Hispolon from phellinus linteus Induces G0/G1 cell cycle arrest and apoptosis in NB4 human leukaemia cells

American Journal of Chinese Medicine

Volumn 41, Issue 6, 2013, Pages 1439-1457

  Chen, Yi Chuan ^a   Chang, Heng Yuan ^a   Deng, Jeng Shyan ^b   Chen, Jian Jung ^a   Huang, Shyh Shyun ^a   Lin, I Hsin ^a   Kuo, Wan Lin ^a   Chao, Wei ^a   Huang, Guan Jhong ^a  

^a CHINA MEDICAL UNIVERSITY   (Taiwan)

^b ASIA UNIVERSITY   (Taiwan)

Author keywords

Apoptosis; Caspase; NB4; p53; Phellinus linteus

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; 4',6 DIAMIDINO 2 PHENYLINDOLE; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DNA; FAS ANTIGEN; FAS LIGAND; HISPOLON; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PHENOL DERIVATIVE; PROTEIN BAX; PROTEIN BCL 2; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL GROWTH; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG EFFECT; FLOW CYTOMETRY; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; LEUKEMIA CELL; PHELLINUS LINTEUS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; WESTERN BLOTTING;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CATECHOLS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; CELL SURVIVAL; DNA FRAGMENTATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; GENES, NEOPLASM; HUMANS; LEUKEMIA; PHYTOTHERAPY; POLYSACCHARIDES;

EID: 84887958084     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X13500961     Document Type: Article

References (30)

1. Ali, N.A., J. Lüdtke, H. Pilgrim and U. Lindequist. Inhibition of chemiluminescence response of human mononuclear cells and suppression of mitogen-induced proliferation of spleen lymphocytes of mice by hispolon and hispidin. Pharmazie 51: 9667-9670, 1996.
2. Chang, H.Y., M.J. Sheu, C.H. Yang, T.C. Lu, Y.S. Chang, W.H. Peng, S.S. Huang and G.J. Huang. Analgesic effects and the mechanisms of anti-inflammation of hispolon in mice. Evid. Based Complement. Alternat. Med. 2011: 478246, 2011.
3. Chen, W.J. and J.K. Lin. Mechanisms of cancer chemoprevention by hop bitter acids (beer aroma) through induction of apoptosis mediated by Fas and caspase cascades. J. Agric. Food Chem. 52: 55-64, 2004.
4. Chen, W., Z. Zhao, L. Li, B. Wu, S.F. Chen, H. Zhou, Y. Wang and Y.Q. Li. Hispolon induces apoptosis in human gastric cancer cells through a ROS-mediated mitochondrial pathway. Free Radic. Biol. Med. 45: 60-72, 2008.
5. Cheng, Y.L., S.C. Lee, H.J. Harn, H.C. Huang and W.L. Chang. The extract of Hibiscus syriacus inducing apoptosis by activating p53 and AIF in human lung cancer cells. Am. J. Chin. Med. 36: 171-184, 2008.
6. Chou, P.Y., G.J. Huang, C.H. Pan, Y.C. Chien, Y.Y. Chen, C.H. Wu, M.J. Sheu and H.C. Cheng. Trilinolein inhibits proliferation of human non-small cell lung carcinoma A549 through the modulation of PI3K/Akt pathway. Am. J. Chin. Med. 39: 803-815, 2011.
7. Earnshaw, W.C., L.M. Martins and S.H. Kaufmann. Mammalian caspases: structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68: 383-424, 1999. (Pubitemid 29449198)
8. Guo, J., T. Zhu, L. Collins, Z.X. Xiao, S.H. Kim and C.Y. Chen. Modulation of lung cancer growth arrest and apoptosis by Phellinus Linteus. Mol. Carcinog. 46: 144-154, 2007.
9. Huang, G.J., M.J. Sheu, H.J. Chen, Y.S. Chang and Y.H. Lin. Growth inhibition and induction of apoptosis in NB4 promyelocytic leukemia cells by trypsin inhibitor from sweet potato storage roots. J. Agric. Food Chem. 55: 2548-2553, 2007.
10. Huang, G.J., C.M. Yang, Y.S. Chang, S. Amagaya, H.C. Wang, W.C. Hou, S.S. Huang and M.L. Hu. Hispolon suppresses SK-Hep1 human hepatoma cell metastasis by inhibiting matrix metalloproteinase-2/9 and urokinase-plasminogen activator through the PI3K/Akt and ERK signaling pathways J. Agric. Food Chem. 58: 9468-9475, 2010.
11. Huang, G.J., W.T. Hsieh, H.Y. Chang, S.S. Huang, Y.C. Lin and Y.H. Kuo.-glucosidase and aldose reductase inhibitor activities from the fruiting body of Phellinus merrillii. J. Agric. Food Chem. 59: 5702-5706, 2011a.
12. Huang, G.J., J.S. Deng, S.S. Huang and M.L. Hu. Hispolon induces apoptosis and cell cycle arrest of human hepatocellular carcinoma Hep3B Cells by modulating ERK phosphorylation. J. Agric. Food Chem. 59: 7104-7113, 2011b.
13. Huang, G.J., J.S. Deng, C.S. Chiu, J.C. Liao, W.T. Hsieh, M.J. Sheu and C.H. Wu. Hispolon protects against acute liver damage in the rat by inhibiting lipid peroxidation, proinflammatory cytokine, oxidative stress and down-regulating the expressions of iNOS, COX-2, and MMP-9. Evid. Based Complement. Alternat. Med. 2012: 480714, 2012.
14. Hsu, Y.L., Y.H. Uen, Y. Chen, H.L. Liang and P.L. Kuo. Tricetin, a dietary flavonoid, inhibits proliferation of human breast adenocarcinoma MCF-7 Cells by blocking cell cycle progression and inducing apoptosis J. Agric. Food Chem. 57: 8688-8695, 2009.
15. Lee, H.J., E.S. Lim, K.S. Ahn, B.S. Shim, H.M. Kim, S.J. Gong, D.K. Kim and S.H. Kim. Cambodian Phellinus linteus inhibits experimental metastasis of melanoma cells in mice via regulation of urokinase type plasminogen activator. Biol. Pharm. Bull. 28: 27-31, 2005.
16. Li, J., K. Zhang, W. Meng and Y. Yang. Tanshinone IIA in acute promyelocytic leukemia. Am. J. Chin. Med. 344: 283-288, 2012.
17. Liu, X.S. and J. Jiang. Molecular mechanism of matrine-induced apoptosis in leukemia K562 cells. Am. J. Chin. Med. 34: 1095-1103, 2006. (Pubitemid 44921253)
18. Lu, T.L., G.J. Huang, T.J. Lu, J.B. Wu, C.H. Wu, T.C. Yang, A. Iizuka and Y.F. Chen. Hispolon from Phellinus linteus has antiproliferative effects via MDM2-recruited ERK1/2 activity in breast and bladder cancer cells. Food Chem. Toxicol. 47: 2013-2021, 2009.
19. Lu, T.L., G.J. Huang, H.J. Wang, J.L. Chen, H.P. Hsu and T.J. Lu. Hispolon promotes MDM2 downregulation through chaperone-mediated autophagy. Biochem. Biophys. Res. Commun. 398: 26-31, 2010.
20. Nicholson, D.W. and N.A. Thornberry. Caspases: killer proteases. Trends Biochem. Sci. 22: 299-306, 1997. (Pubitemid 27327087)
21. Ravindran, J.G., V. Subbaraju, M.V. Ramani, B. Sung and B.B. Aggarwal. Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro. Biochem. Pharmacol. 79: 1658-1666, 2010.
22. Shen, K.H., J.K. Chang, Y.L. Hsu and P.L. Kuo. Chalcone arrests cell cycle progression and induces apoptosis through induction of mitochondrial pathway and inhibition of nuclear factor kappa B signalling in human bladder cancer cells. Basic Clin. Pharmacol. Toxicol. 101: 254-261, 2007.
23. Shen, K.H., Z.T. Chen and P.D. Duh. Cytotoxic effect of Eucalyptus citriodora resin on human hepatoma HepG2 Cells. Am. J. Chin. Med. 40: 399-413, 2012.
24. Shi, P., Z. Huang and G. Chen. Rhein induces apoptosis and cell cycle arrest in human hepatocellular carcinoma BEL-7402 Cells. Am. J. Chin. Med. 36: 805-813, 2008.
25. Shin, S.W., C.I. Park, C.H. Yang and J.W. Park. Protective effect of rehmannia glutinosa on the UV-Induced apoptosis in U937 cells. Am. J. Chin. Med. 36: 1159-1170, 2008.
26. Song, T.Y., S.L. Hsu, C.T. Yeh and G.C. Yen. Mycelia from Antrodia camphorata in submerged culture induce apoptosis of human hepatoma HepG2 cells possibly through regulation of Fas pathway. J. Agric. Food Chem. 53: 5559-5564, 2005.
27. Suda, T., T. Takahashi, P. Golstein and S. Nagata. Molecular cloning and expression of the Fas ligand, a novel member of the TNF family. Cell 75: 1169-1178, 1993. (Pubitemid 24006113)
28. Xu Z., G. Wu, X. Wei, X. Chen, Y. Wang and L. Chen. Celastrol induced DNA damage, cell cycle arrest, and apoptosis in human rheumatoid fibroblast-like synovial cells. Am. J. Chin. Med. 41: 615-628, 2013.
29. Yeh, T.C., P.C. Chiang, T.K. Li, J.L. Hsu, C.J. Lin, S.W. Wang, C.Y. Peng and J.H. Guh. Genistein induces apoptosis in human hepatocellular carcinomas via interaction of endoplasmic reticulum stress and mitochondrial insult. Biochem. Pharmacol. 73: 782-792, 2007.
30. Yun, J.M. M.H. Kweon, H. Kwon, J.K. Hwang and H. Mukhtar. Induction of apoptosis and cell cycle arrest by a chalcone panduratin A isolated from Kaempferia pandurata in androgen-independent human prostate cancer cells PC3 and DU145. Carcinogenesis 27: 1454-1464, 2006. (Pubitemid 43985420)