Downregulation of brain phosphodiesterase type IV measured with 11C-(R)-rolipram positron emission tomography in major depressive disorder

Biological Psychiatry

Volumn 72, Issue 7, 2012, Pages 548-554

  Fujita, Masahiro ^a   Hines, Christina S ^a   Zoghbi, Sami S ^a   Mallinger, Alan G ^a   Dickstein, Leah P ^a   Liow, Jeih San ^a   Zhang, Yi ^a   Pike, Victor W ^a   Drevets, Wayne C ^b   Innis, Robert B ^a   Zarate Jr , Carlos A ^a  

^a NATIONAL INSTITUTE OF MENTAL HEALTH   (United States)

^b University of Oklahoma Tulsa College of Medicine   (United States)

Author keywords

cAMP; compartmental analysis; in vivo imaging; second messenger; unipolar depression; unmedicated

Indexed keywords

CYCLIC AMP; PHOSPHODIESTERASE IV; ROLIPRAM;

ADULT; ARTICLE; BINDING AFFINITY; BRAIN BLOOD FLOW; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVITY; FEMALE; HUMAN; MAJOR DEPRESSION; MALE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL;

ADULT; ANIMALS; BRAIN; BRAIN MAPPING; CARBON ISOTOPES; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DEPRESSIVE DISORDER, MAJOR; DOWN-REGULATION; FEMALE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MEMBRANE TRANSPORT PROTEINS; MICE; MICE, KNOCKOUT; MIDDLE AGED; PHOSPHODIESTERASE 4 INHIBITORS; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; ROLIPRAM; TIME FACTORS;

EID: 84866038675     PISSN: 00063223     EISSN: 18732402     Source Type: Journal    
DOI: 10.1016/j.biopsych.2012.04.030     Document Type: Article

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