Pro-apoptotic TP53 homolog TAp63 is repressed via epigenetic silencing and B-cell receptor signalling in chronic lymphocytic leukaemia

British Journal of Haematology

Volumn 163, Issue 5, 2013, Pages 590-602

  Humphries, Leigh A ^a   Godbersen, J Claire ^a   Danilova, Olga V ^a   Kaur, Prabhjot ^a   Christensen, Brock C ^b   Danilov, Alexey V ^a  

^a DARTMOUTH HITCHCOCK MEDICAL CENTER   (United States)

^b DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

B cell receptor; Chronic lymphocytic leukaemia; Methylation; TP63

Indexed keywords

B LYMPHOCYTE RECEPTOR; MESSENGER RNA; ONCOPROTEIN; PROTEIN BAX; PROTEIN NOXA; PROTEIN TP63; PUMA PROTEIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ARTICLE; BAX GENE; BBC3 GENE; CANCER CELL DESTRUCTION; CELL PROLIFERATION; CELL SURVIVAL; CHEMOSENSITIVITY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; DOWN REGULATION; EPIGENETICS; GENE; GENE EXPRESSION; GENE REPRESSION; GENE SILENCING; GENETIC VARIABILITY; HUMAN; HUMAN CELL; LYMPHOMA CELL LINE; MAJOR CLINICAL STUDY; PMAIP1 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAJI CELL; RNA METHYLATION; SIGNAL TRANSDUCTION; TAP63 ALPHA GENE; TP63 GENE; UPREGULATION;

B-CELL RECEPTOR; CHRONIC LYMPHOCYTIC LEUKAEMIA; METHYLATION; TP63;

ALTERNATIVE SPLICING; ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CELL LINE, TUMOR; DNA METHYLATION; DRUG RESISTANCE, NEOPLASM; EPIGENETIC REPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; IMMUNOGLOBULIN HEAVY CHAINS; IMMUNOGLOBULIN VARIABLE REGION; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOMA, B-CELL; MICE; MICRORNAS; MOLECULAR TARGETED THERAPY; NEOPLASM PROTEINS; PROMOTER REGIONS, GENETIC; RECEPTORS, ANTIGEN, B-CELL; RNA, MESSENGER; RNA, NEOPLASM; RNA, SMALL INTERFERING; STROMAL CELLS; TRANSCRIPTION FACTORS; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

EID: 84887611978     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/bjh.12580     Document Type: Article

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