Separation and identification of underivatized plasma acylcarnitine isomers using liquid chromatography-tandem mass spectrometry for the differential diagnosis of organic acidemias and fatty acid oxidation defects

Journal of Chromatography A

Volumn 1319, Issue , 2013, Pages 97-106

  Peng, Minzhi ^a   Fang, Xiefan ^b   Huang, Yonglan ^a   Cai, Yanna ^a   Liang, Cuili ^a   Lin, Ruizhu ^a   Liu, Li ^a  

^a Guangzhou Women and Children's Medical Center   (China)

^b UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

Acylcarnitine; LC MS MS; Plasma; Product ion spectrum; Stereoisomer

Indexed keywords

ACYLCARNITINE; INFORMATION-DEPENDENT ACQUISITIONS; LC-MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; PRODUCT ION SPECTRA; SEPARATION AND IDENTIFICATION; STEREOISOMER; TRIPLE QUADRUPOLE LINEAR ION TRAP MASS SPECTROMETRIES;

DEFECTS; DIAGNOSIS; FATTY ACIDS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMAS; SEPARATION; STEREOCHEMISTRY;

ISOMERS;

2 METHYL 3 HYDROXYBUTYRYLCARNITINE; FATTY ACID ESTER; GLUTARYLCARNITINE; HYDROXYHEXANOYLCARNITINE; METHYLMALONYLCARNITINE; UNCLASSIFIED DRUG; UNDERIVATIZED ACYLCARNITINE ISOMER;

ACIDEMIA; ADOLESCENT; ARTICLE; BETA KETOTHIOLASE DEFICIENCY; BLOOD SAMPLING; CALIBRATION; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIFFERENTIAL DIAGNOSIS; DISORDERS OF CARBOHYDRATE METABOLISM; DISORDERS OF LIPID AND LIPOPROTEIN METABOLISM; ENZYME ASSAY; FALSE POSITIVE RESULT; FATTY ACID OXIDATION DEFECT; GENOTYPE; GLUTARIC ACIDEMIA TYPE I; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH RISK PATIENT; HUMAN; INFANT; ION TRAP MASS SPECTROMETRY; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MAJOR CLINICAL STUDY; METHYLMALONIC ACIDEMIA; MULTIPLE ACYL COA DEHYDROGENASE DEFICIENCY; PRIORITY JOURNAL; PROCESS DEVELOPMENT; PROPIONIC ACIDEMIA; REFERENCE VALUE; REVERSED PHASE LIQUID CHROMATOGRAPHY; SEPARATION TECHNIQUE; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; VALIDATION STUDY;

ACYLCARNITINE; LC-MS/MS; PLASMA; PRODUCT ION SPECTRUM; STEREOISOMER;

CARNITINE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIAGNOSIS, DIFFERENTIAL; FATTY ACIDS; HUMANS; ISOMERISM; METABOLISM, INBORN ERRORS; OXIDATION-REDUCTION; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84887609917     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2013.10.036     Document Type: Article

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