FoxO3a contributes to the reprogramming process and the differentiation of induced pluripotent stem cells

Stem Cells and Development

Volumn 22, Issue 22, 2013, Pages 2954-2963

  Wang, Yongxiang ^a,b,c   Tian, Changhai ^a,b,c   Zheng, Jialin C ^a,b,c,d  

^a Laboratory of Neuroimmunology and Regenerative Therapy   (China)

^b Department of Pharmacology and Experimental Neuroscience ^*  (China)

^c TONGJI UNIVERSITY SCHOOL OF MEDICINE   (China)

^d UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; TRANSCRIPTION FACTOR FKHRL1;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; EMBRYONIC STEM CELL; FIBROBLAST; HOMEOSTASIS; KINETICS; MOUSE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN FUNCTION; WILD TYPE;

ALKALINE PHOSPHATASE; ANIMALS; BIOLOGICAL MARKERS; CELL DIFFERENTIATION; CELLS, CULTURED; EMBRYO, MAMMALIAN; FIBROBLASTS; FORKHEAD TRANSCRIPTION FACTORS; GENE EXPRESSION REGULATION, DEVELOPMENTAL; INDUCED PLURIPOTENT STEM CELLS; MICE; MICE, KNOCKOUT; NEURONS; NUCLEAR REPROGRAMMING; SIGNAL TRANSDUCTION; TERATOMA;

EID: 84888051069     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2013.0044     Document Type: Article

References (45)

1. Nishikawa S, RA Goldstein and CR Nierras. (2008). The promise of human induced pluripotent stem cells for research and therapy. Nat Rev Mol Cell Biol 9:725-729.
2. Takahashi K and S Yamanaka. (2006). Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126:663-676.
3. Takahashi K, K Tanabe, M Ohnuki, M Narita, T Ichisaka, K Tomoda and S Yamanaka. (2007). Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131:861-872.
4. Yu J, MA Vodyanik, K Smuga-Otto, J Antosiewicz-Bourget, JL Frane, S Tian, J Nie, GA Jonsdottir, V Ruotti, et al. (2007). Induced pluripotent stem cell lines derived from human somatic cells. Science 318:1917-1920.
5. Robinton DA and GQ Daley. (2012). The promise of induced pluripotent stem cells in research and therapy. Nature 481:295-305.
6. Karumbayaram S, BG Novitch, M Patterson, JA Umbach, L Richter, A Lindgren, AE Conway, AT Clark, SA Goldman, et al. (2009). Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem Cells 27:806-811.
7. Cooper O, G Hargus, M Deleidi, A Blak, T Osborn, E Marlow, K Lee, A Levy, E Perez-Torres, A Yow and O Isacson. (2010). Differentiation of human ES and Parkinson's disease iPS cells into ventral midbrain dopaminergic neurons requires a high activity form of SHH, FGF8a and specific regionalization by retinoic acid. Mol Cell Neurosci 45:258-266.
8. Carpenter L, C Carr, CT Yang, DJ Stuckey, K Clarke and SM Watt. (2012). Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat. Stem Cells Dev 21:977-986.
9. Zhang Q, Y Yang, J Zhang, GY Wang, W Liu, DB Qiu, ZQ Hei, QL Ying and GH Chen. (2011). Efficient derivation of functional hepatocytes from mouse induced pluripotent stem cells by a combination of cytokines and sodium butyrate. Chin Med J (Engl) 124:3786-3793.
10. Hargus G, O Cooper, M Deleidi, A Levy, K Lee, E Marlow, A Yow, F Soldner, D Hockemeyer, et al. (2010). Differentiated Parkinson patient-derived induced pluripotent stem cells grow in the adult rodent brain and reduce motor asymmetry in Parkinsonian rats. Proc Natl Acad Sci U S A 107:15921-15926.
11. Fu W, SJ Wang, GD Zhou, W Liu, Y Cao and WJ Zhang. (2012). Residual undifferentiated cells during differentiation of induced pluripotent stem cells in vitro and in vivo. Stem Cells Dev 21:521-529.
12. Monsalve M and Y Olmos. (2011). The complex biology of FOXO. Curr Drug Targets 12:1322-1350.
13. Cui M, Y Huang, Y Zhao and J Zheng. (2009). New insights for FOXO and cell-fate decision in HIV infection and HIV associated neurocognitive disorder. Adv Exp Med Biol 665:143-159.
14. Salih DA and A Brunet. (2008). FoxO transcription factors in the maintenance of cellular homeostasis during aging. Curr Opin Cell Biol 20:126-136.
15. Huang H, KM Regan, Z Lou, J Chen and DJ Tindall. (2006). CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science 314:294-297.
16. Greer EL, D Dowlatshahi, MR Banko, J Villen, K Hoang, D Blanchard, SP Gygi and A Brunet. (2007). An AMPK-FOXO pathway mediates longevity induced by a novel method of dietary restriction in C. elegans. Curr Biol 17:1646-1656.
17. Gomis RR, C Alarcon, C Nadal, C Van Poznak and J Massague. (2006). C/EBPbeta at the core of the TGFbeta cytostatic response and its evasion in metastatic breast cancer cells. Cancer Cell 10:203-214.
18. Bakker WJ, IS Harris and TW Mak. (2007). FOXO3a is activated in response to hypoxic stress and inhibits HIF1- induced apoptosis via regulation of CITED2. Mol Cells 28:941-953.
19. Lin K, JB Dorman, A Rodan and C Kenyon. (1997). daf-16: An HNF-3/forkhead family member that can function to double the life-span of Caenorhabditis elegans. Science 278:1319-1322.
20. Willcox BJ, TA Donlon, Q He, R Chen, JS Grove, K Yano, KH Masaki, DC Willcox, B Rodriguez and JD Curb. (2008). FOXO3A genotype is strongly associated with human longevity. Proc Natl Acad Sci U S A 105:13987-13992.
21. Flachsbart F, A Caliebe, R Kleindorp, H Blanche, H von Eller-Eberstein, S Nikolaus, S Schreiber and A Nebel. (2009). Association of FOXO3A variation with human longevity confirmed in German centenarians. Proc Natl Acad Sci U S A 106:2700-2705.
22. Soerensen M, S Dato, K Christensen, M McGue, T Stevnsner, VA Bohr and L Christiansen. (2010). Replication of an association of variation in the FOXO3A gene with human longevity using both case-control and longitudinal data. Aging Cell 9:1010-1017.
23. Miyamoto K, KY Araki, K Naka, F Arai, K Takubo, S Yamazaki, S Matsuoka, T Miyamoto, K Ito, et al. (2007). Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell 1:101-112.
24. Renault VM, VA Rafalski, AA Morgan, DA Salih, JO Brett, AE Webb, SA Villeda, PU Thekkat, C Guillerey, et al. (2009). FoxO3 regulates neural stem cell homeostasis. Cell Stem Cell 5:527-539.
25. Paik JH, Z Ding, R Narurkar, S Ramkissoon, F Muller, WS Kamoun, SS Chae, H Zheng, H Ying, et al. (2009). FoxOs cooperatively regulate diverse pathways governing neural stem cell homeostasis. Cell Stem Cell 5:540-553.
26. Yalcin S, D Marinkovic, SK Mungamuri, X Zhang, W Tong, R Sellers and S Ghaffari. (2010). ROS-mediated amplification of AKT/mTOR signalling pathway leads to myeloproliferative syndrome in Foxo3(-/-) mice. EMBO J 29:4118-4131.
27. Wu Y, H Peng, M Cui, NP Whitney, Y Huang and JC Zheng. (2009). CXCL12 increases human neural progenitor cell proliferation through Akt-1/FOXO3a signaling pathway. J Neurochem 109:1157-1167.
28. Shao L, W Feng, Y Sun, H Bai, J Liu, C Currie, J Kim, R Gama, Z Wang, et al. (2009). Generation of iPS cells using defined factors linked via the self-cleaving 2A sequences in a single open reading frame. Cell Res 19:296-306.
29. Lee SH, N Lumelsky, L Studer, JM Auerbach and RD McKay. (2000). Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells. Nat Biotechnol 18:675-679.
30. Ying QL, M Stavridis, D Griffiths, M Li and A Smith. (2003). Conversion of embryonic stemcells into neuroectodermal precursors in adherentmonoculture. Nat Biotechnol 21:183-186.
31. Cui M, Y Huang, C Tian, Y Zhao and J Zheng. (2011). FOXO3a inhibits TNF-alpha- and IL-1beta-induced astrocyte proliferation: implication for reactive astrogliosis. Glia 59:641-654.
32. Wernig M, A Meissner, R Foreman, T Brambrink, M Ku, K Hochedlinger, BE Bernstein and R Jaenisch. (2007). In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Nature 448:318-324.
33. Brambrink T, R Foreman, GG Welstead, CJ Lengner, M Wernig, H Suh and R Jaenisch. (2008). Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Cell Stem Cell 2:151-159.
34. Burgering BM and RH Medema. (2003). Decisions on life and death: FOXO Forkhead transcription factors are in command when PKB/Akt is off duty. J Leukoc Biol 73:689-701.
35. Tian C, Y Wang, L Sun, K Ma and JC Zheng. (2011). Reprogrammed mouse astrocytes retain a "memory" of tissue origin and possess more tendencies for neuronal differentiation than reprogrammed mouse embryonic fibroblasts. Protein Cell 2:128-140.
36. Ghorpade A. (2011). Reprogrammed astrocytes with old "memories" blossom into region-specific neurons. Protein Cell 2:87-89.
37. Brunet A, A Bonni, MJ Zigmond, MZ Lin, P Juo, LS Hu, MJ Anderson, KC Arden, J Blenis and ME Greenberg. (1999). Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 96:857-868.
38. Ferber EC, B Peck, O Delpuech, GP Bell, P East and A Schulze. (2012). FOXO3a regulates reactive oxygen metabolism by inhibiting mitochondrial gene expression. Cell Death Differ 19:968-979.
39. Yoshida Y, K Takahashi, K Okita, T Ichisaka and S Yamanaka. (2009). Hypoxia enhances the generation of induced pluripotent stem cells. Cell Stem Cell 5:237-241.
40. Utikal J, JM Polo, M Stadtfeld, N Maherali, W Kulalert, RM Walsh, A Khalil, JG Rheinwald and K Hochedlinger. (2009). Immortalization eliminates a roadblock during cellular reprogramming into iPS cells. Nature 460:1145-1148.
41. Dirac AM and R Bernards. (2003). Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J Biol Chem 278:11731-11734.
42. Chen JH, SE Ozanne and CN Hales. (2007). Methods of cellular senescence induction using oxidative stress. Methods Mol Biol 371:179-189.
43. Zhang X, S Yalcin, DF Lee, TY Yeh, SM Lee, J Su, SK Mungamuri, P Rimmele, M Kennedy, et al. (2011). FOXO1 is an essential regulator of pluripotency in human embryonic stem cells. Nat Cell Biol 13:1092-1099.
44. Thier M, P Worsdorfer, YB Lakes, R Gorris, S Herms, T Opitz, D Seiferling, T Quandel, P Hoffmann, et al. (2012). Direct conversion of fibroblasts into stably expandable neural stem cells. Cell Stem Cell 10:473-479.
45. Tian C, RJ Ambroz, L Sun, Y Wang, K Ma, Q Chen, B Zhu and JC Zheng. (2012). Direct conversion of dermal fibroblasts into neural progenitor cells by a novel cocktail of defined factors. Curr Mol Med 12:126-137.