메뉴 건너뛰기




Volumn 334, Issue 1, 2013, Pages 101-108

Withaferin A-induced apoptosis in human breast cancer cells is associated with suppression of inhibitor of apoptosis family protein expression

Author keywords

Apoptosis; Breast cancer; Survivin; Withaferin A; XIAP

Indexed keywords

INHIBITOR OF APOPTOSIS PROTEIN; SURVIVIN; WITHAFERIN A; X LINKED INHIBITOR OF APOPTOSIS; ANTINEOPLASTIC AGENT; BIRC3 PROTEIN, HUMAN; BIRC5 PROTEIN, HUMAN; WITHANOLIDE; XIAP PROTEIN, HUMAN;

EID: 84888197797     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2012.08.026     Document Type: Article
Times cited : (63)

References (42)
  • 1
    • 34247482433 scopus 로고    scopus 로고
    • From ancient medicine to modern medicine: Ayurvedic concepts of health and their role in inflammation and cancer
    • Garodia P., Ichikawa H., Malani N., Sethi G., Aggarwal B.B. From ancient medicine to modern medicine: Ayurvedic concepts of health and their role in inflammation and cancer. J. Soc. Integr. Oncol. 2007, 5(1):25-37.
    • (2007) J. Soc. Integr. Oncol. , vol.5 , Issue.1 , pp. 25-37
    • Garodia, P.1    Ichikawa, H.2    Malani, N.3    Sethi, G.4    Aggarwal, B.B.5
  • 2
    • 78650162192 scopus 로고    scopus 로고
    • Triphala, Ayurvedic formulation for treating and preventing cancer: a review
    • Baliga M.S. Triphala, Ayurvedic formulation for treating and preventing cancer: a review. J. Altern. Complement. Med. 2010, 16(12):1301-1308.
    • (2010) J. Altern. Complement. Med. , vol.16 , Issue.12 , pp. 1301-1308
    • Baliga, M.S.1
  • 3
    • 0033845752 scopus 로고    scopus 로고
    • Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review
    • Mishra L.C., Singh B.B., Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (Ashwagandha): a review. Altern. Med. Rev. 2000, 5(4):334-346.
    • (2000) Altern. Med. Rev. , vol.5 , Issue.4 , pp. 334-346
    • Mishra, L.C.1    Singh, B.B.2    Dagenais, S.3
  • 4
    • 33845959087 scopus 로고    scopus 로고
    • Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology
    • Winters M. Ancient medicine, modern use: Withania somnifera and its potential role in integrative oncology. Altern. Med. Rev. 2006, 11(4):269-277.
    • (2006) Altern. Med. Rev. , vol.11 , Issue.4 , pp. 269-277
    • Winters, M.1
  • 5
    • 4344577070 scopus 로고    scopus 로고
    • Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment
    • Gupta S.K., Mohanty I., Talwar K.K., Dinda A., Joshi S., Bansal P., Saxena A., Arya D.S. Cardioprotection from ischemia and reperfusion injury by Withania somnifera: a hemodynamic, biochemical and histopathological assessment. Mol. Cell. Biochem. 2004, 260(1-2):39-47.
    • (2004) Mol. Cell. Biochem. , vol.260 , Issue.1-2 , pp. 39-47
    • Gupta, S.K.1    Mohanty, I.2    Talwar, K.K.3    Dinda, A.4    Joshi, S.5    Bansal, P.6    Saxena, A.7    Arya, D.S.8
  • 6
    • 18044398197 scopus 로고    scopus 로고
    • Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats
    • Ahmad M., Saleem S., Ahmad A.S., Ansari M.A., Yousuf S., Hoda M.N., Islam F. Neuroprotective effects of Withania somnifera on 6-hydroxydopamine induced Parkinsonism in rats. Hum. Exp. Toxicol. 2005, 24(3):137-147.
    • (2005) Hum. Exp. Toxicol. , vol.24 , Issue.3 , pp. 137-147
    • Ahmad, M.1    Saleem, S.2    Ahmad, A.S.3    Ansari, M.A.4    Yousuf, S.5    Hoda, M.N.6    Islam, F.7
  • 7
    • 0031665691 scopus 로고    scopus 로고
    • Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice
    • Panda S., Kar A. Changes in thyroid hormone concentrations after administration of ashwagandha root extract to adult male mice. J. Pharm. Pharmacol. 1998, 50(9):1065-1068.
    • (1998) J. Pharm. Pharmacol. , vol.50 , Issue.9 , pp. 1065-1068
    • Panda, S.1    Kar, A.2
  • 8
    • 0027323414 scopus 로고
    • Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180
    • Devi P.U., Sharada A.C., Solomon F.E. Antitumor and radiosensitizing effects of Withania somnifera (Ashwagandha) on a transplantable mouse tumor, Sarcoma-180. Indian J. Exp. Biol. 1993, 31(7):607-611.
    • (1993) Indian J. Exp. Biol. , vol.31 , Issue.7 , pp. 607-611
    • Devi, P.U.1    Sharada, A.C.2    Solomon, F.E.3
  • 9
    • 1642344588 scopus 로고    scopus 로고
    • Effect of Withania somnifera on B16F-10 melanoma induced metastasis in mice
    • Leyon P.V., Kuttan G. Effect of Withania somnifera on B16F-10 melanoma induced metastasis in mice. Phytother. Res. 2004, 18(2):118-122.
    • (2004) Phytother. Res. , vol.18 , Issue.2 , pp. 118-122
    • Leyon, P.V.1    Kuttan, G.2
  • 11
    • 34247536630 scopus 로고    scopus 로고
    • Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect
    • Widodo N., Kaur K., Shrestha B.G., Takagi Y., Ishii T., Wadhwa R., Kaul S.C. Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect. Clin. Cancer Res. 2007, 13(7):2298-2306.
    • (2007) Clin. Cancer Res. , vol.13 , Issue.7 , pp. 2298-2306
    • Widodo, N.1    Kaur, K.2    Shrestha, B.G.3    Takagi, Y.4    Ishii, T.5    Wadhwa, R.6    Kaul, S.C.7
  • 12
    • 33646082019 scopus 로고    scopus 로고
    • Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis
    • Mathur R., Gupta S.K., Singh N., Mathur S., Kochupillai V., Velpandian T. Evaluation of the effect of Withania somnifera root extracts on cell cycle and angiogenesis. J. Ethnopharmacol. 2006, 105(3):336-341.
    • (2006) J. Ethnopharmacol. , vol.105 , Issue.3 , pp. 336-341
    • Mathur, R.1    Gupta, S.K.2    Singh, N.3    Mathur, S.4    Kochupillai, V.5    Velpandian, T.6
  • 13
    • 0015227605 scopus 로고
    • Effect of withaferin A on ehrlich ascites tumor cells. II. Target tumor cell destruction in vivo by immune activation
    • Shohat B., Joshua H. Effect of withaferin A on ehrlich ascites tumor cells. II. Target tumor cell destruction in vivo by immune activation. Int. J. Cancer 1971, 8(3):487-496.
    • (1971) Int. J. Cancer , vol.8 , Issue.3 , pp. 487-496
    • Shohat, B.1    Joshua, H.2
  • 14
    • 6744248839 scopus 로고    scopus 로고
    • Radiosensitization of a mouse melanoma by withaferin A: in vivo studies
    • Devi P.U., Kamath R., Rao B.S. Radiosensitization of a mouse melanoma by withaferin A: in vivo studies. Indian J. Exp. Biol. 2000, 38(5):432-437.
    • (2000) Indian J. Exp. Biol. , vol.38 , Issue.5 , pp. 432-437
    • Devi, P.U.1    Kamath, R.2    Rao, B.S.3
  • 15
    • 67650648734 scopus 로고    scopus 로고
    • Protective effect of Withaferin-A on tumour formation in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis in hamsters
    • Manoharan S., Panjamurthy K., Menon V.P., Balakrishnan S., Alias L.M. Protective effect of Withaferin-A on tumour formation in 7,12-dimethylbenz[a]anthracene induced oral carcinogenesis in hamsters. Indian J. Exp. Biol. 2009, 47(1):16-23.
    • (2009) Indian J. Exp. Biol. , vol.47 , Issue.1 , pp. 16-23
    • Manoharan, S.1    Panjamurthy, K.2    Menon, V.P.3    Balakrishnan, S.4    Alias, L.M.5
  • 16
    • 33846436451 scopus 로고    scopus 로고
    • Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells
    • Srinivasan S., Ranga R.S., Burikhanov R., Han S.S., Chendil D. Par-4-dependent apoptosis by the dietary compound withaferin A in prostate cancer cells. Cancer Res. 2007, 67(1):246-253.
    • (2007) Cancer Res. , vol.67 , Issue.1 , pp. 246-253
    • Srinivasan, S.1    Ranga, R.S.2    Burikhanov, R.3    Han, S.S.4    Chendil, D.5
  • 17
    • 54749130365 scopus 로고    scopus 로고
    • Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo
    • Stan S.D., Hahm E.R., Warin R., Singh S.V. Withaferin A causes FOXO3a- and Bim-dependent apoptosis and inhibits growth of human breast cancer cells in vivo. Cancer Res. 2008, 68(18):7661-7669.
    • (2008) Cancer Res. , vol.68 , Issue.18 , pp. 7661-7669
    • Stan, S.D.1    Hahm, E.R.2    Warin, R.3    Singh, S.V.4
  • 19
    • 55949092309 scopus 로고    scopus 로고
    • Ayurvedic medicine constituent withaferin A causes G2 and M phase cell cycle arrest in human breast cancer cells
    • Stan S.D., Zeng Y., Singh S.V. Ayurvedic medicine constituent withaferin A causes G2 and M phase cell cycle arrest in human breast cancer cells. Nutr. Cancer 2008, 60(S1):51-60.
    • (2008) Nutr. Cancer , vol.60 , Issue.S1 , pp. 51-60
    • Stan, S.D.1    Zeng, Y.2    Singh, S.V.3
  • 20
    • 56349123756 scopus 로고    scopus 로고
    • Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation
    • Oh J.H., Lee T.J., Kim S.H., Choi Y.H., Lee S.H., Lee J.M., Kim Y.H., Park J.W., Kwon T.K. Induction of apoptosis by withaferin A in human leukemia U937 cells through down-regulation of Akt phosphorylation. Apoptosis 2008, 13(12):1494-1504.
    • (2008) Apoptosis , vol.13 , Issue.12 , pp. 1494-1504
    • Oh, J.H.1    Lee, T.J.2    Kim, S.H.3    Choi, Y.H.4    Lee, S.H.5    Lee, J.M.6    Kim, Y.H.7    Park, J.W.8    Kwon, T.K.9
  • 21
    • 56349141560 scopus 로고    scopus 로고
    • Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade
    • Mandal C., Dutta A., Mallick A., Chandra S., Misra L., Sangwan R.S., Mandal C. Withaferin A induces apoptosis by activating p38 mitogen-activated protein kinase signaling cascade in leukemic cells of lymphoid and myeloid origin through mitochondrial death cascade. Apoptosis 2008, 13(12):1450-1464.
    • (2008) Apoptosis , vol.13 , Issue.12 , pp. 1450-1464
    • Mandal, C.1    Dutta, A.2    Mallick, A.3    Chandra, S.4    Misra, L.5    Sangwan, R.S.6    Mandal, C.7
  • 22
    • 84891934074 scopus 로고    scopus 로고
    • Autophagy fails to alter withaferin A-mediated lethality in human breast cancer cells
    • in press.
    • E.R. Hahm, S.V. Singh, Autophagy fails to alter withaferin A-mediated lethality in human breast cancer cells. Curr. Cancer Drug Targets, in press.
    • Curr. Cancer Drug Targets
    • Hahm, E.R.1    Singh, S.V.2
  • 23
    • 80051512168 scopus 로고    scopus 로고
    • Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species
    • Hahm E.R., Moura M.B., Kelley E.E., Van Houten B., Shiva S., Singh S.V. Withaferin A-induced apoptosis in human breast cancer cells is mediated by reactive oxygen species. PLoS One 2011, 6(8):e23354.
    • (2011) PLoS One , vol.6 , Issue.8
    • Hahm, E.R.1    Moura, M.B.2    Kelley, E.E.3    Van Houten, B.4    Shiva, S.5    Singh, S.V.6
  • 24
    • 84855744068 scopus 로고    scopus 로고
    • Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2
    • Mayola E., Gallerne C., Esposti D.D., Martel C., Pervaiz S., Larue L., Debuire B., Lemoine A., Brenner C., Lemaire C. Withaferin A induces apoptosis in human melanoma cells through generation of reactive oxygen species and down-regulation of Bcl-2. Apoptosis 2011, 16(10):1014-1027.
    • (2011) Apoptosis , vol.16 , Issue.10 , pp. 1014-1027
    • Mayola, E.1    Gallerne, C.2    Esposti, D.D.3    Martel, C.4    Pervaiz, S.5    Larue, L.6    Debuire, B.7    Lemoine, A.8    Brenner, C.9    Lemaire, C.10
  • 25
    • 79952701908 scopus 로고    scopus 로고
    • Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition
    • Yang E.S., Choi M.J., Kim J.H., Choi K.S., Kwon T.K. Withaferin A enhances radiation-induced apoptosis in Caki cells through induction of reactive oxygen species, Bcl-2 downregulation and Akt inhibition. Chem. Biol. Interact. 2011, 190(1):9-15.
    • (2011) Chem. Biol. Interact. , vol.190 , Issue.1 , pp. 9-15
    • Yang, E.S.1    Choi, M.J.2    Kim, J.H.3    Choi, K.S.4    Kwon, T.K.5
  • 26
    • 79960020557 scopus 로고    scopus 로고
    • Withaferin A suppresses estrogen receptor-α expression in human breast cancer cells
    • Hahm E.R., Lee J., Huang Y., Singh S.V. Withaferin A suppresses estrogen receptor-α expression in human breast cancer cells. Mol. Carcinog. 2011, 50(8):614-624.
    • (2011) Mol. Carcinog. , vol.50 , Issue.8 , pp. 614-624
    • Hahm, E.R.1    Lee, J.2    Huang, Y.3    Singh, S.V.4
  • 27
    • 33746048055 scopus 로고    scopus 로고
    • Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB-regulated gene expression
    • Ichikawa H., Takada Y., Shishodia S., Jayaprakasam B., Nair M.G., Aggarwal B.B. Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB-regulated gene expression. Mol. Cancer Ther. 2006, 5(6):1434-1445.
    • (2006) Mol. Cancer Ther. , vol.5 , Issue.6 , pp. 1434-1445
    • Ichikawa, H.1    Takada, Y.2    Shishodia, S.3    Jayaprakasam, B.4    Nair, M.G.5    Aggarwal, B.B.6
  • 28
    • 78149239365 scopus 로고    scopus 로고
    • Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells
    • Lee J., Hahm E.R., Singh S.V. Withaferin A inhibits activation of signal transducer and activator of transcription 3 in human breast cancer cells. Carcinogenesis 2010, 31(11):1991-1998.
    • (2010) Carcinogenesis , vol.31 , Issue.11 , pp. 1991-1998
    • Lee, J.1    Hahm, E.R.2    Singh, S.V.3
  • 29
    • 33846454701 scopus 로고    scopus 로고
    • The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from "Indian winter cherry"
    • Yang H., Shi G., Dou Q.P. The tumor proteasome is a primary target for the natural anticancer compound withaferin A isolated from "Indian winter cherry" Mol. Pharmacol. 2007, 71(2):426-437.
    • (2007) Mol. Pharmacol. , vol.71 , Issue.2 , pp. 426-437
    • Yang, H.1    Shi, G.2    Dou, Q.P.3
  • 31
    • 0032410818 scopus 로고    scopus 로고
    • The inhibitors of apoptosis (IAPs) and their emerging role in cancer
    • LaCasse E.C., Baird S., Korneluk R.G., MacKenzie A.E. The inhibitors of apoptosis (IAPs) and their emerging role in cancer. Oncogene 1998, 17(25):3247-3259.
    • (1998) Oncogene , vol.17 , Issue.25 , pp. 3247-3259
    • LaCasse, E.C.1    Baird, S.2    Korneluk, R.G.3    MacKenzie, A.E.4
  • 32
    • 0033082995 scopus 로고    scopus 로고
    • IAP family proteins - suppressors of apoptosis
    • Deveraux Q.L., Reed J.C. IAP family proteins - suppressors of apoptosis. Genes Dev. 1999, 13(3):239-252.
    • (1999) Genes Dev. , vol.13 , Issue.3 , pp. 239-252
    • Deveraux, Q.L.1    Reed, J.C.2
  • 34
    • 79953838313 scopus 로고    scopus 로고
    • Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer
    • Powolny A.A., Bommareddy A., Hahm E.R., Normolle D.P., Beumer J.H., Nelson J.B., Singh S.V. Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer. J. Natl Cancer Inst. 2011, 103(7):571-584.
    • (2011) J. Natl Cancer Inst. , vol.103 , Issue.7 , pp. 571-584
    • Powolny, A.A.1    Bommareddy, A.2    Hahm, E.R.3    Normolle, D.P.4    Beumer, J.H.5    Nelson, J.B.6    Singh, S.V.7
  • 35
    • 77449136104 scopus 로고    scopus 로고
    • XIAP as a ubiquitin ligase in cellular signaling
    • Galbán S., Duckett C.S. XIAP as a ubiquitin ligase in cellular signaling. Cell Death Differ. 2010, 17(1):54-60.
    • (2010) Cell Death Differ. , vol.17 , Issue.1 , pp. 54-60
    • Galbán, S.1    Duckett, C.S.2
  • 36
    • 43049091895 scopus 로고    scopus 로고
    • IAPs: what's in a name?
    • Srinivasula S.M., Ashwell J.D. IAPs: what's in a name?. Mol. Cell 2008, 30(2):123-135.
    • (2008) Mol. Cell , vol.30 , Issue.2 , pp. 123-135
    • Srinivasula, S.M.1    Ashwell, J.D.2
  • 37
    • 43549111150 scopus 로고    scopus 로고
    • IAPs: more than just inhibitors of apoptosis proteins
    • Dubrez-Daloz L., Dupoux A., Cartier J. IAPs: more than just inhibitors of apoptosis proteins. Cell Cycle 2008, 7(8):1036-1046.
    • (2008) Cell Cycle , vol.7 , Issue.8 , pp. 1036-1046
    • Dubrez-Daloz, L.1    Dupoux, A.2    Cartier, J.3
  • 38
    • 36749062005 scopus 로고    scopus 로고
    • X-linked inhibitor of apoptosis protein as a therapeutic target
    • Dean E.J., Ranson M., Blackhall F., Dive C. X-linked inhibitor of apoptosis protein as a therapeutic target. Expert Opin. Ther. Targets 2007, 11(11):1459-1471.
    • (2007) Expert Opin. Ther. Targets , vol.11 , Issue.11 , pp. 1459-1471
    • Dean, E.J.1    Ranson, M.2    Blackhall, F.3    Dive, C.4
  • 39
    • 0034607655 scopus 로고    scopus 로고
    • Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli
    • Yang Y., Fang S., Jensen J.P., Weissman A.M., Ashwell J.D. Ubiquitin protein ligase activity of IAPs and their degradation in proteasomes in response to apoptotic stimuli. Science 2000, 288(5467):874-877.
    • (2000) Science , vol.288 , Issue.5467 , pp. 874-877
    • Yang, Y.1    Fang, S.2    Jensen, J.P.3    Weissman, A.M.4    Ashwell, J.D.5
  • 40
    • 33750611276 scopus 로고    scopus 로고
    • The case for survivin as a regulator of microtubule dynamics and cell-death decisions
    • Altieri D.C. The case for survivin as a regulator of microtubule dynamics and cell-death decisions. Curr. Opin. Cell Biol. 2006, 18(6):609-615.
    • (2006) Curr. Opin. Cell Biol. , vol.18 , Issue.6 , pp. 609-615
    • Altieri, D.C.1
  • 41
    • 0030746636 scopus 로고    scopus 로고
    • A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma
    • Ambrosini G., Adida C., Altieri D.C. A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma. Nat. Med. 1997, 3(8):917-921.
    • (1997) Nat. Med. , vol.3 , Issue.8 , pp. 917-921
    • Ambrosini, G.1    Adida, C.2    Altieri, D.C.3
  • 42
    • 34447315861 scopus 로고    scopus 로고
    • Targeting survivin in cancer therapy: fulfilled promises and open questions
    • Pennati M., Folini M., Zaffaroni N. Targeting survivin in cancer therapy: fulfilled promises and open questions. Carcinogenesis 2007, 28(6):1133-1139.
    • (2007) Carcinogenesis , vol.28 , Issue.6 , pp. 1133-1139
    • Pennati, M.1    Folini, M.2    Zaffaroni, N.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.