Stereoselective quantitation of a serine protease inhibitor using LC-MS/MS at elevated column temperature

Journal of Separation Science

Volumn 31, Issue 2, 2008, Pages 242-254

  Shen, Jim X ^a   Merka, Eric A ^a   Dreyer, Daniel P ^a   Clement, Robert P ^a   Hayes, Roger N ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

High temperature HPLC; Ion pairing; LC MS; MS; Quantitation

Indexed keywords

DIASTEREOMERS; ION PAIRING; STEREOSELECTIVE QUANTITATION;

BIOASSAY; ENZYME INHIBITION; MASS SPECTROMETRY; PLASMA (HUMAN); SEPARATION; STEREOSELECTIVITY; TEMPERATURE DISTRIBUTION;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; N [3 AMINO 1 (CYCLOBUTYLMETHYL) 2,3 DIOXOPROPYL] 3 [2 (3 TERT BUTYLUREIDO) 3,3 DIMETHYL 1 OXOBUTYL] 6,6 DIMETHYL 3 AZABICYCLO[3.1.0]HEXANE 2 CARBOXAMIDE; N [3 AMINO 1 (CYCLOBUTYLMETHYL) 2,3 DIOXOPROPYL] 3 [2 [[[(1,1 DIMETHYLETHYL)AMINO]CARBONYL]AMINO] 3,3 DIMETHYL 1 OXOBUTYL] 6,6 DIMETHYL 3 AZABICYCLO[3.1.0]HEXAN 2 CARBOXAMIDE; REAGENT; SCH 534128; SCH 534129; SERINE PROTEINASE INHIBITOR; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIASTEREOISOMER; DRUG STRUCTURE; HUMAN; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA; PRIORITY JOURNAL; QUALITY CONTROL; QUANTITATIVE ANALYSIS; SENSITIVITY ANALYSIS; SEPARATION TECHNIQUE; STEREOCHEMISTRY; TEMPERATURE; VALIDATION PROCESS;

CHROMATOGRAPHY, LIQUID; HYDROGEN-ION CONCENTRATION; INDICATORS AND REAGENTS; REFERENCE STANDARDS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; SERINE PROTEINASE INHIBITORS; STEREOISOMERISM; TANDEM MASS SPECTROMETRY; TEMPERATURE;

EID: 39549098908     PISSN: 16159306     EISSN: 16159314     Source Type: Journal    
DOI: 10.1002/jssc.200700401     Document Type: Article

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