A rapid UPLC-MS/MS method for simultaneous separation of 48 acylcarnitines in dried blood spots and plasma useful as a second-tier test for expanded newborn screening

Analytical and Bioanalytical Chemistry

Volumn 404, Issue 3, 2012, Pages 741-751

  Gucciardi, Antonina ^a   Pirillo, Paola ^a   Di Gangi, Iole Maria ^a   Naturale, Mauro ^a   Giordano, Giuseppe ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

Acylcarnitines; Mass spectrometry; Metabolic disease; Newborn screening; Secondtier test; Ultraperformance liquid chromatography

Indexed keywords

ACYLCARNITINES; METABOLIC DISEASE; NEWBORN SCREENING; SECONDTIER TEST; ULTRAPERFORMANCE LIQUID CHROMATOGRAPHY;

BLOOD; CHROMATOGRAPHIC ANALYSIS; ELECTROSPRAY IONIZATION; ETHYLENE; ISOMERS; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METABOLISM; PATIENT MONITORING; PLASMAS;

DIAGNOSIS;

ACYLCARNITINE; CARNITINE; DRUG DERIVATIVE;

ARTICLE; BLOOD; CALIBRATION; DRIED BLOOD SPOT TESTING; ELECTROSPRAY MASS SPECTROMETRY; FLOW INJECTION ANALYSIS; HUMAN; INBORN ERROR OF METABOLISM; ISOMERISM; LIMIT OF DETECTION; LIQUID CHROMATOGRAPHY; METABOLISM; METHODOLOGY; NEWBORN; NEWBORN SCREENING; TANDEM MASS SPECTROMETRY;

CALIBRATION; CARNITINE; CHROMATOGRAPHY, LIQUID; DRIED BLOOD SPOT TESTING; FLOW INJECTION ANALYSIS; HUMANS; INFANT, NEWBORN; ISOMERISM; LIMIT OF DETECTION; METABOLISM, INBORN ERRORS; NEONATAL SCREENING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84865475218     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-6194-1     Document Type: Article

References (13)

1. Chace DH, Kalas TA, Naylor EW (2003) Clin Chem 49(11):1797-1817
2. Ferrer I, Ruiz-Sala P, Vicente Y, Merinero B, Perez-Cerda C, Ugarte M (2007) J Chromatogr B Anal Technol Biomed Life Sci 860(1):121-126
3. Minkler PE, Stoll MS, Ingalls ST, Yang S, Kerner J, Hoppel CL (2008) Clin Chem 54(9):1451-1462
4. Maeda Y, Ito T, Suzuki A, Kurono Y, Ueta A, Yokoi K et al (2007) Rapid Commun Mass Spectrom 21(5):799-806
5. Minkler PE, Ingalls ST, Hoppel CL (2005) Anal Chem 77 (5):1448-1457
6. Jauregui O, Sierra AY, Carrasco P, Gratacos E, Hegardt FG, Casals N (2007) Anal Chim Acta 599(1):1-6
7. Vernez L, Wenk M, Krahenbuhl S (2004) Rapid Commun Mass Spectrom 18(11):1233-1238
8. Maeda Y, Ito T, Ohmi H, Yokoi K, Nakajima Y, Ueta A et al (2008) J Chromatogr B Anal Technol Biomed Life Sci 870(2):154-159
9. Horvath TD, Stratton SL, Bogusiewicz A, Pack L, Moran J, Mock DM (2010) Anal Chem 82(10):4140-4444
10. Forni S, Fu X, Palmer SE, Sweetman L (2010) Mol Genet Metab 101(1):25-32
11. Moore T, Le A, Cowan TM(2012) J Inherit Metab Dis 35(3):431-435
12. Ogier De Baulny H, Dionisi-Vici C, Wendel U (2011) In: Saudubray JM, Van Den Berghe G, Walter JH (eds) Inborn metabolic diseases: diagnosis and treatment, 5th edn. Springer, Heidelberg, pp 277-296
13. Vianey-Saban C, Boyer S, Levrat V, Cheillan D, Piraud M, Guffon N, Maire I (2004) J Inherit Metab Dis 27(Suppl 1):94