The glial scar-monocyte interplay: A pivotal resolution phase in spinal cord repair

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Shechter, Ravid ^a   Raposo, Catarina ^a   London, Anat ^a   Sagi, Irit ^a   Schwartz, Michal ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE 3; DIPHTHERIA TOXIN; PROTEOCHONDROITIN SULFATE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL INFILTRATION; CELL INTERACTION; CELL POPULATION; CELL REGENERATION; CONTROLLED STUDY; EXTRACELLULAR MATRIX; FEEDBACK SYSTEM; GLIA CELL; GLIA SCAR MATRIX; IN VITRO STUDY; MONOCYTE; MOUSE; NERVE CELL INHIBITION; NERVE FIBER GROWTH; NONHUMAN; PHENOTYPE; POLARIZATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCAR FORMATION; SPINAL CORD INJURY; SPINAL CORD REGENERATION; ANIMAL; BIOSYNTHESIS; GLIA; IMMUNOLOGY; INFLAMMATION; MACROPHAGE; MALE; METABOLISM; PATHOLOGY; PATHOPHYSIOLOGY; SCAR;

ANIMALS; CHONDROITIN SULFATE PROTEOGLYCANS; CICATRIX; INFLAMMATION; MACROPHAGES; MALE; MATRIX METALLOPROTEINASE 13; MICE; MONOCYTES; NEUROGLIA; PHENOTYPE; SPINAL CORD INJURIES; SPINAL CORD REGENERATION;

EID: 83755174410     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0027969     Document Type: Article

References (39)

1. Block ML, Zecca L, Hong JS, (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8: 57-69.
2. Popovich PG, Guan Z, Wei P, Huitinga I, van Rooijen N, et al. (1999) Depletion of hematogenous macrophages promotes partial hindlimb recovery and neuroanatomical repair after experimental spinal cord injury. Exp Neurol 158: 351-365.
3. Silver J, Miller JH, (2004) Regeneration beyond the glial scar. Nat Rev Neurosci 5: 146-156.
4. Luo Y, Raper JA, (1994) Inhibitory factors controlling growth cone motility and guidance. Curr Opin Neurobiol 4: 648-654.
5. Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, et al. (2002) Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 416: 636-640.
6. Moon LD, Asher RA, Rhodes KE, Fawcett JW, (2001) Regeneration of CNS axons back to their target following treatment of adult rat brain with chondroitinase ABC. Nat Neurosci 4: 465-466.
7. Baptiste DC, Fehlings MG, (2007) Update on the treatment of spinal cord injury. Prog Brain Res 161: 217-233.
8. Rolls A, Shechter R, Schwartz M, (2009) The bright side of the glial scar in CNS repair. Nat Rev Neurosci 10: 235-241.
9. Rolls A, Shechter R, London A, Segev Y, Jacob-Hirsch J, et al. (2008) Two faces of chondroitin sulfate proteoglycan in spinal cord repair: a role in microglia/macrophage activation. PLoS Med 5: e171.
10. Ma M, Wei T, Boring L, Charo IF, Ransohoff RM, et al. (2002) Monocyte recruitment and myelin removal are delayed following spinal cord injury in mice with CCR2 chemokine receptor deletion. J Neurosci Res 68: 691-702.
11. Kigerl KA, Gensel JC, Ankeny DP, Alexander JK, Donnelly DJ, et al. (2009) Identification of two distinct macrophage subsets with divergent effects causing either neurotoxicity or regeneration in the injured mouse spinal cord. J Neurosci 29: 13435-13444.
12. Barrette B, Hebert MA, Filali M, Lafortune K, Vallieres N, et al. (2008) Requirement of myeloid cells for axon regeneration. J Neurosci 28: 9363-9376.
13. Stirling DP, Liu S, Kubes P, Yong VW, (2009) Depletion of Ly6G/Gr-1 leukocytes after spinal cord injury in mice alters wound healing and worsens neurological outcome. J Neurosci 29: 753-764.
14. Shechter R, London A, Varol C, Raposo C, Cusimano M, et al. (2009) Infiltrating blood-derived macrophages are vital cells playing an anti-inflammatory role in recovery from spinal cord injury in mice. PLoS Med 6: e1000113.
15. Rapalino O, Lazarov-Spiegler O, Agranov E, Velan GJ, Yoles E, et al. (1998) Implantation of stimulated homologous macrophages results in partial recovery of paraplegic rats. Nat Med 4: 814-821.
16. Gordon S, (2003) Alternative activation of macrophages. Nat Rev Immunol 3: 23-35.
17. Mosser DM, Edwards JP, (2008) Exploring the full spectrum of macrophage activation. Nat Rev Immunol 8: 958-969.
18. Arnold L, Henry A, Poron F, Baba-Amer Y, van Rooijen N, et al. (2007) Inflammatory monocytes recruited after skeletal muscle injury switch into antiinflammatory macrophages to support myogenesis. J Exp Med 204: 1057-1069.
19. Nahrendorf M, Swirski FK, Aikawa E, Stangenberg L, Wurdinger T, et al. (2007) The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med 204: 3037-3047.
20. Qian BZ, Pollard JW, (2010) Macrophage diversity enhances tumor progression and metastasis. Cell 141: 39-51.
21. Donnelly DJ, Popovich PG, (2008) Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. Exp Neurol 209: 378-388.
22. Gordon S, Taylor PR, (2005) Monocyte and macrophage heterogeneity. Nat Rev Immunol 5: 953-964.
23. Sorokin L, (2010) The impact of the extracellular matrix on inflammation. Nat Rev Immunol 10: 712-723.
24. Sofroniew MV, (2009) Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci 32: 638-647.
25. Simard AR, Soulet D, Gowing G, Julien JP, Rivest S, (2006) Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49: 489-502.
26. Jung S, Aliberti J, Graemmel P, Sunshine MJ, Kreutzberg GW, et al. (2000) Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion. Mol Cell Biol 20: 4106-4114.
27. Mildner A, Schmidt H, Nitsche M, Merkler D, Hanisch UK, et al. (2007) Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions. Nat Neurosci 10: 1544-1553.
28. Rosamond S, Brown L, Gomez C, Braciale TJ, Schwartz BD, (1987) Xyloside inhibits synthesis of the class II-associated chondroitin sulfate proteoglycan and antigen presentation events. J Immunol 139: 1946-1951.
29. Boven LA, Van Meurs M, Van Zwam M, Wierenga-Wolf A, Hintzen RQ, et al. (2006) Myelin-laden macrophages are anti-inflammatory, consistent with foam cells in multiple sclerosis. Brain 129: 517-526.
30. Sun X, Wang X, Chen T, Li T, Cao K, et al. (2010) Myelin activates FAK/Akt/NF-kappaB pathways and provokes CR3-dependent inflammatory response in murine system. PLoS One 5: e9380.
31. Vallieres N, Berard JL, David S, Lacroix S, (2006) Systemic injections of lipopolysaccharide accelerates myelin phagocytosis during Wallerian degeneration in the injured mouse spinal cord. Glia 53: 103-113.
32. Fallowfield JA, Mizuno M, Kendall TJ, Constandinou CM, Benyon RC, et al. (2007) Scar-associated macrophages are a major source of hepatic matrix metalloproteinase-13 and facilitate the resolution of murine hepatic fibrosis. J Immunol 178: 5288-5295.
33. Yiu G, He Z, (2006) Glial inhibition of CNS axon regeneration. Nat Rev Neurosci 7: 617-627.
34. Jung S, Unutmaz D, Wong P, Sano G, De los Santos K, et al. (2002) In vivo depletion of CD11c(+) dendritic cells abrogates priming of CD8(+) T cells by exogenous cell-associated antigens. Immunity 17: 211-220.
35. Inada M, Wang Y, Byrne MH, Rahman MU, Miyaura C, et al. (2004) Critical roles for collagenase-3 (Mmp13) in development of growth plate cartilage and in endochondral ossification. Proc Natl Acad Sci U S A 101: 17192-17197.
36. Basso DM, Fisher LC, Anderson AJ, Jakeman LB, McTigue DM, et al. (2006) Basso Mouse Scale for locomotion detects differences in recovery after spinal cord injury in five common mouse strains. J Neurotrauma 23: 635-659.
37. Bush TG, Puvanachandra N, Horner CH, Polito A, Ostenfeld T, et al. (1999) Leukocyte infiltration, neuronal degeneration, and neurite outgrowth after ablation of scar-forming, reactive astrocytes in adult transgenic mice. Neuron 23: 297-308.
38. Okada S, Nakamura M, Katoh H, Miyao T, Shimazaki T, et al. (2006) Conditional ablation of Stat3 or Socs3 discloses a dual role for reactive astrocytes after spinal cord injury. Nat Med 12: 829-834.
39. Varol C, Landsman L, Fogg DK, Greenshtein L, Gildor B, et al. (2007) Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J Exp Med 204: 171-180.