Nicotinamide pre-treatment ameliorates NAD(H) hyperoxidation and improves neuronal function after severe hypoxia

Neurobiology of Disease

Volumn 62, Issue , 2014, Pages 469-478

  Shetty, Pavan K ^a   Galeffi, Francesca ^a   Turner, Dennis A ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Brain; Hippocampus; Hypoxia; Nicotinamide; PARP 1; Spreading depression

Indexed keywords

ADENOSINE TRIPHOSPHATE; N (5,6 DIHYDRO 6 OXO 2 PHENANTHRIDINYL) 2 DIMETHYLAMINOACETAMIDE; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN HYPOXIA; BRAIN SLICE; CELL COMPARTMENTALIZATION; CELL FUNCTION; CELL LOSS; CONTROLLED STUDY; CYTOSOL; DISEASE SEVERITY; DRUG MECHANISM; ENZYME INHIBITION; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPUS; INCUBATION TIME; MALE; MITOCHONDRION; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; REOXYGENATION; SPREADING CORTICAL DEPRESSION;

ACSF; AIF; APOPTOSIS-INDUCING FACTOR; ARTIFICIAL CEREBROSPINAL FLUID; BRAIN; CA1; CORNU AMMONIS REGION 1; DENTATE GYRUS; DG; FEPSP; FIELD EXCITATORY POST-SYNAPTIC POTENTIAL; H; HIPPOCAMPUS; HSD; HYPOXIA; HYPOXIC SPREADING DEPRESSION; NAD(+); NAD(H); NAM; NICOTINAMIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE; PARP-1; POLY(ADP-RIBOSE) POLYMERASE-1; REACTIVE OXYGEN SPECIES; REGION OF INTEREST; REOX; REOXYGENATION; ROI; ROS; SILENT MATING-TYPE INFORMATION REGULATION 1; SIRT-1; SPREADING DEPRESSION; SR; STRATUM RADIATUM; TCA CYCLE; TOTAL NAD(+) AND NADH CONTENT; TRICARBOXYLIC ACID CYCLE;

ADENOSINE TRIPHOSPHATE; ANIMALS; HIPPOCAMPUS; HYPOXIA, BRAIN; MALE; MITOCHONDRIA; NAD; NEURONS; NEUROPROTECTIVE AGENTS; NIACINAMIDE; RATS; RATS, INBRED F344;

EID: 84888026125     PISSN: 09699961     EISSN: 1095953X     Source Type: Journal    
DOI: 10.1016/j.nbd.2013.10.025     Document Type: Article

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