Membrane hyperpolarization drives cation influx and fungicidal activity of amiodarone

Journal of Biological Chemistry

Volumn 284, Issue 5, 2009, Pages 2795-2802

  Maresova, Lydie ^a   Muend, Sabina ^b   Zhang, Yong Qiang ^b   Sychrova, Hana ^a   Rao, Rajini ^a,b  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINITY; BIOLOGICAL MEMBRANES; CALCIUM; CELL DEATH; CELL GROWTH; DRUG INTERACTIONS; GLUCOSE; KETONES; LIGHT METALS; MEMBRANES; METAL RECOVERY; POLARIZATION; POSITIVE IONS; TOXICITY; YEAST;

ACTIVE COMPOUNDS; ALKALI METAL CATIONS; AMIODARONE; AMPHIPATHIC; ANTI-FUNGAL ACTIVITIES; BIOLOGICAL EFFECTS; CELL ELONGATIONS; CELLULAR HOMEOSTASIS; DOSE DEPENDENTS; FUNGICIDAL ACTIVITIES; HYPERPOLARIZATION; IN CELLS; IN PLANTS; LIPID MEMBRANES; LOW CONCENTRATIONS; MEMBRANE POLARIZATIONS; MEMBRANE POTENTIALS; PH DEPENDENTS; POLLEN TUBES; SACCHAROMYCES CEREVISIAE; SELECTIVE AGENTS; TOXIC LEVELS;

CELL MEMBRANES;

AMIODARONE; CALCIUM CHANNEL; CALCIUM ION; FUNGAL PROTEIN; GLUCOSE; METAL ION; PROTEIN TOK1; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; UNCLASSIFIED DRUG;

ARTICLE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG MECHANISM; FUNGAL STRAIN; FUNGICIDAL ACTIVITY; HYPERPOLARIZATION; NONHUMAN; PRIORITY JOURNAL;

AMIODARONE; FLUORESCENCE; HUMANS; IMMUNOPRECIPITATION; ION TRANSPORT; MEMBRANE PROTEINS; SACCHAROMYCES CEREVISIAE;

SACCHAROMYCES CEREVISIAE;

EID: 59149090186     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M806693200     Document Type: Article

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