-
1
-
-
34547106018
-
Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets
-
Hideshima T, Mitsiades C, Tonon G, Richardson PG, Anderson KC. Understanding multiple myeloma pathogenesis in the bone marrow to identify new therapeutic targets. Nat Rev Cancer 2007; 7: 585-598.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 585-598
-
-
Hideshima, T.1
Mitsiades, C.2
Tonon, G.3
Richardson, P.G.4
Anderson, K.C.5
-
2
-
-
33751193178
-
Multiple myeloma bone disease: Pathophysiology of osteoblast inhibition
-
Giuliani N, Rizzoli V, Roodman GD. Multiple myeloma bone disease: pathophysiology of osteoblast inhibition. Blood 2006; 108: 3992-3996.
-
(2006)
Blood
, vol.108
, pp. 3992-3996
-
-
Giuliani, N.1
Rizzoli, V.2
Roodman, G.D.3
-
3
-
-
0019350348
-
Relation of osteoclast activating factor production to extent of bone disease in multiple myeloma
-
Durie BGM, Salmon SE, Mundy GR. Relation of osteoclast activating factor production to extent of bone disease in multiple myeloma. Br J Hematol 1981; 47: 21-30.
-
(1981)
Br J Hematol
, vol.47
, pp. 21-30
-
-
Durie, B.G.M.1
Salmon, S.E.2
Mundy, G.R.3
-
4
-
-
0037673933
-
Control of osteoblast function and regulation of bone mass
-
Harada S, Rodan G. Control of osteoblast function and regulation of bone mass. Nature 2003; 423: 349-355.
-
(2003)
Nature
, vol.423
, pp. 349-355
-
-
Harada, S.1
Rodan, G.2
-
5
-
-
5044228112
-
Wnt signaling in osteoblasts and bone diseases
-
Westendorf JJ, Kahler RA, Schroeder TM. Wnt signaling in osteoblasts and bone diseases. Gene 2004; 341: 19-39.
-
(2004)
Gene
, vol.341
, pp. 19-39
-
-
Westendorf, J.J.1
Kahler, R.A.2
Schroeder, T.M.3
-
6
-
-
0346363760
-
The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma
-
Tian E, Zhan F, Walker R, Rasmussen E, Ma Y, Barlogie B et al. The role of the Wnt-signaling antagonist DKK1 in the development of osteolytic lesions in multiple myeloma. N Engl J Med 2003; 349 2483-2494.
-
(2003)
N Engl J Med
, vol.349
, pp. 2483-2494
-
-
Tian, E.1
Zhan, F.2
Walker, R.3
Rasmussen, E.4
Ma, Y.5
Barlogie, B.6
-
7
-
-
33847397091
-
Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo
-
Yaccoby S, Ling W, Zhan F, Walker R, Barlogie B, Shaughnessy Jr JD. Antibody-based inhibition of DKK1 suppresses tumor-induced bone resorption and multiple myeloma growth in vivo. Blood 2007; 109 2106-2111.
-
(2007)
Blood
, vol.109
, pp. 2106-2111
-
-
Yaccoby, S.1
Ling, W.2
Zhan, F.3
Walker, R.4
Barlogie, B.5
Shaughnessy Jr, J.D.6
-
8
-
-
34248394360
-
The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells
-
Colla S, Zhan F, Xiong W, Wu X, Xu H, Stephens O et al. The oxidative stress response regulates DKK1 expression through the JNK signaling cascade in multiple myeloma plasma cells. Blood 2007; 109: 4470-4477.
-
(2007)
Blood
, vol.109
, pp. 4470-4477
-
-
Colla, S.1
Zhan, F.2
Xiong, W.3
Wu, X.4
Xu, H.5
Stephens, O.6
-
9
-
-
34548828781
-
Dickkopf-1 (DKK-1) is a widely expressed and potent tumor-associated antigen in multiple myeloma
-
Qian J, Xie J, Hong S, Yang J, Zhang L, Han X et al. Dickkopf-1 (DKK-1) is a widely expressed and potent tumor-associated antigen in multiple myeloma. Blood 2007; 110: 1587-1594.
-
(2007)
Blood
, vol.110
, pp. 1587-1594
-
-
Qian, J.1
Xie, J.2
Hong, S.3
Yang, J.4
Zhang, L.5
Han, X.6
-
10
-
-
0035664488
-
Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease
-
Choi SJ, Oba Y, Gazitt Y, Alsina M, Cruz J, Anderson J et al. Antisense inhibition of macrophage inflammatory protein 1-alpha blocks bone destruction in a model of myeloma bone disease. J Clin Invest 2001; 108: 1833-1841.
-
(2001)
J Clin Invest
, vol.108
, pp. 1833-1841
-
-
Choi, S.J.1
Oba, Y.2
Gazitt, Y.3
Alsina, M.4
Cruz, J.5
Anderson, J.6
-
11
-
-
0038386032
-
Macrophage inflammatory protein 1-alpha (MIP-1 alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells
-
Lentzsch S, Gries M, Janz M, Bargou R, Dorken B, Mapara MY. Macrophage inflammatory protein 1-alpha (MIP-1 alpha) triggers migration and signaling cascades mediating survival and proliferation in multiple myeloma (MM) cells. Blood 2003; 101: 3568-3573.
-
(2003)
Blood
, vol.101
, pp. 3568-3573
-
-
Lentzsch, S.1
Gries, M.2
Janz, M.3
Bargou, R.4
Dorken, B.5
Mapara, M.Y.6
-
12
-
-
36348988548
-
MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts
-
Vallet S, Raje N, Ishitsuka K, Hideshima T, Podar K, Chhetri S et al MLN3897, a novel CCR1 inhibitor, impairs osteoclastogenesis and inhibits the interaction of multiple myeloma cells and osteoclasts. Blood 2007; 110: 3744-3752.
-
(2007)
Blood
, vol.110
, pp. 3744-3752
-
-
Vallet, S.1
Raje, N.2
Ishitsuka, K.3
Hideshima, T.4
Podar, K.5
Chhetri, S.6
-
13
-
-
33745779502
-
The molecular classification of multiple myeloma
-
Zhan F, Huang Y, Colla S, Stewart JP, Hanamura I, Gupta S et al. The molecular classification of multiple myeloma. Blood 2006; 108: 2020-2028.
-
(2006)
Blood
, vol.108
, pp. 2020-2028
-
-
Zhan, F.1
Huang, Y.2
Colla, S.3
Stewart, J.P.4
Hanamura, I.5
Gupta, S.6
-
14
-
-
34047195753
-
Magnetic resonance imaging in multiple myeloma: Diagnostic and clinical implications
-
Walker R, Barlogie B, Haessler J, Tricot G, Anaissie E, Shaughnessy Jr JD et al. Magnetic resonance imaging in multiple myeloma: diagnostic and clinical implications. J Clin Oncol 2007; 25: 1121-1128.
-
(2007)
J Clin Oncol
, vol.25
, pp. 1121-1128
-
-
Walker, R.1
Barlogie, B.2
Haessler, J.3
Tricot, G.4
Anaissie, E.5
Shaughnessy Jr, J.D.6
-
15
-
-
58149380751
-
Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping
-
Johnson DC, Corthals S, Ramos C, Hoering A, Cocks K, Dickens NJ et al Genetic associations with thalidomide mediated venous thrombotic events in myeloma identified using targeted genotyping. Blood 2008; 112: 4924-4934.
-
(2008)
Blood
, vol.112
, pp. 4924-4934
-
-
Johnson, D.C.1
Corthals, S.2
Ramos, C.3
Hoering, A.4
Cocks, K.5
Dickens, N.J.6
-
16
-
-
52449099461
-
Genomic variation in myeloma: Design, content, and initial application of the bank on a cure SNP panel to analysis of survival
-
pages not specified
-
Van Ness B, Ramos C, Haznadar M, Hoering A, Haessler J, Crowley J et al. Genomic variation in myeloma: Design, content, and initial application of the bank on a cure SNP panel to analysis of survival. BMC Med 2008; 6: 26 [pages not specified].
-
(2008)
BMC Med
, vol.6
, pp. 26
-
-
Van Ness, B.1
Ramos, C.2
Haznadar, M.3
Hoering, A.4
Haessler, J.5
Crowley, J.6
-
17
-
-
70350126347
-
-
Terry MT, Elizabeth J, Atkinson R. An introduction to recursive partitioning using the rpart routines. 1997.Technical report 61, Mayo Clinic. Available at http://mayoresearch.mayo.edu/mayo/research/ biostat/techreports.cfm##R package available at http://cran.r-project.org/src/contrib/Descriptions/rpart.html.
-
Terry MT, Elizabeth J, Atkinson R. An introduction to recursive partitioning using the rpart routines. 1997.Technical report 61, Mayo Clinic. Available at http://mayoresearch.mayo.edu/mayo/research/ biostat/techreports.cfm##R package available at http://cran.r-project.org/src/contrib/Descriptions/rpart.html.
-
-
-
-
19
-
-
0035478854
-
Random forests
-
Breiman L. Random forests. Machine Learning 2001; 45: 5-32.
-
(2001)
Machine Learning
, vol.45
, pp. 5-32
-
-
Breiman, L.1
-
21
-
-
33845382806
-
Nonparametric estimation from incomplete observations
-
Kaplan EL, Meier P. Nonparametric estimation from incomplete observations. J Am Stat Assoc 1958; 53: 457-481.
-
(1958)
J Am Stat Assoc
, vol.53
, pp. 457-481
-
-
Kaplan, E.L.1
Meier, P.2
-
23
-
-
0031004964
-
Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase
-
Moghaddam MF, Grant DF, Cheek JM, Green JF, Williamson KC, Hammock BD. Bioactivation of leukotoxins to their toxic diols by epoxide hydrolase. Nature Med 1997; 3: 562-566.
-
(1997)
Nature Med
, vol.3
, pp. 562-566
-
-
Moghaddam, M.F.1
Grant, D.F.2
Cheek, J.M.3
Green, J.F.4
Williamson, K.C.5
Hammock, B.D.6
-
24
-
-
34248522806
-
Activation of dioxin response element (DRE)-associated genes by benzo (A) pyrene3,6-quinone and benzo (A) pyrene1,6-quinone in MCF-10A human mammary epithelial cells
-
Burchiel SW, Thompson TA, Lauer FT, Oprea TI. Activation of dioxin response element (DRE)-associated genes by benzo (A) pyrene3,6-quinone and benzo (A) pyrene1,6-quinone in MCF-10A human mammary epithelial cells. Toxicol Appl Pharmacol 2007; 221: 203-214.
-
(2007)
Toxicol Appl Pharmacol
, vol.221
, pp. 203-214
-
-
Burchiel, S.W.1
Thompson, T.A.2
Lauer, F.T.3
Oprea, T.I.4
-
25
-
-
33747758320
-
The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes
-
Shi C-S, Huang N-N, Harrison K, Han S-B, Kehrl JH. The mitogen-activated protein kinase kinase kinase kinase GCKR positively regulates canonical and noncanonical Wnt signaling in B lymphocytes. Mol Cell Biol 2006; 26: 6511-6521.
-
(2006)
Mol Cell Biol
, vol.26
, pp. 6511-6521
-
-
Shi, C.-S.1
Huang, N.-N.2
Harrison, K.3
Han, S.-B.4
Kehrl, J.H.5
-
26
-
-
33846026749
-
Wnt/b signaling is a normal physiological response to mechanical loading in bone
-
Robinson JA, Chatterjee-Kishore M, Yaworsky PJ, Cullen DM, ZhaoW LC et al. Wnt/b signaling is a normal physiological response to mechanical loading in bone. J Biol Chem 2006; 281: 31720-31728.
-
(2006)
J Biol Chem
, vol.281
, pp. 31720-31728
-
-
Robinson, J.A.1
Chatterjee-Kishore, M.2
Yaworsky, P.J.3
Cullen, D.M.4
ZhaoW, L.C.5
-
27
-
-
0033557972
-
GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway
-
Shi C-S, Tuscano JM, Witte ON, Kehrl JH. GCKR links the Bcr-Abl oncogene and Ras to the stress-activated protein kinase pathway. Blood 1999; 93: 1338-1345.
-
(1999)
Blood
, vol.93
, pp. 1338-1345
-
-
Shi, C.-S.1
Tuscano, J.M.2
Witte, O.N.3
Kehrl, J.H.4
-
28
-
-
61349192318
-
Thalidomide resistance is based upon the capacity of the glutathione-dependent antioxidant defense
-
Knobloch J, Reimann K, Klotz L-O, Ruther U. Thalidomide resistance is based upon the capacity of the glutathione-dependent antioxidant defense. Mol Pharmaceutics 2008; 5: 1138-1144.
-
(2008)
Mol Pharmaceutics
, vol.5
, pp. 1138-1144
-
-
Knobloch, J.1
Reimann, K.2
Klotz, L.-O.3
Ruther, U.4
-
29
-
-
41949093576
-
Target Wnt signaling in myeloma in vivo; differential effects on tumor burden and myeloma bone disease
-
Edwards CM, Edwards JR, Lwin ST, Mundy GR. Target Wnt signaling in myeloma in vivo; differential effects on tumor burden and myeloma bone disease. Blood 2008; 111: 2833-2842.
-
(2008)
Blood
, vol.111
, pp. 2833-2842
-
-
Edwards, C.M.1
Edwards, J.R.2
Lwin, S.T.3
Mundy, G.R.4
-
30
-
-
44849134456
-
Nuclear GSK-3b inhibits the canonical Wnt signalling pathway in a β-catenin phosphorylation-independent manner
-
Caspi M, Zilberberg A, Eldar-Finkelman H, Rosin-Arbesfeld R. Nuclear GSK-3b inhibits the canonical Wnt signalling pathway in a β-catenin phosphorylation-independent manner. Oncogene 2008; 27: 3546-3555.
-
(2008)
Oncogene
, vol.27
, pp. 3546-3555
-
-
Caspi, M.1
Zilberberg, A.2
Eldar-Finkelman, H.3
Rosin-Arbesfeld, R.4
-
31
-
-
48749101937
-
WNT signalling in the immune system: WNT is spreading its wings
-
Staal FJT, Luis TC, Tiemessen MM. WNT signalling in the immune system: WNT is spreading its wings. Immunology 2008; 8: 581-593.
-
(2008)
Immunology
, vol.8
, pp. 581-593
-
-
Staal, F.J.T.1
Luis, T.C.2
Tiemessen, M.M.3
-
32
-
-
47249140444
-
Myeloma-derived Dixkkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: A potential mechanism underlying osteolytic bone lesions in multiple myeloma
-
Qiang Y-W, Chen Y, Stephens O, Brown N, Chen B, Epstein J et al. Myeloma-derived Dixkkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: A potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood 2008; 112 196-207.
-
(2008)
Blood
, vol.112
, pp. 196-207
-
-
Qiang, Y.-W.1
Chen, Y.2
Stephens, O.3
Brown, N.4
Chen, B.5
Epstein, J.6
-
33
-
-
47649120741
-
Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth
-
Qiang Y-W, Shaughnessy JD, Yaccoby S. Wnt3a signaling within bone inhibits multiple myeloma bone disease and tumor growth. Blood 2008; 112: 374-382.
-
(2008)
Blood
, vol.112
, pp. 374-382
-
-
Qiang, Y.-W.1
Shaughnessy, J.D.2
Yaccoby, S.3
-
34
-
-
61849152472
-
Wnt signaling: Bone's defense against myeloma
-
Edward CM. Wnt signaling: Bone's defense against myeloma. Blood 2008; 112: 216-218.
-
(2008)
Blood
, vol.112
, pp. 216-218
-
-
Edward, C.M.1
-
35
-
-
0034531866
-
Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway
-
Ferlin M, Noraz N, Hertogh C, Brochier J, Taylor N, Klein B. Insulin-like growth factor induces the survival and proliferation of myeloma cells through an interleukin-6-independent transduction pathway. Br J Hematology 2000; 111: 626-634.
-
(2000)
Br J Hematology
, vol.111
, pp. 626-634
-
-
Ferlin, M.1
Noraz, N.2
Hertogh, C.3
Brochier, J.4
Taylor, N.5
Klein, B.6
-
36
-
-
0034667606
-
Insulin-like growth factor 1 is a dual effector of multiple myeloma cell growth
-
Ge N-L, Rudikoff S. Insulin-like growth factor 1 is a dual effector of multiple myeloma cell growth. Blood 2000; 96: 2856-2861.
-
(2000)
Blood
, vol.96
, pp. 2856-2861
-
-
Ge, N.-L.1
Rudikoff, S.2
-
37
-
-
0037158513
-
Activation of NF-kB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma calls: Therapeutic implications
-
Mitsiades CS, Mitsiades N, Poulaki V, Schlossman R, Akivama M, Chauhan D et al. Activation of NF-kB and upregulation of intracellular anti-apoptotic proteins via the IGF-1/Akt signaling in human multiple myeloma calls: Therapeutic implications. Oncogene 2002; 21: 5673-5683.
-
(2002)
Oncogene
, vol.21
, pp. 5673-5683
-
-
Mitsiades, C.S.1
Mitsiades, N.2
Poulaki, V.3
Schlossman, R.4
Akivama, M.5
Chauhan, D.6
-
38
-
-
0037458621
-
Essential role of caveolae in interleukin-6 and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells
-
Podar K, Tai Y-T, Cole CE, Hideshima T, Sattler M, Hamblin A et al Essential role of caveolae in interleukin-6 and insulin-like growth factor I-triggered Akt-1-mediated survival of multiple myeloma cells. J Biol Chem 2003; 278: 5794-5801.
-
(2003)
J Biol Chem
, vol.278
, pp. 5794-5801
-
-
Podar, K.1
Tai, Y.-T.2
Cole, C.E.3
Hideshima, T.4
Sattler, M.5
Hamblin, A.6
-
39
-
-
35748958108
-
Mode of growth hormone action in osteoblasts
-
DiGirolamo DJ, Mukherjee A, Fulzele K, Gan Y, Cao X, Frank SJ et al Mode of growth hormone action in osteoblasts. J Biol Chem 2007; 282: 31666-31674.
-
(2007)
J Biol Chem
, vol.282
, pp. 31666-31674
-
-
DiGirolamo, D.J.1
Mukherjee, A.2
Fulzele, K.3
Gan, Y.4
Cao, X.5
Frank, S.J.6
-
40
-
-
70350100247
-
Kinins-important regulators in inflammation induced bone resorption
-
Dissertation. Department of Oral Cell Biology, Umea University: Umea, Sweden, ISBN 91-7264-195-9
-
Brechter AB. Kinins-important regulators in inflammation induced bone resorption. Umea Univ Odontological Dissertation. Department of Oral Cell Biology, Umea University: Umea, Sweden, 2006 (ISBN 91-7264-195-9).
-
(2006)
Umea Univ Odontological
-
-
Brechter, A.B.1
-
42
-
-
33748659273
-
-
3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: The dubbo osteoporosis epidemiology study (DOES). BMC Med Genet 2006; 7: 57.
-
3-adrenergic receptor gene, body mass index, bone mineral density and fracture risk in elderly men and women: The dubbo osteoporosis epidemiology study (DOES). BMC Med Genet 2006; 7: 57.
-
-
-
-
43
-
-
0027161387
-
Effects of interleukin-4 on human osteoblast-like cells
-
Riancho JA, Zarrabeitia MT, Olmos JM, Amado JA, Gonzalez MJ. Effects of interleukin-4 on human osteoblast-like cells. Bone Miner 1993; 21: 53-61.
-
(1993)
Bone Miner
, vol.21
, pp. 53-61
-
-
Riancho, J.A.1
Zarrabeitia, M.T.2
Olmos, J.M.3
Amado, J.A.4
Gonzalez, M.J.5
-
44
-
-
0033668498
-
RT-PCR amplicons in the plasma of multiple myeloma patients, clinical relevance and molecular pathology
-
Durie BGM, Urnovitz HB, Murphy WH. RT-PCR amplicons in the plasma of multiple myeloma patients, clinical relevance and molecular pathology. Acta Oncologica 2000; 39: 789-796.
-
(2000)
Acta Oncologica
, vol.39
, pp. 789-796
-
-
Durie, B.G.M.1
Urnovitz, H.B.2
Murphy, W.H.3
-
45
-
-
0027935768
-
The human microsomal expoxide hydrolase gene (EPHX1): Complete nucleotide sequence and structural characterization
-
Hassett C, Robinson KB, Beck NB, Omiecinski CJ. The human microsomal expoxide hydrolase gene (EPHX1): Complete nucleotide sequence and structural characterization. Genomics 1994; 23: 433-442.
-
(1994)
Genomics
, vol.23
, pp. 433-442
-
-
Hassett, C.1
Robinson, K.B.2
Beck, N.B.3
Omiecinski, C.J.4
-
46
-
-
0034534035
-
Epoxide hydrolases: Biochemistry and molecular biology
-
Fretland AJ, Omiecinski CJ. Epoxide hydrolases: Biochemistry and molecular biology. Chem Biol Interact 2000; 129: 41-59.
-
(2000)
Chem Biol Interact
, vol.129
, pp. 41-59
-
-
Fretland, A.J.1
Omiecinski, C.J.2
-
47
-
-
0034653356
-
Epoxide hydrolasepolymorphism and role in toxicology
-
Omiecinski CJ, Hassett C, Hosagrahara V. Epoxide hydrolasepolymorphism and role in toxicology. Toxicol Lett 2000; 112-113: 365-370.
-
(2000)
Toxicol Lett
, vol.112-113
, pp. 365-370
-
-
Omiecinski, C.J.1
Hassett, C.2
Hosagrahara, V.3
-
48
-
-
70350115859
-
Large scale evaluation of genetic variation and the risk of multiple myeloma
-
Abstract
-
Berndt SI, Johnson D, Crowley J, Durie BGM, Hoover R, Katz M et al Large scale evaluation of genetic variation and the risk of multiple myeloma. Blood 2008; 112, Abstract # 1679.
-
(2008)
Blood
, vol.112
, Issue.1679
-
-
Berndt, S.I.1
Johnson, D.2
Crowley, J.3
Durie, B.G.M.4
Hoover, R.5
Katz, M.6
|