Effect of the co-occurring olive oil and thyme extracts on the phenolic bioaccesibility and bioavailability assessed by in vitro digestion and cell models

Food Chemistry

Volumn 149, Issue , 2014, Pages 277-284

  Rubió, Laura ^a   Macià, Alba ^a   Castell Auví, Anna ^b   Pinent, Montserrat ^b   Blay, M Teresa ^b   Ardévol, Anna ^b   Romero, Maria Paz ^a   Motilva, Maria José ^a  

^a UNIVERSITY OF LLEIDA   (Spain)

^b UNIVERSITAT ROVIRA I VIRGILI   (Spain)

Author keywords

Caco 2; HepG 2; Metabolism; Olive phenols; Thyme; Transport

Indexed keywords

CACO-2; HEPG-2; OLIVE PHENOLS; THYME; TRANSPORT;

BIOCHEMISTRY; METABOLISM; PHYSIOLOGY;

OLIVE OIL;

ERIODICTYOL; HYDROXYTYROSOL; LUTEOLIN; NARINGENIN; OLIVE OIL; THYME OIL; THYMOL;

ARTICLE; DIGESTION; DRUG BIOAVAILABILITY; DRUG EFFECT; IN VITRO STUDY; OLIVE; THYME;

THYMUS VULGARIS;

CACO-2; HEPG-2; METABOLISM; OLIVE PHENOLS; THYME; TRANSPORT;

BIOLOGICAL AVAILABILITY; CACO-2 CELLS; DIGESTION; FLAVONOIDS; HEP G2 CELLS; HUMANS; MODELS, BIOLOGICAL; OLEA; PHENOLS; PLANT EXTRACTS; PLANT OILS; THYMUS PLANT;

EID: 84887599357     PISSN: 03088146     EISSN: 18737072     Source Type: Journal    
DOI: 10.1016/j.foodchem.2013.10.075     Document Type: Article

References (26)

1. L.S. Artajo, M.P. Romero, M. Suárez, and M.J. Motilva Partition of phenolic compounds during the virgin olive oil industrial extraction procés European Food Research and Technology 225 5-6 2007 617 625 (Pubitemid 47197968)
2. M.G. Boersma, H. Van der Woude, J. Bogaards, S. Boeren, J. Vervoort, and N.H.P. Cnubben Regioselectivity of phase II metabolism of luteolin and quercetin by UDP-glucuronosyl transferases Chemical Research in Toxicology 15 5 2002 662 670 (Pubitemid 34535121)
3. A. Castell-Auví, M.J. Motilva, A. Macià, H. Torrell, C. Bladé, and M. Pinent Organotypic co-culture system to study plant extract bioactivity on hepatocytes Food Chemistry 122 3 2010 775 781
4. G. Corona, X. Tzounis, M.A. Dessì, M. Deiana, E.S. Debnam, and F. Visioli The fate of olive oil polyphenols in the gastrointestinal tract: Implications of gastric and colonic microflora-dependent biotransformation Free Radical Research 40 6 2006 647 658 (Pubitemid 43832520)
5. U. Gawlik-Dziki Changes in the antioxidant activities of vegetables as a consequence of interactions between active compounds Journal of Functional Foods 4 4 2012 872 882
6. F. Herrmann, and M. Wink Synergistic interactions of saponins and monoterpenes in HeLa cells, Cos7 cells and in erythrocytes Phytomedicine 18 13 2011 1191 1196
7. D.O. Kennedy, A.B. Scholey, and K.A. Wesnes Differential, dose dependent changes in cognitive performance following acute administration of a Ginkgo biloba/Panax ginseng combination to healthy young volunteers Nutritional Neuroscience 4 5 2001 399 412 (Pubitemid 33130413)
8. C. Kohlert, G. Schindler, R.W. März, G. Abel, B. Brinkhaus, and H. Derendorf Systemic availability and pharmacokinetics of thymol in humans Journal of Clinical Pharmacology 42 7 2002 731 737 (Pubitemid 34663530)
9. Y.Y. Lee-Hilz, M. Stolaki, W.J.H. van Berkel, J.M.M.J.G. Aarts, and I.M.C.M. Rietjens Activation of EpRE-mediated gene transcription by quercetin glucuronides depends on their deconjugation Food and Chemical Toxicology 46 6 2008 2128 2134
10. Z. Liu, and M. Hu Natural polyphenol disposition via coupled metabolic pathways Expert Opinion on Drug Metabolism and Toxicology 3 3 2007 389 406 (Pubitemid 47316031)
11. C. Manach, G. Williamson, C. Morand, A. Scalbert, and C. Rémésy Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies The American Journal of Clinical Nutrition 81 Suppl. 1 2005 230S 242S
12. R. Mateos, L. Goya, and L. Bravo Metabolism of the olive oil phenols hydroxytyrosol, tyrosol, and hydroxytyrosyl acetate by human hepatoma HepG2 cells Journal of Agricultural and Food Chemistry 53 26 2005 9897 9905 (Pubitemid 43081195)
13. E. Miro-Casas, M. Covas, M. Farre, M. Fito, J. Ortuño, and T. Weinbrenner Hydroxytyrosol disposition in humans Clinical Chemistry 49 6 2003 945 952 (Pubitemid 36623475)
14. N. Ortega, J. Reguant, M. Romero, A. Macià, and M. Motilva Effect of fat content on the digestibility and bioaccessibility of cocoa polyphenol by an in vitro digestion model Journal of Agricultural and Food Chemistry 57 13 2009 5743 5749
15. J. Pinto, F. Paiva-Martins, G. Corona, E.S. Debnam, M. Jose Oruna-Concha, and D. Vauzour Absorption and metabolism of olive oil secoiridoids in the small intestine British Journal of Nutrition 105 11 2011 1607 1618
16. M. Porrini, and P. Riso Factors influencing the bioavailability of antioxidants in foods: A critical appraisal Nutrition, Metabolism and Cardiovascular Diseases 18 10 2008 647 650
17. L. Rubió, M. Motilva, A. Macià, T. Ramo, and M. Romero Development of a phenol-enriched olive oil with both its own phenolic compounds and complementary phenols from thyme Journal of Agricultural and Food Chemistry 60 12 2012 3105 3112
18. L. Rubió, A. Serra, A. Macià, X. Borràs, M. Romero, and M. Motilva Validation of determination of plasma metabolites derived from thyme bioactive compounds by improved liquid chromatography coupled to tandem mass spectrometry Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences 905 2012 75 84
19. F. Saura-Calixto, J. Serrano, and I. Goñi Intake and bioaccessibility of total polyphenols in a whole diet Food Chemistry 101 2 2007 492 501 (Pubitemid 44349109)
20. S. Scholz, and G. Williamson Interactions affecting the bioavailability of dietary polyphenols in vivo International Journal for Vitamin and Nutrition Research 77 3 2007 224 235 (Pubitemid 47607432)
21. K. Shimoi, N. Saka, R. Nozawa, M. Sato, I. Amano, and T. Nakayama Deglucuronidation of a flavonoid, luteolin monoglucuronide, during inflammation Drug Metabolism and Disposition 29 12 2001 1521 1524 (Pubitemid 33111582)
22. A. Soler, M.P. Romero, A. Macià, S. Saha, C.S.M. Furniss, and P.A. Kroon Digestion stability and evaluation of the metabolism and transport of olive oil phenols in the human small-intestinal epithelial Caco-2/TC7 cell line Food Chemistry 119 2 2010 703 714
23. M. Suárez, A. Macià, M. Romero, and M. Motilva Improved liquid chromatography tandem mass spectrometry method for the determination of phenolic compounds in virgin olive oil Journal of Chromatography A 1214 1-2 2008 90 99
24. J. Terao, K. Murota, and Y. Kawai Conjugated quercetin glucuronides as bioactive metabolites and precursors of aglycone in vivo Food and Function 2 1 2011 11 17
25. S. Veda, K. Platel, and K. Srinivasan Influence of food acidulants and antioxidant spices on the bioaccessibility of β-carotene from selected vegetables Journal of Agricultural and Food Chemistry 56 18 2008 8714 8719
26. G. Williamson, I. Aeberli, L. Miguet, Z. Zhang, M. Sanchez, and V. Crespy Interaction of positional isomers of quercetin glucuronides with the transporter ABCC2 (cMOAT, MRP2) Drug Metabolism and Disposition 35 8 2007 1262 1268 (Pubitemid 47121765)