Synthesis and pharmacological evaluation of a second generation of pyridothiadiazine 1,1-dioxides acting as AMPA potentiators

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 23, 2008, Pages 9948-9956

  Francotte, Pierre ^a   Tullio, Pascal de ^a   Podona, Tchao ^a   Diouf, Ousmane ^a   Fraikin, Pierre ^a   Lestage, Pierre ^b   Danober, Laurence ^b   Thomas, Jean Yves ^b   Caignard, Daniel Henri ^b   Pirotte, Bernard ^a  

^a UNIVERSITY OF LIÈGE   (Belgium)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

Allosteric modulation; AMPA potentiator; Cognitive enhancer

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CENTRAL NERVOUS SYSTEM AGENTS; PYRIDOTHIADIAZINE 1,1 DIOXIDE; THIADIAZINE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CHEMICAL STRUCTURE; COGNITION; DRUG EFFECT; DRUG SCREENING; DRUG SYNTHESIS; IN VIVO STUDY; LIPOPHILICITY; MEMORY; NONHUMAN; RAT; WISTAR RAT;

ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; DIAZOXIDE; OOCYTES; RATS; RATS, WISTAR; RECEPTORS, AMPA; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZINES; XENOPUS LAEVIS;

HUMAN ECHOVIRUS 1; RATTUS NORVEGICUS;

EID: 55749106035     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2008.10.036     Document Type: Article

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