A protein kinase, PKN, accumulates in Alzheimer neurofibrillary tangles and associated endoplasmic reticulum-derived vesicles and phosphorylates tau protein

Journal of Neuroscience

Volumn 18, Issue 18, 1998, Pages 7402-7410

  Kawamata, Toshio ^a   Taniguchi, Taizo ^a   Mukai, Hideyuki ^b   Kitagawa, Michinori ^b   Hashimoto, Takeshi ^a   Maeda, Kiyoshi ^a   Ono, Yoshitaka ^b   Tanaka, Chikako ^a  

^a Hyogo Inst Aging Brain Cogn D   (Japan)

^b KOBE UNIVERSITY   (Japan)

Author keywords

Alzheimer's disease; Endoplasmic reticulum; Human brain; Immunocytochemistry; Kinase; Kinase assay; Neurofibrillary tangles; Neuron; Paired helical filaments; Phosphorylation; PKN; PRK1; Tau protein

Indexed keywords

PROTEIN KINASE; TAU PROTEIN;

ADULT; AGED; ALZHEIMER DISEASE; ARTICLE; CLINICAL ARTICLE; ENDOPLASMIC RETICULUM; ENZYME ACTIVITY; FEMALE; GOLGI COMPLEX; HUMAN; HUMAN TISSUE; IMMUNOCYTOCHEMISTRY; MALE; NEUROFIBRILLARY TANGLE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SYNAPSE VESICLE;

EID: 0032530750     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.18-18-07402.1998     Document Type: Article

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