Discovery of 3,4-dihydropyrimidin-2(1 H)-ones as a novel class of potent and selective A2B adenosine receptor antagonists

ACS Medicinal Chemistry Letters

Volumn 4, Issue 11, 2013, Pages 1031-1036

  Crespo, Abel ^a   El Maatougui, Abdelaziz ^a   Biagini, Pierfrancesco ^a   Azuaje, Jhonny ^a   Coelho, Alberto ^a   Brea, José ^a   Loza, María Isabel ^a   Cadavid, María Isabel ^a   García Mera, Xerardo ^a   Gutiérrez De Terán, Hugo ^b   Sotelo, Eddy ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

3,4 dihydropyrimidin 2(1 H) ones; Adenosine antagonists; Biginelli reaction

Indexed keywords

3,4 DIHYDROPYRIMIDIN 2(1H ) ONE DERIVATIVE; ADENOSINE A2B RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; DRUG BINDING; DRUG IDENTIFICATION; DRUG POTENCY; DRUG RESEARCH; DRUG SELECTIVITY; PRIORITY JOURNAL; PROCESS OPTIMIZATION; STRUCTURE ACTIVITY RELATION;

EID: 84887957117     PISSN: None     EISSN: 19485875     Source Type: Journal    
DOI: 10.1021/ml400185v     Document Type: Article

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