Three-dimensional reconstruction of human cystic fibrosis transmembrane conductance regulator chloride channel revealed an ellipsoidal structure with orifices beneath the putative transmembrane domain

Journal of Biological Chemistry

Volumn 283, Issue 44, 2008, Pages 30300-30310

  Mio, Kazuhiro ^a   Ogura, Toshihiko ^a,b   Mio, Muneyo ^a   Shimizu, Hiroyasu ^c,d   Hwang, Tzyh Chang ^c   Sato, Chikara ^a   Sohma, Yoshiro ^c,d,e  

^a NATIONAL INSTITUTE OF ADVANCED INDUSTRIAL SCIENCE AND TECHNOLOGY AIST   (Japan)

^b JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^c UNIVERSITY OF MISSOURI   (United States)

^d OSAKA MEDICAL COLLEGE   (Japan)

^e KEIO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATION ANALYSIS; AFFINITY CHROMATOGRAPHY; ANIMAL CELL CULTURE; BIOLOGICAL MEMBRANES; CELL MEMBRANES; CHLORINE COMPOUNDS; CHROMATOGRAPHIC ANALYSIS; CHROMATOGRAPHY; CROSSLINKING; LAWS AND LEGISLATION; ORIFICES; STOICHIOMETRY; THREE DIMENSIONAL;

ANTIBODY COMPLEXES; BIO-CHEMICALS; CFTR GENES; CHLORIDE CHANNELS; CYSTIC FIBROSES; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATORS; CYTOPLASMIC DOMAINS; DATA SUPPORTS; DIMENSIONAL STRUCTURES; DO-MAINS; ELLIPSOIDAL PARTICLES; EXTRACELLULAR; HEK293 CELLS; NM RESOLUTIONS; PROTEIN TRANSPORTS; REGULATORY DOMAINS; SIZE EXCLUSIONS; THREE STEPS; TRANSMEMBRANE DOMAINS; WHEAT GERM AGGLUTININS;

SIZE EXCLUSION CHROMATOGRAPHY;

CHLORIDE CHANNEL; TRANSMEMBRANE CONDUCTANCE REGULATOR;

AFFINITY CHROMATOGRAPHY; ARTICLE; CONTROLLED STUDY; CYTOPLASM; ELECTRON MICROSCOPY; EMBRYO; GEL PERMEATION CHROMATOGRAPHY; HUMAN; HUMAN CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN PURIFICATION; PROTEIN STRUCTURE; STOICHIOMETRY; WILD TYPE;

CELL LINE; CELL MEMBRANE; CHROMATOGRAPHY; CROSS-LINKING REAGENTS; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; CYTOPLASM; DNA, COMPLEMENTARY; GENE EXPRESSION REGULATION; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KINETICS; MICROSCOPY, ELECTRON, TRANSMISSION; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, TERTIARY;

TRITICUM AESTIVUM;

EID: 57649178312     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M803185200     Document Type: Article

References (56)

1. Riordan, J. R., Rommens, J. M., Kerem, B., Alon, N., Rozmahel, R., Grzelczak, Z., Zielenski, J., Lok, S., Plavsic, N., Chou, J. L., Drumm, M. L., Iannuzzi, M. C., Collins, F. S., and Tsui, L. C. (1989) Science 245, 1066-1073
2. Welsh, M. J., and Smith, A. E. (1993) Cell 73, 1251-1254
3. Tsui, L. C., and Durie, P. (1997) Hosp. Pract. 32, 115-118, 123-129, 134
4. Gabriel, S. E., Brigman, K. N., Koller, B. H., Boucher, R. C., and Stutts, M. J. (1994) Science 266, 107-109
5. Sears, C. L., and Kaper, J. B. (1996) Microbiol. Rev. 60, 167-215
6. Bhattacharya, S. K. (1995) J. Indian Med. Assoc. 93, 237-238
7. Chen, T. Y., and Hwang, T. C. (2008) Physiol. Rev. 88, 351-387
8. Davidson, A. L., and Chen, J. (2004) Annu. Rev. Biochem. 73, 241-268
9. Vergani, P., Lockless, S. W., Nairn, A. C., and Gadsby, D. C. (2005) Nature 433, 876-880
10. Bompadre, S. G., Cho, J. H., Wang, X., Zou, X., Sohma, Y., Li, M., and Hwang, T. C. (2005) J. Gen. Physiol. 125, 377-394
11. Bompadre, S. G., Ai, T., Cho, J. H., Wang, X., Sohma, Y., Li, M., and Hwang, T. C. (2005) J. Gen. Physiol. 125, 361-375
12. Zhou, Z., Wang, X., Li, M., Sohma, Y., Zou, X., and Hwang, T. C. (2005) J. Physiol. 569, 447-457
13. Lewis, H. A., Buchanan, S. G., Burley, S. K., Conners, K., Dickey, M., Dorwart, M., Fowler, R., Gao, X., Guggino, W. B., Hendrickson, W. A., Hunt, J. F., Kearins, M. C., Lorimer, D., Maloney, P. C., Post, K. W., Rajashankar, K. R., Rutter, M. E., Sauder, J. M., Shriver, S., Thibodeau, P. H., Thomas, P. J., Zhang, M., Zhao, X., and Emtage, S. (2004) EMBO J. 23, 282-293
14. Lewis, H. A., Zhao, X., Wang, C., Sauder, J. M., Rooney, I., Noland, B. W., Lorimer, D., Kearins, M. C., Conners, K., Condon, B., Maloney, P. C., Guggino, W. B., Hunt, J. F., and Emtage, S. (2005) J. Biol. Chem. 280, 1346-1353
15. Rosenberg, M. F., Kamis, A. B., Aleksandrov, L. A., Ford, R. C., and Riordan, J. R. (2004) J. Biol. Chem. 279, 39051-39057
16. Awayn, N. H., Rosenberg, M. F., Kamis, A. B., Aleksandrov, L. A., Riordan, J. R., and Ford, R. C. (2005) Biochem. Soc. Trans. 33, 996-999
17. Graham, F. L., and van der Eb, A. J. (1973) Virology 52, 456-467
18. Bompadre, S. G., Sohma, Y., Li, M., and Hwang, T. C. (2007) J. Gen. Physiol. 129, 285-298
19. Zhou, Z., Wang, X., Liu, H. Y., Zou, X., Li, M., and Hwang, T. C. (2006) J. Gen. Physiol. 128, 413-422
20. Laurent, T., C., and Killander, J. (1964) J. Chromatogr. 14, 317-330
21. Mio, K., Ogura, T., Hara, Y., Mori, Y., and Sato, C. (2005) Biochem. Biophys. Res. Commun. 333, 768-777
22. Laemmli, U. K. (1970) Nature 227, 680-685
23. Schagger, H., and von Jagow, G. (1991) Anal. Biochem. 199, 223-231
24. Schagger, H., Cramer, W. A., and von Jagow, G. (1994) Anal. Biochem. 217, 220-230
25. Ogura, T., and Sato, C. (2001) J. Struct. Biol. 136, 227-238
26. Ogura, T., and Sato, C. (2004) J. Struct. Biol. 145, 63-75
27. Ogura, T., Iwasaki, K., and Sato, C. (2003) J. Struct. Biol. 143, 185-200
28. Ogura, T., and Sato, C. (2004) J. Struct. Biol. 146, 344-358
29. Ogura, T., and Sato, C. (2006) J. Struct. Biol. 156, 371-386
30. Yazawa, M., Ferrante, C., Feng, J., Mio, K., Ogura, T., Zhang, M., Lin, P. H., Pan, Z., Komazaki, S., Kato, K., Nishi, M., Zhao, X., Weisleder, N., Sato, C., Ma, J., and Takeshima, H. (2007) Nature 448, 78-82
31. van Heel, M., Harauz, G., Orlova, E. V., Schmidt, R., and Schatz, M. (1996) J. Struct. Biol. 116, 17-24
32. Frank, J. (2006) Three-Dimensional Electron Microscopy of Macromolecular Assemblies: Visualization of Biological Molecules in Their Native State, Oxford University Press, New York
33. van Heel, M., Gowen, B., Matadeen, R., Orlova, E. V., Finn, R., Pape, T., Cohen, D., Stark, H., Schmidt, R., Schatz, M., and Patwardhan, A. (2000) Q. Rev. Biophys. 33, 307-369
34. Penczek, P., Radermacher, M., and Frank, J. (1992) Ultramicroscopy 40, 33-53
35. Penczek, P. A., Grassucci, R. A., and Frank, J. (1994) Ultramicroscopy 53, 251-270
36. Harauz, G., and van Heel, M. (1986) Optik 73, 146-156
37. Cheng, S. H., Gregory, R. J., Marshall, J., Paul, S., Souza, D. W., White, G. A., O'Riordan, C. R., and Smith, A. E. (1990) Cell 63, 827-834
38. Denning, G. M., Ostedgaard, L. S., Cheng, S. H., Smith, A. E., and Welsh, M. J. (1992) J. Clin. Investig. 89, 339-349
39. O'Riordan, C. R., Lachapelle, A. L., Marshall, J., Higgins, E. A., and Cheng, S. H. (2000) Glycobiology 10, 1225-1233
40. Wang, X., Venable, J., LaPointe, P., Hutt, D. M., Koulov, A. V., Coppinger, J., Gurkan, C., Kellner, W., Matteson, J., Plutner, H., Riordan, J. R., Kelly, J. W., Yates, J. R., III, and Balch, W. E. (2006) Cell 127, 803-815
41. Steck, T. L., and Yu, J. (1973) J. Supramol. Struct. 1, 220-232
42. Gadsby, D. C., and Nairn, A. C. (1999) Physiol. Rev. 79, S77-S107
43. Baker, J. M., Hudson, R. P., Kanelis, V., Choy, W. Y., Thibodeau, P. H., Thomas, P. J., and Forman-Kay, J. D. (2007) Nat. Struct. Mol. Biol. 14, 738-745
44. Mendoza, J. L., and Thomas, P. J. (2007) J. Bioenerg. Biomembr. 39, 499-505
45. Sato, C., Ueno, Y., Asai, K., Takahashi, K., Sato, M., Engel, A., and Fujiyoshi, Y. (2001) Nature 409, 1047-1051
46. Long, S. B., Campbell, E. B., and Mackinnon, R. (2005) Science 309, 897-903
47. Riordan, J. R. (2005) Annu. Rev. Physiol. 67, 701-718
48. Bear, C. E., Li, C. H., Kartner, N., Bridges, R. J., Jensen, T. J., Ramjeesingh, M., and Riordan, J. R. (1992) Cell 68, 809-818
49. Chen, J. H., Chang, X. B., Aleksandrov, A. A., and Riordan, J. R. (2002) J. Membr. Biol. 188, 55-71
50. Ramjeesingh, M., Li, C., Kogan, I., Wang, Y., Huan, L. J., and Bear, C. E. (2001) Biochemistry 40, 10700-10706
51. Zhang, Z. R., Cui, G., Liu, X., Song, B., Dawson, D. C., and McCarty, N. A. (2005) J. Biol. Chem. 280, 458-468
52. Eskandari, S., Wright, E. M., Kreman, M., Starace, D. M., and Zampighi, G. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 11235-11240
53. Schillers, H., Shahin, V., Albermann, L., Schafer, C., and Oberleithner, H. (2004) Cell Physiol. Biochem. 14, 1-10
54. Zerhusen, B., Zhao, J., Xie, J., Davis, P. B., and Ma, J. (1999) J. Biol. Chem. 274, 7627-7630
55. Raghuram, V., Mak, D. O., and Foskett, J. K. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 1300-1305
56. Ramjeesingh, M., Kidd, J. F., Huan, L. J., Wang, Y., and Bear, C. E. (2003) Biochem. J. 374, 793-797