Role of genotype and precore/basal core promoter mutations of hepatitis B virus in patients with chronic hepatitis B with acute exacerbation

Scandinavian Journal of Gastroenterology

Volumn 43, Issue 2, 2008, Pages 196-201

  Tsai, Wei Lun ^a,b   Lo, Gin Ho ^a,b   Hsu, Ping I ^a,b   Lai, Kwok Hung ^a,b   Lin, Chiun Ku ^a,b   Chan, Hoi Hung ^a,b   Chen, Wen Chi ^a,b   Cheng, Jin Shiung ^a,b   Liu, Yung Ching ^a,b   Huang, Tsi Shu ^a,b   Ger, Luo Ping ^a   Lin, Hsi Hsun ^c  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c E DA HOSPITAL   (Taiwan)

Author keywords

Acute exacerbation; Basal core promoter mutation; Genotype; Hepatitis B; Precore mutation

Indexed keywords

ALBUMIN; ASPARTATE AMINOTRANSFERASE;

ADULT; ANTIVIRAL THERAPY; ARTICLE; CHRONIC HEPATITIS; CONTROLLED STUDY; DECOMPENSATED LIVER CIRRHOSIS; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; GENE MUTATION; GENE SEQUENCE; GENETIC ASSOCIATION; GENOTYPE; HEPATITIS B; HEPATITIS B VIRUS; HUMAN; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROMOTER REGION; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; THROMBOCYTE COUNT;

ACUTE DISEASE; ADULT; AGED; FEMALE; GENOTYPE; HEPATITIS B CORE ANTIGENS; HEPATITIS B VIRUS; HEPATITIS B, CHRONIC; HUMANS; MALE; MIDDLE AGED; POINT MUTATION; POLYMORPHISM, RESTRICTION FRAGMENT LENGTH; PROMOTER REGIONS (GENETICS); SEVERITY OF ILLNESS INDEX;

EID: 38549104208     PISSN: 00365521     EISSN: 15027708     Source Type: Journal    
DOI: 10.1080/00365520701745693     Document Type: Article

References (45)

1. Lee W. Hepatitis B infection. N Engl J Med 1997;337:1733-45.
2. Seeff LB, Koff RS. Evolving concepts of the clinical and serological consequences of hepatitis B infection. Semin Liver Dis 1986;6:11-22.
3. Lok AS, Lai CL. Acute exacerbations in Chinese patients with chronic hepatitis B virus (HBV) infection. Incidence, predisposing factors and etiology. J Hepatol 1990;10:29-34.
4. Liaw YF. Acute exacerbation and superinfection in patients with chronic viral hepatitis. J Formos Med Assoc 1995;94:521-8.
5. Perrillo RP. Acute flares in chronic hepatitis B: the natural and unnatural history of an immunologically mediated liver disease. Gastroenterology 2001;120:1009-22.
6. Sheen IS, Laiw YF, Tai DI, Chu CM. Hepatic decompensation associated with hepatitis B e antigen clearance in chronic type B hepatitis. Gastroenterology 1985;89:732-5.
7. Davis GL, Hoofnagle JH, Waggoner JG. Reactivation of chronic type B hepatitis B presenting as acute viral hepatitis. Ann Intern Med 1985;102:762-5.
8. Kao JH. Hepatitis B viral genotypes: clinical relevance and molecular characteristics. J Gastroenterol Hepatol 2002;17:643-50.
9. Kramvis A, Kew MC. Relationship of genotypes of hepatitis B virus to mutations, disease and response to antiviral therapy. J Viral Hepatitis 2005;12:456-64.
10. Fung SK, Lok ASF. Hepatitis B virus genotypes: do they play a role in the outcome of HBV infection? Hepatology 2004;40:790-2.
11. Yu MW, Yeh SH, Chen PJ, Liaw YF, Lin CL, Liu CJ, et al. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. J Natl Cancer Inst 2005;97:265-72.
12. Chu CM, Liaw YF. Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B and progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline. J Hepatol 2005;43:411-7.
13. Locarnini S, Mcmillan J, Bartholomeusz A. The hepatitis B virus and common mutants. Semin Liver Dis 2003;23:5-20.
14. Hunt CM, McGill JM, Allen MI, Condreay LD. Clinical relevance of hepatitis B viral mutations. Hepatology 2000;31:1037-44.
15. Aritomi T, Yatsuhashi H, Futsuya T, Yamasaki K, Inoue O, Koga M, et al. Association of mutations in the core promoter and precore region of hepatitis virus with fulminant and severe acute hepatitis B in Japan. J Gastroenterol Hepatol 1998;13:1125-32.
16. Sato S, Suzuki K, Akahane Y, Akamatsu K, Akiyama K, Yunomura K, et al. Hepatitis B virus strains with mutations in the core promoter in patients with fulminant hepatitis. Ann Intern Med 1995;122:241-8.
17. Omata M, Ehata T, Yokosuka O, Hosoda K, Masao O. Mutations in the precore region of hepatitis B virus DNA in patients with fulminant and severe hepatitis. N Engl J Med 1991;324:1699-704.
18. Chu CM, Liaw YF, Pao CC, Hung MJ. The etiology of acute hepatitis superimposed upon previously unrecognized asymptomatic HBsAg carriers. Hepatology 1989;9:452-6.
19. Laiw YF. Acute exacerbation and superinfection in patients with chronic viral hepatitis. J Formos Med Assoc 1995;94:521-8.
20. Lin DY, Sheen IS, Chiu CT, Lin SM, Kuo YC, Liaw YF. Ultrasonographic changes of early liver cirrhosis in chronic hepatitis B: a longitudinal study. J Clin Ultrasound 1993;21:303-8.
21. Yeh SH, Tsai CY, Kao JH, Liu CJ, Kuo TJ, Lin MW, et al. Combined real time PCR quantification and signature single nucleotide polymorphism genotyping of hepatitis B virus in one-tube reaction. J Hepatol 2004;41:659-66.
22. Mizokami M, Nakano T, Orito E, Tanaka Y, Sakugawa H, Mukaide M, et al. Hepatitis B virus genotype assignment using restriction fragment length polymorphism patterns. FEBS Lett 1999;450:66-71.
23. Cho SW, Hahm KB, Kim JH. Reversion from precore/core promoter mutants to wild-type hepatitis B virus during the course of lamivudine therapy. Hepatology 2000;32:1163-9.
24. Liaw YF, Tai DI, Chu CM, Chen TJ. The development of cirrhosis in patients with chronic type B hepatitis: a prospective study. Hepatology 1988;8:493-6.
25. Fattovich G. Natural history and prognosis of hepatitis B. Semin Liver Dis 2003;23:47-58.
26. Laskus T, Persing DH, Nowicki MJ, Mosley JW, Rakela J. Nucleotide sequence analysis of the precore region in patients with fulminant hepatitis B in the United States. Gastroenterology 1993;105:1173-8.
27. Laskus T, Rakela J, Nowicki MJ, Persing DH. Hepatitis B virus core promoter sequence analysis in fulminant and chronic hepatitis B. Gastroenterology 1995;109:1618-23.
28. Hsu HY, Chang MH, Lee CY, Hsieh KH, Ni YH, Chen PJ, et al. Precore mutant of hepatitis B virus in childhood fulminant hepatitis B: an infrequent association.
29. Lindh M, Horal P, Dhillon AP, Furuta Y, Norkrans G. Hepatitis B virus carriers without precore mutations in hepatitis B e antigen-negative stage show more severe liver danage. Hepatology 1996;24:494-501.
30. Lindh M, Horal P, Dhillon AP, Norkrans G. Hepatitis B virus DNA levels, precore mutations, genotypes and histological activity in chronic hepatitis B. J Viral Hepatol 2000;7:258-67.
31. Yuen MF, Tanaka Y, Ng OL, Mizokami M, Yuen JCH, Wong KH, et al. Hepatic necroinflammation and fibrosis in patients with genotype Ba and C, core-promoter and precore mutations. J Viral Hepatol 2005;12:513-8.
32. Chan HL, Leung NWY, Hussain M, Wong ML, Lok ASF. Hepatitis B e antigen-negative chronic hepatitis B in Hong Kong. Hepatology 2000;31:763-8.
33. Kao JH, Chen PJ, Lai MY, Chen DS. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carriers. Gastroenterology 2003;124:327-34.
34. Wai CT, Fontana RJ. Clinical significance of hepatitis B virus genotypes, variants, and mutants. Clin Liver Dis 2004;8: 321-52.
35. Yuen MF, Sablon E, Tanaka Y, Kato T, Mizokami M, Doutreloigne J, et al. Epidemiological study of hepatitis B virus genotypes, core promoter and precore mutations of chronic hepatitis B infection in Hong Kong. J Hepatol 2004;41:119-25.
36. Yuen MF, Tanaka Y, Mizokami M, Yuen JCH, Wong DKH, Yuan HJ, et al. Role of hepatitis B virus genotypes Ba and C, core promoter and precore mutations on hepatocellular carcinoma: a case control study. Carcinogenesis 2004;25:1593-8.
37. Chan HLY, Tsang SWC, Wong ML, Tse CH, Leung NEY, Chan FKL, et al. Genotype B hepatitis B virus is associated with severe icteric flare-up of chronic hepatitis B infection in Hong Kong. Am J Gastroenterol 2002;97:2629-33.
38. Yuen MF, Sablon E, Wong DKH, Yuan HJ, Wong BCY, Chan AOO, et al. Role of hepatitis B virus genotypes in chronic hepatitis B exacerbation. Clin Infect Dis 2003;37:593-7.
39. Kao JH, Chen PJ, Lai MY, Chen DS. Genotypes and clinical phenotypes of hepatitis B virus in patients with chronic hepatitis B virus infection. J Clin Microb 2002;40:1207-9.
40. Kao JH, Chen PJ, Lai MY, Chen DS. Hepatitis B virus genotypes and spontaneous hepatitis B e antigen seroconversion in Taiwanese hepatitis carriers. J Med Virol 2004;72:363-9.
41. Kao JH, Chen PJ, Lai MY, Chen DS. Basal core promoter mutations of hepatitis B virus increase the risk of hepatocellular carcinoma in hepatitis B carrier. Gastroenterology 2003;124:327-34.
42. Kramvis A, Kew MC. Relationship of genotypes of hepatitis B virus to mutations, disease progression and response to antiviral therapy. J Viral Hepat 2005;12:456-64.
43. Teo EK, Ostapowicz G, Hussain M, Lee WM, Fontana RJ, Lok ASF, and the US ALF study group. Hepatitis B infection in patients with acute liver failure in the United States. Hepatology; 2001:33:972-6.
44. Liu CJ, Kao JH, Lai MY, Chen PJ, Chen DS. Precore/core promoter mutations and genotypes of hepatitis B virus in chronic hepatitis B patients with fulminant or subfulminant hepatitis. J Med Virol 2004;72:545-50.
45. Yuen MF, Sablon E, Hui CK, Yuan HJ, Wong KH, Doutreloigne J, et al. Prognostic factors in severe exacerbation of chronic hepatitis B. Clin Infect Dis 2003;36:979-84.