Regulation of hepcidin through GDF-15 in cancer-related anemia

Clinica Chimica Acta

Volumn 428, Issue , 2014, Pages 14-19

  Jiang, Fang ^a   Yu, Wen Jun ^b   Wang, Xue Hua ^a   Tang, Yue Ting ^a   Guo, Li ^a   Jiao, Xiao Yang ^a  

^a THE FIRST AFFILIATED HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

^b THE SECOND AFFILIATED HOSPITAL OF SHANTOU UNIVERSITY MEDICAL COLLEGE   (China)

Author keywords

CRA; GDF 15; Hepcidin; Iron

Indexed keywords

GROWTH DIFFERENTIATION FACTOR 15; HEPCIDIN; IRON; GDF15 PROTEIN, HUMAN;

ADULT; ANEMIA; ARTICLE; BLOOD ANALYSIS; CANCER PROGNOSIS; CANCER STAGING; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DOWN REGULATION; ESOPHAGUS CANCER; FEMALE; HEMATOLOGICAL PARAMETERS; HUMAN; IRON OVERLOAD; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SECRETION; RECTUM CANCER; STOMACH CANCER; TUMOR GROWTH; BLOOD; GASTROINTESTINAL NEOPLASMS; METABOLISM; MIDDLE AGED;

ANEMIA; FEMALE; GASTROINTESTINAL NEOPLASMS; GROWTH DIFFERENTIATION FACTOR 15; HEPCIDINS; HUMANS; MALE; MIDDLE AGED;

EID: 84887564721     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2013.10.015     Document Type: Article

References (38)

1. Caro J.J., Salas M., Ward A., Goss G. Anemia as an independent prognostic factor for survival in patients with cancer: a systemic, quantitative review. Cancer 2001, 91:2214-2221.
2. Khan F.A., Shukla A.N., Joshi S.C. Anaemia and cancer treatment: a conceptual change. Singapore Med J 2008, 49:759-764.
3. Weiss G., Goodnough L.T. Anemia of chronic disease. N Engl J Med 2005, 352:1011-1023.
4. Andrews N.C. Anemia of inflammation: the cytokine-hepcidin link. J Clin Invest 2004, 113:1251-1253.
5. Nemeth E., Tuttle M.S., Powelson J., et al. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 2004, 306:2090-2093.
6. Nemeth E., Ganz T. Hepcidin and iron-loading anemias. Haematologica 2006, 91:727-732.
7. Cheng P.P., Jiao X.Y., Wang X.H., Lin J.H., Cai Y.M. Hepcidin expression in anemia of chronic disease and concomitant iron-deficiency anemia. Clin Exp Med 2011, 11:33-42.
8. Maes K., Nemeth E., Roodman G.D., et al. In anemia of multiple myeloma, hepcidin is induced by increased bone morphogenetic protein 2. Blood 2010, 116:3635-3644.
9. Henry D.H., Dahl N.V., Auerbach M., Tchekmedyian S., Laufman L.R. Intravenous ferric gluconate significantly improves response to epoetin alfa versus oral iron or no iron in anemic patients with cancer receiving chemotherapy. Oncologist 2007, 12:231-242.
10. Ganz T. Hepcidin-a regulator of intestinal iron absorption and iron recycling by macrophages. Best Pract Res Clin Haematol 2005, 18:171-182.
11. Andrews N.C. Forging a field: the golden age of iron biology. Blood 2008, 112:219-230.
12. Babitt J.L., Huang F.W., Wrighting D.M., et al. Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression. Nat Genet 2006, 38:531-539.
13. Welsh J.B., Sapinoso L.M., Kern S.G., et al. Large-scale delineation of secreted protein biomarkers overexpressed in cancer tissue and serum. Proc Natl Acad Sci U S A 2003, 100:3410-3415.
14. Bootcov M.R., Bauskin A.R., Valenzuela S.M., et al. MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci U S A 1997, 94:11514-11519.
15. Ksiaa F., Ziadi S., Amara K., Korbi S., Trimeche M. Biological significance of promoter hypermethylation of tumor-related genes in patients with gastric carcinoma. Clin Chim Acta 2009, 404:128-133.
16. Johnen H., Lin S., Kuffner T., et al. Tumor-induced anorexia and weight loss are mediated by the TGF-beta superfamily cytokine MIC-1. Nat Med 2007, 13:1333-1340.
17. Koopmann J., Buckhaults P., Brown D.A., et al. Serum macrophage inhibitory cytokine 1 as a marker of pancreatic and other periampullary cancers. Clin Cancer Res 2004, 10:2386-2392.
18. Karan D., Holzbeierlein J., Thrasher J.B. Macrophage inhibitory cytokine-1: possible bridge molecule of inflammation and prostate cancer. Cancer Res 2009, 69:2-5.
19. Bauskin A.R., Brown D.A., Kuffner T., et al. Role of macrophage inhibitory cytokine-1 in tumorigenesis and diagnosis of cancer. Cancer Res 2006, 66:4983-4986.
20. Casanovas G., Swinkels D.W., Altamura S., et al. Growth differentiation factor 15 in patients with congenital dyserythropoietic anaemia (CDA) type II. J Mol Med (Berl) 2011, 89:811-816.
21. Finkenstedt A., Bianchi P., Theurl I., et al. Regulation of iron metabolism through GDF15 and hepcidin in pyruvate kinase deficiency. Br J Haematol 2009, 144:789-793.
22. Ramirez J.M., Schaad O., Durual S., et al. Growth differentiation factor 15 production is necessary for normal erythroid differentiation and is increased in refractory anaemia with ring-sideroblasts. Br J Haematol 2009, 144:251-262.
23. Tanno T., Bhanu N.V., Oneal P.A., et al. High levels of GDF15 in thalassemia suppress expression of the iron regulatory protein hepcidin. Nat Med 2007, 13:1096-1101.
24. Schiavetto I., Pedrazzoli P., Basilico V., Siena S. Iron supplementation during treatment with erythropoiesis-stimulating agents for cancer-related anemia. Chemotherapy 2008, 54:417-420.
25. Ganz T. Hepcidin and iron regulation, 10years later. Blood 2011, 117:4425-4433.
26. Macdougall I.C., Malyszko J., Hider R.C., Bansal S.S. Current status of the measurement of blood hepcidin levels in chronic kidney disease. Clin J Am Soc Nephrol 2010, 5:1681-1689.
27. Peters H.P., Rumjon A., Bansal S.S., et al. Intra-individual variability of serum hepcidin-25 in haemodialysis patients using mass spectrometry and ELISA. Nephrol Dial Transplant 2012, 27:3923-3929.
28. Tan M., Wang Y., Guan K., Sun Y. PTGF-beta, a type beta transforming growth factor (TGF-beta) superfamily member, is a p53 target gene that inhibits tumor cell growth via TGF-beta signaling pathway. Proc Natl Acad Sci U S A 2000, 97:109-114.
29. Tamary H., Shalev H., Perez-Avraham G., et al. Elevated growth differentiation factor 15 expression in patients with congenital dyserythropoietic anemia type I. Blood 2008, 112:5241-5244.
30. Theurl I., Finkenstedt A., Schroll A., et al. Growth differentiation factor 15 in anaemia of chronic disease, iron deficiency anaemia and mixed type anaemia. Br J Haematol 2010, 148:449-455.
31. Santini V., Girelli D., Sanna A., et al. Hepcidin levels and their determinants in different types of myelodysplastic syndromes. PLoS One 2011, 6:e23109.
32. Wallin U., Glimelius B., Jirstrom K., et al. Growth differentiation factor 15: a prognostic marker for recurrence in colorectal cancer. Br J Cancer 2011, 104:1619-1627.
33. Mimeault M., Batra S.K. Divergent molecular mechanisms underlying the pleiotropic functions of macrophage inhibitory cytokine-1 in cancer. J Cell Physiol 2010, 224:626-635.
34. Massague J. TGFbeta in cancer. Cell 2008, 134:215-230.
35. Senapati S., Rachagani S., Chaudhary K., Johansson S.L., Singh R.K., Batra S.K. Overexpression of macrophage inhibitory cytokine-1 induces metastasis of human prostate cancer cells through the FAK-RhoA signaling pathway. Oncogene 2010, 29:1293-1302.
36. Brown D.A., Ward R.L., Buckhaults P., et al. MIC-1 serum level and genotype: associations with progress and prognosis of colorectal carcinoma. Clin Cancer Res 2003, 9:2642-2650.
37. Pinnix Z.K., Miller L.D., Wang W., et al. Ferroportin and iron regulation in breast cancer progression and prognosis. Sci Transl Med 2010, 2:43ra56.
38. Torti S.V., Torti F.M. Ironing out cancer. Cancer Res 2011, 71:1511-1514.