Inhibition of human alcohol and aldehyde dehydrogenases by acetaminophen: Assessment of the effects on first-pass metabolism of ethanol

Alcohol

Volumn 47, Issue 7, 2013, Pages 559-565

  Lee, Yung Pin ^a   Liao, Jian Tong ^b   Cheng, Ya Wen ^b   Wu, Ting Lun ^b   Lee, Shou Lun ^c   Liu, Jong Kang ^a   Yin, Shih Jiun ^b  

^a NATIONAL SUN YAT SEN UNIVERSITY   (Taiwan)

^b NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Acetaminophen; Alcohol dehydrogenase; Aldehyde dehydrogenase; Ethanol; First pass metabolism of ethanol; Inhibition kinetics; Metabolic interaction

Indexed keywords

ALCOHOL; ALCOHOL DEHYDROGENASE; ALCOHOL DEHYDROGENASE 1A; ALCOHOL DEHYDROGENASE 1B1; ALCOHOL DEHYDROGENASE 1B2; ALCOHOL DEHYDROGENASE 1B3; ALCOHOL DEHYDROGENASE 1C1; ALCOHOL DEHYDROGENASE 1C2; ALCOHOL DEHYDROGENASE 2; ALCOHOL DEHYDROGENASE 3; ALCOHOL DEHYDROGENASE 4; ALDEHYDE DEHYDROGENASE; PARACETAMOL; UNCLASSIFIED DRUG;

ALCOHOL METABOLISM; ALCOHOL OXIDATION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG EFFECT; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME METABOLISM; INHIBITION KINETICS; MOLECULAR DOCKING; MOLECULAR DYNAMICS; PH MEASUREMENT; PROTEIN CONTENT; QUANTITATIVE ANALYSIS;

ACETAMINOPHEN; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ETHANOL; FIRST-PASS METABOLISM OF ETHANOL; INHIBITION KINETICS; METABOLIC INTERACTION;

ACETAMINOPHEN; ALCOHOL DEHYDROGENASE; ALDEHYDE DEHYDROGENASE; ETHANOL; HUMANS; INTESTINE, SMALL; ISOENZYMES; KINETICS; LIVER; METABOLIC DETOXICATION, DRUG; MOLECULAR DOCKING SIMULATION; STOMACH;

EID: 84887609905     PISSN: 07418329     EISSN: 18736823     Source Type: Journal    
DOI: 10.1016/j.alcohol.2013.09.001     Document Type: Article

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