Investigation of DNA Sequence in the Basal Core Promoter, Precore, and Core Regions of Hepatitis B Virus from Tunisia Shows a Shift in Genotype Prevalence

Hepatitis Monthly

Volumn 12, Issue 11, 2012, Pages

  Ayari, Rym ^a   Lakhoua Gorgi, Yousr ^a   Bouslama, Lamjed ^b   Safar, Imen ^a   Kchouk, Fatma Houissa ^a   Aouadi, Houda ^a   Jendoubi Ayed, Saloua ^a   Najjar, Taoufik ^a   Ayed, Kaled ^a   Abdallah, Taieb Ben ^a  

^a CHARLES NICOLLE HOSPITAL   (Tunisia)

^b CENTRE DE BIOTECHNOLOGIE DE BORJ CÉDRIA   (Tunisia)

Author keywords

Genotypes; Hepatitis B Virus; Mutations; Promoter Regions, Genetic

Indexed keywords

EID: 84888198011     PISSN: 1735143X     EISSN: 17353408     Source Type: Journal    
DOI: 10.5812/hepatmon.6191     Document Type: Article

References (35)

1. Arankalle VA, Murhekar KM, Gandhe SS, Murhekar MV, Ramdasi AY, Padbidri VS, et al. Hepatitis B virus: Predominance of genotype D in primitive tribes of the Andaman and Nicobar islands, India (1989-1999). J Gen Virol. 2003;84(Pt 7):1915-20.
2. Tsai WL,Lo GH, Hsu PI, Lai KH, Lin CK, Chan HH, et al. Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chronic hepatitis B with acute exacerbation. Scand J Gastroenterol. 2008;43(2):196-201.
3. Yuen MF, Tanaka Y, Shinkai N, Poon RT, But DY, Fong DY, et al. Risk for hepatocellular carcinoma with respect to hepatitis B virus genotypes B/C, specific mutations of enhancer II/core promoter/precore regions and HBV DNA levels. Gut. 2008;57(1):98-102.
4. Pumpens P, Grens E,Nassal M. Molecular epidemiology and immunology of hepatitis B virus infection an update. Intervirology. 2002;45(4-6):218-32.
5. Kao JH, Chen PJ, Lai MY, Chen DS. Genotypes and clinical phenotypes of hepatitis B virus in patients with chronic hepatitis B virus infection. J Clin Microbiol. 2002;40(4):1207-9.
6. Tur-Kaspa R, Klein A, Aharonson S. Hepatitis B virus precore mutants are identical in carriers from various ethnic origins and are associated with a range of liver disease severity. Hepatology. 1992;16(6):42-1338.
7. Thakur V, Guptan RC, Kazim SN, Malhotra V, Sarin SK. Profile, spectrum and significance of HBV genotypes in chronic liver disease patients in the Indian subcontinent. J Gastroenterol Hepatol. 2002;17(2):165-70.
8. Ayed K, Gorgi Y, Ayed-Jendoubi S, Aouadi H, Sfar I, Najjar T, et al. Hepatitis B virus genotypes and precore/core-promoter mutations in Tunisian patients with chronic hepatitis B virus infection. J Infect. 2007;54(3):291-7.
9. Chou YC, Yu MW, Wu CF, Yang SY, Lin CL, Liu CJ,et al. Temporal relationship between hepatitis B virus enhancer II/basal core promoter sequence variation and risk of hepatocellular carcinoma. Gut. 2008;57(1):91-7.
10. Takahashi K, Aoyama K, Ohno N, Iwata K, Akahane Y, Baba K, et al. The precore/core promoter mutant (T1762A1764) of hepatitis B virus: Clinical significance and an easy method for detection. J Gen Virol. 1995;76(Pt 12):3159-64.
11. Bahri O, Cheikh I, Hajji N, Djebbi A, Maamouri N, Sadraoui A, et al. Hepatitis B genotypes, precore and core promoter mutants circulating in Tunisia. J Med Virol. 2006;78(3):353-7.
12. Borchani-Chabchoub I, Gargouri A, Mokdad-Gargouri R. Genotyping of Tunisian hepatitis B virus isolates based on the sequencing of preS2 and S regions. Microbes Infect. 2000;2(6):607-12
13. Meldal BH, Moula NM, Barnes IH, Boukef K, Allain JP. A novel hepatitis B virus subgenotype, D7, in Tunisian blood donors. J Gen Virol. 2009;90(Pt 7):1622-8.
14. Naito H, Hayashi S, Abe K. Rapid and specific genotyping system for hepatitis B virus corresponding to six major genotypes by PCR using type-specific primers. J Clin Microbiol. 2001;39(1):362-4.
15. Rodriguez-Frias F, Jardi R. Molecular virology of the hepatitis B virus. Enferm Infecc Microbiol Clin. 2008;26 (Suppl 7):2-10.
16. Kramvis A, Arakawa K, Yu MC, Nogueira R, Stram DO, Kew MC. Relationship of serological subtype, basic core promoter and precore mutations to genotypes/subgenotypes of hepatitis B virus. J Med Virol. 2008;80(1):27-46.
17. Kramvis A, Kew MC. Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy. J Viral Hepat. 2005;12(5):456-64.
18. Okamoto H, Tsuda F, Sakugawa H, Sastrosoewignjo RI, Imai M, Miyakawa Y, et al. Typing hepatitis B virus by homology in nucleotide sequence: comparison of surface antigen subtypes. J Gen Virol. 1988;69(Pt 10):2575-83.
19. Wang Y, Chen P, Wu X, Sun AL, Wang H, Zhu YA, et al. A new enhancer element, ENII, identified in the X gene of hepatitis B virus. J Virol. 1990;64(8):3977-81.
20. Yuh CH, Chang YL, Ting LP. Transcriptional regulation of precore and pregenomic RNAs of hepatitis B virus. J Virol. 1992;66(7):4073-84.
21. Trik i H, Ben Slimane S, Ben Mami N, Sakka T, Ben Ammar A, Dellagi K. High circulation of hepatitis B virus (HBV) precore mutants in Tunisia, North Africa. Epidemiol Infect. 2000;125(1):169-74.
22. Liu CJ, Chen BF, Chen PJ, Lai MY, Huang WL, Kao JH, et al. Role of hepatitis B viral load and basal core promoter mutation in hepatocellular carcinoma in hepatitis B carriers. J Infect Dis. 2006;193(9):1258-65.
23. Banerjee A, Banerjee S, Chowdhury A, Santra A, Chowdhury S, Roychowdhury S, et al. Nucleic acid sequence analysis of basal core promoter/precore/core region of hepatitis B virus isolated from chronic carriers of the virus from Kolkata, eastern India: Low frequency of mutation in the precore region. Intervirology. 2005;48(6):389-99.
24. Deng H, Dong J, Cheng J, Huangfu KJ, Shi SS, Hong Y, et al. Quasispecies groups in the core promoter region of hepatitis B virus. Hepatobiliary Pancreat Dis Int. 2002;1(3):392-6.
25. Baumert TF, Thimme R, von Weizsacker F. Pathogenesis of hepatitis B virus infection. World J Gastroenterol. 2007;13(1):82-90.
26. Cao GW. Clinical relevance and public health significance of hepatitis B virus genomic variations. World J Gastroenterol. 2009;15(46):5761-9.
27. Kim H, Jee Y, Mun HS, Song BC, Park JH, Hyun JW, et al. Comparison of full genome sequences between two hepatitis B virus strains with or without preC mutation (A1896) from a single Korean hepatocellular carcinoma patient. J Microbiol Biotechnol. 2007;17(4):701-4.
28. Biswas A, Chandra PK, Datta S, Panigrahi R, Banerjee A, Chakrabarti S, et al. Frequency and distribution of hepatitis B virus genotypes among eastern Indian voluntary blood donors: Association with precore and basal core promoter mutations. Hepatol Res. 2009;39(1):53-9.
29. Chisari FV. Cytotoxic T cells and viral hepatitis. J Clin Invest. 1997;99(7):1472-7.
30. Lok AS, Akarca U, Greene S. Mutations in the pre-core region of hepatitis B virus serve to enhance the stability of the secondary structure of the pre-genome encapsidation signal. Proc Natl Acad Sci U S A. 1994;91(9):4077-81.
31. Wu W, Chen Y, Ruan B, Li LJ. Gene heterogeneity of hepatitis B virus isolates from patients with severe hepatitis B. Hepatobiliary Pancreat Dis Int. 2005;4(4):530-4.
32. Orito E, Mizokami M. Hepatitis B virus genotypes and hepatocellular carcinoma in Japan. Intervirology. 2003;46(6):408-12.
33. Magnius LO, Norder H. Subtypes,genotypes and molecular epidemiology of the hepatitis B virus as reflected by sequence variability of the S-gene. Intervirology. 1995;38(1-2):24-34.
34. Rodriguez-Frias F, Buti M, Jardi R, Cotrina M, Viladomiu L, Esteban R, et al. Hepatitis B virus infection: Precore mutants and its relation to viral genotypes and core mutations. Hepatology. 1995;22(6):1641-7.
35. Olinger CM, Venard V, Njayou M, Oyefolu AO, Maiga I, Kemp AJ, et al. Phylogenetic analysis of the precore/core gene of hepatitis B virus genotypes E and A in West Africa: New subtypes, mixed infections and recombinations. J Gen Virol. 2006;87(Pt 5):1163-73.