메뉴 건너뛰기




Volumn 7, Issue 1, 2013, Pages 66-72

MEK inhibition reduces glial scar formation and promotes the recovery of sensorimotor function in rats following spinal cord injury

Author keywords

Extracellular signal regulated kinases; Glial fibrillary acidic protein; Glial scar; Spinal cord injury; Vimentin

Indexed keywords

1, 4 DIAMINO 1, 4 BIS (2 AMINOPHENYLTHIO) 2, 3 DICYANOBUTADIENE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; GLIAL FIBRILLARY ACIDIC PROTEIN; UNCLASSIFIED DRUG; VIMENTIN;

EID: 84887857025     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2013.1371     Document Type: Article
Times cited : (35)

References (38)
  • 1
    • 0742288565 scopus 로고    scopus 로고
    • Regeneration beyond the glial scar
    • Silver J and Miller JH: Regeneration beyond the glial scar. Nat Rev Neurosci 5: 146-156, 2004.
    • (2004) Nat Rev Neurosci , vol.5 , pp. 146-156
    • Silver, J.1    Miller, J.H.2
  • 2
    • 33845768784 scopus 로고    scopus 로고
    • Microglia-mediated neurotoxicity: Uncovering the molecular mechanisms
    • Block ML, Zecca L and Hong JS: Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8: 57-69, 2007.
    • (2007) Nat Rev Neurosci , vol.8 , pp. 57-69
    • Block, M.L.1    Zecca, L.2    Hong, J.S.3
  • 3
    • 83755174410 scopus 로고    scopus 로고
    • The glial scar-monocyte interplay: A pivotal resolution phase in spinal cord repair
    • Shechter R, Raposo C, London A, Sagi I and Schwartz M: The glial scar-monocyte interplay: a pivotal resolution phase in spinal cord repair. PLoS One 6: e27969, 2011.
    • (2011) PLoS One , vol.6
    • Shechter, R.1    Raposo, C.2    London, A.3    Sagi, I.4    Schwartz, M.5
  • 4
    • 85016872313 scopus 로고    scopus 로고
    • Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5
    • Ferraguti F, Corti C, Valerio E, Mion S and Xuereb J: Activated astrocytes in areas of kainate-induced neuronal injury upregulate the expression of the metabotropic glutamate receptors 2/3 and 5. Exp Brain Res 137: 1-11, 2001.
    • (2001) Exp Brain Res , vol.137 , pp. 1-11
    • Ferraguti, F.1    Corti, C.2    Valerio, E.3    Mion, S.4    Xuereb, J.5
  • 5
    • 34948833293 scopus 로고    scopus 로고
    • Increased neurogenesis and astrogenesis from neural progenitor cells grafted in the hippocampus of GFAP-/-Vim-/mice
    • Widestrand A, Faijerson J, Wilhelmsson U, et al: Increased neurogenesis and astrogenesis from neural progenitor cells grafted in the hippocampus of GFAP-/-Vim-/mice. Stem Cells 25: 2619-2627, 2007.
    • (2007) Stem Cells , vol.25 , pp. 2619-2627
    • Widestrand, A.1    Faijerson, J.2    Wilhelmsson, U.3
  • 6
    • 33847385827 scopus 로고    scopus 로고
    • Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans
    • Cafferty WB, Yang SH, Duffy PJ, Li S and StrittmatterSM: Functional axonal regeneration through astrocytic scar genetically modified to digest chondroitin sulfate proteoglycans. J Neurosci 27: 2176-2185, 2007.
    • (2007) J Neurosci , vol.27 , pp. 2176-2185
    • Cafferty, W.B.1    Yang, S.H.2    Duffy, P.J.3    Li, S.4    Strittmatter, S.M.5
  • 7
    • 33646442052 scopus 로고    scopus 로고
    • Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury
    • Massey JM, Hubscher CH, Wagoner MR, et al: Chondroitinase ABC digestion of the perineuronal net promotes functional collateral sprouting in the cuneate nucleus after cervical spinal cord injury. J Neurosci 26: 4406-4414, 2006.
    • (2006) J Neurosci , vol.26 , pp. 4406-4414
    • Massey, J.M.1    Hubscher, C.H.2    Wagoner, M.R.3
  • 8
    • 79955776756 scopus 로고    scopus 로고
    • Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection
    • Jefferson SC, Tester NJ and Howland DR: Chondroitinase ABC promotes recovery of adaptive limb movements and enhances axonal growth caudal to a spinal hemisection. J Neurosci 31: 5710-5720, 2011.
    • (2011) J Neurosci , vol.31 , pp. 5710-5720
    • Jefferson, S.C.1    Tester, N.J.2    Howland, D.R.3
  • 10
    • 60549083987 scopus 로고    scopus 로고
    • The bright side of the glial scar in CNS repair
    • Rolls A, Shechter R and Schwartz M: The bright side of the glial scar in CNS repair. Nat Rev Neurosci 10: 235-241, 2009.
    • (2009) Nat Rev Neurosci , vol.10 , pp. 235-241
    • Rolls, A.1    Shechter, R.2    Schwartz, M.3
  • 11
    • 1542376941 scopus 로고    scopus 로고
    • Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury
    • Stirling DP, Khodarahmi K, Liu J, et al: Minocycline treatment reduces delayed oligodendrocyte death, attenuates axonal dieback, and improves functional outcome after spinal cord injury. J Neurosci 24: 2182-2190, 2004.
    • (2004) J Neurosci , vol.24 , pp. 2182-2190
    • Stirling, D.P.1    Khodarahmi, K.2    Liu, J.3
  • 12
    • 33846590145 scopus 로고    scopus 로고
    • Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats
    • Tian DS, Xie MJ, Yu ZY, et al: Cell cycle inhibition attenuates microglia induced inflammatory response and alleviates neuronal cell death after spinal cord injury in rats. Brain Res 1135: 177-185, 2007.
    • (2007) Brain Res , vol.1135 , pp. 177-185
    • Tian, D.S.1    Xie, M.J.2    Yu, Z.Y.3
  • 13
    • 20344398223 scopus 로고    scopus 로고
    • Astrocyte activation and reactive gliosis
    • Pekny M and Nilsson M: Astrocyte activation and reactive gliosis. Glia 50: 427-434, 2005.
    • (2005) Glia , vol.50 , pp. 427-434
    • Pekny, M.1    Nilsson, M.2
  • 14
    • 33745919498 scopus 로고    scopus 로고
    • Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury
    • Okada S, Nakamura M, Katoh H, et al: Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med 12: 829-834, 2006.
    • (2006) Nat Med , vol.12 , pp. 829-834
    • Okada, S.1    Nakamura, M.2    Katoh, H.3
  • 15
    • 0034667593 scopus 로고    scopus 로고
    • Meaningful relationships: The regulation of the Ras/Raf/MEK/ERK pathway by protein interactions
    • Kolch W: Meaningful relationships: the regulation of the Ras/Raf/MEK/ERK pathway by protein interactions, Biochem J 351: 289-305, 2000.
    • (2000) Biochem J , vol.351 , pp. 289-305
    • Kolch, W.1
  • 16
    • 0035116529 scopus 로고    scopus 로고
    • Neuronal plasticity and signal transduction in nociceptive neurons: Implications for the initiation and maintenance of pathological pain
    • Ji RR and Woolf CJ: Neuronal plasticity and signal transduction in nociceptive neurons: implications for the initiation and maintenance of pathological pain. Neurobiol Dis 8: 1-10, 2001.
    • (2001) Neurobiol Dis , vol.8 , pp. 1-10
    • Ji, R.R.1    Woolf, C.J.2
  • 17
    • 0036208464 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase inhibition in traumatic brain injury: In vitro and in vivo effects
    • Mori T, Wang X, Jung JC, et al: Mitogen-activated protein kinase inhibition in traumatic brain injury: in vitro and in vivo effects. J Cereb Blood Flow Metab 22: 444-452, 2002.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 444-452
    • Mori, T.1    Wang, X.2    Jung, J.C.3
  • 18
    • 33947213910 scopus 로고    scopus 로고
    • Inhibition of the MEK/ERK pathway reduces microglial activation and interleukin-1-beta expression in spinal cord ischemia/reperfusion injury in rats
    • Lu K, Cho CL, Liang CL, et al: Inhibition of the MEK/ERK pathway reduces microglial activation and interleukin-1-beta expression in spinal cord ischemia/reperfusion injury in rats. JThorac Cardiovasc Surg 133: 934-941, 2007.
    • (2007) JThorac Cardiovasc Surg , vol.133 , pp. 934-941
    • Lu, K.1    Cho, C.L.2    Liang, C.L.3
  • 20
    • 77953304307 scopus 로고    scopus 로고
    • Inhibition of extracellular signal-regulated kinases 1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: Relationship with the nuclear factor-kappaB-regulated anti-apoptotic mechanisms
    • Lu K, Liang CL, Liliang PC, et al: Inhibition of extracellular signal-regulated kinases 1/2 provides neuroprotection in spinal cord ischemia/reperfusion injury in rats: relationship with the nuclear factor-kappaB-regulated anti-apoptotic mechanisms. JNeurochem 114: 237-246, 2010.
    • (2010) JNeurochem , vol.114 , pp. 237-246
    • Lu, K.1    Liang, C.L.2    Liliang, P.C.3
  • 21
    • 0023832923 scopus 로고
    • Models of spinal cord injury: Part 3. Dynamic load technique
    • Black P, Markowitz RS, Damjanov I, et al: Models of spinal cord injury: Part 3. Dynamic load technique. Neurosurgery 22: 51-60, 1988.
    • (1988) Neurosurgery , vol.22 , pp. 51-60
    • Black, P.1    Markowitz, R.S.2    Damjanov, I.3
  • 22
    • 0030157694 scopus 로고    scopus 로고
    • Graded histological and locomotor outcomes after spinal cord contusion using the NYU weightdrop device versus transection
    • Basso DM, Beattie MS and Bresnahan JC: Graded histological and locomotor outcomes after spinal cord contusion using the NYU weightdrop device versus transection. Exp Neurol 139: 244-256, 1996.
    • (1996) Exp Neurol , vol.139 , pp. 244-256
    • Basso, D.M.1    Beattie, M.S.2    Bresnahan, J.C.3
  • 23
    • 33746308062 scopus 로고    scopus 로고
    • Glial inhibition of CNS axon regeneration
    • Yiu G and He Z: Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 7: 617-627, 2006.
    • (2006) Nat Rev Neurosci , vol.7 , pp. 617-627
    • Yiu, G.1    He, Z.2
  • 24
    • 84861133903 scopus 로고    scopus 로고
    • Promotion of neuronal recovery following experimental SCI via direct inhibition of glial scar formation
    • Parry PV and Engh JA: Promotion of neuronal recovery following experimental SCI via direct inhibition of glial scar formation. Neurosurgery 70: N10-N11, 2012.
    • (2012) Neurosurgery , vol.70
    • Parry, P.V.1    Engh, J.A.2
  • 25
    • 11144353882 scopus 로고    scopus 로고
    • Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury
    • Okada S, Nakamura M, Mikami Y, et al: Blockade of interleukin-6 receptor suppresses reactive astrogliosis and ameliorates functional recovery in experimental spinal cord injury. J Neurosci Res 76: 265-276, 2004.
    • (2004) J Neurosci Res , vol.76 , pp. 265-276
    • Okada, S.1    Nakamura, M.2    Mikami, Y.3
  • 26
    • 84872657724 scopus 로고    scopus 로고
    • The multifaceted effects of agmatine on functional recovery after spinal cord injury through Modulations of BMP-2/4/7 expressions in neurons and glial cells
    • Park YM, Lee WT, Bokara KK, et al: The multifaceted effects of agmatine on functional recovery after spinal cord injury through Modulations of BMP-2/4/7 expressions in neurons and glial cells. PLoS One 8: e53911, 2013.
    • (2013) PLoS One , vol.8
    • Park, Y.M.1    Lee, W.T.2    Bokara, K.K.3
  • 27
    • 84865161494 scopus 로고    scopus 로고
    • Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury
    • Qu WS, Tian DS, Guo ZB, et al: Inhibition of EGFR/MAPK signaling reduces microglial inflammatory response and the associated secondary damage in rats after spinal cord injury. J Neuroinflammation 23: 178, 2012.
    • (2012) J Neuroinflammation , vol.23 , pp. 178
    • Qu, W.S.1    Tian, D.S.2    Guo, Z.B.3
  • 29
    • 63849265332 scopus 로고    scopus 로고
    • Phase II trial of sorafenib in metastatic thyroid cancer
    • Kloos RT, Ringel MD, Knopp MV, et al: Phase II trial of sorafenib in metastatic thyroid cancer. J Clin Oncol 27: 1675-1684, 2009.
    • (2009) J Clin Oncol , vol.27 , pp. 1675-1684
    • Kloos, R.T.1    Ringel, M.D.2    Knopp, M.V.3
  • 30
    • 56349119753 scopus 로고    scopus 로고
    • Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals
    • Cruz CD, Charrua A, Vieira E, Valente J, Avelino A and Cruz F: Intrathecal delivery of resiniferatoxin (RTX) reduces detrusor overactivity and spinal expression of TRPV1 in spinal cord injured animals. Exp Neurol 214: 301-308, 2008.
    • (2008) Exp Neurol , vol.214 , pp. 301-308
    • Cruz, C.D.1    Charrua, A.2    Vieira, E.3    Valente, J.4    Avelino, A.5    Cruz, F.6
  • 32
    • 0032750920 scopus 로고    scopus 로고
    • Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: Insight into mechanisms and implications for cancer growth and ulcer healing
    • Jones MK, Wang H, Peskar BM, et al: Inhibition of angiogenesis by nonsteroidal anti-inflammatory drugs: insight into mechanisms and implications for cancer growth and ulcer healing. Nat Med 5: 1418-1423, 1999.
    • (1999) Nat Med , vol.5 , pp. 1418-1423
    • Jones, M.K.1    Wang, H.2    Peskar, B.M.3
  • 33
    • 14044252008 scopus 로고    scopus 로고
    • ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model
    • Zhuang ZY, Gerner P, Woolf CJ and Ji RR: ERK is sequentially activated in neurons, microglia, and astrocytes by spinal nerve ligation and contributes to mechanical allodynia in this neuropathic pain model. Pain 114: 149-159, 2005.
    • (2005) Pain , vol.114 , pp. 149-159
    • Zhuang, Z.Y.1    Gerner, P.2    Woolf, C.J.3    Ji, R.R.4
  • 34
    • 7944223409 scopus 로고    scopus 로고
    • Astrocyte intermediate filaments in CNS pathologies and regeneration
    • Pekny M and Pekna M: Astrocyte intermediate filaments in CNS pathologies and regeneration. J Pathol 204:428-437, 2004.
    • (2004) J Pathol , vol.204 , pp. 428-437
    • Pekny, M.1    Pekna, M.2
  • 35
    • 0019728990 scopus 로고    scopus 로고
    • Vimentin, the 57000 molecular weight protein of fibroblast filaments, is the major cytoskeletal component in immature glia
    • Dahl D, Ruegger DC, Bignami A, et al: Vimentin, the 57000 molecular weight protein of fibroblast filaments, is the major cytoskeletal component in immature glia. Eur J Cell Biol 24: 191-196, 1998.
    • (1998) Eur J Cell Biol , vol.24 , pp. 191-196
    • Dahl, D.1    Ruegger, D.C.2    Bignami, A.3
  • 36
    • 41149087320 scopus 로고    scopus 로고
    • Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury
    • Genonvese T, Esposito E, Mazzon E, et al: Evidence for the role of mitogen-activated protein kinase signaling pathways in the development of spinal cord injury. J Pharmacol Exp Ther 325: 100-114, 2008.
    • (2008) J Pharmacol Exp Ther , vol.325 , pp. 100-114
    • Genonvese, T.1    Esposito, E.2    Mazzon, E.3
  • 37
    • 20444386209 scopus 로고    scopus 로고
    • Ceramide induces neuronal apeptosis through mitogen-activated protein kinases and causes release of multiape mitochondrial proteins
    • Stoica BA, Movsesyan VA, Knoblach SM and Faden AI: Ceramide induces neuronal apeptosis through mitogen-activated protein kinases and causes release of multiape mitochondrial proteins. Mol Cell Neurosci 29: 355-371, 2005.
    • (2005) Mol Cell Neurosci , vol.29 , pp. 355-371
    • Stoica, B.A.1    Movsesyan, V.A.2    Knoblach, S.M.3    Faden, A.I.4
  • 38
    • 33749257099 scopus 로고    scopus 로고
    • ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury
    • Xu Z, Wang BR, Wang X, Kuang F, Duan XL and Jiao XY: ERK1/2 and p38 mitogen-activated protein kinase mediate iNOS-induced spinal neuron degeneration after acute traumatic spinal cord injury. Life Sci 79: 1895-1905, 2006.
    • (2006) Life Sci , vol.79 , pp. 1895-1905
    • Xu, Z.1    Wang, B.R.2    Wang, X.3    Kuang, F.4    Duan, X.L.5    Jiao, X.Y.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.