Orally administered bovine lactoferrin induces caspase-1 and interleukin-18 in the mouse intestinal mucosa: A possible explanation for inhibition of carcinogenesis and metastasis

Cytokine

Volumn 25, Issue 1, 2004, Pages 36-44

  Iigo, Masaaki ^a   Shimamura, Mariko ^b   Matsuda, Eiji ^c   Fujita, Ken Ichi ^a   Nomoto, Hiroshi ^c   Satoh, Jun ^a   Kojima, Syuji ^c   Alexander, David B ^a   Moore, Malcolm A ^a   Tsuda, Hiroyuki ^a  

^a NATIONAL CANCER CENTER RESEARCH INSTITUTE   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^c TOKYO UNIVERSITY OF SCIENCE   (Japan)

Author keywords

Caspase 1; Interleukin 18; Lactoferrin; Mucosal immunity; Small intestine

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 18; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTOFERRIN; PROTEIN HYDROLYSATE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARCINOGENESIS; CATTLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; INTESTINE MUCOSA; METASTASIS; MOUSE; NATURAL KILLER CELL; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; SMALL INTESTINE; T LYMPHOCYTE; TUMOR CELL;

BOVINAE;

EID: 0348109481     PISSN: 10434666     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.cyto.2003.09.009     Document Type: Article

References (16)

1. Bezault J., Bhimani R., Wiprovnick J., Furmanski P. Human lactoferrin inhibits growth of solid tumors and development of experimental metastases in mice. Cancer Res. 54:1994;2310-2312.
2. Yoo Y.-C., Watanabe S., Watanabe R., Hata K., Shimazaki K., Azuma I. Bovine lactoferrin and lactoferricin, a peptide derived from bovine lactoferrin, inhibit tumor metastasis in mice. Jpn J Cancer Res. 88:1997;184-190.
3. Iigo M., Kuhara T., Ushida Y., Sekine K., Moore M.A., Tsuda H. Inhibitory effects of bovine lactoferrin on colon carcinoma 26 lung metastasis in mice. Clin Exp Metastasis. 17:1999;35-40.
4. Sekine K., Ushida Y., Kuhara T., Iigo M., Baba-Toriyama H., Moore M.A., et al. Inhibition of initiation and early stage development of aberrant crypt foci and enhanced natural killer activity in male rats administered bovine lactoferrin concomitantly with azoxymethane. Cancer Lett. 121:1997;211-216.
5. Wang W.-P., Iigo M., Sato J., Sekine K., Adachi I., Tsuda H. Activation of intestinal mucosal immunity in tumor-bearing mice by lactoferrin. Jpn J Cancer Res. 91:2000;1022-1027.
6. Debbabi H., Dubarry M., Rautureau M., Tome D. Bovine lactoferrin induces both mucosal and systemic immune responses in mice. J Dairy Res. 65:1998;283-293.
7. Kuhara T., Iigo M., Itoh T., Ushida Y., Sekine K., Terada N., et al. Orally administered lactoferrin exerts an antimetastatic effect and enhances production of IL-18 in the intestinal epithelium. Nutr Cancer. 38:2000;192-199.
8. Takeuchi M., Nishizaki Y., Sano O., Ohta T., Ikeda M., Kurimoto M. Immunohistochemical and immuno-electron-microscopic detection of interferon-gamma-inducing factor ("interleukin-18") in mouse intestinal epithelial cells. Cell Tissue Res. 289:1997;499-503.
9. Puren A.J., Razeghi P., Fantuzzi G., Dinarello C.A. Interleukin-18 enhances lipopolysaccharide-induced interferon-gamma production in human whole blood cultures. J Infect Dis. 178:1998;1830-1834.
10. + effector T cells is differentially regulated by IL-18 and IL-12. J Immunol. 162:1999;3202-3211.
11. Cao R., Farnebo J., Kurimoto M., Cao Y. Interleukin-18 acts as an angiogenesis and tumor suppressor. FASEB J. 130:1999;2195-2202.
12. Pirhonen J., Sareneva T., Kurimoto M., Julkunen I., Matikainen S. Virus infection activates IL-1β and IL-18 production in human macrophages by a caspase-1-dependent pathway. J Immunol. 162:1999;7322-7329.
13. Akita K., Ohtsuki T., Nukada Y., Tanimoto T., Namba M., Okura T., et al. Involvement of caspase-1 and caspase-3 in the production and processing of mature human interleukin 18 in monocytic THP.1 cells. J Biol Chem. 272:1997;26595-26603.
14. DinarelloI C.A. Interleukin-18. Methods. 19:1999;121-132.
15. Gu Y., Kida K., Tsutsui H., Ku G., Hsiao K., Fleming M.A., et al. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science. 275:1997;206-209.
16. Coughlin C.M., Salhany K.E., Wysocka M., Aruga E., Kurzawa H., Chang A.E., et al. Interleukin-12 and interleukin-18 synergistically induce murine tumor regression which involves inhibition of angiogenesis. J Clin Invest. 101:1998;1441-1452.