Acute effects of sceletium tortuosum (Zembrin), a dual 5-HT reuptake and PDE4 inhibitor, in the human amygdala and its connection to the hypothalamus

Neuropsychopharmacology

Volumn 38, Issue 13, 2013, Pages 2708-2716

  Terburg, David ^a,b   Syal, Supriya ^b,c   Rosenberger, Lisa A ^a   Heany, Sarah ^b   Phillips, Nicole ^b   Gericke, Nigel ^d   Stein, Dan J ^b   Van Honk, Jack ^a,b  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UNIVERSITY OF CAPE TOWN   (South Africa)

^c UNIVERSITY OF TORONTO   (Canada)

^d HGandH Pharmaceuticals (Pty) Ltd   (South Africa)

Author keywords

amygdala; anxiety; hypothalamus; phosphodiesterase; sceletium; serotonin

Indexed keywords

PHOSPHODIESTERASE IV INHIBITOR; PSYCHOTROPIC AGENT; SEROTONIN NORADRENALIN REUPTAKE INHIBITOR; UNCLASSIFIED DRUG; ZEMBRIN;

ADULT; AFRICAN MEDICINE; AMYGDALOID NUCLEUS; ANXIETY; ARTICLE; BRAIN FUNCTION; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DEPRESSION; DOUBLE BLIND PROCEDURE; DRUG EFFECT; DRUG MECHANISM; EVIDENCE BASED MEDICINE; FEAR; FEMALE; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HUMAN; HYPOTHALAMUS; MALE; MESEMBRYANTHEMUM; NORMAL HUMAN; PRIORITY JOURNAL; PSYCHOLOGICAL WELL BEING; SCELETIUM TORTUOSUM; SOUTH AFRICA; STRESS; TASK PERFORMANCE; TRANQUILIZING ACTIVITY;

ADOLESCENT; AIZOACEAE; AMYGDALA; DOSE-RESPONSE RELATIONSHIP, DRUG; DOUBLE-BLIND METHOD; EMOTIONS; FEMALE; HUMANS; HYPOTHALAMUS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MEDICINE, AFRICAN TRADITIONAL; NEURAL PATHWAYS; OXYGEN; PERCEPTION; PHOSPHODIESTERASE 4 INHIBITORS; SEROTONIN UPTAKE INHIBITORS; YOUNG ADULT;

EID: 84887996097     PISSN: 0893133X     EISSN: 1740634X     Source Type: Journal    
DOI: 10.1038/npp.2013.183     Document Type: Article

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