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Volumn 63, Issue 7, 2013, Pages 696-701

Glutamate and tumor-associated epilepsy: Glial cell dysfunction in the peritumoral environment

Author keywords

Astrocytes; Glioma; Gliosis; Glutamate; Hyperexcitability; Seizures

Indexed keywords

CRE RECOMBINASE; EPIDERMAL GROWTH FACTOR RECEPTOR; GLUTAMATE RECEPTOR; GLUTAMIC ACID; PLATELET DERIVED GROWTH FACTOR ALPHA RECEPTOR; POTASSIUM CHLORIDE; SALAZOSULFAPYRIDINE; SODIUM GLUCOSE COTRANSPORTER 1; STAT3 PROTEIN;

EID: 84888203048     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.01.027     Document Type: Review
Times cited : (47)

References (71)
  • 2
    • 0022969399 scopus 로고
    • Exchange of cystine and glutamate across plasma membrane of human fibroblasts
    • S. Bannai Exchange of cystine and glutamate across plasma membrane of human fibroblasts J. Biol. Chem. 261 1986 2256 2263 (Pubitemid 17205155)
    • (1986) Journal of Biological Chemistry , vol.261 , Issue.5 , pp. 2256-2263
    • Bannai, S.1
  • 3
    • 0033909858 scopus 로고    scopus 로고
    • Extracellular glutamate and other metabolites in and around RG2 rat glioma: An intracerebral microdialysis study
    • DOI 10.1023/A:1006426917654
    • P.F. Behrens, H. Langemann, R. Strohschein, J. Draeger, and J. Hennig Extracellular glutamate and other metabolites in and around RG2 rat glioma: an intracerebral microdialysis study J. Neuro Oncol. 47 2000 11 22 (Pubitemid 30458401)
    • (2000) Journal of Neuro-Oncology , vol.47 , Issue.1 , pp. 11-22
    • Behrens, P.F.1    Langemann, H.2    Strohschein, R.3    Draeger, J.4    Hennig, J.5
  • 4
    • 0032169291 scopus 로고    scopus 로고
    • Properties of human glial cells associated with epileptic seizure foci
    • DOI 10.1016/S0920-1211(98)00059-X, PII S092012119800059X
    • A. Bordey, and H. Sontheimer Properties of human glial cells associated with epileptic seizure foci Epilepsy Res. 32 1998 286 303 (Pubitemid 28419497)
    • (1998) Epilepsy Research , vol.32 , Issue.1-2 , pp. 286-303
    • Bordey, A.1    Sontheimer, H.2
  • 5
    • 84930482848 scopus 로고    scopus 로고
    • Thinking outside the cleft to understand synaptic activity: Contribution of the cystine-glutamate antiporter (system xc-) to normal and pathological glutamatergic signaling
    • R. Bridges, V. Lutgen, D. Lobner, and D.A. Baker Thinking outside the cleft to understand synaptic activity: contribution of the cystine-glutamate antiporter (system xc-) to normal and pathological glutamatergic signaling Pharmacol. Rev. 64 2012 780 802
    • (2012) Pharmacol. Rev. , vol.64 , pp. 780-802
    • Bridges, R.1    Lutgen, V.2    Lobner, D.3    Baker, D.A.4
  • 8
    • 0036139877 scopus 로고    scopus 로고
    • Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains
    • E.A. Bushong, M.E. Martone, Y.Z. Jones, and M.H. Ellisman Protoplasmic astrocytes in CA1 stratum radiatum occupy separate anatomical domains J. Neurosci. 22 2002 183 192 (Pubitemid 34033496)
    • (2002) Journal of Neuroscience , vol.22 , Issue.1 , pp. 183-192
    • Bushong, E.A.1    Martone, M.E.2    Jones, Y.Z.3    Ellisman, M.H.4
  • 9
    • 84865001431 scopus 로고    scopus 로고
    • Human glioma cells induce hyperexcitability in cortical networks
    • S.L. Campbell, S.C. Buckingham, and H. Sontheimer Human glioma cells induce hyperexcitability in cortical networks Epilepsia 53 2012 1360 1370
    • (2012) Epilepsia , vol.53 , pp. 1360-1370
    • Campbell, S.L.1    Buckingham, S.C.2    Sontheimer, H.3
  • 10
    • 0029114107 scopus 로고
    • Glutamate transporters in glial plasma membranes: Highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry
    • F.A. Chaudhry, K.P. Lehre, M. van Lookeren Campagne, O.P. Ottersen, N.C. Danbolt, and J. Storm-Mathisen Glutamate transporters in glial plasma membranes: highly differentiated localizations revealed by quantitative ultrastructural immunocytochemistry Neuron 15 1995 711 720
    • (1995) Neuron , vol.15 , pp. 711-720
    • Chaudhry, F.A.1    Lehre, K.P.2    Van Lookeren Campagne, M.3    Ottersen, O.P.4    Danbolt, N.C.5    Storm-Mathisen, J.6
  • 11
    • 84862321615 scopus 로고    scopus 로고
    • Astrocytic regulation of glutamate homeostasis in epilepsy
    • D.A. Coulter, and T. Eid Astrocytic regulation of glutamate homeostasis in epilepsy Glia 60 2012 1215 1226
    • (2012) Glia , vol.60 , pp. 1215-1226
    • Coulter, D.A.1    Eid, T.2
  • 12
    • 69449102409 scopus 로고    scopus 로고
    • Astrocytic dysfunction in epileptogenesis: Consequence of altered potassium and glutamate homeostasis?
    • Y. David, L.P. Cacheaux, S. Ivens, E. Lapilover, U. Heinemann, D. Kaufer, and A. Friedman Astrocytic dysfunction in epileptogenesis: consequence of altered potassium and glutamate homeostasis? J. Neurosci. 29 2009 10588 10599
    • (2009) J. Neurosci. , vol.29 , pp. 10588-10599
    • David, Y.1    Cacheaux, L.P.2    Ivens, S.3    Lapilover, E.4    Heinemann, U.5    Kaufer, D.6    Friedman, A.7
  • 13
    • 84867494866 scopus 로고    scopus 로고
    • Toward determining the lifetime occurrence of metastatic brain tumors estimated from 2007 United States cancer incidence data
    • F.G. Davis, T.A. Dolecek, B.J. McCarthy, and J.L. Villano Toward determining the lifetime occurrence of metastatic brain tumors estimated from 2007 United States cancer incidence data Neuro Oncol. 14 2012 1171 1177
    • (2012) Neuro Oncol. , vol.14 , pp. 1171-1177
    • Davis, F.G.1    Dolecek, T.A.2    McCarthy, B.J.3    Villano, J.L.4
  • 14
    • 16444366144 scopus 로고    scopus 로고
    • The excitatory amino acid transporter-2 induces apoptosis and decreases glioma growth in vitro and in vivo
    • DOI 10.1158/0008-5472.CAN-04-3626
    • J.F. de Groot, T.J. Liu, G. Fuller, and W.K. Yung The excitatory amino acid transporter-2 induces apoptosis and decreases glioma growth in vitro and in vivo Cancer Res. 65 2005 1934 1940 (Pubitemid 40478623)
    • (2005) Cancer Research , vol.65 , Issue.5 , pp. 1934-1940
    • De Groot, J.F.1    Ta, J.L.2    Fuller, G.3    Yung, W.K.A.4
  • 15
    • 0025931905 scopus 로고
    • Contact spacing among astrocytes in the central nervous system: An hypothesis of their structural role
    • C. Distler, Z. Dreher, and J. Stone Contact spacing among astrocytes in the central nervous system: an hypothesis of their structural role Glia 4 1991 484 494
    • (1991) Glia , vol.4 , pp. 484-494
    • Distler, C.1    Dreher, Z.2    Stone, J.3
  • 16
    • 35448989687 scopus 로고    scopus 로고
    • ir4.1 leads to glial membrane depolarization, inhibition of potassium and glutamate uptake, and enhanced short-term synaptic potentiation
    • DOI 10.1523/JNEUROSCI.0723-07.2007
    • B. Djukic, K.B. Casper, B.D. Philpot, L.-S. Chin, and K.D. McCarthy Conditional Knock-Out of Kir4.1 Leads to Glial Membrane Depolarization, Inhibition of Potassium and Glutamate Uptake, and Enhanced Short-Term Synaptic Potentiation J. Neurosci. 27 2007 11354 11365 (Pubitemid 47621304)
    • (2007) Journal of Neuroscience , vol.27 , Issue.42 , pp. 11354-11365
    • Djukic, B.1    Casper, K.B.2    Philpot, B.D.3    Chin, L.-S.4    McCarthy, K.D.5
  • 18
    • 17844399776 scopus 로고    scopus 로고
    • Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme
    • DOI 10.1215/S1152851704000821
    • C. Giannini, J.N. Sarkaria, A. Saito, J.H. Uhm, E. Galanis, B.L. Carlson, M.A. Schroeder, and C.D. James Patient tumor EGFR and PDGFRA gene amplifications retained in an invasive intracranial xenograft model of glioblastoma multiforme Neuro Oncol. 7 2005 164 176 (Pubitemid 40590516)
    • (2005) Neuro-Oncology , vol.7 , Issue.2 , pp. 164-176
    • Giannini, C.1    Sarkaria, J.N.2    Saito, A.3    Uhm, J.H.4    Galanis, E.5    Carlson, B.L.6    Schroeder, M.A.7    James, C.D.8
  • 19
    • 22544433743 scopus 로고    scopus 로고
    • Epileptic seizures during follow-up of patients treated for primary brain tumors
    • DOI 10.1212/01.wnl.0000168903.09277.8f
    • J. Hildebrand, C. Lecaille, J. Perennes, and J.Y. Delattre Epileptic seizures during follow-up of patients treated for primary brain tumors Neurology 65 2005 212 215 (Pubitemid 41022363)
    • (2005) Neurology , vol.65 , Issue.2 , pp. 212-215
    • Hildebrand, J.1    Lecaille, C.2    Perennes, J.3    Delattre, J.-Y.4
  • 21
    • 33846623307 scopus 로고    scopus 로고
    • TGF-β receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis
    • DOI 10.1093/brain/awl317
    • S. Ivens, D. Kaufer, L.P. Flores, I. Bechmann, D. Zumsteg, O. Tomkins, E. Seiffert, U. Heinemann, and A. Friedman TGF-beta receptor-mediated albumin uptake into astrocytes is involved in neocortical epileptogenesis Brain 130 2007 535 547 (Pubitemid 46181106)
    • (2007) Brain , vol.130 , Issue.2 , pp. 535-547
    • Ivens, S.1    Kaufer, D.2    Flores, L.P.3    Bechmann, I.4    Zumsteg, D.5    Tomkins, O.6    Seiffert, E.7    Heinemann, U.8    Friedman, A.9
  • 23
    • 33645050910 scopus 로고    scopus 로고
    • Epileptiform activity preferentially arises outside tumor invasion zone in glioma xenotransplants
    • R. Kohling, V. Senner, W. Paulus, and E.J. Speckmann Epileptiform activity preferentially arises outside tumor invasion zone in glioma xenotransplants Neurobiol. Dis. 22 2006 64 75
    • (2006) Neurobiol. Dis. , vol.22 , pp. 64-75
    • Kohling, R.1    Senner, V.2    Paulus, W.3    Speckmann, E.J.4
  • 24
    • 33846862901 scopus 로고    scopus 로고
    • Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes
    • DOI 10.1002/glia.20455
    • Y.V. Kucheryavykh, L.Y. Kucheryavykh, C.G. Nichols, H.M. Maldonado, K. Baksi, A. Reichenbach, S.N. Skatchkov, and M.J. Eaton Downregulation of Kir4.1 inward rectifying potassium channel subunits by RNAi impairs potassium transfer and glutamate uptake by cultured cortical astrocytes Glia 55 2007 274 281 (Pubitemid 46225959)
    • (2007) GLIA , vol.55 , Issue.3 , pp. 274-281
    • Kucheryavykh, Y.V.1    Kucheryavykh, L.Y.2    Nichols, C.G.3    Maldonado, H.M.4    Baksi, K.5    Reichenbach, A.6    Skatchkov, S.N.7    Eaton, M.J.8
  • 25
    • 77449140015 scopus 로고    scopus 로고
    • Seizures in patients with low-grade gliomas - Incidence, pathogenesis, surgical management, and pharmacotherapy
    • D. Kurzwelly, U. Herrlinger, and M. Simon Seizures in patients with low-grade gliomas - incidence, pathogenesis, surgical management, and pharmacotherapy Adv. Tech. Stand. Neurosurg. 35 2010 81 111
    • (2010) Adv. Tech. Stand. Neurosurg. , vol.35 , pp. 81-111
    • Kurzwelly, D.1    Herrlinger, U.2    Simon, M.3
  • 26
    • 79960845291 scopus 로고    scopus 로고
    • NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents
    • H.H. Lee, T.Z. Deeb, J.A. Walker, P.A. Davies, and S.J. Moss NMDA receptor activity downregulates KCC2 resulting in depolarizing GABAA receptor-mediated currents Nat. Neurosci. 14 2011 736 743
    • (2011) Nat. Neurosci. , vol.14 , pp. 736-743
    • Lee, H.H.1    Deeb, T.Z.2    Walker, J.A.3    Davies, P.A.4    Moss, S.J.5
  • 27
    • 78651490601 scopus 로고    scopus 로고
    • Non-invasive quantification of brain tumor-induced astrogliosis
    • J. Lee, A.K. Borboa, A. Baird, and B.P. Eliceiri Non-invasive quantification of brain tumor-induced astrogliosis BMC Neurosci. 12 2011 9
    • (2011) BMC Neurosci. , vol.12 , pp. 9
    • Lee, J.1    Borboa, A.K.2    Baird, A.3    Eliceiri, B.P.4
  • 30
    • 84864709456 scopus 로고    scopus 로고
    • The molecular profile of microglia under the influence of glioma
    • W. Li, and M.B. Graeber The molecular profile of microglia under the influence of glioma Neuro Oncol. 14 2012 958 978
    • (2012) Neuro Oncol. , vol.14 , pp. 958-978
    • Li, W.1    Graeber, M.B.2
  • 32
    • 35148854098 scopus 로고    scopus 로고
    • Autocrine glutamate signaling promotes glioma cell invasion
    • DOI 10.1158/0008-5472.CAN-07-2034
    • S.A. Lyons, W.J. Chung, A.K. Weaver, T. Ogunrinu, and H. Sontheimer Autocrine glutamate signaling promotes glioma cell invasion Cancer Res. 67 2007 9463 9471 (Pubitemid 47535936)
    • (2007) Cancer Research , vol.67 , Issue.19 , pp. 9463-9471
    • Lyons, S.A.1    Chung, W.J.2    Weaver, A.K.3    Ogunrinu, T.4    Sontheimer, H.5
  • 34
    • 33745532487 scopus 로고    scopus 로고
    • Inducible gene deletion in astroglia and radial glia - A valuable tool for functional and lineage analysis
    • DOI 10.1002/glia.20350
    • T. Mori, K. Tanaka, A. Buffo, W. Wurst, R. Kuhn, and M. Gotz Inducible gene deletion in astroglia and radial glia - a valuable tool for functional and lineage analysis Glia 54 2006 21 34 (Pubitemid 43980031)
    • (2006) GLIA , vol.54 , Issue.1 , pp. 21-34
    • Mori, T.1    Tanaka, K.2    Buffo, A.3    Wurst, W.4    Kuhn, R.5    Gotz, M.6
  • 36
    • 0037202760 scopus 로고    scopus 로고
    • Häufigkeit von epileptischen anfällen bei patienten mit primären hirntumoren oder zerebralen metastasen: Eine untersuchung des Ludwig Boltzmann Institutes Für Neuroonkologie und der Neurologischen Abteilung des Kaiser Franz Josef Spitals in Wien
    • S. Oberndorfer, T. Schmal, H. Lahrmann, S. Urbanits, K. Lindner, and W. Grisold The frequency of seizures in patients with primary brain tumors or cerebral metastases. An evaluation from the Ludwig Boltzmann Institute of Neuro-Oncology and the Department of Neurology, Kaiser Franz Josef Hospital, Vienna Wien Klin Wochenschr 114 2002 911 916 (Pubitemid 35453292)
    • (2002) Wiener Klinische Wochenschrift , vol.114 , Issue.21-22 , pp. 911-916
    • Oberndorfer, S.1    Schmal, T.2    Lahrmann, H.3    Urbanits, S.4    Lindner, K.5    Grisold, W.6
  • 37
    • 34547818710 scopus 로고    scopus 로고
    • + homeostasis
    • DOI 10.1152/jn.00340.2007
    • M.L. Olsen, S.L. Campbell, and H. Sontheimer Differential Distribution of Kir4.1 in Spinal Cord Astrocytes Suggests Regional Differences in K+ Homeostasis J Neurophysiol. 98 2007 786 793 (Pubitemid 47236032)
    • (2007) Journal of Neurophysiology , vol.98 , Issue.2 , pp. 786-793
    • Olsen, M.L.1    Campbell, S.L.2    Sontheimer, H.3
  • 38
    • 53749085877 scopus 로고    scopus 로고
    • Functional implications for Kir4.1 channels in glial biology: From K+ buffering to cell differentiation
    • M.L. Olsen, and H. Sontheimer Functional implications for Kir4.1 channels in glial biology: from K+ buffering to cell differentiation J. Neurochem. 107 2008 589 601
    • (2008) J. Neurochem. , vol.107 , pp. 589-601
    • Olsen, M.L.1    Sontheimer, H.2
  • 41
    • 20144381062 scopus 로고    scopus 로고
    • Lipopolysaccharide increases microglial GLT-1 expression and glutamate uptake capacity in vitro by a mechanism dependent on TNF-α
    • DOI 10.1002/glia.20191
    • M. Persson, M. Brantefjord, E. Hansson, and L. Ronnback Lipopolysaccharide increases microglial GLT-1 expression and glutamate uptake capacity in vitro by a mechanism dependent on TNF-alpha Glia 51 2005 111 120 (Pubitemid 41277345)
    • (2005) GLIA , vol.51 , Issue.2 , pp. 111-120
    • Persson, M.1    Brantefjord, M.2    Hansson, E.3    Ronnback, L.4
  • 42
    • 34648836756 scopus 로고    scopus 로고
    • Microglial GLT-1 is upregulated in response to herpes simplex virus infection to provide an antiviral defence via glutathione
    • DOI 10.1002/glia.20560
    • M. Persson, M. Brantefjord, J.A. Liljeqvist, T. Bergstrom, E. Hansson, and L. Ronnback Microglial GLT-1 is upregulated in response to herpes simplex virus infection to provide an antiviral defence via glutathione Glia 55 2007 1449 1458 (Pubitemid 47461160)
    • (2007) GLIA , vol.55 , Issue.14 , pp. 1449-1458
    • Persson, M.1    Brantefjord, M.2    Liljeqvist, J.-A.3    Bergstrom, T.4    Hansson, E.5    Ronnback, L.6
  • 43
    • 0014964346 scopus 로고
    • Neuroglia: Gliosis and focal epilepsy
    • D.A. Pollen, and M.C. Trachtenberg Neuroglia: gliosis and focal epilepsy Science 167 1970 1252 1253
    • (1970) Science , vol.167 , pp. 1252-1253
    • Pollen, D.A.1    Trachtenberg, M.C.2
  • 44
    • 77957067789 scopus 로고    scopus 로고
    • Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology
    • K.R. Porter, B.J. McCarthy, S. Freels, Y. Kim, and F.G. Davis Prevalence estimates for primary brain tumors in the United States by age, gender, behavior, and histology Neuro Oncol. 12 2010 520 527
    • (2010) Neuro Oncol. , vol.12 , pp. 520-527
    • Porter, K.R.1    McCarthy, B.J.2    Freels, S.3    Kim, Y.4    Davis, F.G.5
  • 45
    • 34547810939 scopus 로고
    • Activity-dependent K+ accumulation in the rat optic nerve is cleared by temperature-sensitive and temperature-insensitive mechanisms
    • (Part 1)
    • C.B. Ransom, B.R. Ransom, and H. Sontheimer Activity-dependent K+ accumulation in the rat optic nerve is cleared by temperature-sensitive and temperature-insensitive mechanisms Soc. Neurosci. Abs. 21 1995 (Part 1)
    • (1995) Soc. Neurosci. Abs. , vol.21
    • Ransom, C.B.1    Ransom, B.R.2    Sontheimer, H.3
  • 47
    • 34250870091 scopus 로고    scopus 로고
    • Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS
    • DOI 10.1523/JNEUROSCI.0790-07.2007
    • M.R. Regan, Y.H. Huang, Y.S. Kim, M.I. Dykes-Hoberg, L. Jin, A.M. Watkins, D.E. Bergles, and J.D. Rothstein Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS J. Neurosci. 27 2007 6607 6619 (Pubitemid 46983424)
    • (2007) Journal of Neuroscience , vol.27 , Issue.25 , pp. 6607-6619
    • Regan, M.R.1    Huang, Y.H.2    Yu, S.K.3    Dykes-Hoberg, M.I.4    Jin, L.5    Watkins, A.M.6    Bergles, D.E.7    Rothstein, J.D.8
  • 49
    • 78751677843 scopus 로고    scopus 로고
    • The stem cell potential of glia: Lessons from reactive gliosis
    • S. Robel, B. Berninger, and M. Gotz The stem cell potential of glia: lessons from reactive gliosis Nat. Rev. Neurosci. 12 2011 88 104
    • (2011) Nat. Rev. Neurosci. , vol.12 , pp. 88-104
    • Robel, S.1    Berninger, B.2    Gotz, M.3
  • 50
    • 0344642991 scopus 로고    scopus 로고
    • Baseline levels of glucose metabolites, glutamate and glycerol in malignant glioma assessed by stereotactic microdialysis
    • DOI 10.1023/A:1022106910017
    • M. Roslin, R. Henriksson, P. Bergstrom, U. Ungerstedt, and A.T. Bergenheim Baseline levels of glucose metabolites, glutamate and glycerol in malignant glioma assessed by stereotactic microdialysis J. Neuro Oncol. 61 2003 151 160 (Pubitemid 36253661)
    • (2003) Journal of Neuro-Oncology , vol.61 , Issue.2 , pp. 151-160
    • Roslin, M.1    Henriksson, R.2    Bergstrom, P.3    Ungerstedt, U.4    Bergenheim, A.T.5
  • 51
  • 54
    • 0033597349 scopus 로고    scopus 로고
    • Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins
    • H. Sato, M. Tamba, T. Ishii, and S. Bannai Cloning and expression of a plasma membrane cystine/glutamate exchange transporter composed of two distinct proteins J. Biol. Chem. 274 1999 11455 11458
    • (1999) J. Biol. Chem. , vol.274 , pp. 11455-11458
    • Sato, H.1    Tamba, M.2    Ishii, T.3    Bannai, S.4
  • 58
    • 67049137337 scopus 로고    scopus 로고
    • Analysis of astroglial K+ channel expression in the developing hippocampus reveals a predominant role of the Kir4.1 subunit
    • G. Seifert, K. Huttmann, D.K. Binder, C. Hartmann, A. Wyczynski, C. Neusch, and C. Steinhauser Analysis of astroglial K+ channel expression in the developing hippocampus reveals a predominant role of the Kir4.1 subunit J. Neurosci. 29 2009 7474 7488
    • (2009) J. Neurosci. , vol.29 , pp. 7474-7488
    • Seifert, G.1    Huttmann, K.2    Binder, D.K.3    Hartmann, C.4    Wyczynski, A.5    Neusch, C.6    Steinhauser, C.7
  • 59
    • 4544312032 scopus 로고    scopus 로고
    • Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex
    • DOI 10.1523/JNEUROSCI.1751-04.2004
    • E. Seiffert, J.P. Dreier, S. Ivens, I. Bechmann, O. Tomkins, U. Heinemann, and A. Friedman Lasting blood-brain barrier disruption induces epileptic focus in the rat somatosensory cortex J. Neurosci. 24 2004 7829 7836 (Pubitemid 39215686)
    • (2004) Journal of Neuroscience , vol.24 , Issue.36 , pp. 7829-7836
    • Seiffert, E.1    Dreier, J.P.2    Ivens, S.3    Bechmann, I.4    Tomkins, O.5    Heinemann, U.6    Friedman, A.7
  • 60
    • 14844309321 scopus 로고    scopus 로고
    • Protective autoimmunity: Interferon-γ enables microglia to remove glutamate without evoking inflammatory mediators
    • DOI 10.1111/j.1471-4159.2004.02954.x
    • I. Shaked, D. Tchoresh, R. Gersner, G. Meiri, S. Mordechai, X. Xiao, R.P. Hart, and M. Schwartz Protective autoimmunity: interferon-gamma enables microglia to remove glutamate without evoking inflammatory mediators J. Neurochem. 92 2005 997 1009 (Pubitemid 40344291)
    • (2005) Journal of Neurochemistry , vol.92 , Issue.5 , pp. 997-1009
    • Shaked, I.1    Tchoresh, D.2    Gersner, R.3    Meiri, G.4    Mordechai, S.5    Xiao, X.6    Hart, R.P.7    Schwartz, M.8
  • 63
  • 66
    • 78650035858 scopus 로고    scopus 로고
    • Molecular and cellular mechanisms of excitotoxic neuronal death
    • Y. Wang, and Z.H. Qin Molecular and cellular mechanisms of excitotoxic neuronal death Apoptosis 15 2010 1382 1402
    • (2010) Apoptosis , vol.15 , pp. 1382-1402
    • Wang, Y.1    Qin, Z.H.2
  • 67
    • 0032873812 scopus 로고    scopus 로고
    • Amygdala-kindled and pentylenetetrazole-induced seizures in glutamate transporter GLAST-deficient mice
    • DOI 10.1016/S0006-8993(99)01945-9, PII S0006899399019459
    • T. Watanabe, K. Morimoto, T. Hirao, H. Suwaki, K. Watase, and K. Tanaka Amygdala-kindled and pentylenetetrazole-induced seizures in glutamate transporter GLAST-deficient mice Brain Res. 845 1999 92 96 (Pubitemid 29472372)
    • (1999) Brain Research , vol.845 , Issue.1 , pp. 92-96
    • Watanabe, T.1    Morimoto, K.2    Hirao, T.3    Suwaki, H.4    Watase, K.5    Tanaka, K.6
  • 68
    • 42149112453 scopus 로고    scopus 로고
    • Astrocytes in the Epileptic Brain
    • DOI 10.1016/j.neuron.2008.04.002, PII S0896627308003061
    • J. Wetherington, G. Serrano, and R. Dingledine Astrocytes in the epileptic brain Neuron 58 2008 168 178 (Pubitemid 351539007)
    • (2008) Neuron , vol.58 , Issue.2 , pp. 168-178
    • Wetherington, J.1    Serrano, G.2    Dingledine, R.3
  • 69
    • 63349110343 scopus 로고    scopus 로고
    • Agrin, aquaporin-4, and astrocyte polarity as an important feature of the blood-brain barrier
    • H. Wolburg, S. Noell, K. Wolburg-Buchholz, A. Mack, and P. Fallier-Becker Agrin, aquaporin-4, and astrocyte polarity as an important feature of the blood-brain barrier Neuroscientist 15 2009 180 193
    • (2009) Neuroscientist , vol.15 , pp. 180-193
    • Wolburg, H.1    Noell, S.2    Wolburg-Buchholz, K.3    Mack, A.4    Fallier-Becker, P.5
  • 71
    • 0033198997 scopus 로고    scopus 로고
    • Glioma cells release excitotoxic concentrations of glutamate
    • Z.C. Ye, and H. Sontheimer Glioma cells release excitotoxic concentrations of glutamate Cancer Res. 59 1999 4383 4391 (Pubitemid 29418758)
    • (1999) Cancer Research , vol.59 , Issue.17 , pp. 4383-4391
    • Ye, Z.-C.1    Sontheimer, H.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.