Synthesis and antimicrobial activity of novel derivatives of biginelli pyrimidines

Medicinal Chemistry Research

Volumn 21, Issue 12, 2012, Pages 3973-3983

  Sedaghati, Bita ^a   Fassihi, Afshin ^a   Arbabi, Shirin ^a   Ranjbar, Mahnaz ^b   Memarian, Hamid Reza ^b   Saghaie, Lotfollah ^a   Omidi, Adel ^a   Sardari, Alireza ^a   Jalali, Mohammad ^c   Abedi, Daryoush ^c  

^a ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b UNIVERSITY OF ISFAHAN   (Iran)

^c ISFAHAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

1,2,3,4 Tetrahydropyrimidine 5 carboxamides; 1,2,3,4 Tetrahydropyrimidine 5 carboxylate esters; Antibacterial activity; Antifungal activity

Indexed keywords

1,2,3,4 TETRAHYDROPYRIMIDINE DERIVATIVE; 4 [1 BENZYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL] 6 METHYL 2 OXO N (PYRIDIN 2 YL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; 4 [1 BENZYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL] 6 METHYL 2 OXO N (PYRIDIN 3 YL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; 4 [1 BENZYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL] N (2 CHLOROPHENYL) 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDIN 5 CARBOXAMIDE; 4 [1 BENZYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL] N (3 CHLOROPHENYL) 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDIN 5 CARBOXAMIDE; 4 [1 BENZYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL] N (4 CHLOROPHENYL) 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDIN 5 CARBOXAMIDE; 6 METHYL 2 OXO N (PYRIDIN 2 YL) 4 (THIOPHEN 2 YL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; 6 METHYL 2 OXO N (PYRIDIN 3 YL) 4 (THIOPHEN 2 YL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; 6 METHYL 4 [2 (METHYLTHIO) 1 (PHENYLAMINO) 1H IMIDAZOL 5 YL] 2 OXO N (PYRIDIN 2 YL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; 6 METHYL 4 [2 (METHYLTHIO) 1 (PHENYLAMINO) 1H IMIDAZOL 5 YL] 2 OXO N (PYRIDIN 3 YL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; AMIDE; ANTIBIOTIC AGENT; ANTIFUNGAL AGENT; CARBOXYLIC ACID DERIVATIVE; CIPROFLOXACIN; ETHYL 4 [[1 BENZYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL]] 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ETHYL 6 METHYL 4 [2 (METHYLTHIO) 1 (PHENYLAMINO) 1H IMIDAZOL- 5 YL] 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; IMIDAZOLE DERIVATIVE; ISOBUTYL 6 METHYL 4 (THIOPHEN 2 YL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; ISOPROPYL 6 METHYL 4 (THIOPHEN 2 YL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; KETOCONAZOLE; METHYL 4 [(1 BENZYL 2 (METHYLTHIO) 1H IMIDAZOL 5 YL)] 6 METHYL 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; METHYL 6 METHYL 4 [2 (METHYLTHIO) 1 (PHENYLAMINO) 1H IMIDAZOL- 5 YL] 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; N (2 CHLOROPHENYL) 6 METHYL 2 OXO 4 (THIOPHEN 2 YL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; N (2 CHLOROPHENYL) 6 METHYL 4 [2 (METHYLTHIO) 1 (PHENYLAMINO) 1H IMIDAZOL 5 YL] 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; N (3 CHLOROPHENYL) 6 METHYL 2 OXO 4 (THIOPHEN 2 YL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; N (3 CHLOROPHENYL) 6 METHYL 4 [2 (METHYLTHIO) 1 (PHENYLAMINO) 1H IMIDAZOL 5 YL] 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; N (4 CHLOROPHENYL) 6 METHYL 2 OXO 4 (THIOPHEN 2 YL) 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; N (4 CHLOROPHENYL) 6 METHYL 4 [2 (METHYLTHIO) 1 (PHENYLAMINO) 1H IMIDAZOL 5 YL] 2 OXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXAMIDE; N BUTYL 6 METHYL 4 (THIOPHEN 2 YL) 2 THIOXO 1,2,3,4 TETRAHYDROPYRIMIDINE 5 CARBOXYLATE; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ANTIFUNGAL ACTIVITY; ARTICLE; ASPERGILLUS NIGER; BACILLUS SUBTILIS; BIGINELLI REACTION; CANDIDA ALBICANS; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENCY; DRUG SCREENING; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ELEMENTAL ANALYSIS; ESCHERICHIA COLI; IN VITRO STUDY; INFRARED SPECTROSCOPY; LISTERIA MONOCYTOGENES; MEDICINAL CHEMISTRY; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACOPHORE; PROTON NUCLEAR MAGNETIC RESONANCE; PSEUDOMONAS AERUGINOSA; SALMONELLA ENTERICA SEROVAR ENTERITIDIS; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION;

EID: 83655164119     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-011-9931-7     Document Type: Article

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