Differential binding of RhoA, RhoB, and RhoC to protein kinase C-related kinase (PRK) isoforms PRK1, PRK2, and PRK3: PRKs have the highest affinity for RhoB

Biochemistry

Volumn 52, Issue 45, 2013, Pages 7999-8011

  Hutchinson, Catherine L ^a,d   Lowe, Peter N ^b   McLaughlin, Stephen H ^a,c   Mott, Helen R ^a   Owen, Darerca ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b Biomolecular Interactions Consultancy   (United Kingdom)

^c MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^d PHILOCHEM AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINUS; DIFFERENTIAL BINDING; ISOFORMS; N TERMINUS; PROTEIN KINASE; PROTEIN KINASE C; RHO FAMILY; THERMALLY STABLE;

AMINO ACIDS; PROTEINS; THERMODYNAMIC STABILITY;

ENZYMES;

GUANINE NUCLEOTIDE BINDING PROTEIN; HR1A PROTEIN; HR1B PROTEIN; PROTEIN KINASE; PROTEIN KINASE C; PROTEIN KINASE C RELATED KINASE; PROTEIN KINASE C RELATED KINASE 1; PROTEIN KINASE C RELATED KINASE 2; PROTEIN KINASE C RELATED KINASE 3; RHO GUANINE NUCLEOTIDE BINDING PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; RHOC PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CARBOXY TERMINAL SEQUENCE; CIRCULAR DICHROISM; CONTROLLED STUDY; ENZYME SPECIFICITY; LOW TEMPERATURE; MELTING POINT; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; TEMPERATURE DEPENDENCE; THERMOSTABILITY;

CIRCULAR DICHROISM; HUMANS; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN STABILITY; RHO GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; RHOB GTP-BINDING PROTEIN;

EID: 84887572710     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401216w     Document Type: Article

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