Continuous nicotinamide administration improves behavioral recovery and reduces lesion size following bilateral frontal controlled cortical impact injury

Behavioural Brain Research

Volumn 224, Issue 2, 2011, Pages 311-317

  Vonder Haar, Cole ^a   Anderson, Gail D ^b   Hoane, Michael R ^a  

^a SOUTHERN ILLINOIS UNIVERSITY   (United States)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Rat; Recovery of function; Traumatic brain injury; Treatment; Vitamin B 3

Indexed keywords

NICOTINAMIDE; SODIUM CHLORIDE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BEHAVIOR DISORDER; COGNITIVE DEFECT; CONTROLLED STUDY; DRUG ACTIVITY; LOADING DRUG DOSE; LOCOMOTION; MALE; MAZE TEST; MOTOR DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; RAT; SENSORY DYSFUNCTION; TASK PERFORMANCE; TRAUMATIC BRAIN INJURY;

ANIMALS; BEHAVIOR, ANIMAL; BRAIN INJURIES; COGNITION; DATA INTERPRETATION, STATISTICAL; FRONTAL LOBE; LOCOMOTION; MALE; MAZE LEARNING; MEMORY, SHORT-TERM; MOTOR ACTIVITY; NIACINAMIDE; PSYCHOMOTOR PERFORMANCE; RATS; RATS, SPRAGUE-DAWLEY; TOUCH; VITAMIN B COMPLEX;

EID: 80051784028     PISSN: 01664328     EISSN: 18727549     Source Type: Journal    
DOI: 10.1016/j.bbr.2011.06.009     Document Type: Article

References (25)

1. Center for Disease Control Injury prevention and control: traumatic brain injury 2010, from. http://www.cdc.gov/TraumaticBrainInjury/index.html.
2. Corso P., Finkelstein E., Miller T., Fiebelkorn I., Zaloshnja E. Incidence and lifetime costs of injuries in the United States. Injury Prevention 2006, 12:212-218.
3. Maas A.I.R., Marmarou A., Murray G.D., Teasdale G.M., Steyerberg E.W. Prognosis and clinical design in traumatic brain injury: the IMPACT study. Journal of Neurotrauma 2007, 24:232-238.
4. Menon D.K. Unique challenges in clinical trials in traumatic brain injury. Critical Care Medicine 2009, 37:S129-S135.
5. Narayan R.K., Michel M.E., Ansell B., Baethmann A., Biegon A., Bracken M.B., et al. Clinical trials in head injury. Journal of Neurotrauma 2002, 19:503-557.
6. Raghupathi R. Cell death mechanisms following traumatic brain injury. Brain Pathology 2004, 14:215-222.
7. Hoane M.R., Pierce J.L., Kaufman N.A., Beare J.E. Variation in chronic nicotinamide treatment after traumatic brain injury can alter components of functional recovery independent of histological damage. Oxidative Medicine and Cellular Longevity 2008, 1:46-53.
8. 3 improves functional recovery and reduces GFAP expression following traumatic brain injury in rats. Journal of Neurotrauma. 2003, 20:1189-1199.
9. Hoane M.R., Pierce J.L., Holland M.A., Anderson G.D. Nicotinamide treatment induces behavioral recovery when administered up to 4 hours following cortical contusion injury in the rat. Neuroscience 2008, 154:861-868.
10. Hoane M.R., Gilbert D.G., Holland M.A., Pierce J.L. Nicotinamide reduces acute cortical neuronal death and edema in the traumatically injured brain. Neuroscience Letters 2006, 408:35-39.
11. Holland M.A., Tan A.A., Smith D.C., Hoane M.R. Nicotinamide treatment provides acute neuroprotection and GFAP regulation following fluid percussion injury. Journal of Neurotrauma 2008, 25:140-152.
12. Hoane M.R., Kaplan S.A., Ellis A.L. The effects of nicotinamide on apoptosis and blood-brain barrier breakdown following traumatic brain injury. Brain Research 2006, 1125:185-193.
13. +/NADPH in cellular functions and cell death: Regulation and biological consequences. Antioxidants & Redox Signalling 2008, 10:179-206.
14. + precursor nicotinamide. Current Medicinal Chemistry 2006, 13:883-895.
15. Goffus A.M., Anderson G.D., Hoane M.R. Sustained delivery of nicotinamide limits cortical injury and improves functional recovery following traumatic brain injury. Oxidative Medicine and Cellular Longevity 2010, 3:145-152.
16. Hoane M.R., Tan A.A., Pierce J.L., Anderson G.D., Smith D.C. Nicotinamide treatment reduces behavioral impairments and provides cortical protection after fluid percussion injury in the rat. Journal of Neurotrauma 2006, 23:1535-1548.
17. Komotar R.J., Kim G.H., Sughrue M.E., Otten M.L., Rynkowski M.A., Kellner C.P., et al. Neurologic assessment of somatosensory dysfunction following an experimental rodent model of cerebral ischemia. Nature Protocols 2007, 2:2345-2347.
18. Hoane M.R., Pierce J.L., Holland M.A., Birky N.D., Dang T., Vitek M.P., et al. The novel apolipoprotein E-based peptide COG1410 improves sensorimotor performances and reduces injury magnitude following cortical contusion injury. Journal of Neurotrauma 2007, 24:1108-1118.
19. Coggeshall R.E. A consideration of neural counting methods. Trends in Neuroscience 1992, 15:9-13.
20. Neafsey E.J. Motor functions of the neocortex. The cerebral cortex of the rat 1990, 197-212. MIT Press, Cambridge.
21. Lindner M.D., Plone M.A., Cain C.K., Frydel B., Francis J.M., Emerich D.F., et al. Dissociable long-term cognitive deficits after frontal versus sensorimotor cortical contusions. Journal of Neurotrauma 1998, 15:199-216.
22. Yang J., Klaidman L.K., Adams J.D. Medicinal chemistry of nicotinamide in the treatment of ischemia and reperfusion. Mini Reviews in Medicinal Chemistry 2002, 2:125-134.
23. +/NADPH in cell death. Current Pharmaceutical Design 2009, 15:12-19.
24. Quigley A., Tan A.A., Hoane M.R. The effects of hypertonic saline and nicotinamide on sensorimotor and cognitive function following cortical contusion injury in the rat. Brain Research 2009, 1304:138-148.
25. +, as a PARP inhibitor and by partial restoration of mitochondrial function. Pharmacology 2003, 69:150-157.