Stereoselective inhibition of serotonin re-uptake and phosphodiesterase by dual inhibitors as potential agents for depression

Bioorganic and Medicinal Chemistry

Volumn 17, Issue 1, 2009, Pages 337-343

  Cashman, John R ^a   Voelker, Troy ^a   Johnson, Robert ^b   Janowsky, Aaron ^b  

^a HUMAN BIOMOLECULAR RESEARCH INSTITUTE   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

Author keywords

Depression; Dual selective serotonin re uptake inhibitor PDE4 inhibitor; Fluoxetine; Transporters

Indexed keywords

4 [(3,4 DIMETHOXYPHENYL) 2 [[3 (4 TRIFLUOROMETHYLPHENOXY) 3 PHENYL]ETHYLAMINO]PENTYL] 4,5,8,8A TETRAHYDRO 2H PHTHALAZIN 1 ONE; PHOSPHODIESTERASE IV INHIBITOR; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DEPRESSION; DRUG EFFECT; DRUG POTENCY; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IC 50; STEREOCHEMISTRY;

ANTIDEPRESSIVE AGENTS; CROSS-LINKING REAGENTS; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DRUG DELIVERY SYSTEMS; DRUG SYNERGISM; HUMANS; INHIBITORY CONCENTRATION 50; PHOSPHODIESTERASE INHIBITORS; SEROTONIN UPTAKE INHIBITORS; STEREOISOMERISM;

EID: 57749195942     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.065     Document Type: Article

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