Alcohols are inhibitors of Saccharomyces cerevisiae multidrug-resistance pumps Pdr5p and Snq2p

FEMS Yeast Research

Volumn 13, Issue 8, 2013, Pages 782-795

  Gášková, Dana ^a   Plášek, Jaromír ^a   Zahumenský, Jakub ^a   Benešová, Ivana ^a   Buriánková, Ľuboslava ^a   Sigler, Karel ^b  

^a CHARLES UNIVERSITY   (Czech Republic)

^b INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

Alcohols; Fluorescent probe diS C3(3); Membrane potential; Pump inhibitor; Yeast MDR pump

Indexed keywords

ALCOHOL; COMPLEMENT COMPONENT C3; HEXANOL; LIPID; MULTIDRUG RESISTANCE PROTEIN; PDR5P PROTEIN; PROPANOL; SNQ2P PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CHEMICAL STRUCTURE; COMPETITIVE INHIBITION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; GENE MUTATION; NONHUMAN; SACCHAROMYCES CEREVISIAE; YEAST CELL;

ANIMALIA; SACCHAROMYCES CEREVISIAE;

ALCOHOLS; FLUORESCENT PROBE DIS-C3(3); MEMBRANE POTENTIAL; PUMP INHIBITOR; YEAST MDR PUMP;

ADENOSINE TRIPHOSPHATE; ALCOHOLS; ATP-BINDING CASSETTE TRANSPORTERS; CELL MEMBRANE PERMEABILITY; DRUG RESISTANCE, FUNGAL; IONS; MICROBIAL SENSITIVITY TESTS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS;

EID: 84887617077     PISSN: 15671356     EISSN: 15671364     Source Type: Journal    
DOI: 10.1111/1567-1364.12088     Document Type: Article

References (52)

1. Adey G, Wardleysmith B & White D (1975) Mechanism of inhibition of bacterial luciferase by anaesthetics. Life Sci 17: 1849-1854.
2. Alkire MT & Gorski LA (2004) Relative amnesic potency of five inhalational anesthetics follows the Meyer-Overton rule. Anesthesiology 101: 417-429.
3. Balzi E & Goffeau A (1994) Genetics and biochemistry of yeast multidrug resistance. Biochim Biophys Acta 1187: 152-162.
4. Bennis S, Chami F, Chami N, Bouchikhi T & Remmal A (2004) Surface alteration of Saccharomyces cerevisiae induced by thymol and eugenol. Lett Appl Microbiol 38: 454-458.
5. Borst-Pauwels GWFH (1981) Ion transport in yeast. Biochim Biophys Acta 650: 88-127.
6. Cadek R, Chladkova K, Sigler K & Gaskova D (2004) Impact of the growth phase on the activity of multidrug-resistance pumps and membrane potential of S. cerevisiae: effect of pump overproduction and carbon source. Biochim Biophys Acta 1665: 111-117.
7. Cartwright CP, Juroszek JR, Beavan MJ, Ruby FMS, Demorais SMF & Rose AH (1986) Ethanol dissipates the proton-motive force across the plasma membrane of Saccharomyces cerevisiae. J Gen Microbiol 132: 369-377.
8. Carvajal E, van den Hazel HB, Cybularz-Kolaczkowska A, Balzi E & Goffeau A (1997) Molecular and phenotypic characterization of yeast PDR1 mutants that show hyperactive transcription of various ABC multidrug transporter genes. Mol Gen Genet 256: 406-415.
9. Casal M, Cardoso H & Leao C (1998) Effects of ethanol and other alkanols on transport of acetic acid in Saccharomyces cerevisiae. Appl Environ Microbiol 64: 665-668.
10. Chanson M, Bruzzone R, Bosco D & Meda P (1989) Effects of n-alcohols on junctional coupling and amylase secretion of pancreatic acinar cells. J Cell Physiol 139: 147-156.
11. Decottignies A & Goffeau A (1997) Complete inventory of the yeast ABC proteins. Nat Genet 15: 137-145.
12. Decottignies A, Grant AM, Nichols JW, de Wet H, McIntosh DB & Goffeau A (1998) ATPase and multidrug transport activities of the overexpressed yeast ABC protein Yor1p. J Biol Chem 273: 12612-12622.
13. 3(3) fluorescence. Folia Microbiol 42: 221-224.
14. +-ATPase in mutants of the yeast Saccharomyces cerevisiae affected in cAMP metabolism, cAMP-dependent protein phosphorylation and the initiation of glycolysis. Biochim Biophys Acta 1136: 57-67.
15. Ernst R, Klemm R, Schmitt L & Kuchler K (2005) Yeast ATP-binding cassette transporters: cellular cleaning pumps. Methods Enzymol 400: 460-484.
16. Franks NP & Lieb WR (1978) Where do general anaesthetics act? Nature 274: 339-342.
17. Franks NP & Lieb WR (1984) Do general anaesthetics act by competitive binding to specific receptors? Nature 310: 599-601.
18. Franks NP & Lieb WR (1985) Mapping of general anaesthetic target sites provides a molecular basis for cutoff effects. Nature 316: 349-351.
19. 3(3) assay in Saccharomyces cerevisiae. Yeast 14: 1189-1197.
20. 3(3) assay. Int J Biochem Cell Biol 31: 575-584.
21. 3(3) in yeast. BBA-Biomembranes 1511: 74-79.
22. 3(3) fluorescence. Int J Biochem Cell Biol 34: 931-937.
23. Godden EL, Harris RA & Dunwiddie TV (2001) Correlation between molecular volume and effects of n-alcohols on human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes. J Pharmacol Exp Ther 296: 716-722.
24. Goldstein DB (1984) The effects of drugs on membrane fluidity. Annu Rev Pharmacol 24: 43-64.
25. Hamada H, Ishiguro H, Yamamoto A et al. (2005) Dual effects of n-alcohols on fluid secretion from guinea pig pancreatic ducts. Am J Physiol-Cell Physiol 288: C1431-C1439.
26. Hendrych T, Kodedová M, Sigler K & Gášková D (2009) Characterization of the kinetics and mechanisms of inhibition of drugs interacting with the S. cerevisiae multidrug resistance pumps Pdr5p and Snq2p. BBA-Biomembranes 1788: 717-723.
27. Horishita T & Harris RA (2008) n-alcohols inhibit voltage-gated Na+ channels expressed in Xenopus oocytes. J Pharmacol Exp Ther 326: 270-277.
28. Hübner NO, Siebert J & Kramer A (2010) Octenidine dihydrochloride, a modern antiseptic for skin, mucous membranes and wounds. Skin Pharmacol Physiol 23: 244-258.
29. Ingram LO & Buttke TM (1984) Effects of alcohols on microorganisms. Adv Microb Physiol 25: 253-300.
30. Kodedova M, Sigler K, Lemire BD & Gaskova D (2011) Fluorescence method for determining the mechanism and speed of action of surface-active drugs on yeast cells. Biotechniques 50: 58-63.
31. Kolaczkowska A & Goffeau A (1999) Regulation of pleiotropic drug resistance in yeast. Drug Resist Updat 6: 403-414.
32. Kolaczkowski M, van den Rest M, Cybular-Kolaczkowska A, Soumillion JP, Konings WN & Goffeau A (1996) Anticancer drugs, ionophoric peptides and steroids as substrates of the yeast multidrug transporter Pdr5p. J Biol Chem 271: 31543-31548.
33. Kolaczkowski M, Kolaczkowska A, Luczynski J, Witek S & Goffeau A (1998) In vivo characterization of the drug resistance profile of the major ABC transporters and other components of the yeast pleiotropic drug resistance network. Microb Drug Resist 4: 143-158.
34. Korpi ER, Makela R & Uusi-Oukari M (1998) Ethanol: novel actions on nerve cell physiology explain impaired functions. News Physiol Sci 13: 164-170.
35. Leao C & van Uden N (1982) Effects of ethanol and other alkanols on the glucose transport system of Saccharomyces cerevisiae. Biotechnol Bioeng 24: 2601-2604.
36. Leao C & van Uden N (1983) Effects of ethanol and other alkanols on the ammonium transport system of Saccharomyces cerevisiae. Biotechnol Bioeng 25: 2085-2090.
37. Leao C & van Uden N (1984a) Effects of ethanol and other alkanols on the general amino acid permease of Saccharomyces cerevisiae. Biotechnol Bioeng 26: 403-405.
38. Leao C & van Uden N (1984b) Effects of ethanol and other alkanols on passive proton influx in the yeast Saccharomyces cerevisiae. Biochim Biophys Acta 774: 43-48.
39. Li CY, Peoples RW & Weight FF (1994) Alcohol action on a neuronal membrane receptor: evidence for a direct interaction with the receptor protein. P Natl Acad Sci USA 91: 8200-8204.
40. Li CY, Peoples RW & Weight FF (1998) Ethanol-induced inhibition of a neuronal P2X purinoceptor by an allosteric mechanism. Br J Pharmacol 123: 1-3.
41. Lovinger DM (1997) Alcohols and neurotransmitter gated ion channels: past, present and future. Naunyn Schmiedebergs Arch Pharmacol 356: 267-282.
42. Lundbaek JA (2008) Lipid bilayer-mediated regulation of ion channel function by amphiphilic drugs. J Gen Physiol 131: 421-429.
43. Maresova L, Muend S, Zhang YQ, Sychrova H & Rao R (2009) Membrane hyperpolarization drives cation influx and fungicidal activity of amiodarone. J Biol Chem 284: 2795-2802.
44. Moykkynen T & Korpi ER (2012) Acute effects of ethanol on glutamate receptors. Basic Clin Pharmacol 111: 4-13.
45. Nawrocki A, Fey SJ, Goffeau A, Roepstorff P & Larsen PM (2001) The effects of transcription regulating genes PDR1, pdr1-3 and PDR3 in pleiotropic drug resistance. Proteomics 1: 1022-1032. Erratum in: Proteomics 1:1340-1341.
46. Peoples RW, Li CY & Weight FF (1996) Lipid vs protein theories of alcohol action in the nervous system. Annu Rev Pharmacol 36: 185-201.
47. Petrov VV & Okorokov LA (1990) Increase in the anion and proton permeability of Saccharomyces carlsbergensis plasmalemma by normal alcohols as a possible cause of its deenergization. Yeast 6: 311-318.
48. Pringle MJ, Brown KB & Miller KW (1981) Can the lipid theories of anesthesia account for the cutoff in anesthetic potency in homologous series of alcohols? Mol Pharmacol 19: 49-55.
49. Rogers B, Decottignies A, Kolaczkowski M, Carvajal E, Balzi E & Goffeau A (2001) The pleiotropic drug ABC transporters from Saccharomyces cerevisiae. J Mol Microbiol Biotechnol 3: 207-214.
50. Seeman P (1972) The membrane actions of anesthetics and tranquilizers. Pharmacol Rev 24: 583-655.
51. Serrano R (1977) Energy requirements for maltose transport in yeast. Eur J Biochem 80: 97-102.
52. Witek S, Goffeau A, Nader J, Luczynski J, Lachowicz TM, Kuta B & Oblak E (1997) Lysosomotropic aminoesters act as H+-ATPase inhibitors in yeast. Folia Microbiol 42: 252-254.