Monacolin K and monascin attenuated pancreas impairment and hyperglycemia induced by advanced glycation endproducts in BALB/c mice

Food and Function

Volumn 4, Issue 12, 2013, Pages 1742-1750

  Hsu, Wei Hsuan ^a   Lu, Si Shi ^a   Lee, Bao Hong ^a   Hsu, Ya Wen ^b   Pan, Tzu Ming ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b Sunway Biotechnology Company Limited   (Taiwan)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCTS; GLUCOSE TRANSPORTERS; INSULIN EXPRESSIONS; INTRAPERITONEAL INJECTIONS; MONASCUS-FERMENTED PRODUCTS; ORAL GLUCOSE TOLERANCE TESTS; PANCREATIC FUNCTIONS; POTENTIAL MECHANISM;

INSULIN; PATHOLOGY;

MAMMALS;

ADVANCED GLYCATION END PRODUCT; ANTIDIABETIC AGENT; FUSED HETEROCYCLIC RINGS; INSULIN; MEVINOLIN; MONASCIN;

ANIMAL; ARTICLE; BAGG ALBINO MOUSE; CHEMICALLY INDUCED DISORDER; CHEMISTRY; DIABETES MELLITUS; DRUG EFFECT; FEMALE; FERMENTATION; GLUCOSE TOLERANCE TEST; HUMAN; HYPERGLYCEMIA; INSULIN RESISTANCE; MALE; METABOLISM; MICROBIOLOGY; MONASCUS; MOUSE; PANCREAS; RICE;

ANIMALS; DIABETES MELLITUS; FEMALE; FERMENTATION; GLUCOSE TOLERANCE TEST; GLYCOSYLATION END PRODUCTS, ADVANCED; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; HYPERGLYCEMIA; HYPOGLYCEMIC AGENTS; INSULIN; INSULIN RESISTANCE; LOVASTATIN; MALE; MICE; MICE, INBRED BALB C; MONASCUS; ORYZA SATIVA; PANCREAS;

EID: 84888145066     PISSN: 20426496     EISSN: 2042650X     Source Type: Journal    
DOI: 10.1039/c3fo60268k     Document Type: Article

References (35)

1. M. Y. Khuhawar A. J. Kandhro F. D. Khand Liquid chromatographic determination of glyoxal and methylglyoxal from serum of diabetic patients using meso-stilbenediamine as derivatizing agent Anal. Lett. 2006 39 2205 2215
2. C. H. Wu S. M. Huang G. C. Yen Silymarin: a novel antioxidant with antiglycation and antiinflammatory properties in vitro and in vivo Antioxid. Redox Signaling 2011 14 353 366
3. M. O. Kurrer S. V. Pakala H. L. Hanson J. D. Katz Beta cell apoptosis in T cell-mediated autoimmune diabetes Proc. Natl. Acad. Sci. U. S. A. 1997 94 213 218
4. J. L. Leahy S. Bonner-Weir G. C. Weir Beta-cell dysfunction induced by chronic hyperglycemia Diabetes Care 1992 15 442 455
5. 2+ concent ration J. Biol. Chem. 1998 273 33501 33507
6. A. Dhar K. M. Desai L. Wu Alagebrium attenuates acute methylglyoxal-induced glucose intolerance in Sprague-Dawley rats Br. J. Pharmacol. 2010 159 166 175
7. B. H. Lee W. H. Hsu Y. Y. Chang H. F. Kuo Y. W. Hsu T. M. Pan Ankaflavin: a natural novel PPAR-γ agonist upregulates Nrf2 to attenuate methylglyocal-induced diabetes in vivo Free Radical Biol. Med. 2012 53 2008 2016
8. T. Shu Y. Zhu H. Wang Y. Lin Z. Ma X. Han AGEs decrease insulin synthesis in pancreatic beta-cell by repressing PDX-1 protein expression at the post-translational level PLoS One 2011 6 e18782
9. B. H. Lee W. H. Hsu Y. W. Hsu T. M. Pan Dimerumic acid protects pancreas damage and elevates insulin production in methylglyoxal-treated pancreatic RINm5F cells J. Funct. Foods 2013 5 642 650
10. W. Cai M. Ramdas L. Zhu X. Chen G. E. Striker H. Vlassara Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1 Proc. Natl. Acad. Sci. U. S. A. 2012 109 15888 15893
11. C. H. Wu S. M. Huang J. A. Lin G. C. Yen Inhibition of advanced glycation endproduct formation by foodstuffs Food Funct. 2011 2 224 234
12. B. H. Lee W. H. Hsu Y. W. Hsu T. M. Pan Dimerumic acid attenuates receptor for advanced glycation endproducts signal to inhibit inflammation and diabetes mediated by Nrf2 activation and promotes methylglyoxal metabolism into d-lactic acid Free Radical Biol. Med. 2013 60 7 16
13. Y. C. Shi J. W. Liao T. M. Pan Antihypertriglyceridemia and anti-inflammatory activities of Monascus-fermented dioscorea in streptozotocin-induced diabetic rats Exp. Diabetes Res. 2011 2011 710635
14. W. H. Hsu B. H. Lee C. H. Li Y. W. Hsu T. M. Pan Monascin and AITC attenuate methylglyoxal-induced PPAR-γ phosphorylation and degradation through inhibition of the oxidative stress/PKC pathway depending on Nrf2 activation J. Agric. Food Chem. 2013 61 5996 6006
15. O. S. Choi S. J. Park S. W. Seo C. S. Park J. J. Cho H. J. Ahn The 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor, lovastatin (statin) ameliorates CCK-induced acute pancreatitis in rats Biol. Pharm. Bull. 2005 28 1394 1397
16. S. H. Wang J. C. Chang R. Pokkaew J. F. Lee Y. Y. Chiou Modified fast procedure for the detection and screening of antiglycative phytochemicals J. Agric. Food Chem. 2011 59 6906 6912
17. B. Thorens GLUT2 in pancreatic and extra-pancreatic gluco-detection Mol. Membr. Biol. 2001 18 265 273
18. L. C. Hsu Y. W. Hsu Y. H. Liang Y. H. Kuo T. M. Pan Anti-tumor and anti-inflammatory properties of ankaflavin and monaphilone A from Monascus purpureus NTU 568 J. Agric. Food Chem. 2011 59 1124 1130
19. 2-terminal kinase pathway Diabetes 2007 56 1865 1871
20. B. H. Lee W. H. Hsu T. Huang Y. Y. Chang Y. W. Hsu T. M. Pan Monascin improves diabetes and dyslipidemia by regulating PPARgamma and inhibiting lipogenesis in fructose-rich diet-induced BALB/c mice Food Funct. 2013 4 950
21. B. H. Lee W. H. Hsu T. H. Liao T. M. Pan The Monascus metabolite monascin against TNF-alpha-induced insulin resistance via suppressing PPARgamma phosphorylation in C2C12 myotubes Food Chem. Toxicol. 2011 49 2609 2617
22. Z. Zhao C. Zhao X. H. Zhang F. Zheng W. Cai H. Vlassara Z. A. Ma Advanced glycation end products inhibit glucose-stimulated insulin secretion through nitric oxide-dependent inhibition of cytochrome c oxidase and adenosine triphosphate synthesis Endocrinology 2009 150 2569 2576
23. N. Irwin J. M. McKinney C. J. Bailey N. H. McClenaghan P. R. Flatt Acute and long-term effects of peroxisome proliferator activated receptor-γ activation on the function and insulin secretory responsiveness of clonal beta-cells Horm. Metab. Res. 2011 43 244 249
24. J. A. Moibi D. Gupta T. L. Jetton M. Peshavaria R. Desai J. L. Leahy Peroxisome proliferator-activated receptor-γ regulates expression of PDX-1 and NKX6.1 in INS-1 cells Diabetes 2007 56 88 95
25. D. Gupta T. L. Jetton R. M. Mortensen S. Z. Duan M. Peshavaria J. L. Leahy In vivo and in vitro studies of a functional peroxisome preliferator-activated receptor-γ response element in the mouse pdx-1 promoter J. Biol. Chem. 2008 283 32462 32470
26. M. Dubois F. Pattou J. Kerr-Conte V. Gmyr B. Vandewalle P. Desreumaux J. Auwerx K. Schoonjans J. Lefebvre Expression of peroxisome proliferator-activated receptor gamma (PPAR-gamma) in normal human pancreatic islet cells Diabetologia 2000 43 1165 1169
27. A. Puddu R. Sanguineti A. Durante G. L. Viviani Pioglitazone attenuates the detrimental effects of advanced glycation end-products in the pancreatic beta cell line HIT-T15 Regul. Pept. 2012 177 79 84
28. M. C. Musacchio V. Cappelli A. Di Sabatino G. Morgante V. De Leo Evaluation of the myo-inositol-monacolin K association on hyperandrogenism and on the lipidic metabolism parameters in PCOS women Minerva Ginecol. 2013 65 89 97
29. M. Fujimoto K. Tsuneyama S. Y. Chen T. Nishida J. L. Chen Y. C. Chen T. Fujimoto J. Imura Y. Shimada Study of the effects of monacolin K and other constituents of red yeast rice on obesity, insulin-resistance, hyperlipidemia, and nonalcoholic steatohepatitis using a mouse model of metabolic syndrome J. Evidence-Based Complementary Altern. Med. 2012 2012 892697
30. B. Y. Ho T. M. Pan The Monascus metabolite monacolin K reduces tumor progression and metastasis of Lewis lung carcinoma cells J. Agric. Food Chem. 2009 57 8258 8265
31. A. T. Cheung J. Wang D. Ree J. K. Kolls M. Bryer-Ash Tumor necrosis factor-alpha induces hepatic insulin resistance in obese zucker (fa/fa) rats via interaction of leukocyte antigen-related tyrosine phosphatase with focal adhesion kinase Diabetes 2000 49 810 819
32. J. H. Kim R. A. Bachmann J. Chen Interleukin-6 and insulin resistance Vitam. Horm. 2009 80 613 633
33. C. J. Tack R. Stienstra L. A. Joosten M. G. Netea Inflammation links excess fat to insulin resistance: the role of the interleukin-1 family Immunol. Rev. 2012 249 239 252
34. 2+ influx J. Endocrinol. 2008 198 549 560
35. B. M. Tan N. W. Zammit A. O. Yam R. Slattery S. N. Walters E. Malle S. T. Grey Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor kappaB and c-Jun N-terminal kinase signaling in mouse pancreatic beta cells Diabetologia 2013 56 520 532