EC Borden 1987 Inhibition of angiogenesis by interferons: effects on tumor- and lymphocyte-induced vascular responses Cancer Res 47 5155 5161 1:CAS:528:DyaL2sXmtFGqsbk%3D 2441862
    • (1987) Cancer Res , vol.47 , pp. 5155-5161
    • Sidky, Y.A.1    Borden, E.C.2
  • 40
    • 48749104758 scopus 로고    scopus 로고
    • Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells
    • 10.1096/fj.07-098038 1:CAS:528:DC%2BD1cXpsVygsLg%3D 18364398
    • M Spadaro C Caorsi P Ceruti, et al. 2008 Lactoferrin, a major defense protein of innate immunity, is a novel maturation factor for human dendritic cells FASEB J 22 2747 2757 10.1096/fj.07-098038 1:CAS:528:DC%2BD1cXpsVygsLg%3D 18364398
    • (2008) FASEB J , vol.22 , pp. 2747-2757
    • Spadaro, M.1    Caorsi, C.2    Ceruti, P.3
  • 41
    • 4444316208 scopus 로고    scopus 로고
    • Magnifying endoscopy with indigo carmine contrast for differential diagnosis of neoplastic and nonneoplastic colonic polyps
    • DOI 10.1023/B:DDAS.0000037798.55845.f7
    • MY Su YP Ho PC Chen, et al. 2004 Magnifying endoscopy with indigo carmine contrast for differential diagnosis of neoplastic and nonneoplastic colonic polyps Dig Dis Sci 49 1123 1127 10.1023/B:DDAS.0000037798.55845.f7 15387332 (Pubitemid 39178076)
    • (2004) Digestive Diseases and Sciences , vol.49 , Issue.7-8 , pp. 1123-1127
    • Su, M.-Y.1    Ho, Y.-P.2    Chen, P.-C.3    Chiu, C.-T.4    Wu, C.-S.5    Hsu, C.-M.6    Tung, S.-Y.7
  • 42
    • 0030798384 scopus 로고    scopus 로고
    • Immunohistochemical and immuno-electron-microscopic detection of interferon-γ-inducing factor ('interleukin-18') in mouse intestinal epithelial cells
    • DOI 10.1007/s004410050895
    • M Takeuchi Y Nishizaki O Sano, et al. 1997 Immunohistochemical and immuno-electron-microscopic detection of interferon-gamma-inducing factor ("interleukin-18") in mouse intestinal epithelial cells Cell Tissue Res 289 499 503 10.1007/s004410050895 1:CAS:528:DyaK2sXkvVaquro%3D 9232828 (Pubitemid 27367886)
    • (1997) Cell and Tissue Research , vol.289 , Issue.3 , pp. 499-503
    • Takeuchi, M.1    Nishizaki, Y.2    Sano, O.3    Ohta, T.4    Ikeda, M.5    Kurimoto, M.6
  • 43
    • 59849112395 scopus 로고    scopus 로고
    • Lack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats
    • 18712982
    • S Tamano K Sekine M Takase, et al. 2008 Lack of chronic oral toxicity of chemopreventive bovine lactoferrin in F344/DuCrj rats Asian Pac J Cancer Prev 9 313 316 18712982
    • (2008) Asian Pac J Cancer Prev , vol.9 , pp. 313-316
    • Tamano, S.1    Sekine, K.2    Takase, M.3
  • 44
    • 0034055694 scopus 로고    scopus 로고
    • Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats
    • 1:CAS:528:DC%2BD3cXitVWmu74%3D 10744041
    • T Tanaka K Kawabata H Kohno, et al. 2000 Chemopreventive effect of bovine lactoferrin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male F344 rats Jpn J Cancer Res 91 25 33 1:CAS:528:DC%2BD3cXitVWmu74%3D 10744041
    • (2000) Jpn J Cancer Res , vol.91 , pp. 25-33
    • Tanaka, T.1    Kawabata, K.2    Kohno, H.3
  • 45
    • 0033407078 scopus 로고    scopus 로고
    • Efficacy of magnifying endoscopy in the differential diagnosis of neoplastic and non-neoplastic polyps of the large bowel
    • 10.1007/BF02236215 1:STN:280:DC%2BD3c%2FnvVKnsA%3D%3D 10613481
    • K Togashi F Konishi T Ishizuka, et al. 1999 Efficacy of magnifying endoscopy in the differential diagnosis of neoplastic and non-neoplastic polyps of the large bowel Dis Colon Rectum 42 1602 1608 10.1007/BF02236215 1:STN:280:DC%2BD3c%2FnvVKnsA%3D%3D 10613481
    • (1999) Dis Colon Rectum , vol.42 , pp. 1602-1608
    • Togashi, K.1    Konishi, F.2    Ishizuka, T.3
  • 46
    • 2942545512 scopus 로고    scopus 로고
    • Milk components as cancer chemopreventive agents
    • 12716300
    • H Tsuda K Sekine 2000 Milk components as cancer chemopreventive agents Asian Pac J Cancer Prev 1 277 282 12716300
    • (2000) Asian Pac J Cancer Prev , vol.1 , pp. 277-282
    • Tsuda, H.1    Sekine, K.2
  • 47
    • 0031681365 scopus 로고    scopus 로고
    • Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in F344 rats
    • 1:CAS:528:DyaK1cXnvFOhtb0%3D 9781370
    • H Tsuda K Sekine J Nakamura, et al. 1998 Inhibition of azoxymethane initiated colon tumor and aberrant crypt foci development by bovine lactoferrin administration in F344 rats Adv Exp Med Biol 443 273 284 1:CAS:528: DyaK1cXnvFOhtb0%3D 9781370
    • (1998) Adv Exp Med Biol , vol.443 , pp. 273-284
    • Tsuda, H.1    Sekine, K.2    Nakamura, J.3
  • 48
    • 0032783423 scopus 로고    scopus 로고
    • Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats
    • DOI 10.1016/S0304-3835(99)00130-5, PII S0304383599001305
    • H Tsuda K Sekine N Uehara, et al. 1999 Heterocyclic amine mixture carcinogenesis and its enhancement by caffeine in F344 rats Cancer Lett 143 229 234 10.1016/S0304-3835(99)00130-5 1:CAS:528:DyaK1MXltlCrsb8%3D 10503909 (Pubitemid 29392962)
    • (1999) Cancer Letters , vol.143 , Issue.2 , pp. 229-234
    • Tsuda, H.1    Sekine, K.2    Uehara, N.3    Takasuka, N.4    Moore, M.A.5    Konno, Y.6    Nakashita, K.7    Degawa, M.8
  • 49
    • 0036188351 scopus 로고    scopus 로고
    • Cancer prevention by bovine lactoferrin and underlying mechanisms - A review of experimental and clinical studies
    • DOI 10.1139/o01-239
    • H Tsuda K Sekine K Fujita, et al. 2002 Cancer prevention by bovine lactoferrin and underlying mechanisms-a review of experimental and clinical studies Biochem Cell Biol 80 131 136 10.1139/o01-239 1:CAS:528: DC%2BD38XitlCntrw%3D 11908637 (Pubitemid 34194239)
    • (2002) Biochemistry and Cell Biology , vol.80 , Issue.1 , pp. 131-136
    • Tsuda, H.1    Sekine, K.2    Fujita, K.-I.3    Iigo, M.4
  • 50
    • 0032806625 scopus 로고    scopus 로고
    • Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2
    • DOI 10.1016/S0304-3835(99)00137-8, PII S0304383599001378
    • RJ Turesky A Constable LB Fay, et al. 1999 Interspecies differences in metabolism of heterocyclic aromatic amines by rat and human P450 1A2 Cancer Lett 143 109 112 10.1016/S0304-3835(99)00137-8 1:CAS:528:DyaK1MXltlCrsrc%3D 10503887 (Pubitemid 29392940)
    • (1999) Cancer Letters , vol.143 , Issue.2 , pp. 109-112
    • Turesky, R.J.1    Constable, A.2    Fay, L.B.3    Guengerich, F.P.4
  • 51
    • 0032417373 scopus 로고    scopus 로고
    • Inhibitory effects of bovine lactoferrin on intestinal polyposis in the Apc(Min) mouse
    • DOI 10.1016/S0304-3835(98)00249-3, PII S0304383598002493
    • Y Ushida K Sekine T Kuhara, et al. 1998 Inhibitory effects of bovine lactoferrin on intestinal polyposis in the Apc(Min) mouse Cancer Lett 134 141 145 10.1016/S0304-3835(98)00249-3 1:CAS:528:DyaK1MXivVWrsw%3D%3D 10025873 (Pubitemid 29070730)
    • (1998) Cancer Letters , vol.134 , Issue.2 , pp. 141-145
    • Ushida, Y.1    Sekine, K.2    Kuhara, T.3    Takasuka, N.4    Iigo, M.5    Tsuda, H.6
  • 52
    • 0032913302 scopus 로고    scopus 로고
    • Possible chemopreventive effects of bovine lactoferrin on esophagus and lung carcinogenesis in the rat
    • 1:CAS:528:DyaK1MXjtVKrsb8%3D 10359039
    • Y Ushida K Sekine T Kuhara, et al. 1999 Possible chemopreventive effects of bovine lactoferrin on esophagus and lung carcinogenesis in the rat Jpn J Cancer Res 90 262 267 1:CAS:528:DyaK1MXjtVKrsb8%3D 10359039
    • (1999) Jpn J Cancer Res , vol.90 , pp. 262-267
    • Ushida, Y.1    Sekine, K.2    Kuhara, T.3
  • 56
    • 0037454239 scopus 로고    scopus 로고
    • Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis
    • Z von Marschall A Scholz T Cramer, et al. 2003 Effects of interferon alpha on vascular endothelial growth factor gene transcription and tumor angiogenesis J Natl Cancer Inst 95 437 448
    • (2003) J Natl Cancer Inst , vol.95 , pp. 437-448
    • Von Marschall, Z.1    Scholz, A.2    Cramer, T.3
  • 57
    • 35548933234 scopus 로고    scopus 로고
    • Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines
    • 1:CAS:528:DC%2BD2sXhtFagtLk%3D 17143494
    • Y Wada K Yoshida Y Tsutani, et al. 2007 Neutrophil elastase induces cell proliferation and migration by the release of TGF-alpha, PDGF and VEGF in esophageal cell lines Oncol Rep 17 161 167 1:CAS:528:DC%2BD2sXhtFagtLk%3D 17143494
    • (2007) Oncol Rep , vol.17 , pp. 161-167
    • Wada, Y.1    Yoshida, K.2    Tsutani, Y.3
  • 58
    • 33644913949 scopus 로고    scopus 로고
    • Modulation of immunity-related gene expression in small intestines of mice by oral administration of lactoferrin
    • DOI 10.1128/CVI.13.2.239-245.2006
    • H Wakabayashi N Takakura K Yamauchi, et al. 2006 Modulation of immunity-related gene expression in small intestines of mice by oral administration of lactoferrin Clin Vaccine Immunol 13 239 245 10.1128/CVI.13.2.239-245.2006 1:CAS:528:DC%2BD28Xhs1Gmsbc%3D 16467332 (Pubitemid 43383793)
    • (2006) Clinical and Vaccine Immunology , vol.13 , Issue.2 , pp. 239-245
    • Wakabayashi, H.1    Takakura, N.2    Yamauchi, K.3    Tamura, Y.4
  • 59
    • 0033767482 scopus 로고    scopus 로고
    • Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin
    • 1:CAS:528:DC%2BD3cXnslKiu70%3D 11050473
    • WP Wang M Iigo J Sato, et al. 2000 Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin Jpn J Cancer Res 91 1022 1027 1:CAS:528:DC%2BD3cXnslKiu70%3D 11050473
    • (2000) Jpn J Cancer Res , vol.91 , pp. 1022-1027
    • Wang, W.P.1    Iigo, M.2    Sato, J.3
  • 60
    • 0027278825 scopus 로고
    • Heterocyclic amines in cooked foods: Possible human carcinogens
    • 1:STN:280:DyaK3s3ltFCksQ%3D%3D 8485729
    • JH Weisburger 1993 Heterocyclic amines in cooked foods: possible human carcinogens Cancer Res 53 2422 2424 1:STN:280:DyaK3s3ltFCksQ%3D%3D 8485729
    • (1993) Cancer Res , vol.53 , pp. 2422-2424
    • Weisburger, J.H.1
  • 61
    • 34250718748 scopus 로고    scopus 로고
    • Neutrophils promote aerogenous spread of lung adenocarcinoma with bronchioloalveolar carcinoma features
    • DOI 10.1158/1078-0432.CCR-06-2558
    • M Wislez M Antoine N Rabbe, et al. 2007 Neutrophils promote aerogenous spread of lung adenocarcinoma with bronchioloalveolar carcinoma features Clin Cancer Res 13 3518 3527 10.1158/1078-0432.CCR-06-2558 1:CAS:528: DC%2BD2sXmsFCqtb4%3D 17575214 (Pubitemid 46955111)
    • (2007) Clinical Cancer Research , vol.13 , Issue.12 , pp. 3518-3527
    • Wislez, M.1    Antoine, M.2    Rabbe, N.3    Gounant, V.4    Poulot, V.5    Lavole, A.6    Fleury-Feith, J.7    Cadranel, J.8
  • 62
    • 1642578175 scopus 로고    scopus 로고
    • Lactoferrin inhibits growth of malignant tumors of the head and neck
    • 1:CAS:528:DC%2BD2cXkt12ntQ%3D%3D 14730178
    • JS Wolf D Li RJ Taylor, et al. 2003 Lactoferrin inhibits growth of malignant tumors of the head and neck ORL J Otorhinolaryngol Relat Spec 65 245 249 1:CAS:528:DC%2BD2cXkt12ntQ%3D%3D 14730178
    • (2003) ORL J Otorhinolaryngol Relat Spec , vol.65 , pp. 245-249
    • Wolf, J.S.1    Li, D.2    Taylor, R.J.3
  • 64
    • 70350036225 scopus 로고    scopus 로고
    • Alarmins link neutrophils and dendritic cells
    • 10.1016/j.it.2009.07.004
    • D Yang G de la Rosa P Tewary, et al. 2009 Alarmins link neutrophils and dendritic cells Trends Immunol 11 531 537 10.1016/j.it.2009.07.004
    • (2009) Trends Immunol , vol.11 , pp. 531-537
    • Yang, D.1    De La Rosa, G.2    Tewary, P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.